PB0092

DATABASE

Click here to access PB0092 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0092	P05186	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	AP-TNAP, APTNAP, HOPS, HPPA, HPPC, HPPI, HPPO, TNALP, TNAP, TNSALP, alkaline phosphatase, biomineralization associated, tissue-nonspecific isozyme	Homo_sapiens	During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).

Domains

Gene Ontology

PF00245 (Alk_phosphatase)

GO:0003824 (enables) catalytic activity GO:0004035 (enables) alkaline phosphatase activity GO:0004427 (enables) inorganic diphosphatase activity GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0016462 (enables) pyrophosphatase activity GO:0016787 (enables) hydrolase activity GO:0016791 (enables) phosphatase activity GO:0016887 (enables) ATP hydrolysis activity GO:0033883 (enables) pyridoxal phosphatase activity GO:0043262 (enables) adenosine-diphosphatase activity GO:0046872 (enables) metal ion binding GO:0050187 (enables) phosphoamidase activity GO:0052732 (enables) phosphoethanolamine phosphatase activity GO:0001501 (involved in) skeletal system development GO:0001649 (involved in) osteoblast differentiation GO:0001958 (involved in) endochondral ossification GO:0003006 (involved in) developmental process involved in reproduction GO:0016311 (involved in) dephosphorylation GO:0030282 (involved in) bone mineralization GO:0031214 (involved in) biomineral tissue development GO:0032496 (involved in) response to lipopolysaccharide GO:0033280 (involved in) response to vitamin D GO:0042822 (involved in) pyridoxal phosphate metabolic process GO:0046677 (involved in) response to antibiotic GO:0051384 (involved in) response to glucocorticoid GO:0071407 (involved in) cellular response to organic cyclic compound GO:0071529 (involved in) cementum mineralization GO:0120162 (involved in) positive regulation of cold-induced thermogenesis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005739 (located in) mitochondrion GO:0005758 (located in) mitochondrial intermembrane space GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0031012 (located in) extracellular matrix GO:0031225 (located in) anchored component of membrane GO:0031966 (located in) mitochondrial membrane GO:0065010 (located in) extracellular membrane-bounded organelle GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF >tr|F1Q5B5|F1Q5B5_DANRE Alkaline phosphatase OS=Danio rerio OX=7955 GN=alpl PE=1 SV=1 MWECGCFLVLWSELSVVWHPWNVKIRKRRLIDNKMKVVQLLILSCLVWEGKTKVQFPEQE KRPDYWRDFAQRSLKDALKLQELNKNIAKNIILFLGDGMGVPTVTAARILKGQLSGQNGE ETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCNTTQ GNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALQSGCKD IARQLFENIPDINVIMGGGRRSMYPKNTPDVEYPGDKKQNGTRKDGRNLVGEWIDRVKEK RGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKKNE RGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFS FGGYTPRGNSIFGLAPTLSDVDQKPFTAILYGNGPGFKLVNGARENVSTVDYQQNNYQAQ SAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQHYIPHVMAYAACIGQNKDHCRTNSGSS SYFSHISPALLFPLLVKWLLC
Selected proteins from model organisms >sp|P05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF >tr|F1Q5B5|F1Q5B5_DANRE Alkaline phosphatase OS=Danio rerio OX=7955 GN=alpl PE=1 SV=1 MWECGCFLVLWSELSVVWHPWNVKIRKRRLIDNKMKVVQLLILSCLVWEGKTKVQFPEQE KRPDYWRDFAQRSLKDALKLQELNKNIAKNIILFLGDGMGVPTVTAARILKGQLSGQNGE ETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCNTTQ GNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALQSGCKD IARQLFENIPDINVIMGGGRRSMYPKNTPDVEYPGDKKQNGTRKDGRNLVGEWIDRVKEK RGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKKNE RGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFS FGGYTPRGNSIFGLAPTLSDVDQKPFTAILYGNGPGFKLVNGARENVSTVDYQQNNYQAQ SAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQHYIPHVMAYAACIGQNKDHCRTNSGSS SYFSHISPALLFPLLVKWLLC >NP_031457.2 alkaline phosphatase, tissue-nonspecific isozyme preproprotein [Mus musculus] MISPFLVLAIGTCLTNSFVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDP SRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCI GANLDHCAWAGSGSAPSPGALLLPLAVLSLRTLF >NP_037191.2 alkaline phosphatase, tissue-nonspecific isozyme precursor [Rattus norvegicus] MILPFLVLAIGTCLTNSFVPEKEKDPSYWRQQAQETLKNALKLQKLNTNVAKNIIMFLGDGMGVSTVTAA RILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDP SRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCI GANLDHCAWASSASSPSPGALLLPLALFPLRTLF >XP_043300839.1 alkaline phosphatase, tissue-nonspecific isozyme [Cervus canadensis] MISPFLVLAIGTCLTNCLVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHN PGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKS VGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDE KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKIL NKNSKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAP MVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI PHVMAYAACIGANRDHCASASSSSSPAPGPLLLLLALLPLGSLF >KAF4013850.1 hypothetical protein G4228_005382 [Cervus hanglu yarkandensis] MISPFLVLAIGTCLTNCLVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHN PGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKS VGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNVIMGGGRKYMFPKNRTDVEYELDEKARGT RLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPK GFFLLVEEGFALVSQGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFG LAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQ NYIPHVMAYAACIGANRDHCASASSSSSPAPGPLLLLLALLPLGSLF >KAB0359714.1 hypothetical protein FD754_003870 [Muntiacus muntjak] MQEDSTCFSSNEKRSATRGSPQKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHH NPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGK SVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELD EKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHAVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKI LNKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLA PMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNY IPHVMAYAACIGANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >KAB0380534.1 hypothetical protein FD755_008318 [Muntiacus reevesi] MLGVGCWSSPKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNH ATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLN LIDIWKSFKPKHKHSHYVWNRTDLLALDPHAVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPRGFFLLV EGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFT AILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAIFAKGPMAHLLHGVHEQNYIPHVMAYAACIG ANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >XP_018083785.1 alkaline phosphatase, tissue-nonspecific isozyme [Xenopus laevis] MVKLGVLLLLGTLSETLTFPEQEKNPNYWRRQAQETLRNALQLQNLNTNIAKNVIMFLGDGMGVSTVTATRILKGQLSGQ PGEETELEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAAAVRGQCNTTKGNEVDSILKWAKQAGKS AGVVTTTRINHATPSAAYAHCVNRDWYSDLEMPKEAVDQGCKDIAWQLMHNVPNIEVIMGGGRKYMFPKNTSDVEYPNDD KSSGTRLDGLNLTQIWLDQKPNKKAARYVWNREQLLSVKPEAVDHLLGLFEPVDMPYELERNTTMDPSLPEMVEMAIKIL GKNPMGFFLLVEGGRIDHGHHEGKAKQALHEAVQMDVAIGVSGNMTSVEDTLTVVTADHSHVFTFGGYTYRGNSIFGLAP APSDLDLKPFTSILYGNGPGYKLVNGQRENVSSVDFSQSNYLAQSAVPLRMETHGGEDVAVFAKGPMAHLLHGVHEQNYI PHVMAYASCIGHNQDHCTSSRGNDGARTSLILLSVLLPIFSLQLFY >XP_010715105.1 intestinal-type alkaline phosphatase-like [Meleagris gallopavo] MRLLVPLTLCLGLWAELGAAVIPVEEEDPTFWNRKAAAALNATLKIEPRMTEAKNLIIFLGDGFGVPSITATRILKGQLK GNLGPETPLALDSFPYVALSKTYTVDRVVPDSAGTATAYLCGVKGNYKTVGLSAAARYGQCNTTKGNEVISVLERARNAG KAVGIVTTSRVQHASPSGTYAHVVDRNWYADASMPAEAIAEGCKDIAWQLVHNVDINVILGGGRIYMTPAGTPDPEYPEY SSENGIRNDGQNLIDMWLSKQQGARYVWNRTEMLAAAADPSVTYLMGLFEPMDMKYEMVHNSTLDPSLTEMTEAAINVLS RNPNGFYLFVEGGRIDHGHHEGMAQRALTEAVEFDTAIERAGELLDEADTLTVVTADHSHVFSFGGYTLRGTSIFGLAPL QATDQKNYTSILYGNGPGYPGATRPDVNSSIAEEFSYMQQAAVPLSSETHGGEDVAILAKGPMAYLFHGVQEQNYIAHAM AYAACLEPYENCRQRTNAAPSAHLTPLALLLPALLLSLFH >NP_990691.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Gallus gallus] MKAFLLTLLAQLCSASLVPEREKDPEYWRQQAQETLRDALRLQHLNQNVAKNLILFLGDGMGVSTVTAAR ILKGQLQHRKGEESLLEMDKFPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNT TKGQEVTSILRWAKDEGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPLDALEGGCKDIARQLVDN IPDIEVILGGGRKYMFPKNTSDVEYPQEERHRGTRLDGKDLVQAWHDTKPAGKVAKYVWHRRELLALNVS RVDFLLGLFEPGDMVYELDRNNETDPSLSEMVAVAIRMLQKNPRGFFLLVEGGRIDHGHHEGKAKQALHE AVELDRAVGLAGRLTSPRDTLSVVTADHSHVFTFGGYTPRGNPIFGLAPMQSDVDRKPFTSILYGNGPGY KIVGGERENVSAVDFAHANYQAQAAVPLRQETHGGEDVAVFARGPMAHLLHGVDEQNYIPHAMAYAACIG PNRAHCSSAARPAATATLLPVLLLLLLLC >XP_038513640.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Canis lupus familiaris] MISLFLVLVIGTCLTNSLVPEKEKDPKYWRDQAQQTLKYALRLQNLNTNVAKNVIMFLGDGMGVSTVTAT RILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NVKDIEVIMGGGRKYMFPKNRTDVEYEMDEKSRGTRLDGLNLIDIWKNFKPRHKHSHYVWNRTELLALDP YTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEIAIKILSKNPRGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGKAGVMTSLEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACI GANQDHCASASSAGGPSSPGPLLLLLALLPVGILF >XP_016811306.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan troglodytes] MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALKLQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACI GANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >NP_001036028.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Felis catus] MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQQTLKNALRLQKLNTNVVKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCN TTQGNEVTSILRWAKDSGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NVRDIEVIMGGGRKYMFPKNRTDVEYEMDEKARGTRLDGLNLVDIWKSFKPRHKHSHYVWNRTELLTLDP YGVDYLLGLFEPGDMQYELNRNSTTDPSLSEMVEIAIKILSKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGRAGAMTSVEDTLTIVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTSILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACI GANLDHCASASSAGGPSPGPLFLLLALPSLGILF >XP_020953340.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sus scrofa] MLQFENHYAGRLNSGLEHQLTPDHWAAHPLPPPPSYLWAPERKQVLECTMISLFLVLAIGSCLTNSLVPE KEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHKPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQGNEVTSILRWAKDAGKSV GIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALIQGCKDIAYQLMHNIRDIEVIMGGGRKYMFPKNR TDVEYEMDEKARGTRLDGLNLIDVWKSFKPRHKHSHYIWNRTELLALDPHTVDYLLGLFEPGDMQYELNR NNVTDPSLSEMVEMAIRILIKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIEQAGSMTSVEDT LTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHDNY QAQSAVPLRHETHGGEDVAIFARGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPL LLLLALLPLGILF >XP_017201978.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Oryctolagus cuniculus] MSACAVQPWVSPSVSLSLVKRGEETPGPQARLRPLTGACLRSRGVSEVSHWRALLRVQASRPSAVRCGGS ATRGRTDCPSLCTEQEKDPKYWRDQAQQTLKNALGLQKLNTKVAKNVILFLGDGMGVSTVTAARILKGQL HHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEV TSILRWAKDAGKAVGIMITTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRNIDV IMGGGRKYMYPKNKTDVEYEVDEKARGTRLDGLDLVDIWRSFKPRHKHSHFVWNRTELLALDPYTVDYLL GLFEPGDMQYELNRNNITDPSLSEMVEVAIKILKKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDR AIGKAGTMTSLEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGE RENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHC AWASSAGSLAPGALLLPLTLLPLSVLF >XP_002811389.2 alkaline phosphatase, tissue-nonspecific isozyme [Pongo abelii] MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYEIDEKARGTRLDGLDLVDTWKSFKPRHKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACI GANLDHCASASSAGSLAAGPLLLALALFPLSVLF >XP_003813996.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan paniscus] MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALKLQKLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACI GANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >XP_012008208.3 alkaline phosphatase, tissue-nonspecific isozyme [Ovis aries] MISPFLVLAIGTCLASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLVDIWKSFKPKHKHSHYVWNRTDLLALDP HTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACI GANRDHCASASSSSSPSPGPLLLLLALLPLGGLF >XP_004024892.1 alkaline phosphatase, tissue-nonspecific isozyme [Gorilla gorilla gorilla] MISPFLVLAIGTCLSNSLVPEKEKDPKYWRDQAQETLKYALKLQRLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHKHSHFIWNRTELLTLDP HNVDYLLGLFEPGDMQYELNRNNMTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACI GANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >XP_004069357.1 alkaline phosphatase, tissue-nonspecific isozyme [Oryzias latipes] MLSALLIICSCLSVRSSGKPMFPENEKSPAFWNNGAQKTLKEALSTQELNKNKAKNLILFLGDGMGVPTV TAARILKGQLNGQSGEEYQLEMDKFPFVSLSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRS QCNTTKGNEVTSILKWAKDAGKSVGIVTTTRINHATPSAAYAHSVDRDWYSDNEMPSEALQAGCKDIARQ LFENIPNIDVIMGGGRKYMFPKNMSDVDYPGVAKYNGVRNDGRNLVQEWIDRMKDQGGHYVWNKQQLLSL NPKKTSYLLGLFGPVDLPYDLERNADSDPSLTQMVEVAIKVLQNNPKGFYLLVEGGRIDHGHHEGKAKQA LYEAVEMDRAIGRADLLTSAQDTLTVVTADHSHVFTFGGYTRRGNTIFGLAPMVSDVDHKPFTSILYGNG PGYKLVGGARENVSTVDFAENNYKAQSAVPLTSETHGGEDVAVFAKGPLAHLLHGVHEQNFIPHVMAYAA CIGQNRGHCPSGGTAALRPVFSSMAAVLTVTLLLC >XP_021137822.1 LOW QUALITY PROTEIN: alkaline phosphatase, tissue-nonspecific isozyme [Columba livia] MKALLLLLLAPLCTPSLIPEREKDPEFWRRQAQXFFQRLNQNVAKNLILFLGDGMGVSTVTAARILKGQL QNRKGEESLLEMDKFPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTKGQEV TSILRWAKDSGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPPDALEGGCKDIARQLVENIPDIEV GGGQGHQEQGQGHGSPSTCGTGGGGALSRVDFLLGLFEPGDMVYELDRNNETDPSLTEMVAVAIRMLQKN PRGFFLLVEGGRIDHGHHEGKAKQALHEAVELDRAIGLATRVTSPQDTLSVVTADHSHVFTFGGYTPRGN PIFGLAPMQSDVDRKPFTSILYGNGPGYKIVAGERENVSAVDFAHADYQAQSAVPLRQETHGGEDVAVFA RGPMAHLLHGVHEQNYIPHAMAYAACIGANHSALGVQMVL >XP_017910699.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Capra hircus] MISPFLVLAIGTCLASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHHPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDP HTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGQAGAMTSIEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACV GANRDHCASASSSGSPSPGPLLLPLALLPLGGLF >XP_006023251.1 alkaline phosphatase, tissue-nonspecific isozyme [Alligator sinensis] MKALLLVLLIELCLGSLFPEKEKNPKYWRDQAQQTLRNALKLQKLNTNVAKNIIMFLGDGMGISTVTAAR ILKGQLQHMQGEETMLEMDKFPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNT TAGNEVTSILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPLEAIQQGCKDIAQQLFEN IPNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKEKKPKDKNAHYVWNRQDLMALNLD KVDFLLGLFEPVDLMYELDRNNQTDPSLTEMVEVAIKILQKNPKGFFLLVEGGRIDHGHHEGKAKQALHE TVEMDRAIGLAGRLTKENDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMQSDVDKKPFTSILYGNGPGY KLIGGGRENVSTVNFAHANYQAQSAVPLRQETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACVG PNTNHCRSGAARGTGVALPLLSTFASLFILLCLF >XP_006261757.2 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Alligator mississippiensis] MKALLLVLLIELCLGSLFPEKEKNPKYWLDQAQQTLRNALKLQKLNTNVAKNIIMFLGDGMGISTVTAAR ILKGQLQHMQGEETMLEMDKFPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNT TAGNEVTSILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPPEAIQQGCKDIAQQLFEN IPNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKEKKPKDKNAHYVWNRQDLMALNLD KVDFLLGLFEPVDLMYELDRNNQTDPSLTEMVEVAIKILQKNPKGFFLLVEGGRIDHGHHEGKAKQALHE TVEMDRAIGLAGRLTKENDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMQSDVDKKPFTSILYGNGPGY KLIGGGRENVSTVDFAHANYQAQSAVPLRQETHGGEDVAIFAKGPMAHLLHGVHEQNYIPHVMAYAACVG PNTNHCRSGAARGTGVALPLLSTFASLFILLCLF >XP_015813883.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Nothobranchius furzeri] MYAAGLLIACSCLISESYQRAPFPEQEKDPTFWNTWAQKTLKNALTLQTLNTNKAKNVILFLGDGMGVPT VTATRILKGQLSGHYGEETQLEMDKFPFVSLAKTYNTDAQVPDSAGTATAYLCGVKANEGTLGVSAAAVR SQCNTTKGNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDNEMPAEALMHGCKDIAR QLFENIPNIDVIMGGGRKFMYPQNTSDVEYPTQPKMSGTRKDGRNLVQEWIDKMKDKKGNYVWNKQQLLS LNPNNVDYLLGLFEPSELAYELERNNDSDPSLTEMVDVAIKVLKKNQNGFYLLVEGGRIDHGHHEGKAKL ALYDAVEMDRAIGRADLLTSIHETLTVVTADHSHVFTFGGYTLRGNSIFGLAPKVSDADQKPFTAISYGN GPGYKIVNGGRENISTVNYESSHYQAQAAVPLLSETHGGDDVAVFAKGPMAHLLHGIHEQNYIPHVMAYA ACIGQNQNHCMSSGGTVGLQPAFSSMASVLAVTRFLW >XP_019837576.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Bos indicus] MISPFLLLAIGTCLASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDP HSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACI GANRDHCASASSSGSPSPGPLLLLLALLPLGSLFCGPGARAPTSP >XP_020730180.1 alkaline phosphatase, tissue-nonspecific isozyme [Odocoileus virginianus texanus] MIPPFLVLAIGTCLTSCLVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAA RILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCN TTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMH NVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLDLIDIWKSFKPKHKHSHYVWNRTDLLALDP HTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPKGFFLLVEGGRIDHGHHEGKAKQALH EAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACI GANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >XP_030275039.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sparus aurata] MPPNAARPRGDGGPASSASQKWHVMSRGTRQPHRDDNMKMTSLLLIVCSCLIAGSVGRPQFPEKEKDPKY WNAGAQMTLKNALTLQTLNKNKAENLILFLGDGMGVPTVTAARILKGQLSGQSGEETQLEMDKFPFVSLA KTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTEGNEVTSILRWAKDAGKSVGIVTTTR VNHATPSAAYAHSVDRDWYSDNEMPAEALQAGCKDIARQLFENIPNIDVIMGGGRKYMFPKNRSDVEYPG VAKHSGTRKDGRDLVQEWIDKTKDKKGHYVWNKKQLLSLNPNNVDYLLGLFEPGDLPYDLERNSETDPSL TEMVEVAIKILRKNPSGFYLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGRASLLTSIHDTLTIVTADH SHMFNFGGYTPRGNTIFGLAPMLSDADQKPFTSILYGNGPGYKLVNGARENVSTIDYQENNYQAQAAVPL SMETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAGCIGQNREHCLSRSGTAGLHPVLSTIATLFTV TRLLC >XP_040190415.1 alkaline phosphatase, tissue-nonspecific isozyme [Rana temporaria] MIITLWTLLFVVKLSTSVSFPEKEKNPEYWRKQAQDTLRLALNLQDLNRNVAKNTIMFLGDGMGVPTVTA TRILKGQLAGQPGEETQLEMDKFPHVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAASVRGQC NTTKGNEVASILKWAKDAGKSVGVVTTTRVNHATPSAAYAHCVNRDWFSDNEMPKEAVAEGCKDIAWQLM HNIADIEVIMGGGRKYMFPKNTPDIEYPKEEKANGTRLDGLNLTKIWMENKPRNKIARYVWNRDQLLGLK PEETDYVLGLFEPSDMVYELDRNTSTEPSLVEMVKVAISILKKNPKGFFLLVEGGRIDHGHHEGKAKHAL HEAIQMDIAIGLAGEMTSTEDTLTVVTADHSHVFTFGGYTHRGNSIFGLAPALSDLDSKPYTSILYGNGP GYKLVNGSRGNVSTVDYAQPNYQAQSAVPLKQETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHAMAYATC IGQNRDHCNSRSSGHSFKTSVTMVSSALSVLAALQLF >XP_039258402.1 alkaline phosphatase-like [Styela clava] MYLLLYQVLLFISIVSGKRDIEAEKKPSFWKANAKKELEAALDAQRLNTNVAKNVIIFLGDGMGISTVTAGRILKGQLRG ESGEETKLTMETLPHAALSKTYSANAQVSDSAATATAYLCGVKSNWYTLGVNAATVYDNCESIKGNGVESVLVDSYKAGK SAGVVTTTRIQHATPGATYAHAPNREWYGDADLTEEAKQNGCKDIALQFYEASDMITVALGGGRKYMQPENTTDYEYPKM SNSRKDGKDLIQMWKNKMASAGFESKFVWNKKQFDDVDVESTDRLLGLFEPSDMHYDAERSKDGEGEPSIAEMTSKAIQM LQKNDKGYFLLVEGGRIDHGHHSGNAYLSLHDVVAFDNAIAEALRMTSQEDTMIIVTADHSHVFTIGGKSIRGNNIFGLQ PDVSNPVNALDNKPYTTLIYANGPGFHGEYFVNAMGYNEPIIKNGSSREDLTNVNTTAPDYLQQSAIPLDSETHGGEDVA IFASGPMAHLFHGVHEQSYIAYVMRYASCVGPDQGHCMKEDDIGHIEYLGSSISVSTANSTLRIQFIFLIILSVVIFILL LLLIRNSLNSKRKANYKESGKAPDVPLSTRP >XP_038075941.1 alkaline phosphatase-like [Patiria miniata] MRFTGWTMIWLLLCLAFAGCTWAQNAQFWNIQAQDTLQKALTREASLNRNVAKNIVFFLGDGMGVSTVTAARIMKGQQAG MTGEETVLSWEKFSSVALSKTYNTNRQVPDSAGTATAYFCGVKTKEEMIGVDDQAVLGDCQSSLNAAVDSVMTDAEKEGK ATGFVTTARVTHATPACLYAHSPDRNWENNADVPEAEAALGCTDIAHQLVTLGQNIKVIMGGGRREMLPDNFTDYEYSAL TGQRTDGRNLVDEWLASKDAQTSHFVWNLDQFNEVDPENTEYLLGLFESSHMQYEGERTNEPSIAEMTEKAIRILQKDTD GFFLMVEAGRIDHAHHDGFAGNALNDTVAFDAAVAKAVELTNEEDTLIIVTADHSHVMTLGGYQSRGNPILGLVDLSSAE DDLPFTSIGYTNGPGGIAEQVSYKLFGRRRNLTDNDTENPRFTQPGIVPRESETHGGEDVAIYANGPMSHLFHGVHEQNY IAHVVRYAACLGNRQHCDEYVAPCGSGASSVPSGGVTMITVLLNLWLALVLPK >XP_030842761.1 alkaline phosphatase [Strongylocentrotus purpuratus] MTPYLLLPLFLSALLSLATSQDAAFWNNQAQRTLEEALNLRQNQGIAKNVIFFLGDGMDITTTTAARILRGQMDGETGEE GSLAWDDFPHVALSKTYNTDQQVADSAGTATAFLCGVKAKAGTLGIDDGAERGSCASVAGTEVDSVLVEANRAGKATGLI STARVTHATPAAAYAHSAERDWENNDRVPDEEADEGCIDIARQLVEENNFINLILGGGRVNFLPNTTLDPEYGDENTTGY RTDGLNLIEQWLSVKGSSAQYVWNKTALDRVDLSSTEYLLGLFEPSHMKYEVDRLNDTAGEPSIAEMTELAINMLSSDED GFFLMVESGRIDHGHHMGVAHKALTDTIAFHEAVAKAIEMTDSDDTLILVTADHGHAFAIGGYASRGNPIFGYDDRNNGS DDKPYLTLSYANGPGGIALADSYINTGARPNHYTSDYDSEGFVQDATVPAISETHGGADVAIYAHGPWSHLFHGTHEQNY IPHVVRYAACYSDSEDNACTRATEEPPMCTGSAHPTVLARCASVILPLISLIFLWISM >XP_031549411.1 alkaline phosphatase-like [Actinia tenebrosa] MTNNLVLLLYLLLPWCFSIVSTTFAASALNNEAKNEWFQSGVDLIKDNLRLRENRQTAKNVIMFLGDGMGPTTVTSARIL EGQLRGETGEENALSWEKFPWSAFSKTYNTDQQVADSAGTATAYLNGVKTRAGVIAVDETVRKGYCADMTEATKVKSILT LAEEAGMSTGIVTTTRITHASPSVLYSYSPDRNWENDMKMKSKAKDDSSSCKDIALQLAEYSVGDGIEVLFGGGRQNFYP KNQSDPEYPQLQGKRGDGRNLVNEWLANNPDSQFLWNKTAFDALDVKTVKHVMGLFEYSHMQYEVERVNDTGGEPSIAEM TAKAIEILSKNPKGFFLFVEGGRIDHGHHGGKAVKALMDTVAMAKAVDKAVSIVGEEETLMITTADHSHVLSIAGYPRRG NPIFELVVEKDNATSVGKDGLPYTTLGYANGPGGLSLNESRQNLTGVNTADKDFLQQALVKTSSESHAGEDVGIYATGPG AYLFHGVVEQHYIFHVMDHALCLTSSKQDKCFKHGMRGGEVVTRGPPRSGSAPLIPLAMLIIFVSFVVAMF >XP_006566949.1 alkaline phosphatase isoform X1 [Apis mellifera] MWRYLQYIIFGLTVVLLTIHEIVFVQAGEQERVAWYEGATRAIEGRIRASAATWSAPPAGGVARGVVLFVGDGMGMSTLT AARILSGQRRGNTGEEAQLAWDSFPAVALARTYNMDAQVGESSACATALLCGVKANYETVGLDSSARFENCYSSFDARVP SLINWAQEQGKSTGLVTTTRVTHATPAALYAHAASRYWEDDGKVPPAARTSCKDIARQLLEDEPGRNINVILGGGRRHFV SKVTQDPEEPDKEGRRLDGRNLIEEWSRNHRLRNVAAKYVANKEQFESVDPRKVNHLLGLFSYSHMDFDVDRNTNGSGDP SLAEMTIKALRILAKNPEGYFLFVEGGRIDHAHHYNNAYRALDETLALEEAVRAVMKEVDLSETLLVVTADHSHVLTLGG LATHRGNPIFGSDSKMSDVDGQPYTTLLYSNGPGYTQPRNILREAGKDSIQTAGVPRAWATHGGEDVPVFAIGPLANVLF SGSIDQSYIPHAISYASCLGQHATRCSRDPASSNDTINVPISCPSAEPNSAAISSDVMNDQARNPPAKSAASTLLLLAPA APLLPLVLAALPSPSTLRGTS >NP_649315.1 alkaline phosphatase 1, isoform A [Drosophila melanogaster] MRALRFFAALALQLTACSSQYKYGPEQSWDLDSISELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTV TAGRIFDGQLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQN RLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQNPGNCPDIAQQLIDGDVGKRLRVVMGGG TIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNNDAQNTDFLLGLFNASHLAYHMDDSIDTPTLP EMTAAAINVLSRDPNGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPD VNNSIVGLNSELSNVDQLPYTSISYANGPAYERFYKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAH GPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPKARYSP
Mafft alignment of selected proteins >sp|P05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSL-----------VPEKEKDPKYWRDQAQETL KYALELQK------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKS-FKPRY KHSHFIWNRTELLTLDPH-NVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVVVAIQIL RKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMLSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAH-L LHGVHEQNYVPHVMAYAACIGANLGH-CAPAS---------------SAGSL-AAGPLLL A----------------------LALYPLSVLF--------------------------- ----------- >tr|F1Q5B5|F1Q5B5_DANRE Alkaline phosphatase OS=Danio rerio OX=7955 GN=alpl PE=1 SV=1 MWECGCFLVL----------------------------------WSELSVVWHPWNVKIR K-RRLIDNKMKVVQLLILSCLVWEGKTKVQ-----------FPEQEKRPDYWRDFAQRSL KDALKLQE------LNKNIAKNIILFLGDGMGVPTVTAARILKGQLSGQNGEETQLEMDK FPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCNTTQ--GNEVTS ILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEAL--QSG-CKDIAR QLFENI--PDINVIMGGGRRSMYPKNTPDVEYPGDKKQNGTRKDGRNLVGEWID--RVKE KRGFYVWNKKDLLSLNPN-NVDYLLGLFEPADLNYELERNT--ENDPSLTEMVDVAIKIL KKNERGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTL TVVTADHSHVFSFGGY-TPRGNSIFGLAPTLSD-----VDQKPFTAILYGNGPGFK---- -----------LVNGARENVSTVDYQQNNYQAQSAVPLRMETHGGEDVAIFSKGPMAH-L LHGVQEQHYIPHVMAYAACIGQNKDH-CRTNS---------------GSSSYFSHISPAL L----------------------FPLLVKWLLC--------------------------- ----------- >NP_031457.2 alkaline phosphatase, tissue-nonspecific isozyme preproprotein [Mus musculus] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSF-----------VPEKERDPSYWRQQAQETL KNALKLQK------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKS-FKPRH KHSHYVWNRTELLALDPS-RVDYLLGLFEPGDMQYELNRNN--LTDPSLSEMVEVALRIL TKNLKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYASCIGANLDH-CAWAG---------------SGSAP-SPGALLL P----------------------LAVLSLRTLF--------------------------- ----------- >NP_037191.2 alkaline phosphatase, tissue-nonspecific isozyme precursor [Rattus norvegicus] ------------------------------------------------------------ --------MILPFLVLAIGTC----LTNSF-----------VPEKEKDPSYWRQQAQETL KNALKLQK------LNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKS-FKPRH KHSHYVWNRTELLALDPS-RVDYLLGLFEPGDMQYELNRNN--LTDPSLSEMVEVALRIL TKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYASCIGANLDH-CAWAS---------------SASSP-SPGALLL P----------------------LALFPLRTLF--------------------------- ----------- >XP_043300839.1 alkaline phosphatase, tissue-nonspecific isozyme [Cervus canadensis] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNCL-----------VPEKEKDPKYWREQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIKIL NKNSKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-APGPLLL L----------------------LALLPLGSLF--------------------------- ----------- >KAF4013850.1 hypothetical protein G4228_005382 [Cervus hanglu yarkandensis] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNCL-----------VPEKEKDPKYWREQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHN-------VIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIKIL NKNPKGFFLLVEEGFALVSQGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-APGPLLL L----------------------LALLPLGSLF--------------------------- ----------- >KAB0359714.1 hypothetical protein FD754_003870 [Muntiacus muntjak] ------------------------------------------------------------ --------------MQEDSTC----FSSNEK----RSATRGSPQKEKDPKYWREQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-AVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIKIL NKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-SPGPLLL L----------------------LALLPLGSLF--------------------------- ----------- >KAB0380534.1 hypothetical protein FD755_008318 [Muntiacus reevesi] ------------------------------------------------------------ --------------MLGVG-C----W---------------SSPKEKDPKYWREQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-AVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIKIL NKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAIFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-SPGPLLL L----------------------LALLPLGSLF--------------------------- ----------- >XP_018083785.1 alkaline phosphatase, tissue-nonspecific isozyme [Xenopus laevis] ------------------------------------------------------------ --------MVKLGVLLLLGTL----SETLT-----------FPEQEKNPNYWRRQAQETL RNALQLQN------LNTNIAKNVIMFLGDGMGVSTVTATRILKGQLSGQPGEETELEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAAAVRGQCNTTK--GNEVDS ILKWAKQAGKSAGVVTTTRINHATPSAAYAHCVNRDWYSDLEMPKEAV--DQG-CKDIAW QLMHNV--PNIEVIMGGGRKYMFPKNTSDVEYPNDDKSSGTRLDGLNLTQIWLD-QKPNK KAARYVWNREQLLSVKPE-AVDHLLGLFEPVDMPYELERNT--TMDPSLPEMVEMAIKIL GKNPMGFFLLVE--------GGRIDHGHHEGKAKQALHEAVQMDVAIGVSGNMTSVEDTL TVVTADHSHVFTFGGY-TYRGNSIFGLAPAPSD-----LDLKPFTSILYGNGPGYK---- -----------LVNGQRENVSSVDFSQSNYLAQSAVPLRMETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYASCIGHNQDH-CTSSR---------------GNDGA-RTSLILL S----------------------VLLPIFSLQLFY------------------------- ----------- >XP_010715105.1 intestinal-type alkaline phosphatase-like [Meleagris gallopavo] M----------------------------------------------------------- ------RLLVPLTLCLGLWAE----LGAAV-----------IPVEEEDPTFWNRKAAAAL NATLKIEP-------RMTEAKNLIIFLGDGFGVPSITATRILKGQLKGNLGPETPLALDS FPYVALSKTYTVDRVVPDSAGTATAYLCGVKGNYKTVGLSAAARYGQCNTTK--GNEVIS VLERARNAGKAVGIVTTSRVQHASPSGTYAHVVDRNWYADASMPAEAI--AEG-CKDIAW QLVHNV---DINVILGGGRIYMTPAGTPDPEYPEYSSENGIRNDGQNLIDMWLS----KQ QGARYVWNRTEMLAAAADPSVTYLMGLFEPMDMKYEMVHNS--TLDPSLTEMTEAAINVL SRNPNGFYLFVE--------GGRIDHGHHEGMAQRALTEAVEFDTAIERAGELLDEADTL TVVTADHSHVFSFGGY-TLRGTSIFGLAPLQA------TDQKNYTSILYGNGPGYP---- -------------GATRPDVNSSIAEEFSYMQQAAVPLSSETHGGEDVAILAKGPMAY-L FHGVQEQNYIAHAMAYAACLEPYEN--CRQRTN--------------AAPSA-HLTPLAL L----------------------LPALLLSLFH--------------------------- ----------- >NP_990691.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Gallus gallus] ------------------------------------------------------------ ---------MKAFLLTLLAQL----CSASL-----------VPEREKDPEYWRQQAQETL RDALRLQH------LNQNVAKNLILFLGDGMGVSTVTAARILKGQLQHRKGEESLLEMDK FPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTK--GQEVTS ILRWAKDEGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPLDAL--EGG-CKDIAR QLVDNI--PDIEVILGGGRKYMFPKNTSDVEYPQEERHRGTRLDGKDLVQAWHD-TKPAG KVAKYVWHRRELLALNVS-RVDFLLGLFEPGDMVYELDRNN--ETDPSLSEMVAVAIRML QKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVELDRAVGLAGRLTSPRDTL SVVTADHSHVFTFGGY-TPRGNPIFGLAPMQSD-----VDRKPFTSILYGNGPGYK---- -----------IVGGERENVSAVDFAHANYQAQAAVPLRQETHGGEDVAVFARGPMAH-L LHGVDEQNYIPHAMAYAACIGPNRAH-CSSAAR--------------PAATA-TLLPVLL L---------------------------LLLLC--------------------------- ----------- >XP_038513640.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Canis lupus familiaris] ------------------------------------------------------------ --------MISLFLVLVIGTC----LTNSL-----------VPEKEKDPKYWRDQAQQTL KYALRLQN------LNTNVAKNVIMFLGDGMGVSTVTATRILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYEMDEKSRGTRLDGLNLIDIWKN-FKPRH KHSHYVWNRTELLALDPY-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEIAIKIL SKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGKAGVMTSLEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANQDH-CASAS---------------SAGGPSSPGPLLL L----------------------LALLPVGILF--------------------------- ----------- >XP_016811306.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan troglodytes] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSL-----------VPEKEKDPKYWRDQAQETL KYALKLQK------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTS ILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKS-FKPRH KHSHFIWNRTELLTLDPH-NVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVVVAIQIL RKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMLSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CAPAS---------------SAGSL-AAGPLLL A----------------------LALFPLSVLF--------------------------- ----------- >NP_001036028.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Felis catus] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSL-----------VPEKEKDPKYWRDQAQQTL KNALRLQK------LNTNVVKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQ--GNEVTS ILRWAKDSGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--RDIEVIMGGGRKYMFPKNRTDVEYEMDEKARGTRLDGLNLVDIWKS-FKPRH KHSHYVWNRTELLTLDPY-GVDYLLGLFEPGDMQYELNRNS--TTDPSLSEMVEIAIKIL SKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGRAGAMTSVEDTL TIVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTSILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CASAS---------------SAGGP-SPGPLFL L----------------------LALPSLGILF--------------------------- ----------- >XP_020953340.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sus scrofa] M------------LQFENHYAGRLNSGLEHQLTPDHWAA--HPLPPPPSYLWAPERKQVL E-----CTMISLFLVLAIGSC----LTNSL-----------VPEKEKDPKYWRDQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHKPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--IQG-CKDIAY QLMHNI--RDIEVIMGGGRKYMFPKNRTDVEYEMDEKARGTRLDGLNLIDVWKS-FKPRH KHSHYIWNRTELLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIRIL IKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIEQAGSMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHDNYQAQSAVPLRHETHGGEDVAIFARGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSGSP-SPGPLLL L----------------------LALLPLGILF--------------------------- ----------- >XP_017201978.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Oryctolagus cuniculus] MSACAVQPWVSPSVSLSLVKRGEETPGPQARLRPLTGACLRSRGVSEVSHWRALLRVQAS R-----PSAVRCGGSATRGRT----DCPSL-----------CTEQEKDPKYWRDQAQQTL KNALGLQK------LNTKVAKNVILFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKAVGIMITTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RNIDVIMGGGRKYMYPKNKTDVEYEVDEKARGTRLDGLDLVDIWRS-FKPRH KHSHFVWNRTELLALDPY-TVDYLLGLFEPGDMQYELNRNN--ITDPSLSEMVEVAIKIL KKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGKAGTMTSLEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CAWAS---------------SAGSL-APGALLL P----------------------LTLLPLSVLF--------------------------- ----------- >XP_002811389.2 alkaline phosphatase, tissue-nonspecific isozyme [Pongo abelii] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSL-----------VPEKEKDPKYWRDQAQETL KYALELQK------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYEIDEKARGTRLDGLDLVDTWKS-FKPRH KHSHFIWNRTELLTLDPH-NVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVVVAIQIL RKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMLSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CASAS---------------SAGSL-AAGPLLL A----------------------LALFPLSVLF--------------------------- ----------- >XP_003813996.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan paniscus] ------------------------------------------------------------ --------MISPFLVLAIGTC----LTNSL-----------VPEKEKDPKYWRDQAQETL KYALKLQK------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTS ILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKS-FKPRH KHSHFIWNRTELLTLDPH-NVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVVVAIQIL RKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMLSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CAPAS---------------SAGSL-AAGPLLL A----------------------LALFPLSVLF--------------------------- ----------- >XP_012008208.3 alkaline phosphatase, tissue-nonspecific isozyme [Ovis aries] ------------------------------------------------------------ --------MISPFLVLAIGTC----LASSL-----------VPEKEKDPKYWRDQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETKLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLVDIWKS-FKPKH KHSHYVWNRTDLLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIRIL NKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-SPGPLLL L----------------------LALLPLGGLF--------------------------- ----------- >XP_004024892.1 alkaline phosphatase, tissue-nonspecific isozyme [Gorilla gorilla gorilla] ------------------------------------------------------------ --------MISPFLVLAIGTC----LSNSL-----------VPEKEKDPKYWRDQAQETL KYALKLQR------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--RDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKS-FKPRH KHSHFIWNRTELLTLDPH-NVDYLLGLFEPGDMQYELNRNN--MTDPSLSEMVVVAIQIL RKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMLSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAH-L LHGVHEQNYIPHVMAYAACIGANLDH-CAPAS---------------SAGSL-AAGPLLL A----------------------LALFPLSVLF--------------------------- ----------- >XP_004069357.1 alkaline phosphatase, tissue-nonspecific isozyme [Oryzias latipes] ------------------------------------------------------------ ---------MLSALLIICSCLSVRSSGKPM-----------FPENEKSPAFWNNGAQKTL KEALSTQE------LNKNKAKNLILFLGDGMGVPTVTAARILKGQLNGQSGEEYQLEMDK FPFVSLSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTK--GNEVTS ILKWAKDAGKSVGIVTTTRINHATPSAAYAHSVDRDWYSDNEMPSEAL--QAG-CKDIAR QLFENI--PNIDVIMGGGRKYMFPKNMSDVDYPGVAKYNGVRNDGRNLVQEWID--RMKD QGGHYVWNKQQLLSLNPK-KTSYLLGLFGPVDLPYDLERNA--DSDPSLTQMVEVAIKVL QNNPKGFYLLVE--------GGRIDHGHHEGKAKQALYEAVEMDRAIGRADLLTSAQDTL TVVTADHSHVFTFGGY-TRRGNTIFGLAPMVSD-----VDHKPFTSILYGNGPGYK---- -----------LVGGARENVSTVDFAENNYKAQSAVPLTSETHGGEDVAVFAKGPLAH-L LHGVHEQNFIPHVMAYAACIGQNRGH-CPSG----------------GTAAL-RPVFSSM A----------------------AVLTVTLLLC--------------------------- ----------- >XP_021137822.1 LOW QUALITY PROTEIN: alkaline phosphatase, tissue-nonspecific isozyme [Columba livia] ------------------------------------------------------------ ---------MKALLLLLLAPL----CTPSL-----------IPEREKDPEFWRRQAQXF- -----FQR------LNQNVAKNLILFLGDGMGVSTVTAARILKGQLQNRKGEESLLEMDK FPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTK--GQEVTS ILRWAKDSGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPPDAL--EGG-CKDIAR QLVENI--PDIEV--GGGQGHQ-----EQGQGHGSPSTCGTGGGGA-------------- ----------------LS-RVDFLLGLFEPGDMVYELDRNN--ETDPSLTEMVAVAIRML QKNPRGFFLLVE--------GGRIDHGHHEGKAKQALHEAVELDRAIGLATRVTSPQDTL SVVTADHSHVFTFGGY-TPRGNPIFGLAPMQSD-----VDRKPFTSILYGNGPGYK---- -----------IVAGERENVSAVDFAHADYQAQSAVPLRQETHGGEDVAVFARGPMAH-L LHGVHEQNYIPHAMAYAACIGANHS----------------------------ALGVQMV L----------------------------------------------------------- ----------- >XP_017910699.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Capra hircus] ------------------------------------------------------------ --------MISPFLVLAIGTC----LASSL-----------VPEKEKDPKYWRDQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHHPGEETKLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIRIL NKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSIEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACVGANRDH-CASAS---------------SSGSP-SPGPLLL P----------------------LALLPLGGLF--------------------------- ----------- >XP_006023251.1 alkaline phosphatase, tissue-nonspecific isozyme [Alligator sinensis] ------------------------------------------------------------ ---------MKALLLVLLIEL----CLGSL-----------FPEKEKNPKYWRDQAQQTL RNALKLQK------LNTNVAKNIIMFLGDGMGISTVTAARILKGQLQHMQGEETMLEMDK FPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNTTA--GNEVTS ILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPLEAI--QQG-CKDIAQ QLFENI--PNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKE-KKPKD KNAHYVWNRQDLMALNLD-KVDFLLGLFEPVDLMYELDRNN--QTDPSLTEMVEVAIKIL QKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHETVEMDRAIGLAGRLTKENDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMQSD-----VDKKPFTSILYGNGPGYK---- -----------LIGGGRENVSTVNFAHANYQAQSAVPLRQETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACVGPNTNH-CRSGA---------------ARGTG-VALPLLS T----------------------FASL-FILLCLF------------------------- ----------- >XP_006261757.2 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Alligator mississippiensis] ------------------------------------------------------------ ---------MKALLLVLLIEL----CLGSL-----------FPEKEKNPKYWLDQAQQTL RNALKLQK------LNTNVAKNIIMFLGDGMGISTVTAARILKGQLQHMQGEETMLEMDK FPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNTTA--GNEVTS ILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPPEAI--QQG-CKDIAQ QLFENI--PNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKE-KKPKD KNAHYVWNRQDLMALNLD-KVDFLLGLFEPVDLMYELDRNN--QTDPSLTEMVEVAIKIL QKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHETVEMDRAIGLAGRLTKENDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMQSD-----VDKKPFTSILYGNGPGYK---- -----------LIGGGRENVSTVDFAHANYQAQSAVPLRQETHGGEDVAIFAKGPMAH-L LHGVHEQNYIPHVMAYAACVGPNTNH-CRSGA---------------ARGTG-VALPLLS T----------------------FASL-FILLCLF------------------------- ----------- >XP_015813883.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Nothobranchius furzeri] ------------------------------------------------------------ --------MYAAGLLIACSCLISESYQRAP-----------FPEQEKDPTFWNTWAQKTL KNALTLQT------LNTNKAKNVILFLGDGMGVPTVTATRILKGQLSGHYGEETQLEMDK FPFVSLAKTYNTDAQVPDSAGTATAYLCGVKANEGTLGVSAAAVRSQCNTTK--GNEVTS ILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDNEMPAEAL--MHG-CKDIAR QLFENI--PNIDVIMGGGRKFMYPQNTSDVEYPTQPKMSGTRKDGRNLVQEWID--KMKD KKGNYVWNKQQLLSLNPN-NVDYLLGLFEPSELAYELERNN--DSDPSLTEMVDVAIKVL KKNQNGFYLLVE--------GGRIDHGHHEGKAKLALYDAVEMDRAIGRADLLTSIHETL TVVTADHSHVFTFGGY-TLRGNSIFGLAPKVSD-----ADQKPFTAISYGNGPGYK---- -----------IVNGGRENISTVNYESSHYQAQAAVPLLSETHGGDDVAVFAKGPMAH-L LHGIHEQNYIPHVMAYAACIGQNQNH-CMSSG---------------GTVGL-QPAFSSM A----------------------SVLAVTRFLW--------------------------- ----------- >XP_019837576.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Bos indicus] ------------------------------------------------------------ --------MISPFLLLAIGTC----LASSL-----------VPEKEKDPKYWRDQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNI--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-SVDYLLGLFEPGDMQYELNRNN--ATDPSLSEMVEMAIRIL NKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSGSP-SPGPLLL L----------------------LALLPLGSLF--------------------------- CGPGARAPTSP >XP_020730180.1 alkaline phosphatase, tissue-nonspecific isozyme [Odocoileus virginianus texanus] ------------------------------------------------------------ --------MIPPFLVLAIGTC----LTSCL-----------VPEKEKDPKYWREQAQQTL KNALRLQT------LNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDK FPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQ--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEAL--SQG-CKDIAY QLMHNV--KDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLDLIDIWKS-FKPKH KHSHYVWNRTDLLALDPH-TVDYLLGLFEPGDMQYELNRNN--VTDPSLSEMVEMAIKIL NKNPKGFFLLVE--------GGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTL TVVTADHSHVFTFGGY-TPRGNSIFGLAPMVSD-----TDKKPFTAILYGNGPGYK---- -----------VVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAACIGANRDH-CASAS---------------SSSSP-SPGPLLL L----------------------LALLPLGSLF--------------------------- ----------- >XP_030275039.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sparus aurata] MPPNAARP------------RGDGGP------------------ASSASQKWHVMSRGTR QPHRDDNMKMTSLLLIVCSCLIAGSVGRPQ-----------FPEKEKDPKYWNAGAQMTL KNALTLQT------LNKNKAENLILFLGDGMGVPTVTAARILKGQLSGQSGEETQLEMDK FPFVSLAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTE--GNEVTS ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSVDRDWYSDNEMPAEAL--QAG-CKDIAR QLFENI--PNIDVIMGGGRKYMFPKNRSDVEYPGVAKHSGTRKDGRDLVQEWID--KTKD KKGHYVWNKKQLLSLNPN-NVDYLLGLFEPGDLPYDLERNS--ETDPSLTEMVEVAIKIL RKNPSGFYLLVE--------GGRIDHGHHEGKAKQALHEAVEMDRAIGRASLLTSIHDTL TIVTADHSHMFNFGGY-TPRGNTIFGLAPMLSD-----ADQKPFTSILYGNGPGYK---- -----------LVNGARENVSTIDYQENNYQAQAAVPLSMETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHVMAYAGCIGQNREH-CLSRS---------------GTAGL-HPVLSTI A----------------------TLFTVTRLLC--------------------------- ----------- >XP_040190415.1 alkaline phosphatase, tissue-nonspecific isozyme [Rana temporaria] M----------------------------------------------------------- --------IITLWTLLFVVKL----STSVS-----------FPEKEKNPEYWRKQAQDTL RLALNLQD------LNRNVAKNTIMFLGDGMGVPTVTATRILKGQLAGQPGEETQLEMDK FPHVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAASVRGQCNTTK--GNEVAS ILKWAKDAGKSVGVVTTTRVNHATPSAAYAHCVNRDWFSDNEMPKEAV--AEG-CKDIAW QLMHNI--ADIEVIMGGGRKYMFPKNTPDIEYPKEEKANGTRLDGLNLTKIWME-NKPRN KIARYVWNRDQLLGLKPE-ETDYVLGLFEPSDMVYELDRNT--STEPSLVEMVKVAISIL KKNPKGFFLLVE--------GGRIDHGHHEGKAKHALHEAIQMDIAIGLAGEMTSTEDTL TVVTADHSHVFTFGGY-THRGNSIFGLAPALSD-----LDSKPYTSILYGNGPGYK---- -----------LVNGSRGNVSTVDYAQPNYQAQSAVPLKQETHGGEDVAVFAKGPMAH-L LHGVHEQNYIPHAMAYATCIGQNRDH-CNSRS---------------SGHSF-KTSVTMV S----------------------SALSVLAALQLF------------------------- ----------- >XP_039258402.1 alkaline phosphatase-like [Styela clava] M----------------------------------------------------------- --------YLLLYQVLLFISI----VSGKR-----------DIEAEKKPSFWKANAKKEL EAALDAQR------LNTNVAKNVIIFLGDGMGISTVTAGRILKGQLRGESGEETKLTMET LPHAALSKTYSANAQVSDSAATATAYLCGVKSNWYTLGVNAATVYDNCESIK--GNGVES VLVDSYKAGKSAGVVTTTRIQHATPGATYAHAPNREWYGDADLTEEAK--QNG-CKDIAL QFYEAS--DMITVALGGGRKYMQPENTTDYEYP---KMSNSRKDGKDLIQMWKNKMASAG FESKFVWNKKQFDDVDVE-STDRLLGLFEPSDMHYDAERSKDGEGEPSIAEMTSKAIQML QKNDKGYFLLVE--------GGRIDHGHHSGNAYLSLHDVVAFDNAIAEALRMTSQEDTM IIVTADHSHVFTIGGK-SIRGNNIFGLQPDVSNPVN-ALDNKPYTTLIYANGPGFHGEYF VNAMGYNEPIIKNGSSREDLTNVNTTAPDYLQQSAIPLDSETHGGEDVAIFASGPMAH-L FHGVHEQSYIAYVMRYASCVGPDQGH-CMKEDDIG------HIEYLGSSISV-STANSTL R----------------------IQFIFLIILSVVIFILLLLLIRNSLNSKRKANYKESG KAPDVPLSTRP >XP_038075941.1 alkaline phosphatase-like [Patiria miniata] M----------------------------------------------------------- ----------RFTGWTMIWLLL---CLAFA-----------GCTWAQNAQFWNIQAQDTL QKALTREA-----SLNRNVAKNIVFFLGDGMGVSTVTAARIMKGQQAGMTGEETVLSWEK FSSVALSKTYNTNRQVPDSAGTATAYFCGVKTKEEMIGVDDQAVLGDCQSSL--NAAVDS VMTDAEKEGKATGFVTTARVTHATPACLYAHSPDRNWENNADVPEAEA--ALG-CTDIAH QLVTLG--QNIKVIMGGGRREMLPDNFTDYEYS---ALTGQRTDGRNLVDEWLA--SKDA QTSHFVWNLDQFNEVDPE-NTEYLLGLFESSHMQYEGERTN----EPSIAEMTEKAIRIL QKDTDGFFLMVE--------AGRIDHAHHDGFAGNALNDTVAFDAAVAKAVELTNEEDTL IIVTADHSHVMTLGGY-QSRGNPILGLVDLSSA-----EDDLPFTSIGYTNGPGGIAE-- -------QVSYKLFGRRRNLTDNDTENPRFTQPGIVPRESETHGGEDVAIYANGPMSH-L FHGVHEQNYIAHVVRYAACLG-NRQH-CDEYV----------APCGSGASSV-PSGGVTM I----------------------TVLLNLWLALVL------------------------- --PK------- >XP_030842761.1 alkaline phosphatase [Strongylocentrotus purpuratus] M----------------------------------------------------------- ------------TPYLLLPLF----LSALL-----------SLATSQDAAFWNNQAQRTL EEALNLRQ-------NQGIAKNVIFFLGDGMDITTTTAARILRGQMDGETGEEGSLAWDD FPHVALSKTYNTDQQVADSAGTATAFLCGVKAKAGTLGIDDGAERGSCASVA--GTEVDS VLVEANRAGKATGLISTARVTHATPAAAYAHSAERDWENNDRVPDEEA--DEG-CIDIAR QLVEEN--NFINLILGGGRVNFLPNTTLDPEYG-DENTTGYRTDGLNLIEQWLS---VKG SSAQYVWNKTALDRVDLS-STEYLLGLFEPSHMKYEVDRLNDTAGEPSIAEMTELAINML SSDEDGFFLMVE--------SGRIDHGHHMGVAHKALTDTIAFHEAVAKAIEMTDSDDTL ILVTADHGHAFAIGGY-ASRGNPIFGYDDRNNG-----SDDKPYLTLSYANGPGGIAL-- -------ADSYINTGARPNHYTSDYDSEGFVQDATVPAISETHGGADVAIYAHGPWSH-L FHGTHEQNYIPHVVRYAACYSDSEDNACTRATEEP------PMCTGSAHPTV-LARCASV I----------------------LPLISLIFLWISM------------------------ ----------- >XP_031549411.1 alkaline phosphatase-like [Actinia tenebrosa] MT---------------------------------------------------------- ------NNLVLLLYLLLPWCFSI--VSTTFAA---------SALNNEAKNEWFQSGVDLI KDNLRLRE-------NRQTAKNVIMFLGDGMGPTTVTSARILEGQLRGETGEENALSWEK FPWSAFSKTYNTDQQVADSAGTATAYLNGVKTRAGVIAVDETVRKGYCADMT-EATKVKS ILTLAEEAGMSTGIVTTTRITHASPSVLYSYSPDRNWENDMKMKSKAKDDSSS-CKDIAL QLAEYSVGDGIEVLFGGGRQNFYPKNQSDPEYP---QLQGKRGDGRNLVNEWLA----NN PDSQFLWNKTAFDALDVK-TVKHVMGLFEYSHMQYEVERVNDTGGEPSIAEMTAKAIEIL SKNPKGFFLFVE--------GGRIDHGHHGGKAVKALMDTVAMAKAVDKAVSIVGEEETL MITTADHSHVLSIAGY-PRRGNPIFELVVEKDNATSVGKDGLPYTTLGYANGPGGL---- -----------SLNESRQNLTGVNTADKDFLQQALVKTSSESHAGEDVGIYATGPGAY-L FHGVVEQHYIFHVMDHALCLTSSKQDKCFKHGMRGGEVV---TRGPPRSGSA-PLIPLAM L----------------------IIFVSFVVAMF-------------------------- ----------- >XP_006566949.1 alkaline phosphatase isoform X1 [Apis mellifera] MWRY-------------------------------------------------------- ------LQYIIFGLTVVLLTI----HEIVF-----------VQAGEQERVAWYEGATRAI EGRIRASAATWSAPPAGGVARGVVLFVGDGMGMSTLTAARILSGQRRGNTGEEAQLAWDS FPAVALARTYNMDAQVGESSACATALLCGVKANYETVGLDSSARFENCYSSF--DARVPS LINWAQEQGKSTGLVTTTRVTHATPAALYAHAASRYWEDDGKVPPAA---RTS-CKDIAR QLLEDEPGRNINVILGGGRRHFVSKVTQDPEEP---DKEGRRLDGRNLIEEWSRNHRLRN VAAKYVANKEQFESVDPR-KVNHLLGLFSYSHMDFDVDRNTNGSGDPSLAEMTIKALRIL AKNPEGYFLFVE--------GGRIDHAHHYNNAYRALDETLALEEAVRAVMKEVDLSETL LVVTADHSHVLTLGGLATHRGNPIFGSDSKMSD-----VDGQPYTTLLYSNGPGYT---- -----------------QPRNILREAGKDSIQTAGVPRAWATHGGEDVPVFAIGPLANVL FSGSIDQSYIPHAISYASCLGQHATR-CSRDPASSNDTINVPISCPSAEPNS-AAISSDV MNDQARNPPAKSAASTLLLLAPAAPLLPLVLAALPS------------------------ --PSTLRGTS- >NP_649315.1 alkaline phosphatase 1, isoform A [Drosophila melanogaster] M----------------------------------------------------------- -------RALRFFAALALQLTA---CSSQYKYGPEQSWDLDSISELKSKEFWFHDAQRTL YNKLSTPP-------NQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRLEFEK FNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSS IAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQ--NPGNCPDIAQ QLIDGDVGKRLRVVMGGGTIKFLPNTTNDVF-----GNKGQRLDNRNLIEEWQQ---TKP GNARVVFSRTDLLNNDAQ-NTDFLLGLFNASHLAYHMDDSID---TPTLPEMTAAAINVL SRDPNGYFLFVE--------GGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTL IVVSADHGHTVTISGY-PDVNNSIVGLNSELSN-----VDQLPYTSISYANGPAYERF-- -------YKSTDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAHGPWSH-L FTGVYEQSTLPHLMGFASCLGPGITY-CDLQPK--------------ARYSP-------- ------------------------------------------------------------ -----------
BMGE Cleaned alignment of selected proteins >sp|P05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 FLVLAIGTCVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF >tr|F1Q5B5|F1Q5B5_DANRE Alkaline phosphatase OS=Danio rerio OX=7955 GN=alpl PE=1 SV=1 VQLLILSCLFPEQEKRPDYWRDFAQRSLKDALKLQELNKNIAKNIILFLGDGMGVPTVTAARILKGQLSGQNGEETQLEMDKFPHVALSKTYNTNAQVPDSAGTATAFLCGVKANEGTVGVSAAAVRSQCNTTQGNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDADMPNEALCKDIARQLFENIPDINVIMGGGRRSMYPKNTPDVEYPGDKKQNGTRKDGRNLVGEWID-RVKERGFYVWNKKDLLSLNPNNVDYLLGLFEPADLNYELERNTENDPSLTEMVDVAIKILKKNERGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAITRAGLLTSEYDTLTVVTADHSHVFSFGGYTPRGNSIFGLAPTLSDVDQKPFTAILYGNGPGFKLVNGARENVSTVDYQQNNYQAQSAVPLRMETHGGEDVAIFSKGPMAHLLHGVQEQHYIPHVMAYAACIGQNKDHCRTNSGSSSYSHISPALLFPLLVKWLLC >NP_031457.2 alkaline phosphatase, tissue-nonspecific isozyme preproprotein [Mus musculus] FLVLAIGTCVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGSGSAPSPGALLLPLAVLSLRTLF >NP_037191.2 alkaline phosphatase, tissue-nonspecific isozyme precursor [Rattus norvegicus] FLVLAIGTCVPEKEKDPSYWRQQAQETLKNALKLQKLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWASSASSPSPGALLLPLALFPLRTLF >XP_043300839.1 alkaline phosphatase, tissue-nonspecific isozyme [Cervus canadensis] FLVLAIGTCVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNSKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPAPGPLLLLLALLPLGSLF >KAF4013850.1 hypothetical protein G4228_005382 [Cervus hanglu yarkandensis] FLVLAIGTCVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHN-----VIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPAPGPLLLLLALLPLGSLF >KAB0359714.1 hypothetical protein FD754_003870 [Muntiacus muntjak] --MQEDSTCSPQKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHAVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >KAB0380534.1 hypothetical protein FD755_008318 [Muntiacus reevesi] --MLGVG-CSSPKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHAVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAIFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >XP_018083785.1 alkaline phosphatase, tissue-nonspecific isozyme [Xenopus laevis] GVLLLLGTLFPEQEKNPNYWRRQAQETLRNALQLQNLNTNIAKNVIMFLGDGMGVSTVTATRILKGQLSGQPGEETELEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAAAVRGQCNTTKGNEVDSILKWAKQAGKSAGVVTTTRINHATPSAAYAHCVNRDWYSDLEMPKEAVCKDIAWQLMHNVPNIEVIMGGGRKYMFPKNTSDVEYPNDDKSSGTRLDGLNLTQIWLDQKPNKAARYVWNREQLLSVKPEAVDHLLGLFEPVDMPYELERNTTMDPSLPEMVEMAIKILGKNPMGFFLLVEGGRIDHGHHEGKAKQALHEAVQMDVAIGVSGNMTSVEDTLTVVTADHSHVFTFGGYTYRGNSIFGLAPAPSDLDLKPFTSILYGNGPGYKLVNGQRENVSSVDFSQSNYLAQSAVPLRMETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGHNQDHCTSSRGNDGARTSLILLSVLLPIFSLQL >XP_010715105.1 intestinal-type alkaline phosphatase-like [Meleagris gallopavo] TLCLGLWAEIPVEEEDPTFWNRKAAAALNATLKIEP-RMTEAKNLIIFLGDGFGVPSITATRILKGQLKGNLGPETPLALDSFPYVALSKTYTVDRVVPDSAGTATAYLCGVKGNYKTVGLSAAARYGQCNTTKGNEVISVLERARNAGKAVGIVTTSRVQHASPSGTYAHVVDRNWYADASMPAEAICKDIAWQLVHNV-DINVILGGGRIYMTPAGTPDPEYPEYSSENGIRNDGQNLIDMWLS---KQGARYVWNRTEMLAAAADSVTYLMGLFEPMDMKYEMVHNSTLDPSLTEMTEAAINVLSRNPNGFYLFVEGGRIDHGHHEGMAQRALTEAVEFDTAIERAGELLDEADTLTVVTADHSHVFSFGGYTLRGTSIFGLAPLQA-TDQKNYTSILYGNGPGYP--GATRPDVNSSIAEEFSYMQQAAVPLSSETHGGEDVAILAKGPMAYLFHGVQEQNYIAHAMAYAACLEPYEN-CRQRTAAPSAHLTPLALLLPALLLSLFH >NP_990691.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Gallus gallus] FLLTLLAQLVPEREKDPEYWRQQAQETLRDALRLQHLNQNVAKNLILFLGDGMGVSTVTAARILKGQLQHRKGEESLLEMDKFPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTKGQEVTSILRWAKDEGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPLDALCKDIARQLVDNIPDIEVILGGGRKYMFPKNTSDVEYPQEERHRGTRLDGKDLVQAWHDTKPAGVAKYVWHRRELLALNVSRVDFLLGLFEPGDMVYELDRNNETDPSLSEMVAVAIRMLQKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVELDRAVGLAGRLTSPRDTLSVVTADHSHVFTFGGYTPRGNPIFGLAPMQSDVDRKPFTSILYGNGPGYKIVGGERENVSAVDFAHANYQAQAAVPLRQETHGGEDVAVFARGPMAHLLHGVDEQNYIPHAMAYAACIGPNRAHCSSAAPAATATLLPVLLL-----LLLLC >XP_038513640.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Canis lupus familiaris] FLVLVIGTCVPEKEKDPKYWRDQAQQTLKYALRLQNLNTNVAKNVIMFLGDGMGVSTVTATRILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYEMDEKSRGTRLDGLNLIDIWKNFKPRHHSHYVWNRTELLALDPYTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEIAIKILSKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGKAGVMTSLEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANQDHCASASSAGGPSPGPLLLLLALLPVGILF >XP_016811306.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan troglodytes] FLVLAIGTCVPEKEKDPKYWRDQAQETLKYALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >NP_001036028.1 alkaline phosphatase, tissue-nonspecific isozyme precursor [Felis catus] FLVLAIGTCVPEKEKDPKYWRDQAQQTLKNALRLQKLNTNVVKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQGNEVTSILRWAKDSGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVRDIEVIMGGGRKYMFPKNRTDVEYEMDEKARGTRLDGLNLVDIWKSFKPRHHSHYVWNRTELLTLDPYGVDYLLGLFEPGDMQYELNRNSTTDPSLSEMVEIAIKILSKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGRAGAMTSVEDTLTIVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTSILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCASASSAGGPSPGPLFLLLALPSLGILF >XP_020953340.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sus scrofa] FLVLAIGSCVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHKPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRTQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIEVIMGGGRKYMFPKNRTDVEYEMDEKARGTRLDGLNLIDVWKSFKPRHHSHYIWNRTELLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIRILIKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIEQAGSMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHDNYQAQSAVPLRHETHGGEDVAIFARGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGILF >XP_017201978.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Oryctolagus cuniculus] GGSATRGRTCTEQEKDPKYWRDQAQQTLKNALGLQKLNTKVAKNVILFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKAVGIMITTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRNIDVIMGGGRKYMYPKNKTDVEYEVDEKARGTRLDGLDLVDIWRSFKPRHHSHFVWNRTELLALDPYTVDYLLGLFEPGDMQYELNRNNITDPSLSEMVEVAIKILKKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGKAGTMTSLEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCAWASSAGSLAPGALLLPLTLLPLSVLF >XP_002811389.2 alkaline phosphatase, tissue-nonspecific isozyme [Pongo abelii] FLVLAIGTCVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYEIDEKARGTRLDGLDLVDTWKSFKPRHHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCASASSAGSLAAGPLLLALALFPLSVLF >XP_003813996.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Pan paniscus] FLVLAIGTCVPEKEKDPKYWRDQAQETLKYALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILHWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >XP_012008208.3 alkaline phosphatase, tissue-nonspecific isozyme [Ovis aries] FLVLAIGTCVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLVDIWKSFKPKHHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPSPGPLLLLLALLPLGGLF >XP_004024892.1 alkaline phosphatase, tissue-nonspecific isozyme [Gorilla gorilla gorilla] FLVLAIGTCVPEKEKDPKYWRDQAQETLKYALKLQRLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRHHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNMTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYIPHVMAYAACIGANLDHCAPASSAGSLAAGPLLLALALFPLSVLF >XP_004069357.1 alkaline phosphatase, tissue-nonspecific isozyme [Oryzias latipes] ALLIICSCLFPENEKSPAFWNNGAQKTLKEALSTQELNKNKAKNLILFLGDGMGVPTVTAARILKGQLNGQSGEEYQLEMDKFPFVSLSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTKGNEVTSILKWAKDAGKSVGIVTTTRINHATPSAAYAHSVDRDWYSDNEMPSEALCKDIARQLFENIPNIDVIMGGGRKYMFPKNMSDVDYPGVAKYNGVRNDGRNLVQEWID-RMKDGGHYVWNKQQLLSLNPKKTSYLLGLFGPVDLPYDLERNADSDPSLTQMVEVAIKVLQNNPKGFYLLVEGGRIDHGHHEGKAKQALYEAVEMDRAIGRADLLTSAQDTLTVVTADHSHVFTFGGYTRRGNTIFGLAPMVSDVDHKPFTSILYGNGPGYKLVGGARENVSTVDFAENNYKAQSAVPLTSETHGGEDVAVFAKGPLAHLLHGVHEQNFIPHVMAYAACIGQNRGHCPSG-GTAALRPVFSSMAAVLTVTLLLC >XP_021137822.1 LOW QUALITY PROTEIN: alkaline phosphatase, tissue-nonspecific isozyme [Columba livia] LLLLLLAPLIPEREKDPEFWRRQAQXF------FQRLNQNVAKNLILFLGDGMGVSTVTAARILKGQLQNRKGEESLLEMDKFPYVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAGVTRDRCNTTKGQEVTSILRWAKDSGKAVGIVTTTRVTHATPSAAYAHSANRDWYSDGEMPPDALCKDIARQLVENIPDIEV--GGGQGHQ-----EQGQGHGSPSTCGTGGGGA----------------------------LSRVDFLLGLFEPGDMVYELDRNNETDPSLTEMVAVAIRMLQKNPRGFFLLVEGGRIDHGHHEGKAKQALHEAVELDRAIGLATRVTSPQDTLSVVTADHSHVFTFGGYTPRGNPIFGLAPMQSDVDRKPFTSILYGNGPGYKIVAGERENVSAVDFAHADYQAQSAVPLRQETHGGEDVAVFARGPMAHLLHGVHEQNYIPHAMAYAACIGANHS-----------ALGVQMVL---------- >XP_017910699.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Capra hircus] FLVLAIGTCVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHHPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSIEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACVGANRDHCASASSSGSPSPGPLLLPLALLPLGGLF >XP_006023251.1 alkaline phosphatase, tissue-nonspecific isozyme [Alligator sinensis] LLLVLLIELFPEKEKNPKYWRDQAQQTLRNALKLQKLNTNVAKNIIMFLGDGMGISTVTAARILKGQLQHMQGEETMLEMDKFPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNTTAGNEVTSILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPLEAICKDIAQQLFENIPNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKEKKPKDNAHYVWNRQDLMALNLDKVDFLLGLFEPVDLMYELDRNNQTDPSLTEMVEVAIKILQKNPKGFFLLVEGGRIDHGHHEGKAKQALHETVEMDRAIGLAGRLTKENDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMQSDVDKKPFTSILYGNGPGYKLIGGGRENVSTVNFAHANYQAQSAVPLRQETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACVGPNTNHCRSGAARGTGVALPLLSTFASL-FILLC >XP_006261757.2 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Alligator mississippiensis] LLLVLLIELFPEKEKNPKYWLDQAQQTLRNALKLQKLNTNVAKNIIMFLGDGMGISTVTAARILKGQLQHMQGEETMLEMDKFPYVALSKTYNTDAQVPDSAGTATAYLCGVKANEGTVGVSAAVMRDQCNTTAGNEVTSILKWSKEAGKSVGIVTTTRVNHATPSAAYAHSANRDWYSDNEMPPEAICKDIAQQLFENIPNIEVIMGGGRKYMFPKNTTDVEYQTEDKYRGTRLDGKTLTSVWKEKKPKDNAHYVWNRQDLMALNLDKVDFLLGLFEPVDLMYELDRNNQTDPSLTEMVEVAIKILQKNPKGFFLLVEGGRIDHGHHEGKAKQALHETVEMDRAIGLAGRLTKENDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMQSDVDKKPFTSILYGNGPGYKLIGGGRENVSTVDFAHANYQAQSAVPLRQETHGGEDVAIFAKGPMAHLLHGVHEQNYIPHVMAYAACVGPNTNHCRSGAARGTGVALPLLSTFASL-FILLC >XP_015813883.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Nothobranchius furzeri] GLLIACSCLFPEQEKDPTFWNTWAQKTLKNALTLQTLNTNKAKNVILFLGDGMGVPTVTATRILKGQLSGHYGEETQLEMDKFPFVSLAKTYNTDAQVPDSAGTATAYLCGVKANEGTLGVSAAAVRSQCNTTKGNEVTSILKWAKDAGKSVGIVTTTRVNHATPSAAYAHCVDRDWYSDNEMPAEALCKDIARQLFENIPNIDVIMGGGRKFMYPQNTSDVEYPTQPKMSGTRKDGRNLVQEWID-KMKDKGNYVWNKQQLLSLNPNNVDYLLGLFEPSELAYELERNNDSDPSLTEMVDVAIKVLKKNQNGFYLLVEGGRIDHGHHEGKAKLALYDAVEMDRAIGRADLLTSIHETLTVVTADHSHVFTFGGYTLRGNSIFGLAPKVSDADQKPFTAISYGNGPGYKIVNGGRENISTVNYESSHYQAQAAVPLLSETHGGDDVAVFAKGPMAHLLHGIHEQNYIPHVMAYAACIGQNQNHCMSSGGTVGLQPAFSSMASVLAVTRFLW >XP_019837576.1 PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme [Bos indicus] FLLLAIGTCVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLNLIDIWKSFKPKHHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELNRNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF >XP_020730180.1 alkaline phosphatase, tissue-nonspecific isozyme [Odocoileus virginianus texanus] FLVLAIGTCVPEKEKDPKYWREQAQQTLKNALRLQTLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAHSADRDWYSDNEMPPEALCKDIAYQLMHNVKDIEVIMGGGRKYMFPKNRTDVEYELDEKARGTRLDGLDLIDIWKSFKPKHHSHYVWNRTDLLALDPHTVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVEMAIKILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGQAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIGANRDHCASASSSSSPSPGPLLLLLALLPLGSLF >XP_030275039.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Sparus aurata] LLLIVCSCLFPEKEKDPKYWNAGAQMTLKNALTLQTLNKNKAENLILFLGDGMGVPTVTAARILKGQLSGQSGEETQLEMDKFPFVSLAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAAAVRSQCNTTEGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSVDRDWYSDNEMPAEALCKDIARQLFENIPNIDVIMGGGRKYMFPKNRSDVEYPGVAKHSGTRKDGRDLVQEWID-KTKDKGHYVWNKKQLLSLNPNNVDYLLGLFEPGDLPYDLERNSETDPSLTEMVEVAIKILRKNPSGFYLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGRASLLTSIHDTLTIVTADHSHMFNFGGYTPRGNTIFGLAPMLSDADQKPFTSILYGNGPGYKLVNGARENVSTIDYQENNYQAQAAVPLSMETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYAGCIGQNREHCLSRSGTAGLHPVLSTIATLFTVTRLLC >XP_040190415.1 alkaline phosphatase, tissue-nonspecific isozyme [Rana temporaria] WTLLFVVKLFPEKEKNPEYWRKQAQDTLRLALNLQDLNRNVAKNTIMFLGDGMGVPTVTATRILKGQLAGQPGEETQLEMDKFPHVALAKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAASVRGQCNTTKGNEVASILKWAKDAGKSVGVVTTTRVNHATPSAAYAHCVNRDWFSDNEMPKEAVCKDIAWQLMHNIADIEVIMGGGRKYMFPKNTPDIEYPKEEKANGTRLDGLNLTKIWMENKPRNIARYVWNRDQLLGLKPEETDYVLGLFEPSDMVYELDRNTSTEPSLVEMVKVAISILKKNPKGFFLLVEGGRIDHGHHEGKAKHALHEAIQMDIAIGLAGEMTSTEDTLTVVTADHSHVFTFGGYTHRGNSIFGLAPALSDLDSKPYTSILYGNGPGYKLVNGSRGNVSTVDYAQPNYQAQSAVPLKQETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHAMAYATCIGQNRDHCNSRSSGHSFKTSVTMVSSALSVLAALQ >XP_039258402.1 alkaline phosphatase-like [Styela clava] YQVLLFISIDIEAEKKPSFWKANAKKELEAALDAQRLNTNVAKNVIIFLGDGMGISTVTAGRILKGQLRGESGEETKLTMETLPHAALSKTYSANAQVSDSAATATAYLCGVKSNWYTLGVNAATVYDNCESIKGNGVESVLVDSYKAGKSAGVVTTTRIQHATPGATYAHAPNREWYGDADLTEEAKCKDIALQFYEASDMITVALGGGRKYMQPENTTDYEYP---KMSNSRKDGKDLIQMWKNMASAGESKFVWNKKQFDDVDVESTDRLLGLFEPSDMHYDAERSKEGEPSIAEMTSKAIQMLQKNDKGYFLLVEGGRIDHGHHSGNAYLSLHDVVAFDNAIAEALRMTSQEDTMIIVTADHSHVFTIGGKSIRGNNIFGLQPDVSNLDNKPYTTLIYANGPGFHKNGSSREDLTNVNTTAPDYLQQSAIPLDSETHGGEDVAIFASGPMAHLFHGVHEQSYIAYVMRYASCVGPDQGHCMKEDSSISVSTANSTLRIQFIFLIILS >XP_038075941.1 alkaline phosphatase-like [Patiria miniata] TGWTMIWLLGCTWAQNAQFWNIQAQDTLQKALTREALNRNVAKNIVFFLGDGMGVSTVTAARIMKGQQAGMTGEETVLSWEKFSSVALSKTYNTNRQVPDSAGTATAYFCGVKTKEEMIGVDDQAVLGDCQSSLNAAVDSVMTDAEKEGKATGFVTTARVTHATPACLYAHSPDRNWENNADVPEAEACTDIAHQLVTLGQNIKVIMGGGRREMLPDNFTDYEYS---ALTGQRTDGRNLVDEWLA-SKDATSHFVWNLDQFNEVDPENTEYLLGLFESSHMQYEGERTN--EPSIAEMTEKAIRILQKDTDGFFLMVEAGRIDHAHHDGFAGNALNDTVAFDAAVAKAVELTNEEDTLIIVTADHSHVMTLGGYQSRGNPILGLVDLSSAEDDLPFTSIGYTNGPGGIKLFGRRRNLTDNDTENPRFTQPGIVPRESETHGGEDVAIYANGPMSHLFHGVHEQNYIAHVVRYAACLG-NRQHCDEYVGASSVPSGGVTMITVLLNLWLAL >XP_030842761.1 alkaline phosphatase [Strongylocentrotus purpuratus] TPYLLLPLFSLATSQDAAFWNNQAQRTLEEALNLRQ-NQGIAKNVIFFLGDGMDITTTTAARILRGQMDGETGEEGSLAWDDFPHVALSKTYNTDQQVADSAGTATAFLCGVKAKAGTLGIDDGAERGSCASVAGTEVDSVLVEANRAGKATGLISTARVTHATPAAAYAHSAERDWENNDRVPDEEACIDIARQLVEENNFINLILGGGRVNFLPNTTLDPEYG-DENTTGYRTDGLNLIEQWLS--VKGSAQYVWNKTALDRVDLSSTEYLLGLFEPSHMKYEVDRLNAGEPSIAEMTELAINMLSSDEDGFFLMVESGRIDHGHHMGVAHKALTDTIAFHEAVAKAIEMTDSDDTLILVTADHGHAFAIGGYASRGNPIFGYDDRNNGSDDKPYLTLSYANGPGGIINTGARPNHYTSDYDSEGFVQDATVPAISETHGGADVAIYAHGPWSHLFHGTHEQNYIPHVVRYAACYSDSEDNCTRATAHPTVLARCASVILPLISLIFLW >XP_031549411.1 alkaline phosphatase-like [Actinia tenebrosa] LYLLLPWCFSALNNEAKNEWFQSGVDLIKDNLRLRE-NRQTAKNVIMFLGDGMGPTTVTSARILEGQLRGETGEENALSWEKFPWSAFSKTYNTDQQVADSAGTATAYLNGVKTRAGVIAVDETVRKGYCADMTATKVKSILTLAEEAGMSTGIVTTTRITHASPSVLYSYSPDRNWENDMKMKSKAKCKDIALQLAEYSDGIEVLFGGGRQNFYPKNQSDPEYP---QLQGKRGDGRNLVNEWLA---NNDSQFLWNKTAFDALDVKTVKHVMGLFEYSHMQYEVERVNGGEPSIAEMTAKAIEILSKNPKGFFLFVEGGRIDHGHHGGKAVKALMDTVAMAKAVDKAVSIVGEEETLMITTADHSHVLSIAGYPRRGNPIFELVVEKDNKDGLPYTTLGYANGPGGLSLNESRQNLTGVNTADKDFLQQALVKTSSESHAGEDVGIYATGPGAYLFHGVVEQHYIFHVMDHALCLTSSKQDCFKHGRSGSAPLIPLAMLIIFVSFVVAM >XP_006566949.1 alkaline phosphatase isoform X1 [Apis mellifera] GLTVVLLTIVQAGEQERVAWYEGATRAIEGRIRASAPAGGVARGVVLFVGDGMGMSTLTAARILSGQRRGNTGEEAQLAWDSFPAVALARTYNMDAQVGESSACATALLCGVKANYETVGLDSSARFENCYSSFDARVPSLINWAQEQGKSTGLVTTTRVTHATPAALYAHAASRYWEDDGKVPPAA-CKDIARQLLEDERNINVILGGGRRHFVSKVTQDPEEP---DKEGRRLDGRNLIEEWSRHRLRNAAKYVANKEQFESVDPRKVNHLLGLFSYSHMDFDVDRNTSGDPSLAEMTIKALRILAKNPEGYFLFVEGGRIDHAHHYNNAYRALDETLALEEAVRAVMKEVDLSETLLVVTADHSHVLTLGGLTHRGNPIFGSDSKMSDVDGQPYTTLLYSNGPGYT------QPRNILREAGKDSIQTAGVPRAWATHGGEDVPVFAIGPLANLFSGSIDQSYIPHAISYASCLGQHATRCSRDPAEPNSAAISSDVMAPLLPLVLAA >NP_649315.1 alkaline phosphatase 1, isoform A [Drosophila melanogaster] FAALALQLTSISELKSKEFWFHDAQRTLYNKLSTPP-NQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRQNRLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTKLGQCPDIAQQLIDGDKRLRVVMGGGTIKFLPNTTNDVF-----GNKGQRLDNRNLIEEWQQ--TKPNARVVFSRTDLLNNDAQNTDFLLGLFNASHLAYHMDDSI--TPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNVDQLPYTSISYANGPAYEDGVVERVDLRNLDFSKPDAIYPHGVPMTEETHGGGDVAVYAHGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCDLQPARYSP------------------
PhyML tree of selected proteins (XP_030842761_1_alkaline_phosphatase__Strongylocentrotus_purpuratus_:0.72507132,XP_038075941_1_alkaline_phosphatase_like__Patiria_miniata_:0.65785376,(XP_031549411_1_alkaline_phosphatase_like__Actinia_tenebrosa_:1.10300872,((XP_039258402_1_alkaline_phosphatase_like__Styela_clava_:0.80751155,(XP_010715105_1_intestinal_type_alkaline_phosphatase_like__Meleagris_gallopavo_:0.8458995,(((XP_040190415_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Rana_temporaria_:0.19806026,XP_018083785_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Xenopus_laevis_:0.17485724):0.13731232,(tr_F1Q5B5_F1Q5B5_DANRE_Alkaline_phosphatase_OS_Danio_rerio_OX_7955_GN_alpl_PE_1_SV_1:0.17845335,(XP_030275039_1_alkaline_phosphatase__tissue_nonspecific_isozyme_isoform_X1__Sparus_aurata_:0.07560945,(XP_015813883_1_PREDICTED__alkaline_phosphatase__tissue_nonspecific_isozyme__Nothobranchius_furzeri_:0.16001439,XP_004069357_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Oryzias_latipes_:0.13690732):0.03451046):0.10248465):0.12510054):0.0445268,(((XP_021137822_1_LOW_QUALITY_PROTEIN__alkaline_phosphatase__tissue_nonspecific_isozyme__Columba_livia_:0.16393257,NP_990691_1_alkaline_phosphatase__tissue_nonspecific_isozyme_precursor__Gallus_gallus_:0.04305077):0.18641964,(XP_006261757_2_PREDICTED__alkaline_phosphatase__tissue_nonspecific_isozyme__Alligator_mississippiensis_:0.00456935,XP_006023251_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Alligator_sinensis_:0.00469226):0.15532286):0.07772713,((((XP_017201978_1_PREDICTED__alkaline_phosphatase__tissue_nonspecific_isozyme__Oryctolagus_cuniculus_:0.07614507,(XP_002811389_2_alkaline_phosphatase__tissue_nonspecific_isozyme__Pongo_abelii_:0.00000001,(sp_P05186_PPBT_HUMAN_Alkaline_phosphatase__tissue_nonspecific_isozyme_OS_Homo_sapiens_OX_9606_GN_ALPL_PE_1_SV_4:0.00936935,((XP_016811306_1_alkaline_phosphatase__tissue_nonspecific_isozyme_isoform_X1__Pan_troglodytes_:0.00000001,XP_003813996_1_alkaline_phosphatase__tissue_nonspecific_isozyme_isoform_X1__Pan_paniscus_:0.00000001):0.00232316,XP_004024892_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Gorilla_gorilla_gorilla_:0.00467534):0.00231498):0.00481903):0.05125078):0.02068986,(NP_037191_2_alkaline_phosphatase__tissue_nonspecific_isozyme_precursor__Rattus_norvegicus_:0.00634456,NP_031457_2_alkaline_phosphatase__tissue_nonspecific_isozyme_preproprotein__Mus_musculus_:0.01954299):0.05854589):0.03051652,(XP_038513640_1_alkaline_phosphatase__tissue_nonspecific_isozyme_isoform_X1__Canis_lupus_familiaris_:0.02854062,NP_001036028_1_alkaline_phosphatase__tissue_nonspecific_isozyme_precursor__Felis_catus_:0.03599182):0.0083933):0.00597265,(XP_020953340_1_alkaline_phosphatase__tissue_nonspecific_isozyme_isoform_X1__Sus_scrofa_:0.02700049,((XP_020730180_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Odocoileus_virginianus_texanus_:0.00229313,((KAB0359714_1_hypothetical_protein_FD754_003870__Muntiacus_muntjak_:0.01013238,KAB0380534_1_hypothetical_protein_FD755_008318__Muntiacus_reevesi_:0.00885969):0.01489025,(KAF4013850_1_hypothetical_protein_G4228_005382__Cervus_hanglu_yarkandensis_:0.00000001,XP_043300839_1_alkaline_phosphatase__tissue_nonspecific_isozyme__Cervus_canadensis_:0.00229508):0.00229685):0.00000001):0.00603776,(XP_019837576_1_PREDICTED__alkaline_phosphatase__tissue_nonspecific_isozyme__Bos_indicus_:0.01168743,(XP_017910699_1_PREDICTED__alkaline_phosphatase__tissue_nonspecific_isozyme__Capra_hircus_:0.00940466,XP_012008208_3_alkaline_phosphatase__tissue_nonspecific_isozyme__Ovis_aries_:0.00460467):0.00242186):0.00325106):0.02067953):0.00804478):0.18305852):0.05180882):0.19530839):0.36068565):0.22991893,(XP_006566949_1_alkaline_phosphatase_isoform_X1__Apis_mellifera_:1.29657384,NP_649315_1_alkaline_phosphatase_1__isoform_A__Drosophila_melanogaster_:1.70931517):0.12520593):0.17100027):0.22841376);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)