PB0088

DATABASE

Click here to access PB0088 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0088	P02655	Apolipoprotein C-II	APOC2	APO-CII, APOC-II, apolipoprotein C2	Homo_sapiens	Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

Domains

Gene Ontology

PF05355 (Apo-CII)

GO:0005515 (enables) protein binding GO:0008047 (enables) enzyme activator activity GO:0008289 (enables) lipid binding GO:0016004 (enables) phospholipase activator activity GO:0043274 (enables) phospholipase binding GO:0055102 (enables) lipase inhibitor activity GO:0060230 (enables) lipoprotein lipase activator activity GO:0006629 (involved in) lipid metabolic process GO:0006869 (involved in) lipid transport GO:0010518 (involved in) positive regulation of phospholipase activity GO:0010898 (involved in) positive regulation of triglyceride catabolic process GO:0010902 (involved in) positive regulation of very-low-density lipoprotein particle remodeling GO:0010916 (involved in) negative regulation of very-low-density lipoprotein particle clearance GO:0016042 (involved in) lipid catabolic process GO:0032375 (involved in) negative regulation of cholesterol transport GO:0033344 (involved in) cholesterol efflux GO:0033700 (involved in) phospholipid efflux GO:0034370 (involved in) triglyceride-rich lipoprotein particle remodeling GO:0034371 (involved in) chylomicron remodeling GO:0034372 (involved in) very-low-density lipoprotein particle remodeling GO:0034382 (involved in) chylomicron remnant clearance GO:0034384 (involved in) high-density lipoprotein particle clearance GO:0042632 (involved in) cholesterol homeostasis GO:0043086 (involved in) negative regulation of catalytic activity GO:0043691 (involved in) reverse cholesterol transport GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process GO:0045833 (involved in) negative regulation of lipid metabolic process GO:0048261 (involved in) negative regulation of receptor-mediated endocytosis GO:0051006 (involved in) positive regulation of lipoprotein lipase activity GO:0060697 (involved in) positive regulation of phospholipid catabolic process GO:0070328 (involved in) triglyceride homeostasis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005769 (located in) early endosome GO:0034361 (part of) very-low-density lipoprotein particle GO:0034362 (part of) low-density lipoprotein particle GO:0034363 (part of) intermediate-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0034366 (part of) spherical high-density lipoprotein particle GO:0042627 (part of) chylomicron

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P02655|APOC2_HUMAN Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1 MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYE KTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >tr|E9QEQ1|E9QEQ1_DANRE Apolipoprotein C-II OS=Danio rerio OX=7955 GN=apoc2 PE=1 SV=1 MNKILAITVFVAFLALGAESFRVPRQAEDEKGTIAVVVDTLKSYYDQSVDTASGYVETIK GYKLEEKAKTIYSDTVRAVGTYAGIFQDQLYHILYSQDSH
Selected proteins from model organisms >sp|P02655|APOC2_HUMAN Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1 MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYE KTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >tr|E9QEQ1|E9QEQ1_DANRE Apolipoprotein C-II OS=Danio rerio OX=7955 GN=apoc2 PE=1 SV=1 MNKILAITVFVAFLALGAESFRVPRQAEDEKGTIAVVVDTLKSYYDQSVDTASGYVETIK GYKLEEKAKTIYSDTVRAVGTYAGIFQDQLYHILYSQDSH >NP_001264873.1 apolipoprotein C-II precursor [Mus musculus] MGSRFFLALFLVILMLGNEVQGNQEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKLRD MYSKSSAAMSTYAGIFTDQLLTLLRGE >NP_001078821.1 apolipoprotein C-II precursor [Rattus norvegicus] MGSRFFLALFLALLVLGNEVQGTEEDDPGSSALLDTVQEHLFSYWNSAKAAAGELYQKTYLTSVDEKLRD MYSKSSAAMTTYAGIFTDQLLTLLKGE >XP_038509382.1 apolipoprotein C-II isoform X2 [Canis lupus familiaris] MDIRTKLSQWSRSSEAMGTRYLLVLLLVLLVLGFEVQGAHESQQDETTSSALLTQMQESLYSYWGTARSA AEDLYKKAYPTTMDEKIRDIYSKSTAAVSTYAGIFTDQLLSMLKGDS >XP_015313666.2 apolipoprotein C-II isoform X1 [Bos taurus] MPPPPQLSPSHPCSPVGQDFGRGVEVGVEGWISRAIKPFSAHLELLRTAARVWSPDAMGTRYFLVGFLIL LVLGFEVQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPAVDEKIRDIYSKSTAAVT TYAGIITDQVFSVLSGKD >XP_043293858.1 apolipoprotein C-II [Cervus canadensis] MGTRYFLVGFLILLVLGFEAQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKIRDIYSKSTA AVTTYAGIITDQVFSMLSGED >KAB0346346.1 hypothetical protein FD754_011203 [Muntiacus muntjak] MGGRGLQASRFGVEGEGWRASCWPGLWPRCRGGGGGGGVDLKSYKAFLCPFGIAEDSRQSLCSRSPDAMGTRYFLVGFLI LLVLGFETQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQ FFSMLSGED >NP_001230828.1 apolipoprotein C-II precursor [Pan troglodytes] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEK LRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >NP_001170799.1 apolipoprotein C-II precursor [Sus scrofa] MGARSFLALFLILLLLASEAQGAHVPPQDEPDSPALLTKVQESLYGYWDTAKATAQDLYRKTYLPTVDEK IRDMYSKSTAAVTIYAGIFTDQVLSLLTGDH >XP_009231041.1 apolipoprotein C-II [Pongo abelii] MGTRFLPALFLVLLVLGFEVQGAPPPQQDELPSPAFLTQVQESLSSYWESAKAAAQNLYEKTYLPAVDEK LRDLYSKSTTAMSTYTGIFTDQVLSVLKGEE >XP_008969010.1 apolipoprotein C-II [Pan paniscus] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEK LRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >XP_003997697.2 apolipoprotein C-II [Felis catus] MGTRCLLVLLLVLLVLRCDVQGDDMARQDEATGPTLLSKMQESLYGYWGSAKAAAQDLYKKTYLTTVDEK IRDMYSTSTAAVRIYTGILTDQILSMLSGDS >XP_004015363.3 apolipoprotein C-II isoform X2 [Ovis aries] MGTRYFLVGFLILLVLGFEAQGAHVPQQDEASSPALLTKMQESLLGYWDTAKAAAHKLYKKTYLPTVDEK IRDIYSKSTAAVTTYAGIITDQVFSILSGED >XP_013832559.1 PREDICTED: apolipoprotein C-II isoform X1 [Capra hircus] MGTRYFLVGFLILLVLGFAGPSATLTHSPPAEAQGAHVPQQDEASSPALLTKMQKSLLGYWDTAKAAAHK LYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQVFSILSGED >XP_017195234.1 PREDICTED: apolipoprotein C-II [Oryctolagus cuniculus] MEPTPSERGWVRIPSPAPRGAAPATLPSAFQVTADTMGPRLLLAVCLILLVLGCGELVQGSHLPQNDEPA SPALLTKVQESLSSYWDSAKAAAQGLYNNTYLTAVDEKIRDMYSKSTAAMTTYASIVTDQLLTLLKGDP >XP_018870627.1 apolipoprotein C-II [Gorilla gorilla gorilla] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSLTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEK LRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >XP_020753892.1 apolipoprotein C-II [Odocoileus virginianus texanus] METPDLMPGGHPGPLIPPQPPIQPVSLSIPRHLPPSFPLPPLQSCWPGLWPRCRSGGGGVDLKSYKAFLC PFGAAEDRRQSLCSRSPDAMGTRYFLVGFLILLVLRFGAQGAHVPQQDEASSPALLTQVQESLLGYWDTA KAAAHKLYKKTYLPIVDEKIRDIYSKSTAAVTTYAGIITDQVFSMLSGED >XP_030250521.1 apolipoprotein C-II [Sparus aurata] MNKLLVITVLVGLLALSADSFRMPRQVEEEEGTISKITGTIRSYYDSAVNTATEYIESIKGLKLEEKAKNLYADTTEVAS TYAGIMQDQLYHIFSSQ >XP_015805614.1 PREDICTED: apolipoprotein C-II-like [Nothobranchius furzeri] MNKLLVVTVLVAFLALSVESFRVPRQAEEDEGTLTQITGAVKSYYDSAVNTVSGYVESIKDLKLEEKAKNLYHETTTVLG TYAGIAHDQLYHFFHH >XP_018082198.1 apolipoprotein C-II [Xenopus laevis] MKSQIIAVSLLLLLLSTGIESYRIHKREAPTYLSQVQDAVSYSWLQVSNKAQDWFEAVRNHQVEEKAKEIFDKGTSAVKP YYNIFSDQLYHWWHAQ
Mafft alignment of selected proteins >sp|P02655|APOC2_HUMAN Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1 ------------------------------------------------------------ ------------------------------------MGTRLLPALFLVLLVLGF------ -------EVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKL RDLYSKSTAAMSTYTGIFTDQVLSVLKGEE-- >tr|E9QEQ1|E9QEQ1_DANRE Apolipoprotein C-II OS=Danio rerio OX=7955 GN=apoc2 PE=1 SV=1 ------------------------------------------------------------ ------------------------------------MNK--ILAITVFVAFLAL------ -------GAESFRVPRQAE-DEKGTIAVVVDTLKSYYDQSVDTASGYVETIKGYKLEEKA KTIYSDTVRAVGTYAGIFQDQLYHILYSQDSH >NP_001264873.1 apolipoprotein C-II precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------MGSRFFLALFLVILMLGN------ -------EVQGN---QEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKL RDMYSKSSAAMSTYAGIFTDQLLTLLRGE--- >NP_001078821.1 apolipoprotein C-II precursor [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------MGSRFFLALFLALLVLGN------ -------EVQGT---EEDDPGSSALLDTVQEHLFSYWNSAKAAAGELYQKTYLTSVDEKL RDMYSKSSAAMTTYAGIFTDQLLTLLKGE--- >XP_038509382.1 apolipoprotein C-II isoform X2 [Canis lupus familiaris] M----------------------------------------------------------- ---------------------DIRTKLSQWSRSSEAMGTRYLLVLLLVLLVLGF------ -------EVQGAHESQQDETTSSALLTQMQESLYSYWGTARSAAEDLYKKAYPTTMDEKI RDIYSKSTAAVSTYAGIFTDQLLSMLKGDS-- >XP_015313666.2 apolipoprotein C-II isoform X1 [Bos taurus] MP---------PPPQLSPSHPCSPVGQDFGRGVEV------------------------- ----GVEGWISRA-IKPFSAHLELLRTAARVWSPDAMGTRYFLVGFLILLVLGF------ -------EVQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPAVDEKI RDIYSKSTAAVTTYAGIITDQVFSVLSGKD-- >XP_043293858.1 apolipoprotein C-II [Cervus canadensis] ------------------------------------------------------------ ------------------------------------MGTRYFLVGFLILLVLGF------ -------EAQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKI RDIYSKSTAAVTTYAGIITDQVFSMLSGED-- >KAB0346346.1 hypothetical protein FD754_011203 [Muntiacus muntjak] MG---------------------------GRGLQASRFGVEGEGWRASCWPGLWPRCRGG GGGGGVDLKSYKAFLCPFGI-AEDSRQSLCSRSPDAMGTRYFLVGFLILLVLGF------ -------ETQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKI RDIYSKSTAAVTTYAGIITDQFFSMLSGED-- >NP_001230828.1 apolipoprotein C-II precursor [Pan troglodytes] ------------------------------------------------------------ ------------------------------------MGTRLLPALFLVLLVLGF------ -------EVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKL RDLYSKSTAAMSTYTGIFTDQVLSVLKGEE-- >NP_001170799.1 apolipoprotein C-II precursor [Sus scrofa] ------------------------------------------------------------ ------------------------------------MGARSFLALFLILLLLAS------ -------EAQGAHVPPQDEPDSPALLTKVQESLYGYWDTAKATAQDLYRKTYLPTVDEKI RDMYSKSTAAVTIYAGIFTDQVLSLLTGDH-- >XP_009231041.1 apolipoprotein C-II [Pongo abelii] ------------------------------------------------------------ ------------------------------------MGTRFLPALFLVLLVLGF------ -------EVQGAPPPQQDELPSPAFLTQVQESLSSYWESAKAAAQNLYEKTYLPAVDEKL RDLYSKSTTAMSTYTGIFTDQVLSVLKGEE-- >XP_008969010.1 apolipoprotein C-II [Pan paniscus] ------------------------------------------------------------ ------------------------------------MGTRLLPALFLVLLVLGF------ -------EVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKL RDLYSKSTAAMSTYTGIFTDQVLSVLKGEE-- >XP_003997697.2 apolipoprotein C-II [Felis catus] ------------------------------------------------------------ ------------------------------------MGTRCLLVLLLVLLVLRC------ -------DVQGDDMARQDEATGPTLLSKMQESLYGYWGSAKAAAQDLYKKTYLTTVDEKI RDMYSTSTAAVRIYTGILTDQILSMLSGDS-- >XP_004015363.3 apolipoprotein C-II isoform X2 [Ovis aries] ------------------------------------------------------------ ------------------------------------MGTRYFLVGFLILLVLGF------ -------EAQGAHVPQQDEASSPALLTKMQESLLGYWDTAKAAAHKLYKKTYLPTVDEKI RDIYSKSTAAVTTYAGIITDQVFSILSGED-- >XP_013832559.1 PREDICTED: apolipoprotein C-II isoform X1 [Capra hircus] ------------------------------------------------------------ ------------------------------------MGTRYFLVGFLILLVLGFAGPSAT LTHSPPAEAQGAHVPQQDEASSPALLTKMQKSLLGYWDTAKAAAHKLYKKTYLPTVDEKI RDIYSKSTAAVTTYAGIITDQVFSILSGED-- >XP_017195234.1 PREDICTED: apolipoprotein C-II [Oryctolagus cuniculus] ME---------PTPS--------------ERG---------------------WVRIPS- --------------PAPRGA-APATLPSAFQVTADTMGPRLLLAVCLILLVLGCG----- ------ELVQGSHLPQNDEPASPALLTKVQESLSSYWDSAKAAAQGLYNNTYLTAVDEKI RDMYSKSTAAMTTYASIVTDQLLTLLKGDP-- >XP_018870627.1 apolipoprotein C-II [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------MGTRLLPALFLVLLVLGF------ -------EVQGTQQPQQDETPSLTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKL RDLYSKSTAAMSTYTGIFTDQVLSVLKGEE-- >XP_020753892.1 apolipoprotein C-II [Odocoileus virginianus texanus] METPDLMPGGHPGPLIPPQPPIQPVSLSIPRHLPPS-FPLPP---LQSCWPGLWPRCR-- SGGGGVDLKSYKAFLCPFGA-AEDRRQSLCSRSPDAMGTRYFLVGFLILLVLRF------ -------GAQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAHKLYKKTYLPIVDEKI RDIYSKSTAAVTTYAGIITDQVFSMLSGED-- >XP_030250521.1 apolipoprotein C-II [Sparus aurata] ------------------------------------------------------------ ------------------------------------MNK--LLVITVLVGLLAL------ -------SADSFRMPRQVE-EEEGTISKITGTIRSYYDSAVNTATEYIESIKGLKLEEKA KNLYADTTEVASTYAGIMQDQLYHIFSSQ--- >XP_015805614.1 PREDICTED: apolipoprotein C-II-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------MNK--LLVVTVLVAFLAL------ -------SVESFRVPRQAE-EDEGTLTQITGAVKSYYDSAVNTVSGYVESIKDLKLEEKA KNLYHETTTVLGTYAGIAHDQLYHFFHH---- >XP_018082198.1 apolipoprotein C-II [Xenopus laevis] ------------------------------------------------------------ ------------------------------------MKSQ-IIAVSLLLLLLST------ -------GIESYRIHKR---EAPTYLSQVQDAVSYSWLQVSNKAQDWFEAVRNHQVEEKA KEIFDKGTSAVKPYYNIFSDQLYHWWHAQ---
BMGE Cleaned alignment of selected proteins >sp|P02655|APOC2_HUMAN Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1 MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >tr|E9QEQ1|E9QEQ1_DANRE Apolipoprotein C-II OS=Danio rerio OX=7955 GN=apoc2 PE=1 SV=1 MNK--ILAITVFVAFLALGAESFRVPRQAE-DEKGTIAVVVDTLKSYYDQSVDTASGYVETIKGYKLEEKAKTIYSDTVRAVGTYAGIFQDQLYHILYSQD >NP_001264873.1 apolipoprotein C-II precursor [Mus musculus] MGSRFFLALFLVILMLGNEVQGN---QEDDSGSLALLGTVQGSLLSYWTSAKEVAKDLYQKTYPISMDEKLRDMYSKSSAAMSTYAGIFTDQLLTLLRGE- >NP_001078821.1 apolipoprotein C-II precursor [Rattus norvegicus] MGSRFFLALFLALLVLGNEVQGT---EEDDPGSSALLDTVQEHLFSYWNSAKAAAGELYQKTYLTSVDEKLRDMYSKSSAAMTTYAGIFTDQLLTLLKGE- >XP_038509382.1 apolipoprotein C-II isoform X2 [Canis lupus familiaris] MGTRYLLVLLLVLLVLGFEVQGAHESQQDETTSSALLTQMQESLYSYWGTARSAAEDLYKKAYPTTMDEKIRDIYSKSTAAVSTYAGIFTDQLLSMLKGDS >XP_015313666.2 apolipoprotein C-II isoform X1 [Bos taurus] MGTRYFLVGFLILLVLGFEVQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPAVDEKIRDIYSKSTAAVTTYAGIITDQVFSVLSGKD >XP_043293858.1 apolipoprotein C-II [Cervus canadensis] MGTRYFLVGFLILLVLGFEAQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQVFSMLSGED >KAB0346346.1 hypothetical protein FD754_011203 [Muntiacus muntjak] MGTRYFLVGFLILLVLGFETQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAQKLYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQFFSMLSGED >NP_001230828.1 apolipoprotein C-II precursor [Pan troglodytes] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >NP_001170799.1 apolipoprotein C-II precursor [Sus scrofa] MGARSFLALFLILLLLASEAQGAHVPPQDEPDSPALLTKVQESLYGYWDTAKATAQDLYRKTYLPTVDEKIRDMYSKSTAAVTIYAGIFTDQVLSLLTGDH >XP_009231041.1 apolipoprotein C-II [Pongo abelii] MGTRFLPALFLVLLVLGFEVQGAPPPQQDELPSPAFLTQVQESLSSYWESAKAAAQNLYEKTYLPAVDEKLRDLYSKSTTAMSTYTGIFTDQVLSVLKGEE >XP_008969010.1 apolipoprotein C-II [Pan paniscus] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >XP_003997697.2 apolipoprotein C-II [Felis catus] MGTRCLLVLLLVLLVLRCDVQGDDMARQDEATGPTLLSKMQESLYGYWGSAKAAAQDLYKKTYLTTVDEKIRDMYSTSTAAVRIYTGILTDQILSMLSGDS >XP_004015363.3 apolipoprotein C-II isoform X2 [Ovis aries] MGTRYFLVGFLILLVLGFEAQGAHVPQQDEASSPALLTKMQESLLGYWDTAKAAAHKLYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQVFSILSGED >XP_013832559.1 PREDICTED: apolipoprotein C-II isoform X1 [Capra hircus] MGTRYFLVGFLILLVLGFEAQGAHVPQQDEASSPALLTKMQKSLLGYWDTAKAAAHKLYKKTYLPTVDEKIRDIYSKSTAAVTTYAGIITDQVFSILSGED >XP_017195234.1 PREDICTED: apolipoprotein C-II [Oryctolagus cuniculus] MGPRLLLAVCLILLVLGCLVQGSHLPQNDEPASPALLTKVQESLSSYWDSAKAAAQGLYNNTYLTAVDEKIRDMYSKSTAAMTTYASIVTDQLLTLLKGDP >XP_018870627.1 apolipoprotein C-II [Gorilla gorilla gorilla] MGTRLLPALFLVLLVLGFEVQGTQQPQQDETPSLTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE >XP_020753892.1 apolipoprotein C-II [Odocoileus virginianus texanus] MGTRYFLVGFLILLVLRFGAQGAHVPQQDEASSPALLTQVQESLLGYWDTAKAAAHKLYKKTYLPIVDEKIRDIYSKSTAAVTTYAGIITDQVFSMLSGED >XP_030250521.1 apolipoprotein C-II [Sparus aurata] MNK--LLVITVLVGLLALSADSFRMPRQVE-EEEGTISKITGTIRSYYDSAVNTATEYIESIKGLKLEEKAKNLYADTTEVASTYAGIMQDQLYHIFSSQ- >XP_015805614.1 PREDICTED: apolipoprotein C-II-like [Nothobranchius furzeri] MNK--LLVVTVLVAFLALSVESFRVPRQAE-EDEGTLTQITGAVKSYYDSAVNTVSGYVESIKDLKLEEKAKNLYHETTTVLGTYAGIAHDQLYHFFHH-- >XP_018082198.1 apolipoprotein C-II [Xenopus laevis] MKSQ-IIAVSLLLLLLSTGIESYRIHKR---EAPTYLSQVQDAVSYSWLQVSNKAQDWFEAVRNHQVEEKAKEIFDKGTSAVKPYYNIFSDQLYHWWHAQ-
PhyML tree of selected proteins (tr_E9QEQ1_E9QEQ1_DANRE_Apolipoprotein_C_II_OS_Danio_rerio_OX_7955_GN_apoc2_PE_1_SV_1:0.19180391,(XP_018082198_1_apolipoprotein_C_II__Xenopus_laevis_:0.70439786,(XP_017195234_1_PREDICTED__apolipoprotein_C_II__Oryctolagus_cuniculus_:0.19541902,((NP_001078821_1_apolipoprotein_C_II_precursor__Rattus_norvegicus_:0.0705067,NP_001264873_1_apolipoprotein_C_II_precursor__Mus_musculus_:0.21551692):0.18555244,((XP_009231041_1_apolipoprotein_C_II__Pongo_abelii_:0.02624437,(sp_P02655_APOC2_HUMAN_Apolipoprotein_C_II_OS_Homo_sapiens_OX_9606_GN_APOC2_PE_1_SV_1:0.00000001,((NP_001230828_1_apolipoprotein_C_II_precursor__Pan_troglodytes_:0.00000001,XP_008969010_1_apolipoprotein_C_II__Pan_paniscus_:0.00000001):0.00000001,XP_018870627_1_apolipoprotein_C_II__Gorilla_gorilla_gorilla_:0.01015959):0.01016178):0.07529895):0.19579752,(NP_001170799_1_apolipoprotein_C_II_precursor__Sus_scrofa_:0.18017181,((XP_015313666_2_apolipoprotein_C_II_isoform_X1__Bos_taurus_:0.03199909,(KAB0346346_1_hypothetical_protein_FD754_011203__Muntiacus_muntjak_:0.01941175,(XP_043293858_1_apolipoprotein_C_II__Cervus_canadensis_:0.00000001,(XP_020753892_1_apolipoprotein_C_II__Odocoileus_virginianus_texanus_:0.03140119,(XP_004015363_3_apolipoprotein_C_II_isoform_X2__Ovis_aries_:0.00000001,XP_013832559_1_PREDICTED__apolipoprotein_C_II_isoform_X1__Capra_hircus_:0.01008847):0.03109829):0.00995991):0.00476737):0.00551961):0.09281497,(XP_003997697_2_apolipoprotein_C_II__Felis_catus_:0.24319574,XP_038509382_1_apolipoprotein_C_II_isoform_X2__Canis_lupus_familiaris_:0.16153342):0.11394895):0.03699563):0.10970565):0.06424459):0.02312911):1.06592863):0.73523525,(XP_015805614_1_PREDICTED__apolipoprotein_C_II_like__Nothobranchius_furzeri_:0.20868521,XP_030250521_1_apolipoprotein_C_II__Sparus_aurata_:0.18751708):0.1650173);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)