PB0086

DATABASE

Click here to access PB0086 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0086	P02647	Apolipoprotein A-I	APOA1	HPALP2, apo(a), apolipoprotein A1	Homo_sapiens	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Domains

Gene Ontology

PF01442 (Apolipoprotein)

GO:0001540 (enables) amyloid-beta binding GO:0005102 (enables) signaling receptor binding GO:0005319 (enables) lipid transporter activity GO:0005515 (enables) protein binding GO:0005543 (enables) phospholipid binding GO:0008035 (enables) high-density lipoprotein particle binding GO:0008289 (enables) lipid binding GO:0015485 (enables) cholesterol binding GO:0019899 (enables) enzyme binding GO:0031072 (enables) heat shock protein binding GO:0031210 (enables) phosphatidylcholine binding GO:0034190 (enables) apolipoprotein receptor binding GO:0034191 (enables) apolipoprotein A-I receptor binding GO:0042802 (enables) identical protein binding GO:0045499 (enables) chemorepellent activity GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity GO:0070653 (enables) high-density lipoprotein particle receptor binding GO:0071813 (enables) lipoprotein particle binding GO:0120020 (enables) cholesterol transfer activity GO:0001932 (involved in) regulation of protein phosphorylation GO:0001935 (involved in) endothelial cell proliferation GO:0002719 (involved in) negative regulation of cytokine production involved in immune response GO:0006629 (involved in) lipid metabolic process GO:0006644 (involved in) phospholipid metabolic process GO:0006656 (involved in) phosphatidylcholine biosynthetic process GO:0006695 (involved in) cholesterol biosynthetic process GO:0006869 (involved in) lipid transport GO:0007186 (involved in) G protein-coupled receptor signaling pathway GO:0007229 (involved in) integrin-mediated signaling pathway GO:0008202 (involved in) steroid metabolic process GO:0008203 (involved in) cholesterol metabolic process GO:0008211 (involved in) glucocorticoid metabolic process GO:0010804 (involved in) negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010873 (involved in) positive regulation of cholesterol esterification GO:0010875 (involved in) positive regulation of cholesterol efflux GO:0010898 (involved in) positive regulation of triglyceride catabolic process GO:0010903 (involved in) negative regulation of very-low-density lipoprotein particle remodeling GO:0018158 (involved in) protein oxidation GO:0018206 (involved in) peptidyl-methionine modification GO:0019915 (involved in) lipid storage GO:0030300 (involved in) regulation of intestinal cholesterol absorption GO:0030301 (involved in) cholesterol transport GO:0030325 (involved in) adrenal gland development GO:0032489 (involved in) regulation of Cdc42 protein signal transduction GO:0032691 (involved in) negative regulation of interleukin-1 beta production GO:0033344 (involved in) cholesterol efflux GO:0033700 (involved in) phospholipid efflux GO:0034115 (involved in) negative regulation of heterotypic cell-cell adhesion GO:0034372 (involved in) very-low-density lipoprotein particle remodeling GO:0034375 (involved in) high-density lipoprotein particle remodeling GO:0034380 (involved in) high-density lipoprotein particle assembly GO:0034384 (involved in) high-density lipoprotein particle clearance GO:0035025 (involved in) positive regulation of Rho protein signal transduction GO:0042157 (involved in) lipoprotein metabolic process GO:0042158 (involved in) lipoprotein biosynthetic process GO:0042632 (involved in) cholesterol homeostasis GO:0043534 (involved in) blood vessel endothelial cell migration GO:0043691 (involved in) reverse cholesterol transport GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process GO:0046470 (involved in) phosphatidylcholine metabolic process GO:0046889 (involved in) positive regulation of lipid biosynthetic process GO:0050728 (involved in) negative regulation of inflammatory response GO:0050766 (involved in) positive regulation of phagocytosis GO:0050821 (involved in) protein stabilization GO:0050919 (involved in) negative chemotaxis GO:0051006 (involved in) positive regulation of lipoprotein lipase activity GO:0051180 (involved in) vitamin transport GO:0051345 (involved in) positive regulation of hydrolase activity GO:0051346 (involved in) negative regulation of hydrolase activity GO:0051496 (involved in) positive regulation of stress fiber assembly GO:0055091 (involved in) phospholipid homeostasis GO:0060354 (involved in) negative regulation of cell adhesion molecule production GO:0060761 (involved in) negative regulation of response to cytokine stimulus GO:0070328 (involved in) triglyceride homeostasis GO:0070508 (involved in) cholesterol import GO:0120009 (involved in) intermembrane lipid transfer GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading GO:1902995 (involved in) positive regulation of phospholipid efflux GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005769 (located in) early endosome GO:0005788 (located in) endoplasmic reticulum lumen GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0030139 (located in) endocytic vesicle GO:0031410 (located in) cytoplasmic vesicle GO:0034774 (located in) secretory granule lumen GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:0071682 (located in) endocytic vesicle lumen GO:0072562 (located in) blood microparticle GO:1903561 (located in) extracellular vesicle GO:0034361 (part of) very-low-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0034366 (part of) spherical high-density lipoprotein particle GO:0042627 (part of) chylomicron

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P02647|APOA1_HUMAN Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ GLLPVLESFKVSFLSALEEYTKKLNTQ >tr|A0A0R4IKF0|A0A0R4IKF0_DANRE Apolipoprotein A-Ib OS=Danio rerio OX=7955 GN=apoa1b PE=1 SV=1 MMRFVALALTVFLAGCQARFLQDEPPSQLEHVKSALQVYADHLKQAAHKSLTHLDDTEFK DYKVFLGQSIDNLHSHFQNFFQVITPLGSQVMDATNPIREKLNKDMEDLRKDIEPKREEL RAVLEKHFNEYRDELKPFMDDYLVKQRQHMEEVRAKLEPVVLSLKEKIPPNWEETKSKLM PILEAIRGKVAENVQELRTMLEPYVQEYKDQMEKGALEFREKVKSGELRKELTELGEQVK PHFEGIFKALQKFASKE
Selected proteins from model organisms >sp|P02647|APOA1_HUMAN Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ GLLPVLESFKVSFLSALEEYTKKLNTQ >tr|A0A0R4IKF0|A0A0R4IKF0_DANRE Apolipoprotein A-Ib OS=Danio rerio OX=7955 GN=apoa1b PE=1 SV=1 MMRFVALALTVFLAGCQARFLQDEPPSQLEHVKSALQVYADHLKQAAHKSLTHLDDTEFK DYKVFLGQSIDNLHSHFQNFFQVITPLGSQVMDATNPIREKLNKDMEDLRKDIEPKREEL RAVLEKHFNEYRDELKPFMDDYLVKQRQHMEEVRAKLEPVVLSLKEKIPPNWEETKSKLM PILEAIRGKVAENVQELRTMLEPYVQEYKDQMEKGALEFREKVKSGELRKELTELGEQVK PHFEGIFKALQKFASKE >NP_033822.2 apolipoprotein A-I preproprotein [Mus musculus] MKAVVLAVALVFLTGSQAWHVWQQDEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLL ENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQKVQPYLDEFQKKWKEDVELYRQ KVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTL NEYHTRAKTHLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ >NP_036870.1 apolipoprotein A-I preproprotein [Rattus norvegicus] MKAAVLAVALVFLTGCQAWEFWQQDEPQSQWDRVKDFATVYVDAVKDSGRDYVSQFESSTLGKQLNLNLL DNWDTLGSTVGRLQEQLGPVTQEFWANLEKETDWLRNEMNKDLENVKQKMQPHLDEFQEKWNEEVEAYRQ KLEPLGTELHKNAKEMQRHLKVVAEEFRDRMRVNADALRAKFGLYSDQMRENLAQRLTEIKNHPTLIEYH TKASDHLKTLGEKAKPALDDLGQGLMPVLEAWKAKIMSMIDEAKKKLNA >NP_776667.2 apolipoprotein A-I preproprotein [Bos taurus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLL DNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQ KVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGS LAEYHAKASEQLKALGEKAKPVLEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ >NP_990856.1 apolipoprotein A-I preproprotein [Gallus gallus] MRGVLVTLAVLFLTGTQARSFWQHDEPQTPLDRIRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLA DNLDTLSAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVKEKIRPFLDQFSAKWTEELEQYRQ RLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIREKGIP QASEYQAKVMEQLSNLREKMTPLVQEFRERLTPYAENLKNRLISFLDELQKSVA >NP_999563.1 apolipoprotein A-I preproprotein [Sus scrofa] MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDFATVYVDAIKDSGRDYVAQFEASALGKHLNLKLL DNWDSLGSTFTKVREQLGPVTQEFWDNLEKETEALRQEMSKDLEEVKKKVQPYLDDFQNKWQEEMETYRQ KMPLGAEFREGARQKVQELQEKLSPLAEELRDRLRAHVAALRQHVAPYSDDLRQRMAARFEALKEGGDSL AEYQAKAQEQLKALGEKAKPALEDLRQGLLPVLENLKVSILAAIDEASKKLNAQ >XP_013968873.1 apolipoprotein A-I [Canis lupus familiaris] MKAALLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDAVKDSGRDYVAQFEASALGKQLNLKLL DNWDSLSSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVKQKVQPYLDDFQKKWQEEVELYRQ KVAPLGSELREGARQKLQELQEKLSPLGEELRDRARTHVDALRAQLAPYSDDLRERLAARLQALKEGGGA SLAEYHARASEQLSALGEKARPALEDLRQGLLPVLESFKVSLLAAIDEATKKLNAQ >NP_001095157.1 apolipoprotein A-I preproprotein [Oryctolagus cuniculus] MKAVVLTLAVLFLTGSQARHFWQRDEPRSSWDKIKDFATVYVDTVKDSGREYVAQFEASAFGKQLNLKLL DNWDSLSSTVSKLQEQLGPVTQEFWDNLEKETEGLREEMNKDLQEVRQKVQPFLDEFQKKWQEEVERYRQ KVEPLGAELGESARQKLTELQEKLSPLAEELRDSARTHVDTLRTKLAPYSNELQRLAARLESIKEGGGAK LAEYQAKAREHLSVLSEKARPALEDLRQGLLPVLESFKASVQNVVDEATKKLNTQ >XP_024110625.1 apolipoprotein A-I isoform X1 [Pongo abelii] MKAAVLTLAVLFLTGSQARHFWQQDEPPQTPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL LDNWDSMTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELHEKLSPLGEEMRDRARAHVDALRTHLAPYTDELRQRLAARLEALKENGG ARLAEYHAKASEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_010722021.1 apolipoprotein A-I [Meleagris gallopavo] MRGVLVTLAVLFLTGTQARSFWQHDDPQTPLDRIRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLA DNLDTLGAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVKEKIRPFLDQFSTKWTEELEQYRQ RLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIREKGIP QAAEYQAKVVEQLSNLREKMTPLVQEFRERLTPYAENLKNRLITLLDELQKTVA >XP_003820129.1 apolipoprotein A-I [Pan paniscus] MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSTLGKQLNLKL LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_011284668.1 apolipoprotein A-I [Felis catus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDLVTVYVDAVKDGGREYVAQFEASALGKQLNLKLL DNWDTLGSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVKQKVQPYLDDFQKKWQEEVELYRQ KVAPLGTELREGARQKLQELHEKLSPLGEELRDRARTHVDALRAQLAPYSDELRERLAARLQALKESGGA SLAEYHAKASEHLSTLSEKAKPALEDLRQGLLPVLESFKVGLMAIVDEATKKLNAQ >XP_011950887.2 apolipoprotein A-I isoform X1 [Ovis aries] MKAVVLTLAVLFLTGSQARHFWQQDEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLL DNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVRQKVQPYLDEFQKKWHEEVEIYRQ KVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGS LAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ >XP_004052230.1 apolipoprotein A-I [Gorilla gorilla gorilla] MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_021140876.1 apolipoprotein A-I [Columba livia] MRAVVVALALLCLTGTQARSFWQHDEPQAPLDRLRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLA DNLDTLSAAVAKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVKEKIRPFLDQFSAKWTEELEQYRQ RLVPLAQELKDITKQKVELVQERLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIRDKGIP QAAEYQAKVVEHLGNLREKLTPLAQDFKERLAPYAESLKTRIIALLDDFQKRVA >XP_017915238.1 PREDICTED: apolipoprotein A-I [Capra hircus] MKAVVLTLAVLFLTGSQARHFWQQDEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLL DNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVRQKVQPYLDEFQKKWHEEVEIYRQ KVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGS LAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ >XP_006030393.1 apolipoprotein A-I [Alligator sinensis] MRAIVVTLALVFLTGTQARYFWQHDDPQTRLDRFKDMLNVYMETMKASGKEVVAQFDASAVGKQLDLKVG DTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVRQKFQTALEQFAQQWGAEVDQYRE KLVPVVSNMKELSRQKLELLQQQLTPLAEEAQGRMRGHVDELRKNLAPYKEELTQKIQKLHESFPYTSNV RDQAVQHLSSLREKVTPLVQDFRERVKPYTDSVKTHLLNLFQEARKTLS >XP_016777528.1 apolipoprotein A-I [Pan troglodytes] MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_019336206.1 PREDICTED: apolipoprotein A-I [Alligator mississippiensis] MRAIVVTLALVFLTGTQARYFWQHDDPQTRLDRFKDMLNVYMETMKASGKEVVAQFDASAVGKQLDLKVG DTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVRQKFQTALEQFAQQWGAEVDQYRE KLVPVVSNVKDLSRQKLELLQQQLTPLAEEAQERMRGHVDKLRKTLAPYKEELTQKMQKLRESLPYTSNV RDQAVQHLSNLREKVTPLVQDLRESIKPYTESIKTHLLNLFQEARKTLS >XP_020758270.1 apolipoprotein A-I [Odocoileus virginianus texanus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLL DNWDSLASTLTKVREQLGPVTQEFWDNLEKETGSLRQEMSKDLEEVKQKIQPYLDEFQKKWHEEVEIYRQ KVAPLGEEFREGARQKVQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGS LAEYHAKASEHLKALGEKAKPALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ >XP_043338085.1 apolipoprotein A-I [Cervus canadensis] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDSLASTL TKVREQLGPVTQEFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQEL QDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAKASEQLKALGEKAKPALEDLRQGL LPVLESLKVSILAAIDEASKKLNAQ >KAB0347352.1 hypothetical protein FD754_012209 [Muntiacus muntjak] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDNLASTL TKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQEL QDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGSLAEYHAXXXXAVP >KAB0370818.1 hypothetical protein FD755_017227 [Muntiacus reevesi] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDNLASTL TKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQEL QDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGGSXXXXWSCLHSCPFHQQLKQPETVHRGLSFS PTTQN >OWK17945.1 APOA1 [Cervus elaphus hippelaphus] MQSHTGKARALSCSSGGSQGAGRCSLREPSLSPCSLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETASLRQEMSK DLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSD DLRQRLTARLEALKEGGGSLADVS >NP_001079732.1 apolipoprotein A-I precursor [Xenopus laevis] MKSLVLLAVLFLSGTQANYFPWQHDEPRTPVQQVREVLESYVHKVRDLGREAVSQLETSDLGKQLDLKITEKLDTFGTNA MNLRKQINPYVENIREQVSKELEKELPIIKEKIRPILEGFQKRWAEDAKAYQEKISPLVAELQKQTKSNLDSLYKKITPI AEEVRDKVRVDVDALRSRLTPYSDEIRQKLVAKLEELKANAGPKSEEYRTQLSQYIENVKEKYGPLAQSIRERLVPHAEE ARSNLAKIWENLKARLRQDA >XP_040183603.1 apolipoprotein A-I-like [Rana temporaria] MKSLTLTIALVFLTGTQARYPWQNEEPQTPIQQVREAIEGYLITLQDIGKTAVAQAESYDVAKQLDLKLTEKFDAFSTNA LALRKQLNPYVDNVREKVSAELEKDIPLLREKIRPFIETFQKNWAAEVTSFKENIAPVVEDWKKQTKENIDGFYKKAQPQ LEGLRVKLGSEFDSLKTKIAPYKEEIRQKLIEKFEEVKANAGPRAEEYKAQLAQHAETLKQRLGPVVENLKEQLGPKLEE AKIKLAQLWQTVQARIAERYA >XP_030267150.1 apolipoprotein A-I-like [Sparus aurata] MKVLVVLALAVFSGCNANILWQEPPKTSLDMVKDAFWDYVAKATSTAEDSLNQIRQSELGQEVNTKISQSADTVNQYVVS LRTQVAPVTQDFMTRFTQEAEQLKTRLEKDMSAVSANLQPLAQEMVANLQKQVEELQREAAPYVEAMDPEPLKAVLLQKS QELKVQLEKRMADVQAQMVPYTEEIKEKMEQSVDEFQKSVIPLTQSFEAQLTQKTQEIQQNLVPLGEELKAKLDASAQDL QAQLTSLWESFTRKTQ >XP_004078298.1 apolipoprotein A-I [Oryzias latipes] MKVFVVLAVAVLSGCHANLFYADAPKPQLEVLTDAFWDYIAKATQTADDTLDMIKTSPIGQEINARLTESADVASRYAVA LQEQLSPAAQDMMNRITKEADVLKNVLTQELSSVRGKLEPYTDNMRAQIQQRVEKLKQDLSPYADSEALRATLLQKSEEL KTNLEQSVKDLQAQLGPYTDDLKQKVDQHLQKFQKSVAPMTEKVQLELSQRANLVKQMVAPYAEDLREKLDPYAQDLQAQ LMSLYQSYVNAN >XP_015805620.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] MKVFVLLAVAVLSGCDANLFYADAPKPQLEVLTDAFWDYISKATQTADDTLQMIRESPLGQEINTRLTKSADMASKYAVT LQEQLPPAAHDLVNKITTEADVLKSVLTKELSSARDKLEPYTENMKAQIQQRVDQLKQELAPYADSLDSEALRTTLMQKS EELKASLEQSVKDLQAQLGPYTDDLKQKVDQHLQNFQKSVASMTEKVQGELSQRANVVKQMVAPYAEDLGEKLNPYAQDL QAQLMSLYQSFINAN
Mafft alignment of selected proteins >sp|P02647|APOA1_HUMAN Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1 -MKAAVLTLAVLFLTGSQARHF-WQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFE GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARA HVDALRTHLAPYSDELRQRLAARLEALKENGGARLAE-----YHAKATEHLSTLSEKAKP ALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ-- >tr|A0A0R4IKF0|A0A0R4IKF0_DANRE Apolipoprotein A-Ib OS=Danio rerio OX=7955 GN=apoa1b PE=1 SV=1 MMRFVALALTV-FLAGCQARFL---QDE-PPSQLEHVKSALQVYADHLKQAAHKSLTHLD DTEF-KDYKVFLGQSIDNLHSHFQNFFQVITPLGSQVMD----ATNPIREKLNKDMEDLR KDIEPKREELRAVLEKHFNEYRDELKPFMDDYLVKQRQHMEEVRAKLEPVVLSLKEKIPP NWEETKSKLMPILEAIRGKVAENVQELRTMLEPYVQE-----YKDQMEKGALEFREKVKS --GELRKELTELGEQVKPHFEGIFKALQKFASKE-- >NP_033822.2 apolipoprotein A-I preproprotein [Mus musculus] -MKAVVLAVALVFLTGSQAWHV-WQQDE-PQSQWDKVKDFANVYVDAVKDSGRDYVSQFE SSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVK QKVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRT HVDSLRTQLAPHSEQMRESLAQRLAELKSN--PTLNE-----YHTRAKTHLKTLGEKARP ALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ-- >NP_036870.1 apolipoprotein A-I preproprotein [Rattus norvegicus] -MKAAVLAVALVFLTGCQAWEF-WQQDE-PQSQWDRVKDFATVYVDAVKDSGRDYVSQFE SSTLGKQLNLNLLDNWDTLGSTVGRLQEQLGPVTQEFWANLEKETDWLRNEMNKDLENVK QKMQPHLDEFQEKWNEEVEAYRQKLEPLGTELHKNAK----EMQRHLKVVAEEFRDRMRV NADALRAKFGLYSDQMRENLAQRLTEIKNH--PTLIE-----YHTKASDHLKTLGEKAKP ALDDLGQGLMPVLEAWKAKIMSMIDEAKKKLNA--- >NP_776667.2 apolipoprotein A-I preproprotein [Bos taurus] -MKAVVLTLAVLFLTGSQARHF-WQQDD-PQSSWDRVKDFATVYVEAIKDSGRDYVAQFE ASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVK QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAKASEQLKALGEKAKP VLEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ-- >NP_990856.1 apolipoprotein A-I preproprotein [Gallus gallus] -MRGVLVTLAVLFLTGTQARSF-WQHDE-PQTPLDRIRDMVDVYLETVKASGKDAIAQFE SSAVGKQLDLKLADNLDTLSAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVK EKIRPFLDQFSAKWTEELEQYRQRLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRG HVEELRKNLAPYSDELRQKLSQKLEEIREKGIPQASE-----YQAKVMEQLSNLREKMTP LVQEFRERLTPYAENLKNRLISFLDELQKSVA---- >NP_999563.1 apolipoprotein A-I preproprotein [Sus scrofa] -MKAVVLTLAVLFLTGSQARHF-WQQDD-PQSPWDRVKDFATVYVDAIKDSGRDYVAQFE ASALGKHLNLKLLDNWDSLGSTFTKVREQLGPVTQEFWDNLEKETEALRQEMSKDLEEVK KKVQPYLDDFQNKWQEEMETYRQKM-PLGAEFREGARQKVQELQEKLSPLAEELRDRLRA HVAALRQHVAPYSDDLRQRMAARFEALKEGGD-SLAE-----YQAKAQEQLKALGEKAKP ALEDLRQGLLPVLENLKVSILAAIDEASKKLNAQ-- >XP_013968873.1 apolipoprotein A-I [Canis lupus familiaris] -MKAALLTLAVLFLTGSQARHF-WQQDE-PQSPWDRVKDLATVYVDAVKDSGRDYVAQFE ASALGKQLNLKLLDNWDSLSSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVK QKVQPYLDDFQKKWQEEVELYRQKVAPLGSELREGARQKLQELQEKLSPLGEELRDRART HVDALRAQLAPYSDDLRERLAARLQALKEGGGASLAE-----YHARASEQLSALGEKARP ALEDLRQGLLPVLESFKVSLLAAIDEATKKLNAQ-- >NP_001095157.1 apolipoprotein A-I preproprotein [Oryctolagus cuniculus] -MKAVVLTLAVLFLTGSQARHF-WQRDE-PRSSWDKIKDFATVYVDTVKDSGREYVAQFE ASAFGKQLNLKLLDNWDSLSSTVSKLQEQLGPVTQEFWDNLEKETEGLREEMNKDLQEVR QKVQPFLDEFQKKWQEEVERYRQKVEPLGAELGESARQKLTELQEKLSPLAEELRDSART HVDTLRTKLAPYSNEL-QRLAARLESIKEGGGAKLAE-----YQAKAREHLSVLSEKARP ALEDLRQGLLPVLESFKASVQNVVDEATKKLNTQ-- >XP_024110625.1 apolipoprotein A-I isoform X1 [Pongo abelii] -MKAAVLTLAVLFLTGSQARHF-WQQDEPPQTPWDRVKDLATVYVDVLKDSGRDYVSQFE GSALGKQLNLKLLDNWDSMTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELHEKLSPLGEEMRDRARA HVDALRTHLAPYTDELRQRLAARLEALKENGGARLAE-----YHAKASEHLSTLSEKAKP ALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ-- >XP_010722021.1 apolipoprotein A-I [Meleagris gallopavo] -MRGVLVTLAVLFLTGTQARSF-WQHDD-PQTPLDRIRDMVDVYLETVKASGKDAIAQFE SSAVGKQLDLKLADNLDTLGAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVK EKIRPFLDQFSTKWTEELEQYRQRLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRG HVEELRKNLAPYSDELRQKLSQKLEEIREKGIPQAAE-----YQAKVVEQLSNLREKMTP LVQEFRERLTPYAENLKNRLITLLDELQKTVA---- >XP_003820129.1 apolipoprotein A-I [Pan paniscus] -MKAAVLTLAVLFLTGSQARHF-WQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFE GSTLGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARA HVDALRTHLAPYSDELRQRLAARLEALKENGGARLAE-----YHAKATEHLSTLSEKAKP ALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ-- >XP_011284668.1 apolipoprotein A-I [Felis catus] -MKAVVLTLAVLFLTGSQARHF-WQQDD-PQSPWDRVKDLVTVYVDAVKDGGREYVAQFE ASALGKQLNLKLLDNWDTLGSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVK QKVQPYLDDFQKKWQEEVELYRQKVAPLGTELREGARQKLQELHEKLSPLGEELRDRART HVDALRAQLAPYSDELRERLAARLQALKESGGASLAE-----YHAKASEHLSTLSEKAKP ALEDLRQGLLPVLESFKVGLMAIVDEATKKLNAQ-- >XP_011950887.2 apolipoprotein A-I isoform X1 [Ovis aries] -MKAVVLTLAVLFLTGSQARHF-WQQDE-PQSSWDRVKDFATVYVEAIKDSGRDYVAQFE ASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVR QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAKATEQLKALGEKAKP ALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ-- >XP_004052230.1 apolipoprotein A-I [Gorilla gorilla gorilla] -MKAAVLTLAVLFLTGSQARHF-WQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFE GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARA HVDALRTHLAPYSDELRQRLAARLEALKENGGARLAE-----YHAKATEHLSTLSEKAKP ALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ-- >XP_021140876.1 apolipoprotein A-I [Columba livia] -MRAVVVALALLCLTGTQARSF-WQHDE-PQAPLDRLRDMVDVYLETVKASGKDAIAQFE SSAVGKQLDLKLADNLDTLSAAVAKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVK EKIRPFLDQFSAKWTEELEQYRQRLVPLAQELKDITKQKVELVQERLTPVAEEARDRLRG HVEELRKNLAPYSDELRQKLSQKLEEIRDKGIPQAAE-----YQAKVVEHLGNLREKLTP LAQDFKERLAPYAESLKTRIIALLDDFQKRVA---- >XP_017915238.1 PREDICTED: apolipoprotein A-I [Capra hircus] -MKAVVLTLAVLFLTGSQARHF-WQQDE-PQSSWDRVKDFATVYVEAIKDSGRDYVAQFE ASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVR QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAKATEQLKALGEKAKP ALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ-- >XP_006030393.1 apolipoprotein A-I [Alligator sinensis] -MRAIVVTLALVFLTGTQARYF-WQHDD-PQTRLDRFKDMLNVYMETMKASGKEVVAQFD ASAVGKQLDLKVGDTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVR QKFQTALEQFAQQWGAEVDQYREKLVPVVSNMKELSRQKLELLQQQLTPLAEEAQGRMRG HVDELRKNLAPYKEELTQKI-QKLHE----SFPYTSN-----VRDQAVQHLSSLREKVTP LVQDFRERVKPYTDSVKTHLLNLFQEARKTLS---- >XP_016777528.1 apolipoprotein A-I [Pan troglodytes] -MKAAVLTLAVLFLTGSQARHF-WQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFE GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVK AKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARA HVDALRTHLAPYSDELRQRLAARLEALKENGGARLAE-----YHAKATEHLSTLSEKAKP ALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ-- >XP_019336206.1 PREDICTED: apolipoprotein A-I [Alligator mississippiensis] -MRAIVVTLALVFLTGTQARYF-WQHDD-PQTRLDRFKDMLNVYMETMKASGKEVVAQFD ASAVGKQLDLKVGDTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVR QKFQTALEQFAQQWGAEVDQYREKLVPVVSNVKDLSRQKLELLQQQLTPLAEEAQERMRG HVDKLRKTLAPYKEELTQKM-QKLRE----SLPYTSN-----VRDQAVQHLSNLREKVTP LVQDLRESIKPYTESIKTHLLNLFQEARKTLS---- >XP_020758270.1 apolipoprotein A-I [Odocoileus virginianus texanus] -MKAVVLTLAVLFLTGSQARHF-WQQDD-PQSSWDRVKDFATVYVEAIKDSGREYVAQFE ASALGKQLNLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETGSLRQEMSKDLEEVK QKIQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQEIRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAKASEHLKALGEKAKP ALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ-- >XP_043338085.1 apolipoprotein A-I [Cervus canadensis] -MKAVVLTLAVLFLTGSQARHF-WQHDD-PQSSWDRVKDFATVYVEAIKDSGREYVAQFE ASALGKQLNLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETASLRQEMSKDLEEVK QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQELQDKLSPLAQEIRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAKASEQLKALGEKAKP ALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ-- >KAB0347352.1 hypothetical protein FD754_012209 [Muntiacus muntjak] -MKAVVLTLAVLFLTGSQARHF-WQHDD-PQSSWDRVKDFATVYVEAIKDSGREYVAQFE ASALGKQLNLKLLDNWDNLASTLTKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVK QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQEIRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAE-----YHAXXXXAVP-------- ------------------------------------ >KAB0370818.1 hypothetical protein FD755_017227 [Muntiacus reevesi] -MKAVVLTLAVLFLTGSQARHF-WQHDD-PQSSWDRVKDFATVYVEAIKDSGREYVAQFE ASALGKQLNLKLLDNWDNLASTLTKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVK QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SXXXXWSCLHSCPFHQQLK------QP --ETVHRGL-----SFSPTTQN-------------- >OWK17945.1 APOA1 [Cervus elaphus hippelaphus] -MQSH---------TG-KARA-------------------LSCSSGGSQGAGRCSLREPS LSP----CSLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETASLRQEMSKDLEEVK QKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQELQDKLSPLAQEIRDRARA HVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAD-VS-------------------- ------------------------------------ >NP_001079732.1 apolipoprotein A-I precursor [Xenopus laevis] -MKSLVL-LAVLFLSGTQANYFPWQHDE-PRTPVQQVREVLESYVHKVRDLGREAVSQLE TSDLGKQLDLKITEKLDTFGTNAMNLRKQINPYVENIR-------EQVSKELEKELPIIK EKIRPILEGFQKRWAEDAKAYQEKISPLVAELQKQTKSNLDSLYKKITPIAEEVRDKVRV DVDALRSRLTPYSDEIRQKLVAKLEELKANAGPKSEE-----YRTQLSQYIENVKEKYGP LAQSIRERLVPHAEEARSNLAKIWENLKARLRQD-A >XP_040183603.1 apolipoprotein A-I-like [Rana temporaria] -MKSLTLTIALVFLTGTQARYP-WQNEE-PQTPIQQVREAIEGYLITLQDIGKTAVAQAE SYDVAKQLDLKLTEKFDAFSTNALALRKQLNPYVDNVR-------EKVSAELEKDIPLLR EKIRPFIETFQKNWAAEVTSFKENIAPVVEDWKKQTKENIDGFYKKAQPQLEGLRVKLGS EFDSLKTKIAPYKEEIRQKLIEKFEEVKANAGPRAEE-----YKAQLAQHAETLKQRLGP VVENLKEQLGPKLEEAKIKLAQLWQTVQARIAERYA >XP_030267150.1 apolipoprotein A-I-like [Sparus aurata] -MKVLVV-LALAVFSGCNANIL-W-QEP-PKTSLDMVKDAFWDYVAKATSTAEDSLNQIR QSELGQEVNTKISQSADTVNQYVVSLRTQVAPVTQDFMTRFTQEAEQLKTRLEKDMSAVS ANLQPLAQEMVANLQKQVEELQREAAPYVEAMDP------EPLKAVLLQKSQELKVQLEK RMADVQAQMVPYTEEIKEKMEQSVDEFQKSVIPLTQS-----FEAQLTQKTQEIQQNLVP LGEELKAKLDASAQDLQAQLTSLWESFTRKTQ---- >XP_004078298.1 apolipoprotein A-I [Oryzias latipes] -MKVFVV-LAVAVLSGCHANLF-Y-ADA-PKPQLEVLTDAFWDYIAKATQTADDTLDMIK TSPIGQEINARLTESADVASRYAVALQEQLSPAAQDMMNRITKEADVLKNVLTQELSSVR GKLEPYTDNMRAQIQQRVEKLKQDLSPYA---DS------EALRATLLQKSEELKTNLEQ SVKDLQAQLGPYTDDLKQKVDQHLQKFQKSVAPMTEK-----VQLELSQRANLVKQMVAP YAEDLREKLDPYAQDLQAQLMSLYQSYVNAN----- >XP_015805620.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] -MKVFVL-LAVAVLSGCDANLF-Y-ADA-PKPQLEVLTDAFWDYISKATQTADDTLQMIR ESPLGQEINTRLTKSADMASKYAVTLQEQLPPAAHDLVNKITTEADVLKSVLTKELSSAR DKLEPYTENMKAQIQQRVDQLKQELAPYADSLDS------EALRTTLMQKSEELKASLEQ SVKDLQAQLGPYTDDLKQKVDQHLQNFQKSVASMTEK-----VQGELSQRANVVKQMVAP YAEDLGEKLNPYAQDLQAQLMSLYQSFINAN-----
BMGE Cleaned alignment of selected proteins >sp|P02647|APOA1_HUMAN Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1 MKAAVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >tr|A0A0R4IKF0|A0A0R4IKF0_DANRE Apolipoprotein A-Ib OS=Danio rerio OX=7955 GN=apoa1b PE=1 SV=1 MRFVALALTV-FLAGCQARFL--QDEPPSQLEHVKSALQVYADHLKQAAHKSLTHLDDTEF-KDYKVFLGQSIDNLHSHFQNFFQVITPLGSQVMD----ATNPIREKLNKDMEDLRKDIEPKREELRAVLEKHFNEYRDELKPFMDDYLVKQRQHMEEVRAKLEPVVLSLKEKIPPNWEETKSKLMPILEAIRGKVAENVQELRTMLEPYVQEYKDQMEKGALEFREKVKS--GELRKELTELGEQVKPHFEGIFKALQKFASKE >NP_033822.2 apolipoprotein A-I preproprotein [Mus musculus] MKAVVLAVALVFLTGSQAWHVWQQDEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQKVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSN--PTLNEYHTRAKTHLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ >NP_036870.1 apolipoprotein A-I preproprotein [Rattus norvegicus] MKAAVLAVALVFLTGCQAWEFWQQDEPQSQWDRVKDFATVYVDAVKDSGRDYVSQFESSTLGKQLNLNLLDNWDTLGSTVGRLQEQLGPVTQEFWANLEKETDWLRNEMNKDLENVKQKMQPHLDEFQEKWNEEVEAYRQKLEPLGTELHKNAK----EMQRHLKVVAEEFRDRMRVNADALRAKFGLYSDQMRENLAQRLTEIKNH--PTLIEYHTKASDHLKTLGEKAKPALDDLGQGLMPVLEAWKAKIMSMIDEAKKKLNA- >NP_776667.2 apolipoprotein A-I preproprotein [Bos taurus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAKASEQLKALGEKAKPVLEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ >NP_990856.1 apolipoprotein A-I preproprotein [Gallus gallus] MRGVLVTLAVLFLTGTQARSFWQHDEPQTPLDRIRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLSAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVKEKIRPFLDQFSAKWTEELEQYRQRLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIREKGIPQASEYQAKVMEQLSNLREKMTPLVQEFRERLTPYAENLKNRLISFLDELQKSVA-- >NP_999563.1 apolipoprotein A-I preproprotein [Sus scrofa] MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDFATVYVDAIKDSGRDYVAQFEASALGKHLNLKLLDNWDSLGSTFTKVREQLGPVTQEFWDNLEKETEALRQEMSKDLEEVKKKVQPYLDDFQNKWQEEMETYRQKM-PLGAEFREGARQKVQELQEKLSPLAEELRDRLRAHVAALRQHVAPYSDDLRQRMAARFEALKEGGD-SLAEYQAKAQEQLKALGEKAKPALEDLRQGLLPVLENLKVSILAAIDEASKKLNAQ >XP_013968873.1 apolipoprotein A-I [Canis lupus familiaris] MKAALLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDAVKDSGRDYVAQFEASALGKQLNLKLLDNWDSLSSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVKQKVQPYLDDFQKKWQEEVELYRQKVAPLGSELREGARQKLQELQEKLSPLGEELRDRARTHVDALRAQLAPYSDDLRERLAARLQALKEGGGASLAEYHARASEQLSALGEKARPALEDLRQGLLPVLESFKVSLLAAIDEATKKLNAQ >NP_001095157.1 apolipoprotein A-I preproprotein [Oryctolagus cuniculus] MKAVVLTLAVLFLTGSQARHFWQRDEPRSSWDKIKDFATVYVDTVKDSGREYVAQFEASAFGKQLNLKLLDNWDSLSSTVSKLQEQLGPVTQEFWDNLEKETEGLREEMNKDLQEVRQKVQPFLDEFQKKWQEEVERYRQKVEPLGAELGESARQKLTELQEKLSPLAEELRDSARTHVDTLRTKLAPYSNEL-QRLAARLESIKEGGGAKLAEYQAKAREHLSVLSEKARPALEDLRQGLLPVLESFKASVQNVVDEATKKLNTQ >XP_024110625.1 apolipoprotein A-I isoform X1 [Pongo abelii] MKAAVLTLAVLFLTGSQARHFWQQDEPQTPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSMTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELHEKLSPLGEEMRDRARAHVDALRTHLAPYTDELRQRLAARLEALKENGGARLAEYHAKASEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_010722021.1 apolipoprotein A-I [Meleagris gallopavo] MRGVLVTLAVLFLTGTQARSFWQHDDPQTPLDRIRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLGAAAAKLREDMAPYYKEVREMWLKDTEALRAELTKDLEEVKEKIRPFLDQFSTKWTEELEQYRQRLTPVAQELKELTKQKVELMQAKLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIREKGIPQAAEYQAKVVEQLSNLREKMTPLVQEFRERLTPYAENLKNRLITLLDELQKTVA-- >XP_003820129.1 apolipoprotein A-I [Pan paniscus] MKAAVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSTLGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_011284668.1 apolipoprotein A-I [Felis catus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSPWDRVKDLVTVYVDAVKDGGREYVAQFEASALGKQLNLKLLDNWDTLGSTVTKLREQIGPVTQEFWDNLEKETEVLRQEMSKDLEEVKQKVQPYLDDFQKKWQEEVELYRQKVAPLGTELREGARQKLQELHEKLSPLGEELRDRARTHVDALRAQLAPYSDELRERLAARLQALKESGGASLAEYHAKASEHLSTLSEKAKPALEDLRQGLLPVLESFKVGLMAIVDEATKKLNAQ >XP_011950887.2 apolipoprotein A-I isoform X1 [Ovis aries] MKAVVLTLAVLFLTGSQARHFWQQDEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVRQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ >XP_004052230.1 apolipoprotein A-I [Gorilla gorilla gorilla] MKAAVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_021140876.1 apolipoprotein A-I [Columba livia] MRAVVVALALLCLTGTQARSFWQHDEPQAPLDRLRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLSAAVAKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVKEKIRPFLDQFSAKWTEELEQYRQRLVPLAQELKDITKQKVELVQERLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIRDKGIPQAAEYQAKVVEHLGNLREKLTPLAQDFKERLAPYAESLKTRIIALLDDFQKRVA-- >XP_017915238.1 PREDICTED: apolipoprotein A-I [Capra hircus] MKAVVLTLAVLFLTGSQARHFWQQDEPQSSWDRVKDFATVYVEAIKDSGRDYVAQFEASALGKQLNLKLLDNWDTLASTLSKVREQLGPVTQEFWDNLEKETASLRQEMHKDLEEVRQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAKATEQLKALGEKAKPALEDLRQGLMPVLESLKVSILAAIDEASKKLNAQ >XP_006030393.1 apolipoprotein A-I [Alligator sinensis] MRAIVVTLALVFLTGTQARYFWQHDDPQTRLDRFKDMLNVYMETMKASGKEVVAQFDASAVGKQLDLKVGDTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVRQKFQTALEQFAQQWGAEVDQYREKLVPVVSNMKELSRQKLELLQQQLTPLAEEAQGRMRGHVDELRKNLAPYKEELTQKI-QKLHE----SFPYTSNVRDQAVQHLSSLREKVTPLVQDFRERVKPYTDSVKTHLLNLFQEARKTLS-- >XP_016777528.1 apolipoprotein A-I [Pan troglodytes] MKAAVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ >XP_019336206.1 PREDICTED: apolipoprotein A-I [Alligator mississippiensis] MRAIVVTLALVFLTGTQARYFWQHDDPQTRLDRFKDMLNVYMETMKASGKEVVAQFDASAVGKQLDLKVGDTLDSLSSTIVQMKEDLAPYYEEMRDAWDKETESLQSEVAQDLEQVRQKFQTALEQFAQQWGAEVDQYREKLVPVVSNVKDLSRQKLELLQQQLTPLAEEAQERMRGHVDKLRKTLAPYKEELTQKM-QKLRE----SLPYTSNVRDQAVQHLSNLREKVTPLVQDLRESIKPYTESIKTHLLNLFQEARKTLS-- >XP_020758270.1 apolipoprotein A-I [Odocoileus virginianus texanus] MKAVVLTLAVLFLTGSQARHFWQQDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETGSLRQEMSKDLEEVKQKIQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAKASEHLKALGEKAKPALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ >XP_043338085.1 apolipoprotein A-I [Cervus canadensis] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAKASEQLKALGEKAKPALEDLRQGLLPVLESLKVSILAAIDEASKKLNAQ >KAB0347352.1 hypothetical protein FD754_012209 [Muntiacus muntjak] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDNLASTLTKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAEYHAXXXXAVP------------------------------------------ >KAB0370818.1 hypothetical protein FD755_017227 [Muntiacus reevesi] MKAVVLTLAVLFLTGSQARHFWQHDDPQSSWDRVKDFATVYVEAIKDSGREYVAQFEASALGKQLNLKLLDNWDNLASTLTKVREQLGPVTQDFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKVQELQDKLSPLAQELRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SXXXHSCPFHQQLK------QP--ETVHRGL-----SFSPTTQN------------ >OWK17945.1 APOA1 [Cervus elaphus hippelaphus] MQSH---------TG-KARA-----------------LSCSSGGSQGAGRCSLREPSLSP----CSLKLLDNWDSLASTLTKVREQLGPVTQEFWDNLEKETASLRQEMSKDLEEVKQKVQPYLDEFQKKWHEEVEIYRQKVAPLGEEFREGARQKLQELQDKLSPLAQEIRDRARAHVETLRQQLAPYSDDLRQRLTARLEALKEGGG-SLAD---------------------------------------------------- >NP_001079732.1 apolipoprotein A-I precursor [Xenopus laevis] MKSLVL-LAVLFLSGTQANYFWQHDEPRTPVQQVREVLESYVHKVRDLGREAVSQLETSDLGKQLDLKITEKLDTFGTNAMNLRKQINPYVENIR-------EQVSKELEKELPIIKEKIRPILEGFQKRWAEDAKAYQEKISPLVAELQKQTKSNLDSLYKKITPIAEEVRDKVRVDVDALRSRLTPYSDEIRQKLVAKLEELKANAGPKSEEYRTQLSQYIENVKEKYGPLAQSIRERLVPHAEEARSNLAKIWENLKARLRQD >XP_040183603.1 apolipoprotein A-I-like [Rana temporaria] MKSLTLTIALVFLTGTQARYPWQNEEPQTPIQQVREAIEGYLITLQDIGKTAVAQAESYDVAKQLDLKLTEKFDAFSTNALALRKQLNPYVDNVR-------EKVSAELEKDIPLLREKIRPFIETFQKNWAAEVTSFKENIAPVVEDWKKQTKENIDGFYKKAQPQLEGLRVKLGSEFDSLKTKIAPYKEEIRQKLIEKFEEVKANAGPRAEEYKAQLAQHAETLKQRLGPVVENLKEQLGPKLEEAKIKLAQLWQTVQARIAER >XP_030267150.1 apolipoprotein A-I-like [Sparus aurata] MKVLVV-LALAVFSGCNANILW-QEPPKTSLDMVKDAFWDYVAKATSTAEDSLNQIRQSELGQEVNTKISQSADTVNQYVVSLRTQVAPVTQDFMTRFTQEAEQLKTRLEKDMSAVSANLQPLAQEMVANLQKQVEELQREAAPYVEAMDP------EPLKAVLLQKSQELKVQLEKRMADVQAQMVPYTEEIKEKMEQSVDEFQKSVIPLTQSFEAQLTQKTQEIQQNLVPLGEELKAKLDASAQDLQAQLTSLWESFTRKTQ-- >XP_004078298.1 apolipoprotein A-I [Oryzias latipes] MKVFVV-LAVAVLSGCHANLFY-ADAPKPQLEVLTDAFWDYIAKATQTADDTLDMIKTSPIGQEINARLTESADVASRYAVALQEQLSPAAQDMMNRITKEADVLKNVLTQELSSVRGKLEPYTDNMRAQIQQRVEKLKQDLSPYA---DS------EALRATLLQKSEELKTNLEQSVKDLQAQLGPYTDDLKQKVDQHLQKFQKSVAPMTEKVQLELSQRANLVKQMVAPYAEDLREKLDPYAQDLQAQLMSLYQSYVNAN--- >XP_015805620.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] MKVFVL-LAVAVLSGCDANLFY-ADAPKPQLEVLTDAFWDYISKATQTADDTLQMIRESPLGQEINTRLTKSADMASKYAVTLQEQLPPAAHDLVNKITTEADVLKSVLTKELSSARDKLEPYTENMKAQIQQRVDQLKQELAPYADSLDS------EALRTTLMQKSEELKASLEQSVKDLQAQLGPYTDDLKQKVDQHLQNFQKSVASMTEKVQGELSQRANVVKQMVAPYAEDLGEKLNPYAQDLQAQLMSLYQSFINAN---
PhyML tree of selected proteins (XP_030267150_1_apolipoprotein_A_I_like__Sparus_aurata_:0.40218981,(XP_004078298_1_apolipoprotein_A_I__Oryzias_latipes_:0.0589577,XP_015805620_1_PREDICTED__apolipoprotein_Eb_like__Nothobranchius_furzeri_:0.11433558):0.36749274,(tr_A0A0R4IKF0_A0A0R4IKF0_DANRE_Apolipoprotein_A_Ib_OS_Danio_rerio_OX_7955_GN_apoa1b_PE_1_SV_1:1.27799594,((NP_001079732_1_apolipoprotein_A_I_precursor__Xenopus_laevis_:0.22648987,XP_040183603_1_apolipoprotein_A_I_like__Rana_temporaria_:0.54149256):0.41213233,(((NP_001095157_1_apolipoprotein_A_I_preproprotein__Oryctolagus_cuniculus_:0.13227403,(((XP_013968873_1_apolipoprotein_A_I__Canis_lupus_familiaris_:0.02425481,XP_011284668_1_apolipoprotein_A_I__Felis_catus_:0.06184326):0.03002728,(NP_999563_1_apolipoprotein_A_I_preproprotein__Sus_scrofa_:0.07438102,((XP_020758270_1_apolipoprotein_A_I__Odocoileus_virginianus_texanus_:0.0115562,((XP_043338085_1_apolipoprotein_A_I__Cervus_canadensis_:0.00000001,OWK17945_1_APOA1__Cervus_elaphus_hippelaphus_:0.20217572):0.00384939,(KAB0347352_1_hypothetical_protein_FD754_012209__Muntiacus_muntjak_:0.01447736,KAB0370818_1_hypothetical_protein_FD755_017227__Muntiacus_reevesi_:0.07152856):0.03240489):0.00385766):0.00763625,((XP_011950887_2_apolipoprotein_A_I_isoform_X1__Ovis_aries_:0.00000001,XP_017915238_1_PREDICTED__apolipoprotein_A_I__Capra_hircus_:0.00000001):0.01545996,NP_776667_2_apolipoprotein_A_I_preproprotein__Bos_taurus_:0.00384862):0.01176636):0.04934346):0.06417857):0.03824286,(XP_024110625_1_apolipoprotein_A_I_isoform_X1__Pongo_abelii_:0.01394584,((XP_004052230_1_apolipoprotein_A_I__Gorilla_gorilla_gorilla_:0.00000001,(sp_P02647_APOA1_HUMAN_Apolipoprotein_A_I_OS_Homo_sapiens_OX_9606_GN_APOA1_PE_1_SV_1:0.00000001,XP_016777528_1_apolipoprotein_A_I__Pan_troglodytes_:0.00000001):0.00000001):0.00000001,XP_003820129_1_apolipoprotein_A_I__Pan_paniscus_:0.00390471):0.00597123):0.09539988):0.03082802):0.04593607,(NP_036870_1_apolipoprotein_A_I_preproprotein__Rattus_norvegicus_:0.21456397,NP_033822_2_apolipoprotein_A_I_preproprotein__Mus_musculus_:0.15479454):0.13125754):0.3744807,((XP_021140876_1_apolipoprotein_A_I__Columba_livia_:0.08216292,(XP_010722021_1_apolipoprotein_A_I__Meleagris_gallopavo_:0.01713979,NP_990856_1_apolipoprotein_A_I_preproprotein__Gallus_gallus_:0.01384285):0.06046874):0.15177509,(XP_006030393_1_apolipoprotein_A_I__Alligator_sinensis_:0.02329241,XP_019336206_1_PREDICTED__apolipoprotein_A_I__Alligator_mississippiensis_:0.0320468):0.42470015):0.17889522):0.17145543):0.3718481):0.75805264);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)