PB0087

DATABASE

Click here to access PB0087 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0087	P02654	Apolipoprotein C-I	APOC1	Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1	Homo_sapiens	Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Domains

Gene Ontology

PF04691 (ApoC-I)

GO:0004859 (enables) phospholipase inhibitor activity GO:0005504 (enables) fatty acid binding GO:0005515 (enables) protein binding GO:0031210 (enables) phosphatidylcholine binding GO:0055102 (enables) lipase inhibitor activity GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity GO:0006629 (involved in) lipid metabolic process GO:0006641 (involved in) triglyceride metabolic process GO:0006869 (involved in) lipid transport GO:0010873 (involved in) positive regulation of cholesterol esterification GO:0010900 (involved in) negative regulation of phosphatidylcholine catabolic process GO:0010916 (involved in) negative regulation of very-low-density lipoprotein particle clearance GO:0032374 (involved in) regulation of cholesterol transport GO:0032375 (involved in) negative regulation of cholesterol transport GO:0033344 (involved in) cholesterol efflux GO:0033700 (involved in) phospholipid efflux GO:0034369 (involved in) plasma lipoprotein particle remodeling GO:0034375 (involved in) high-density lipoprotein particle remodeling GO:0034379 (involved in) very-low-density lipoprotein particle assembly GO:0034382 (involved in) chylomicron remnant clearance GO:0034447 (involved in) very-low-density lipoprotein particle clearance GO:0042157 (involved in) lipoprotein metabolic process GO:0045717 (involved in) negative regulation of fatty acid biosynthetic process GO:0045833 (involved in) negative regulation of lipid metabolic process GO:0048261 (involved in) negative regulation of receptor-mediated endocytosis GO:0050995 (involved in) negative regulation of lipid catabolic process GO:0051005 (involved in) negative regulation of lipoprotein lipase activity GO:0005576 (located in) extracellular region GO:0005783 (located in) endoplasmic reticulum GO:0034361 (part of) very-low-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0042627 (part of) chylomicron

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1 MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSEL SAKMREWFSETFQKVKEKLKIDS >tr|E9QDI1|E9QDI1_DANRE Apolipoprotein C-I OS=Danio rerio OX=7955 GN=apoc1 PE=1 SV=1 MKLYLAAAVLMLVLAVHTAEAQEEPTLEQHFTKFGTQMKEIAEDLADKTKTAFQNIEQSE LGTKTRNWFNDQYEKLKQKMTETFN
Selected proteins from model organisms >sp|P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1 MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSEL SAKMREWFSETFQKVKEKLKIDS >tr|E9QDI1|E9QDI1_DANRE Apolipoprotein C-I OS=Danio rerio OX=7955 GN=apoc1 PE=1 SV=1 MKLYLAAAVLMLVLAVHTAEAQEEPTLEQHFTKFGTQMKEIAEDLADKTKTAFQNIEQSE LGTKTRNWFNDQYEKLKQKMTETFN >NP_001103479.1 apolipoprotein C-I precursor [Mus musculus] MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTRA WFSEAFGKVKEKLKTTFS >NP_036956.1 apolipoprotein C-I precursor [Rattus norvegicus] MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRN WFSETLNKMKEKLKTTFA >NP_001183977.1 apolipoprotein C-I precursor [Canis lupus familiaris] MRLILSLPVLVVVLSMVLEGPAPAQAAGEISSTFERIPDKLKEFGNTLEDKARAAIESIKKSDIPAKTRN WFSEAFKKVKEHLKTAFS >XP_003316492.1 apolipoprotein C-I, basic form [Pan troglodytes] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQNELSAKMREWFSE TFQKVKEKLKIDS >NP_001153753.1 apolipoprotein C-I precursor [Oryctolagus cuniculus] MRLVLSLPVLVLALSMALEGPAPAQAAPDFSTLELIPDKLKEFGNTLEEKARMAIEHIKQSEITTKTRNW FSETISKVKEKFKSTFS >XP_003779249.1 apolipoprotein C-I [Pongo abelii] MRLFLSLPVLVVVLSMVLEGPAPAQGAPDVSSALDKLKEFGNTLEDKAREVINRIKQSELSAKTRDWFSE TFRKVKEKLKINS >XP_034800326.1 apolipoprotein C-I isoform X1 [Pan paniscus] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQNELSAKMRLEPFP GHGRAGVCFWVEPWQMVQDEQIEKKTSPGEADNVPLVTQLDLKGVVFRDISESEGETQD >XP_019674940.1 apolipoprotein C-I [Felis catus] MRLILWLPVLVVVLLMVLEGPAPAQGAPAIASTFSNIPNSLKEFGNNLKDAFESIPEATRKLMTSFAEGL KNLRLPLL >XP_025050846.1 apolipoprotein C-I isoform X1 [Alligator sinensis] MGCECGHRASAAGQRSSELDTAAPALSAWHGPGQAWSLVRTVDKGEGASGKRRKAPLQQALGPGLFAWGA DGLGGEPEAPSSGARAWPWQVLTPAVPREPLFCNAAPGLAWPGLAEEPVSWSRCFHNPNLKLEEENRGEG WGGRGAGKTKRFSAQLGDVCVETRSWPWGPCEEGGYCRLQPTPGTMRPAVSIALALVALLVLADSAQSEP GEPTLMQKLEQFKENVKDFADTIGEKTKAALQELRDSEFSTKTRNWFSEHFKKVKEKLKDTFA >XP_019343569.1 PREDICTED: apolipoprotein C-I [Alligator mississippiensis] MRPAVSIALALVALLVLADSARSEPGEPTLMQKLEQFKENVKVFADNIGEKTKAALQELHDSEFSTKTRN WFSEHFKKVKEKLKDTFA >XP_015805619.1 PREDICTED: apolipoprotein C-I, basic form-like [Nothobranchius furzeri] MKLYLAVAVLMLAFVAYTEAQDATGFADFQEKITDFGKTFAENAKTHFETIKNSEFAQNTQNWFTEQFQK LKDQLQSN >XP_030250215.1 apolipoprotein C-I-like [Sparus aurata] MRLFLAVAVLMLAFIAYTEAQEETTEQTFAKFGEQMTEMGKDLAEKAKTTFENINNSEFAVTSRNWFTQQ LEKLKNRVQEISQ >XP_018870623.1 apolipoprotein C-I [Gorilla gorilla gorilla] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMRDWFSETFQKVKEKLK IDS
Mafft alignment of selected proteins >sp|P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKAREL ISRIKQSELSAKMR-------------EWFSE---------------------------- ----TFQKVKEKLKID-S >tr|E9QDI1|E9QDI1_DANRE Apolipoprotein C-I OS=Danio rerio OX=7955 GN=apoc1 PE=1 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MKLYLAAAVLMLVLAVHT---AEAQEEPTLEQHFTKFGTQMKEIAEDLADKTKTA FQNIEQSELGTKTR-------------NWFND---------------------------- ----QYEKLKQKMTETFN >NP_001103479.1 apolipoprotein C-I precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAA IEHIKQKEILTKTR-------------AWFSE---------------------------- ----AFGKVKEKLKTTFS >NP_036956.1 apolipoprotein C-I precursor [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEFGNTLEDKARAA IEHIKQKEIMIKTR-------------NWFSE---------------------------- ----TLNKMKEKLKTTFA >NP_001183977.1 apolipoprotein C-I precursor [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLILSLPVLVVVLSMVLEGPAPAQAAGEISSTFERIPDKLKEFGNTLEDKARAA IESIKKSDIPAKTR-------------NWFSE---------------------------- ----AFKKVKEHLKTAFS >XP_003316492.1 apolipoprotein C-I, basic form [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKAREL ISRIKQNELSAKMR-------------EWFSE---------------------------- ----TFQKVKEKLKID-S >NP_001153753.1 apolipoprotein C-I precursor [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLVLSLPVLVLALSMALEGPAPAQAAPDFS-TLELIPDKLKEFGNTLEEKARMA IEHIKQSEITTKTR-------------NWFSE---------------------------- ----TISKVKEKFKSTFS >XP_003779249.1 apolipoprotein C-I [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLSLPVLVVVLSMVLEGPAPAQGAPDVSSAL----DKLKEFGNTLEDKAREV INRIKQSELSAKTR-------------DWFSE---------------------------- ----TFRKVKEKLKIN-S >XP_034800326.1 apolipoprotein C-I isoform X1 [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKAREL ISRIKQNELSAKMRLEPFPGHGRAGVCFWVEPWQMVQDEQIEKKTSPGEADNVPLVTQLD LKGVVFRDISESEGETQD >XP_019674940.1 apolipoprotein C-I [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLILWLPVLVVVLLMVLEGPAPAQGAPAIASTFSNIPNSLKEFGNNLKD----A FESI--PEATRKLM-------------TSFAE---------------------------- ----GLKNLRLPLL---- >XP_025050846.1 apolipoprotein C-I isoform X1 [Alligator sinensis] MGCECGHRASAAGQRSSELDTAAPALSAWHGPGQAWSLVRTVDKGEGASGKRRKAPLQQA LGPGLFAWGADGLGGEPEAPSSGARAWPWQVLTPAVPREPLFCNAAPGLAWPGLAEEPVS WSRCFHNPNLKLEEENRGEGWGGRGAGKTKRFSAQLGDVCVETRSWPWGPCEEGGYCRLQ PTPGTMRPAVSIALALVALLVLADSAQSEPGEPTLMQKLEQFKENVKDFADTIGEKTKAA LQELRDSEFSTKTR-------------NWFSE---------------------------- ----HFKKVKEKLKDTFA >XP_019343569.1 PREDICTED: apolipoprotein C-I [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRPAVSIALALVALLVLADSARSEPGEPTLMQKLEQFKENVKVFADNIGEKTKAA LQELHDSEFSTKTR-------------NWFSE---------------------------- ----HFKKVKEKLKDTFA >XP_015805619.1 PREDICTED: apolipoprotein C-I, basic form-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MKLYLAVAVLMLAFVAYT----EAQDAT----GFADFQEKITDFGKTFAENAKTH FETIKNSEFAQNTQ-------------NWFTE---------------------------- ----QFQKLKDQLQSN-- >XP_030250215.1 apolipoprotein C-I-like [Sparus aurata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLAVAVLMLAFIAYT----EAQEETT-EQTFAKFGEQMTEMGKDLAEKAKTT FENINNSEFAVTSR-------------NWFTQ---------------------------- ----QLEKLKNRVQEISQ >XP_018870623.1 apolipoprotein C-I [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKAREL ISRIKQSELSAKMR-------------DWFSE---------------------------- ----TFQKVKEKLKID-S
BMGE Cleaned alignment of selected proteins >sp|P02654|APOC1_HUMAN Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1 MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKID-S >tr|E9QDI1|E9QDI1_DANRE Apolipoprotein C-I OS=Danio rerio OX=7955 GN=apoc1 PE=1 SV=1 MKLYLAAAVLMLVLAVHT---AEAQEEPTLEQHFTKFGTQMKEIAEDLADKTKTAFQNIEQSELGTKTRNWFNDQYEKLKQKMTETFN >NP_001103479.1 apolipoprotein C-I precursor [Mus musculus] MRLFIALPVLIVVVAMTLEGPAPAQAAPDLSGTLESIPDKLKEFGNTLEDKARAAIEHIKQKEILTKTRAWFSEAFGKVKEKLKTTFS >NP_036956.1 apolipoprotein C-I precursor [Rattus norvegicus] MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTTFA >NP_001183977.1 apolipoprotein C-I precursor [Canis lupus familiaris] MRLILSLPVLVVVLSMVLEGPAPAQAAGEISSTFERIPDKLKEFGNTLEDKARAAIESIKKSDIPAKTRNWFSEAFKKVKEHLKTAFS >XP_003316492.1 apolipoprotein C-I, basic form [Pan troglodytes] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMREWFSETFQKVKEKLKID-S >NP_001153753.1 apolipoprotein C-I precursor [Oryctolagus cuniculus] MRLVLSLPVLVLALSMALEGPAPAQAAPDFS-TLELIPDKLKEFGNTLEEKARMAIEHIKQSEITTKTRNWFSETISKVKEKFKSTFS >XP_003779249.1 apolipoprotein C-I [Pongo abelii] MRLFLSLPVLVVVLSMVLEGPAPAQGAPDVSSAL----DKLKEFGNTLEDKAREVINRIKQSELSAKTRDWFSETFRKVKEKLKIN-S >XP_034800326.1 apolipoprotein C-I isoform X1 [Pan paniscus] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKARELISRIKQNELSAKMRFWVEPVFRDISESEGETQD >XP_019674940.1 apolipoprotein C-I [Felis catus] MRLILWLPVLVVVLLMVLEGPAPAQGAPAIASTFSNIPNSLKEFGNNLKD----AFESI--PEATRKLMTSFAEGLKNLRLPLL---- >XP_025050846.1 apolipoprotein C-I isoform X1 [Alligator sinensis] MRPAVSIALALVALLVLADSAQSEPGEPTLMQKLEQFKENVKDFADTIGEKTKAALQELRDSEFSTKTRNWFSEHFKKVKEKLKDTFA >XP_019343569.1 PREDICTED: apolipoprotein C-I [Alligator mississippiensis] MRPAVSIALALVALLVLADSARSEPGEPTLMQKLEQFKENVKVFADNIGEKTKAALQELHDSEFSTKTRNWFSEHFKKVKEKLKDTFA >XP_015805619.1 PREDICTED: apolipoprotein C-I, basic form-like [Nothobranchius furzeri] MKLYLAVAVLMLAFVAYT----EAQDAT----GFADFQEKITDFGKTFAENAKTHFETIKNSEFAQNTQNWFTEQFQKLKDQLQSN-- >XP_030250215.1 apolipoprotein C-I-like [Sparus aurata] MRLFLAVAVLMLAFIAYT----EAQEETT-EQTFAKFGEQMTEMGKDLAEKAKTTFENINNSEFAVTSRNWFTQQLEKLKNRVQEISQ >XP_018870623.1 apolipoprotein C-I [Gorilla gorilla gorilla] MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSAL----DKLKEFGNTLEDKARELISRIKQSELSAKMRDWFSETFQKVKEKLKID-S
PhyML tree of selected proteins (XP_019343569_1_PREDICTED__apolipoprotein_C_I__Alligator_mississippiensis_:0.04818427,XP_025050846_1_apolipoprotein_C_I_isoform_X1__Alligator_sinensis_:0.00000001,((tr_E9QDI1_E9QDI1_DANRE_Apolipoprotein_C_I_OS_Danio_rerio_OX_7955_GN_apoc1_PE_1_SV_1:0.24477642,(XP_015805619_1_PREDICTED__apolipoprotein_C_I__basic_form_like__Nothobranchius_furzeri_:0.37837813,XP_030250215_1_apolipoprotein_C_I_like__Sparus_aurata_:0.16160932):0.27445625):0.40862953,((NP_001153753_1_apolipoprotein_C_I_precursor__Oryctolagus_cuniculus_:0.13025002,(NP_001103479_1_apolipoprotein_C_I_precursor__Mus_musculus_:0.08163165,NP_036956_1_apolipoprotein_C_I_precursor__Rattus_norvegicus_:0.09570877):0.10052115):0.03497778,((XP_019674940_1_apolipoprotein_C_I__Felis_catus_:0.58362182,NP_001183977_1_apolipoprotein_C_I_precursor__Canis_lupus_familiaris_:0.06364371):0.08818333,(XP_003779249_1_apolipoprotein_C_I__Pongo_abelii_:0.00000001,(XP_018870623_1_apolipoprotein_C_I__Gorilla_gorilla_gorilla_:0.00000001,(sp_P02654_APOC1_HUMAN_Apolipoprotein_C_I_OS_Homo_sapiens_OX_9606_GN_APOC1_PE_1_SV_1:0.00000001,(XP_003316492_1_apolipoprotein_C_I__basic_form__Pan_troglodytes_:0.00000001,XP_034800326_1_apolipoprotein_C_I_isoform_X1__Pan_paniscus_:0.25823866):0.01251324):0.01247155):0.09274848):0.1728059):0.0192676):0.50355964):0.58066951);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)