PB0042

DATABASE

Click here to access PB0042 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0042	P48307	Tissue factor pathway inhibitor 2	TFPI2	PP5, REF1, TFPI-2	Homo_sapiens	May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.

Domains

Gene Ontology

PF00014 (3_Kunitz_BPTI)

GO:0004867 (enables) serine-type endopeptidase inhibitor activity GO:0005201 (enables) extracellular matrix structural constituent GO:0030414 (enables) peptidase inhibitor activity GO:0007596 (involved in) blood coagulation GO:0007599 (involved in) hemostasis GO:0010466 (involved in) negative regulation of peptidase activity GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0071498 (involved in) cellular response to fluid shear stress GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0031012 (located in) extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P48307|TFPI2_HUMAN Tissue factor pathway inhibitor 2 OS=Homo sapiens OX=9606 GN=TFPI2 PE=1 SV=1 MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQS CRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSM TCEKFFSGGCHRNRIENRFPDEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRY RTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKKKMPKLRFASRIRKIRKKQF >tr|B0S6C1|B0S6C1_DANRE Tissue factor pathway inhibitor OS=Danio rerio OX=7955 GN=tfpia PE=4 SV=1 MAPYLNSSCKPLLLLSLFGVCFARFERSDGVRSELRIFHQSCALKKDEGPCKAMKDRFYF DIDTGRCEPFEYGGCQGNANNFETLQDCEEMCLVTENKSPCHLEDEPGPCRGLVPRYFFD QKSQECKQFFYGGCFGNANNFKTIKACQQRCQLTAVLKSEEEEAKPVIESPAIHDDAHLN SSHSALRRVSQPAKQEAEFSPPELCMSAVDRGDCDGSERRYVFNPRIGRCQVFRYSGCGG NKNNFIHKRHCMKMCMKDQHRRKQIRIKTRNSNILFRSV
Selected proteins from model organisms >NP_006519.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Homo sapiens] MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCE GNANNFYTWEACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFP DEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAK ALKKKKKMPKLRFASRIRKIRKKQF >KAB0344074.1 hypothetical protein FD754_021000 [Muntiacus muntjak] MDSVRPLWLMLLSLLLVGTALGDAPQAPPGNNAEICLLPPDEGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLE ACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCEKFKSGGCHSNENRFPDEAACMDFCAPKRAPAFCYSPKD EGLCSANVTRYYFNPRHKACEAFTYTGCGGNNNNFVNLKDCKRTCVKPLKKEKNKKMPRLLFASRRLKIKKKQF >XP_043318540.1 tissue factor pathway inhibitor 2 [Cervus canadensis] MDSVRPLWLMLLSLLLVGTALGDAPQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLE ACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCEKFFSGGCHSNENRFPDEAACMDFCAPKRAPAFCYSPKD EGLCSANVTRYYFNPRHKACEVFTYTGCGGNNNNFVNLKDCKRTCVKALKKEKNKKMPRLLFANRRLKIKKKQF >XP_041421830.1 tissue factor pathway inhibitor 2 [Xenopus laevis] MHASSFQALMAASLLIQVFGAPMQGNTTVCLLPLDEGPCKALIPHYYYDRYTQTCQEFFYGGCDGNANNFVSMEDCEKFC WKIKKVPKACRMVPDEGPCRGYIKRYAYNMKTMRCEQFIYGGCYGNDNNFQDKDSCINFCAPRRDAPSFCYSPKDEGSCS ASVTRYYFNIESKACEEFVYTGCGGNSNNFIKVEDCDSVCKKGTKRPRNQNPKIPRIRRPRIQS >XP_040208262.1 tissue factor pathway inhibitor 2-like [Rana temporaria] MLSIVHLLLPVCFLGQVVTSSEQAAPRSNITACLLPRVEGNCRGLIPQFYYDRYTQTCEEFLYGGCDGNANNFETVEDCE KTCWKIKKVPKPCRMEVEPGPCRGYIKRYAYNLLTMKCELFIYGGCYGNDNNYRDEASCLEACSPKRNAPSFCYSPKDEG SCSASVNRYYFNIESKSCEEFQYTGCGGNSNNFIRLEDCNKVCKKGNKRPRNKNRLRRPKINPEQS >AAB26836.1 tissue factor pathway inhibitor [Oryctolagus cuniculus] MKKEHIFWTSICLLLGLVPAPVSSAAEEDEFTNITDIKPPLQKPTHSFCAMKVDDGPCRAYIKRFFFNILTHQCEEFIYG GCEGNENRFESLEECKEKCARDYPKMTTKLTFQKGKPDFCFLEEDPGICRGYITRYFYNNQSKQCERFKYGGCLGNLNNF ESLEECKNTCENPTSDFQVDDHRTQLNTVNNTLINQPTKAPRRWAFHGPSWCLPPADRGLCQANEIRFFYNAIIGKCRPF KYSGCGGNENNFTSKKACITACKKGFIRNLSKGGLIKTKRKKKKQPVKITYVETFVKKT >KAF4026309.1 hypothetical protein G4228_018521 [Cervus hanglu yarkandensis] MINIMKKEQILGVSVCLLLSCASALLNDVPEEDEEYTNITDAELPPLKLVHSFCAMRADDGPCKAIIKRFFFNIHTQQCE EFIYGGCEGNQNRFETLEECKQKCTREKPDFCFLEEDAGICRGYITRYFYNNQSKQCERFKYGGCLGNLNNFESLEECKN TCEDTLNDFQVDDHRTQVDATNNASLTPRPSKEPSIFGKTLF >OWK09488.1 hypothetical protein Celaphus_00006368 [Cervus elaphus hippelaphus] MAGGRLSQARIPAVAVWLLCALVLQGAEAGPSPVTPGLLTADGCLNRFTPGVPDFVLDTDASVRNGATFLRSLTARRGRD CVHACCSSNDCNLALVELQPDGGEDAIVSCFLINCLYEQSFVCKFAPREGFVNYLTREVYRSYRELRTQGFRGSRIPKAW DGIDLKVQPQEPLVLKGVENTDWHLLRGDTDVRVERNSPDQVELWGLKEGSYLFQLTAAGSDQPESTSNVTVTVLSPEQT EEHCLASKKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECKLACRDVQGPSAERHHPVCSGSCHPSKFRC GDGCCIDSFLECDDTPDCPDASDEATCEKYTRDFDKLQRIHFPRDKDLPDTGHCSESIPRWYYNPFTEHCARFTYGGCYG NKNNFEEEEQCLESCRGISKKDVFGLRRESPVPSTGSVEVAVAALLGTCIVVVVAILGYCFFKNQRKDFHRHHHPPPSTP TSSKVSTTDDMEHLVYYQTTRPL >NP_033390.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Mus musculus] MDPAMPLQLWNLPLLLVGSVLGLTSVSAQGNNLEICLLPLDAGPCQALIPKFYYDRDQQKCRRFNYGGCL GNANNFHSRDLCQQTCGSIEKVPPVCRSELKTYPCDKPNIRFFFNLNTMTCEPLRPGLCSRTINVFSEEA TCKGLCEPRKHIPSFCSSPKDEGLCSANVTRFYFNSRNKTCETFTYTGCGGNENNFYYLDACHRACVKGW KKPKRWKIGDFLPRFWKHLS >XP_031550075.1 carboxypeptidase inhibitor SmCI-like [Actinia tenebrosa] MARTASTILFLLCLVLITGYTMARQEHCNLPLEKGKCGGRFERFYYNSHKGKCESFFYGGCSGNDNNFENEEECDKACGA FMTMADANSFCNLPAVVGRCKGYFPRYFYNTEAGKCQRFIYGGCGGNRNNFETVXDCRATCHPREKRALADMTMADANSF CQLPAVVGRCRGRFPRYYYNTEAGKCQRFIYGGCXGNRNNFETVEDCRATCHPREKRALADMTMADANSFCQLPAVVGKC RGYFPRYYYNTEAGKCQQFIYGGCGGNRNNFETVEDCRATCHSHA >NP_775164.2 tissue factor pathway inhibitor 2 precursor [Rattus norvegicus] MDPATSLRLWNLPLLLVGSALGLASVSAQGNNLEICLLPLDMGPCKALIPKFYYDRDQKKCRRFKYGGCL GNANNFHSRKLCEHTCGNKEKVPWVCRSAVRTYPCDKPNTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEA MCKSLCEPRKSIPSFCSSPKDEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKAL KKPKRRKIGDFLPRFWKLRS >NP_877589.1 tissue factor pathway inhibitor 2 precursor [Bos taurus] MDSVRPLWLMLLSLLLVGTALGDASQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCE GNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCKKFISGGCHSNENRFPDEA TCMDFCAPKRAPVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALK KEKNKKMPRLLLANRRLKIKKKQF >XP_015137423.1 tissue factor pathway inhibitor 2 isoform X1 [Gallus gallus] MAAGRRLPLPALLLPLACAALAPRGLTEKQRACLLPPDDGPCRALVPRWYYDRYTQSCQEFSYGGCHGNA NNFLSHDDCEKNCWTIKKVPKLCRMEADTGPCRGYIRRYAFNLSSMRCEEFIYGGCYGNGNNFKDLQSCV DHCLPEKTGPLLCYSPKDEGLCSSSVPRYYYDTTSKSCKEFKYTGCGGNANNFVTEVDCYNVCRKAGSQK PTINKSRSLLRRKMMRKLIKKPQTHNPKS >XP_001168275.1 tissue factor pathway inhibitor 2 [Pan troglodytes] MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCE GNANNFYTWEACDEACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFP DEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAK ALKKKKKMPKLRFASRIRKIRKKQF >XP_532462.3 tissue factor pathway inhibitor 2 [Canis lupus familiaris] MDPAGPFGVLLLPLLLMGTALGDGGAGAPGASSAETCLLPPDVGPCRALIPSYYYDRYTQSCLPFTYGGC RGNANNFETWEACDEACWRIEKVPKICRLEVNEEKCGENKEEYFFNLTSMTCEKFLSGGCHSNENRFPDE AACMNFCAPKKSPSFCYSPKDEGLCSANVTRYYFNPRHRTCEAFAYTGCGGNDNNFVSMKDCKNVCVKAL KKERNKKMTKLSLVNRRLKNWKKQS >tr|B0S6C1|B0S6C1_DANRE Tissue factor pathway inhibitor OS=Danio rerio OX=7955 GN=tfpia PE=4 SV=1 MAPYLNSSCKPLLLLSLFGVCFARFERSDGVRSELRIFHQSCALKKDEGPCKAMKDRFYF DIDTGRCEPFEYGGCQGNANNFETLQDCEEMCLVTENKSPCHLEDEPGPCRGLVPRYFFD QKSQECKQFFYGGCFGNANNFKTIKACQQRCQLTAVLKSEEEEAKPVIESPAIHDDAHLN SSHSALRRVSQPAKQEAEFSPPELCMSAVDRGDCDGSERRYVFNPRIGRCQVFRYSGCGG NKNNFIHKRHCMKMCMKDQHRRKQIRIKTRNSNILFRSV >XP_002818297.1 tissue factor pathway inhibitor 2 isoform X1 [Pongo abelii] MDPARPLGLSILLLLLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLARYYYDRYTQSCRQFLYGGCE GNANNFYTWEACDEACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFP DEATCMGFCAPKKIPSFCYSPKDEGLCFANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAK ALRKKKKMPKLRFASRIRKIRKKQF >XP_005667666.2 tissue factor pathway inhibitor 2 [Sus scrofa] MSLIWVPTVVEEKDVCTVQLWWGIPLPRTLSSQEAAGSELSRRHESASPPAFVKACSALSGVRETFRRPP YIKPRHPPHRNQDCLEVGGCAPSSRRGLLGTTCPTGHFKSDTMNSVRTHGLVLLPLLLVGTALGDAPRAS PGNYSEICLLPPDEGPCRALVPSYYYDRYTQSCREFMYGGCEGNANNFETWEACDEACWRIEKVPKICRL EVSKRQCGELREEYFFNLSSMTCEKFLSGGCHGNANRFLDEATCMGFCAPKKSPSFCYSPKDEGLCSANV TRYYFNPRHKACETFTYTGCGGNDNNFVSMKDCKRACVKALKKEKKMPRLLLASRRLKIKKKQF >XP_003809768.1 tissue factor pathway inhibitor 2 [Pan paniscus] MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCE GNANNFYTWEACDEACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFP DEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAK ALKKKKKMPKLRFASRIRKIRKKQF >XP_003982808.1 tissue factor pathway inhibitor 2 [Felis catus] MDPTGPLGLLLLPLLLLETVLGDGVQEAPGNNAEICLLPPDEGPCRARIPSYYYDRYTQSCRKFMYGGCE GNDNNFETWEACDEACWRIEKVPKICRLEVSEGQCGEPREQYFFNLSSMTCEKFLSGGCHSNENRFPDEA TCMGFCAPKKGPSFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNENNFINMKDCKHVCVKALK KEKNKKMPKLFFANRRLKIWKRQF >XP_004007771.1 tissue factor pathway inhibitor 2 [Ovis aries] MDSVRPLWLMLLSLLLVGTALGDAPQAPPGNNAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCE GNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCEKFISGGCHSDENRFPDKA SCMDFCAPKRAPAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNDNNFVNLKDCKRTCVKALK KEKNKKMPRLLFANRRLKIKKQF >XP_004045805.1 tissue factor pathway inhibitor 2 isoform X1 [Gorilla gorilla gorilla] MDPARPLGLSILLLFLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCE GNANNFDTWEACDEACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFLSGGCHRNRIENRFP DEATCMGFCAPKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAK ALKRKKKMPKLRFASRIRKIRKKQF >XP_004073873.1 tissue factor pathway inhibitor 2 [Oryzias latipes] MEFGMLTLFALFSSLPGGLSLVPKGACLLRVDEGPCRGQIERYFYNTITQKCEVFYYGGCHGNANNFMSF QKCQKTCFRIPKVPQICRFPKEEGHCRALFPSYFFNMSTMQCEPFSYGGCGGNSNRFRDLTSCMDFCSPQ KSVPILCLDPLDKGKCSASMRRFYYNKATKTCEEFAYSGCGGSSNNFVSRESCEDVCLKGAKKHTGLKGR DRLMKRNKKTRFMAFRG >XP_021146623.1 tissue factor pathway inhibitor 2 [Columba livia] MEADGGPCRSHLKRYAFNLSSMRCEEFIYGGCYGNGNNFRDLQSCVDHCLPEKTGPLLCYSPKDEGLCSS SVPRYYYDSSSKSCKEFKYTGCGGNANNFVTEKDCYNVCRKGTQKPGINKPMNAFRRKMMRKLIRKPQTY NPKP >XP_017902909.1 PREDICTED: tissue factor pathway inhibitor 2 [Capra hircus] MDSVRSLWLMLLSLLLVGTALGDAPQAPPGNNAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCE GNANNFETLEACNEACWKIEKVPKICRLKVNKKECGELREQYFFNLSSMTCEKFISGGCHSNENRFPDKA SCMDFCAPKRAPAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNDNNFVNLKDCKRTCVKALK KEKNKKMPRLLFANRRLKIKKQF >XP_025062584.1 tissue factor pathway inhibitor 2 [Alligator sinensis] MSEMQYLVVNWANQQTIWKGPCQKGPVGTAAAKAPQALTAAQRNCLLPVDDGPCRALLPRWYYDRYTQTC EPFSYGGCQGNANNFESSEDCEKSCWFIRKVPKICRMEADPGPCRSYLSRYAFNLSSMMCEPFIYGGCYG NDNNFRKYDSCMETCAPQKTGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYTGCGGNSNNFVSKTD CYKVCRKAGNKKPRIKPKSKVMRKMMRKLQKNPS >XP_006258519.2 PREDICTED: tissue factor pathway inhibitor 2 isoform X1 [Alligator mississippiensis] MAASPRLVRCPLMPLPLPLLLLLLPPRPAAAKAPQALTAAQRSCLLPVDDGPCRALLPRWYYDRYTQTCE PFSYGGCQGNANNFESSEDCEKSCWLIRKVPKICRMEADPGPCRSYLSRYAFNLSSMMCEPFIYGGCYGN DNNFRKYDSCMETCAPQKTGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYTGCGGNSNNFVSKTDC YKVCRKAGNKKPRIKPKSKVMRKMMRKLQKNPS >XP_015811336.1 PREDICTED: tissue factor pathway inhibitor 2 [Nothobranchius furzeri] MESGFLLALFTIISSLRQGVTLLRSKGACLLQVDEGPCKGNIERFYYNTITQNCELFYYGGCLGNSNNFR SYPECQKTCFRIPKVPQICRFPKEEGHCRAILPRYFFNMTSMKCEPFFYGGCGGNSNRFQDLTSCMEYCS PQKTVPMLCLDPLDKGKCSASITRYYYNTATKSCQDFVYTGCGGSSNNFVSQQSCMDVCVKGRKKHAAQV KIRRRGQKKMKRITFL >XP_020769431.1 tissue factor pathway inhibitor 2 [Odocoileus virginianus texanus] MDSVRPLWLMLLSLLLVGTALGDAPQAPPGNNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCE GNANNFETLEACNEACWKIEKVPKICRLKVNKKQCGELREQYFFNLSSMTCEKFISGGCHNNENRFPDEA TCMDFCAPKRAPAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNNNNFVNLKDCKRTCVKALK KEKNKKMPRLLFASRRLKIKKKQF >XP_030267071.1 tissue factor pathway inhibitor 2 [Sparus aurata] MFGKAEQTLQQKSFTMEFYTLTLFALLSLLCSGLALLSPKAVCLLQVDEGPCRGDIERYYYNTITQKCEV FYYGGCQGNANNFRSYQECQKTCFRIPKIPQICRFTRDEGPCRGLFPRYFFNMTTMQCEPFSFGGCAGNS NNFYNLDSCMEYCSPKKSVPVLCLDPLDKGKCSASIPRYYYNTATKMCEEFVYSGCGGSSNNFVSRQSCT DVCVRGGKKHAAQGKIRRMRRNRNNRNSRSGHITILQA
Mafft alignment of selected proteins >NP_006519.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PARPLGLS----------------------------------ILLLFLT----------- --EAALGDAAQEPTG-NNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNAN NFYTWEACDDACWRI-----------EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTC- EKFFSGGCHRNRIENRFPDEATCMGFC--------------------------------- ---------APKK-----------IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYT GCGGNDNNFVSREDCKRACAK-ALKKK--KK----------------------------- -MPKL-RFASRIRKIRKKQ-----------F------------------ >KAB0344074.1 hypothetical protein FD754_021000 [Muntiacus muntjak] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRPLWLM----------------------------------LLSLLLV----------- --GTALGDAPQAPPG-NNAEICLLPPDEGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKQCGELREQYFFNLSSMTC- EKFKSGGCHSN--ENRFPDEAACMDFC--------------------------------- ---------APKR-----------APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYT GCGGNNNNFVNLKDCKRTCVK-PLKKEKNKK----------------------------- -MPRL-LFASRRLKIKKKQ-----------F------------------ >XP_043318540.1 tissue factor pathway inhibitor 2 [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRPLWLM----------------------------------LLSLLLV----------- --GTALGDAPQAPPG-NNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKQCGELREQYFFNLSSMTC- EKFFSGGCHSN--ENRFPDEAACMDFC--------------------------------- ---------APKR-----------APAFCYSPKDEGLCSANVTRYYFNPRHKACEVFTYT GCGGNNNNFVNLKDCKRTCVK-ALKKEKNKK----------------------------- -MPRL-LFANRRLKIKKKQ-----------F------------------ >XP_041421830.1 tissue factor pathway inhibitor 2 [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MH AS----------------------------------------SFQALMA----------- --ASLLIQVFGAPMQ-GNTTVCLLPLDEGPCKALIPHYYYDRYTQTCQEFFYGGCDGNAN NFVSMEDCEKFCWKI-----------KKVPKACRMVPD-EGPCRGYIKRYAYNMKTMRC- EQFIYGGCYGN--DNNFQDKDSCINFC--------------------------------- ---------APRR----------DAPSFCYSPKDEGSCSASVTRYYFNIESKACEEFVYT GCGGNSNNFIKVEDCDSVCKK-GTKRPRNQN----------------------------- --PKIPRIRRPRIQS---------------------------------- >XP_040208262.1 tissue factor pathway inhibitor 2-like [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ML SIVHL-------------------------------------LLPVCFL----------- --GQVVTSSEQAAPR-SNITACLLPRVEGNCRGLIPQFYYDRYTQTCEEFLYGGCDGNAN NFETVEDCEKTCWKI-----------KKVPKPCRMEVE-PGPCRGYIKRYAYNLLTMKC- ELFIYGGCYGN--DNNYRDEASCLEAC--------------------------------- ---------SPKR----------NAPSFCYSPKDEGSCSASVNRYYFNIESKSCEEFQYT GCGGNSNNFIRLEDCNKVCKK-GNKRPRNKN----------------------------- ------RLRRPKINPEQS------------------------------- >AAB26836.1 tissue factor pathway inhibitor [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MK KEHIFWTS---------------------------------ICLLLGLVPAPVSSAAEED -EFTNITDIKPPLQK-PTHSFCAMKVDDGPCRAYIKRFFFNILTHQCEEFIYGGCEGNEN RFESLEECKEKCARDYPKMTTKLTFQKGKPDFCFLEED-PGICRGYITRYFYNNQSKQC- ERFKYGGCLGN--LNNFESLEECKNTCENPTSDFQVDDHRT------------QLNTVNN -TLINQPTKAPRRW-------AFHGPSWCLPPADRGLCQANEIRFFYNAIIGKCRPFKYS GCGGNENNFTSKKACITACKK-GFIRNLSKG----------------------------- --GLI-KTKRKKKKQPVKI---------TYVETFVKKT----------- >KAF4026309.1 hypothetical protein G4228_018521 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MINIMK KEQILGVS---------------------------------VCLLLSCASALLNDVPEED EEYTNITDAELPPLK-LVHSFCAMRADDGPCKAIIKRFFFNIHTQQCEEFIYGGCEGNQN RFETLEECKQKCTRE-------------KPDFCFLEED-AGICRGYITRYFYNNQSKQC- ERFKYGGCLGN--LNNFESLEECKNTCEDTLNDFQVDDHRT------------QVDATNN ASLTPRPSKEP-------------------------------------SIFGK------- ------------------------------------------------------------ --------------------------------TLF-------------- >OWK09488.1 hypothetical protein Celaphus_00006368 [Cervus elaphus hippelaphus] MA----GGRLSQARIPAVAVWLLCAL--VLQGAEAGPSPVTPGLLTADGCLNRFTPGVPD FVLDTDASVRNGATFLRSLTAR------RGRDCVHACCSSNDCNLALVELQPDGGEDAIV SCFLINCLYEQSFVCKFAPREGFVNYLTREVYRSYRELRTQGFRGSRIPKAWDGIDLKVQ PQEPLVLK-GVENTDWHLLRGDTDVRVERNSPDQVELWGLKEGSYLFQLTAAGSDQP--- -ESTSNVTVTVLSPE-QTEEHCLASKKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKN NYLREEECKLACRDV-----------QGPSAERHHPVC-SGSCHPSK----FRCGDGCCI DSFLECDDTPD--CPDASDEATCEKYT-----------------------------RDFD -KLQRIH--FPRDK---------DLP-------DTGHCSESIPRWYYNPFTEHCARFTYG GCYGNKNNFEEEEQCLESCRG-ISKKDVFGLRRESPVPSTGSVEVAVAALLGTCIVVVVA ILGYC-FFKNQRKDFHRHHHPPPSTPTSSKVSTTDDMEHLVYYQTTRPL >NP_033390.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PAMPLQLW----------------------------------NLPLLLV----------- --GSVLGLTSVSAQG-NNLEICLLPLDAGPCQALIPKFYYDRDQQKCRRFNYGGCLGNAN NFHSRDLCQQTCGSI-----------EKVPPVCRSELK-TYPCDKPNIRFFFNLNTMTC- EPLRPGLCSRT--INVFSEEATCKGLC--------------------------------- ---------EPRK----------HIPSFCSSPKDEGLCSANVTRFYFNSRNKTCETFTYT GCGGNENNFYYLDACHRACVK-GWKKPKRWK----------------------------- -IG---DFLPRFWKHLS-------------------------------- >XP_031550075.1 carboxypeptidase inhibitor SmCI-like [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MA RT---------------------------------------ASTILFLL----------- --CLVLITGYTM----ARQEHCNLPLEKGKCGGRFERFYYNSHKGKCESFFYGGCSGNDN NFENEEECDKACGAF---MTM-----ADANSFCNLPAV-VGRCKGYFPRYFYNTEAGKC- QRFIYGGCGGN--RNNFETVXDCRATC--------------------------------- ---------HPREKRALADMTMADANSFCQLPAVVGRCRGRFPRYYYNTEAGKCQRFIYG GCXGNRNNFETVEDCRATCHP-REKRALADMTM-----ADANSFCQLPAVVGKC----RG YFPRY-YYNTEAGKCQQFIY-GGCGGNRNNFETVEDCRATCHSHA---- >NP_775164.2 tissue factor pathway inhibitor 2 precursor [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PATSLRLW----------------------------------NLPLLLV----------- --GSALGLASVSAQG-NNLEICLLPLDMGPCKALIPKFYYDRDQKKCRRFKYGGCLGNAN NFHSRKLCEHTCGNK-----------EKVPWVCRSAVR-TYPCDKPNTEFFFNLKTMTC- EPLRPGLCSRT--TNVFPEEAMCKSLC--------------------------------- ---------EPRK----------SIPSFCSSPKDEGLCSANVTRYYFNSRNKACETFTYT GCGGNENNFYYLDACNRACVK-ALKKPKRRK----------------------------- -IG---DFLPRFWKLRS-------------------------------- >NP_877589.1 tissue factor pathway inhibitor 2 precursor [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRPLWLM----------------------------------LLSLLLV----------- --GTALGDASQAPPG-NNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKQCGELREQYFFNLSSMTC- KKFISGGCHSN--ENRFPDEATCMDFC--------------------------------- ---------APKR-----------APVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYT GCGGNDNNFVNLKDCKRTCVK-ALKKEKNKK----------------------------- -MPRL-LLANRRLKIKKKQ-----------F------------------ >XP_015137423.1 tissue factor pathway inhibitor 2 isoform X1 [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MA AGRRL-------------------------------------PLPALLL----------- --PLACAALAPRGLT-EKQRACLLPPDDGPCRALVPRWYYDRYTQSCQEFSYGGCHGNAN NFLSHDDCEKNCWTI-----------KKVPKLCRMEAD-TGPCRGYIRRYAFNLSSMRC- EEFIYGGCYGN--GNNFKDLQSCVDHC--------------------------------- ---------LPEK----------TGPLLCYSPKDEGLCSSSVPRYYYDTTSKSCKEFKYT GCGGNANNFVTEVDCYNVCRKAGSQKPTINK----------------------------- --SRS-LLRRKMMRKLIKK-----------PQTHNPKS----------- >XP_001168275.1 tissue factor pathway inhibitor 2 [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PARPLGLS----------------------------------ILLLFLT----------- --EAALGDAAQEPTG-NNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNAN NFYTWEACDEACWRI-----------EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTC- EKFFSGGCHRNRIENRFPDEATCMGFC--------------------------------- ---------APKK-----------IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYT GCGGNDNNFVSREDCKRACAK-ALKKK--KK----------------------------- -MPKL-RFASRIRKIRKKQ-----------F------------------ >XP_532462.3 tissue factor pathway inhibitor 2 [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PAGPFGVL----------------------------------LLPLLLM----------- --GTALGDGGAGAPGASSAETCLLPPDVGPCRALIPSYYYDRYTQSCLPFTYGGCRGNAN NFETWEACDEACWRI-----------EKVPKICRLEVN-EEKCGENKEEYFFNLTSMTC- EKFLSGGCHSN--ENRFPDEAACMNFC--------------------------------- ---------APKK-----------SPSFCYSPKDEGLCSANVTRYYFNPRHRTCEAFAYT GCGGNDNNFVSMKDCKNVCVK-ALKKERNKK----------------------------- -MTKL-SLVNRRLKNWKKQ-----------S------------------ >tr|B0S6C1|B0S6C1_DANRE Tissue factor pathway inhibitor OS=Danio rerio OX=7955 GN=tfpia PE=4 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MA PYLNSSCK-----------------------PL--------LLLSLFGVCF--------- -ARFERSDGVRSELR-IFHQSCALKKDEGPCKAMKDRFYFDIDTGRCEPFEYGGCQGNAN NFETLQDCEEMCLV------------TENKSPCHLEDE-PGPCRGLVPRYFFDQKSQEC- KQFFYGGCFGN--ANNFKTIKACQQRCQLTAVLKSEEEEAKPVIESPAIHDDAHLNSSHS -ALRRVS--QPAKQEA-----EFSPPELCMSAVDRGDCDGSERRYVFNPRIGRCQVFRYS GCGGNKNNFIHKRHCMKMCMK-DQHRRKQIR----------------------------- --IKT-RNSNILFRSV--------------------------------- >XP_002818297.1 tissue factor pathway inhibitor 2 isoform X1 [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PARPLGLS----------------------------------ILLLLLT----------- --EAALGDAAQEPTG-NNAEICLLPLDYGPCRALLARYYYDRYTQSCRQFLYGGCEGNAN NFYTWEACDEACWRI-----------EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTC- EKFFSGGCHRNRIENRFPDEATCMGFC--------------------------------- ---------APKK-----------IPSFCYSPKDEGLCFANVTRYYFNPRYRTCDAFTYT GCGGNDNNFVSREDCKRACAK-ALRKK--KK----------------------------- -MPKL-RFASRIRKIRKKQ-----------F------------------ >XP_005667666.2 tissue factor pathway inhibitor 2 [Sus scrofa] MSLIWVPTVVEEKDVCTVQLWWGIPLPRTLSSQEAAGSELSRRHESA-------SP--PA FVKACSALSGVRETFRRPPYIKPRHPPHRNQDCLEV-----------------GG----- --------------CAPSSR--------------------RGLLGTTCPTG-HFKSDTMN SVRTHGLV----------------------------------LLPLLLV----------- --GTALGDAPRASPG-NYSEICLLPPDEGPCRALVPSYYYDRYTQSCREFMYGGCEGNAN NFETWEACDEACWRI-----------EKVPKICRLEVS-KRQCGELREEYFFNLSSMTC- EKFLSGGCHGN--ANRFLDEATCMGFC--------------------------------- ---------APKK-----------SPSFCYSPKDEGLCSANVTRYYFNPRHKACETFTYT GCGGNDNNFVSMKDCKRACVK-ALKKE--KK----------------------------- -MPRL-LLASRRLKIKKKQ-----------F------------------ >XP_003809768.1 tissue factor pathway inhibitor 2 [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PARPLGLS----------------------------------ILLLFLT----------- --EAALGDAAQEPTG-NNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNAN NFYTWEACDEACWRI-----------EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTC- EKFFSGGCHRNRIENRFPDEATCMGFC--------------------------------- ---------APKK-----------IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYT GCGGNDNNFVSREDCKRACAK-ALKKK--KK----------------------------- -MPKL-RFASRIRKIRKKQ-----------F------------------ >XP_003982808.1 tissue factor pathway inhibitor 2 [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PTGPLGLL----------------------------------LLPLLLL----------- --ETVLGDGVQEAPG-NNAEICLLPPDEGPCRARIPSYYYDRYTQSCRKFMYGGCEGNDN NFETWEACDEACWRI-----------EKVPKICRLEVS-EGQCGEPREQYFFNLSSMTC- EKFLSGGCHSN--ENRFPDEATCMGFC--------------------------------- ---------APKK-----------GPSFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYT GCGGNENNFINMKDCKHVCVK-ALKKEKNKK----------------------------- -MPKL-FFANRRLKIWKRQ-----------F------------------ >XP_004007771.1 tissue factor pathway inhibitor 2 [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRPLWLM----------------------------------LLSLLLV----------- --GTALGDAPQAPPG-NNAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKQCGELREQYFFNLSSMTC- EKFISGGCHSD--ENRFPDKASCMDFC--------------------------------- ---------APKR-----------APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYT GCGGNDNNFVNLKDCKRTCVK-ALKKEKNKK----------------------------- -MPRL-LFANRRLKIKKQ------------F------------------ >XP_004045805.1 tissue factor pathway inhibitor 2 isoform X1 [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD PARPLGLS----------------------------------ILLLFLT----------- --EAALGDAAQEPTG-NNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNAN NFDTWEACDEACWRI-----------EKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTC- EKFLSGGCHRNRIENRFPDEATCMGFC--------------------------------- ---------APKK-----------IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYT GCGGNDNNFVSREDCKRACAK-ALKRK--KK----------------------------- -MPKL-RFASRIRKIRKKQ-----------F------------------ >XP_004073873.1 tissue factor pathway inhibitor 2 [Oryzias latipes] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ME FG----------------------------------------MLTLFAL----------- --FSSLPGGLSLV----PKGACLLRVDEGPCRGQIERYFYNTITQKCEVFYYGGCHGNAN NFMSFQKCQKTCFRI-----------PKVPQICRFPKE-EGHCRALFPSYFFNMSTMQC- EPFSYGGCGGN--SNRFRDLTSCMDFC--------------------------------- ---------SPQK----------SVPILCLDPLDKGKCSASMRRFYYNKATKTCEEFAYS GCGGSSNNFVSRESCEDVCLK-GAKKHTGLK----------------------------- --GRD-RLMKRNKKTR--------------FMAFRG------------- >XP_021146623.1 tissue factor pathway inhibitor 2 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MEAD-GGPCRSHLKRYAFNLSSMRC- EEFIYGGCYGN--GNNFRDLQSCVDHC--------------------------------- ---------LPEK----------TGPLLCYSPKDEGLCSSSVPRYYYDSSSKSCKEFKYT GCGGNANNFVTEKDCYNVCRK-GTQKPGINK----------------------------- --PMN-AFRRKMMRKLIRK-----------PQTYNPKP----------- >XP_017902909.1 PREDICTED: tissue factor pathway inhibitor 2 [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRSLWLM----------------------------------LLSLLLV----------- --GTALGDAPQAPPG-NNAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKECGELREQYFFNLSSMTC- EKFISGGCHSN--ENRFPDKASCMDFC--------------------------------- ---------APKR-----------APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYT GCGGNDNNFVNLKDCKRTCVK-ALKKEKNKK----------------------------- -MPRL-LFANRRLKIKKQ------------F------------------ >XP_025062584.1 tissue factor pathway inhibitor 2 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MS EMQYLVVNWANQQTIW-------------KGPCQ------K---------G--------- -PVGTAAAKAPQALT-AAQRNCLLPVDDGPCRALLPRWYYDRYTQTCEPFSYGGCQGNAN NFESSEDCEKSCWFI-----------RKVPKICRMEAD-PGPCRSYLSRYAFNLSSMMC- EPFIYGGCYGN--DNNFRKYDSCMETC--------------------------------- ---------APQK----------TGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYT GCGGNSNNFVSKTDCYKVCRKAGNKKPRI-K----------------------------- --PKS-KVMRKMMRKLQKN-----------PS----------------- >XP_006258519.2 PREDICTED: tissue factor pathway inhibitor 2 isoform X1 [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MA ASPRLV-----------------------RCPLM------PLPLPLLLLLL--------- -PPRPAAAKAPQALT-AAQRSCLLPVDDGPCRALLPRWYYDRYTQTCEPFSYGGCQGNAN NFESSEDCEKSCWLI-----------RKVPKICRMEAD-PGPCRSYLSRYAFNLSSMMC- EPFIYGGCYGN--DNNFRKYDSCMETC--------------------------------- ---------APQK----------TGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYT GCGGNSNNFVSKTDCYKVCRKAGNKKPRI-K----------------------------- --PKS-KVMRKMMRKLQKN-----------PS----------------- >XP_015811336.1 PREDICTED: tissue factor pathway inhibitor 2 [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ME SG---------------------------------------FLLALFTI----------- --ISSLRQGVTLL---RSKGACLLQVDEGPCKGNIERFYYNTITQNCELFYYGGCLGNSN NFRSYPECQKTCFRI-----------PKVPQICRFPKE-EGHCRAILPRYFFNMTSMKC- EPFFYGGCGGN--SNRFQDLTSCMEYC--------------------------------- ---------SPQK----------TVPMLCLDPLDKGKCSASITRYYYNTATKSCQDFVYT GCGGSSNNFVSQQSCMDVCVK-GRKKHAA-Q----------------------------- --VKI-RRRGQKKMKRIT------------FL----------------- >XP_020769431.1 tissue factor pathway inhibitor 2 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MD SVRPLWLM----------------------------------LLSLLLV----------- --GTALGDAPQAPPG-NNAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNAN NFETLEACNEACWKI-----------EKVPKICRLKVN-KKQCGELREQYFFNLSSMTC- EKFISGGCHNN--ENRFPDEATCMDFC--------------------------------- ---------APKR-----------APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYT GCGGNNNNFVNLKDCKRTCVK-ALKKEKNKK----------------------------- -MPRL-LFASRRLKIKKKQ-----------F------------------ >XP_030267071.1 tissue factor pathway inhibitor 2 [Sparus aurata] MF-----GKAEQ----------------TLQQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------KSFTME FY----------------------------------------TLTLFAL----------- --LSLLCSGLALL---SPKAVCLLQVDEGPCRGDIERYYYNTITQKCEVFYYGGCQGNAN NFRSYQECQKTCFRI-----------PKIPQICRFTRD-EGPCRGLFPRYFFNMTTMQC- EPFSFGGCAGN--SNNFYNLDSCMEYC--------------------------------- ---------SPKK----------SVPVLCLDPLDKGKCSASIPRYYYNTATKMCEEFVYS GCGGSSNNFVSRQSCTDVCVR-GGKKHAA-Q----------------------------- --GKI-RRMRRNRNNRNSR--------SGHITILQA-------------
BMGE Cleaned alignment of selected proteins >NP_006519.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Homo sapiens] PLGLSILLLFLTAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDDACWRIEKVPKVCRLQDDQCEGSEKYFFNLSSMTCEKFFSGGCHRNENRFPDEATCM-IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKRFASRIRKI >KAB0344074.1 hypothetical protein FD754_021000 [Muntiacus muntjak] PLWLMLLSLLLVAEICLLPPDEGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKQCGELEQYFFNLSSMTCEKFKSGGCHSNENRFPDEAACM-APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNNNNFVNLKDCKRTCVKPLKKELFASRRLKI >XP_043318540.1 tissue factor pathway inhibitor 2 [Cervus canadensis] PLWLMLLSLLLVAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKQCGELEQYFFNLSSMTCEKFFSGGCHSNENRFPDEAACM-APAFCYSPKDEGLCSANVTRYYFNPRHKACEVFTYTGCGGNNNNFVNLKDCKRTCVKALKKELFANRRLKI >XP_041421830.1 tissue factor pathway inhibitor 2 [Xenopus laevis] -----SFQALMATTVCLLPLDEGPCKALIPHYYYDRYTQTCQEFFYGGCDGNANNFVSMEDCEKFCWKIKKVPKACRMVEGPCRGYKRYAYNMKTMRCEQFIYGGCYGNDNNFQDKDSCIDAPSFCYSPKDEGSCSASVTRYYFNIESKACEEFVYTGCGGNSNNFIKVEDCDSVCKKGTKRPRIRRPRIQS >XP_040208262.1 tissue factor pathway inhibitor 2-like [Rana temporaria] HL---LLPVCFLITACLLPRVEGNCRGLIPQFYYDRYTQTCEEFLYGGCDGNANNFETVEDCEKTCWKIKKVPKPCRMEPGPCRGYKRYAYNLLTMKCELFIYGGCYGNDNNYRDEASCLNAPSFCYSPKDEGSCSASVNRYYFNIESKSCEEFQYTGCGGNSNNFIRLEDCNKVCKKGNKRPRLRRPKINP >AAB26836.1 tissue factor pathway inhibitor [Oryctolagus cuniculus] IFWTSCLLLGLVHSFCAMKVDDGPCRAYIKRFFFNILTHQCEEFIYGGCEGNENRFESLEECKEKCARDKGKPDFCFLEPGICRGYTRYFYNNQSKQCERFKYGGCLGNLNNFESLEECKHGPSWCLPPADRGLCQANEIRFFYNAIIGKCRPFKYSGCGGNENNFTSKKACITACKKGFIRNKTKRKKKKQ >KAF4026309.1 hypothetical protein G4228_018521 [Cervus hanglu yarkandensis] ILGVSCLLLSCAHSFCAMRADDGPCKAIIKRFFFNIHTQQCEEFIYGGCEGNQNRFETLEECKQKCTRE--KPDFCFLEAGICRGYTRYFYNNQSKQCERFKYGGCLGNLNNFESLEECK-------------------------SIFGK------------------------------------------ >OWK09488.1 hypothetical protein Celaphus_00006368 [Cervus elaphus hippelaphus] PLVLKGSYLFQLEEHCLASKKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECKLACRDVQGPSAERHHPSGSCHPS----FRCGDGCCDSFLECDDTPDCPDASDEATCEDLP-------DTGHCSESIPRWYYNPFTEHCARFTYGGCYGNKNNFEEEEQCLESCRGISKKDFFKNQRKDF >NP_033390.1 tissue factor pathway inhibitor 2 isoform 1 precursor [Mus musculus] PLQLWNLPLLLVLEICLLPLDAGPCQALIPKFYYDRDQQKCRRFNYGGCLGNANNFHSRDLCQQTCGSIEKVPPVCRSETYPCDKPIRFFFNLNTMTCEPLRPGLCSRTINVFSEEATCKHIPSFCSSPKDEGLCSANVTRFYFNSRNKTCETFTYTGCGGNENNFYYLDACHRACVKGWKKPDFLPRFWKH >XP_031550075.1 carboxypeptidase inhibitor SmCI-like [Actinia tenebrosa] -----STILFLLQEHCNLPLEKGKCGGRFERFYYNSHKGKCESFFYGGCSGNDNNFENEEECDKACGAFADANSFCNLPVGRCKGYPRYFYNTEAGKCQRFIYGGCGGNRNNFETVXDCRDANSFCQLPAVVGRCRGRFPRYYYNTEAGKCQRFIYGGCXGNRNNFETVEDCRATCHPREKRAYYNTEAGKC >NP_775164.2 tissue factor pathway inhibitor 2 precursor [Rattus norvegicus] SLRLWNLPLLLVLEICLLPLDMGPCKALIPKFYYDRDQKKCRRFKYGGCLGNANNFHSRKLCEHTCGNKEKVPWVCRSATYPCDKPTEFFFNLKTMTCEPLRPGLCSRTTNVFPEEAMCKSIPSFCSSPKDEGLCSANVTRYYFNSRNKACETFTYTGCGGNENNFYYLDACNRACVKALKKPDFLPRFWKL >NP_877589.1 tissue factor pathway inhibitor 2 precursor [Bos taurus] PLWLMLLSLLLVAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKQCGELEQYFFNLSSMTCKKFISGGCHSNENRFPDEATCM-APVFCYSPKDEGLCSANVTRYYFNPRHKACEAFNYTGCGGNDNNFVNLKDCKRTCVKALKKELLANRRLKI >XP_015137423.1 tissue factor pathway inhibitor 2 isoform X1 [Gallus gallus] RL---PLPALLLQRACLLPPDDGPCRALVPRWYYDRYTQSCQEFSYGGCHGNANNFLSHDDCEKNCWTIKKVPKLCRMETGPCRGYRRYAFNLSSMRCEEFIYGGCYGNGNNFKDLQSCVTGPLLCYSPKDEGLCSSSVPRYYYDTTSKSCKEFKYTGCGGNANNFVTEVDCYNVCRKGSQKPLLRRKMMRK >XP_001168275.1 tissue factor pathway inhibitor 2 [Pan troglodytes] PLGLSILLLFLTAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDEACWRIEKVPKVCRLQDDQCEGSEKYFFNLSSMTCEKFFSGGCHRNENRFPDEATCM-IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKRFASRIRKI >XP_532462.3 tissue factor pathway inhibitor 2 [Canis lupus familiaris] PFGVLLLPLLLMAETCLLPPDVGPCRALIPSYYYDRYTQSCLPFTYGGCRGNANNFETWEACDEACWRIEKVPKICRLEEEKCGENEEYFFNLTSMTCEKFLSGGCHSNENRFPDEAACM-SPSFCYSPKDEGLCSANVTRYYFNPRHRTCEAFAYTGCGGNDNNFVSMKDCKNVCVKALKKESLVNRRLKN >tr|B0S6C1|B0S6C1_DANRE Tissue factor pathway inhibitor OS=Danio rerio OX=7955 GN=tfpia PE=4 SV=1 NSSCKLLSLFGVHQSCALKKDEGPCKAMKDRFYFDIDTGRCEPFEYGGCQGNANNFETLQDCEEMCLV-TENKSPCHLEPGPCRGLPRYFFDQKSQECKQFFYGGCFGNANNFKTIKACQSPPELCMSAVDRGDCDGSERRYVFNPRIGRCQVFRYSGCGGNKNNFIHKRHCMKMCMKDQHRRRNSNILFRS >XP_002818297.1 tissue factor pathway inhibitor 2 isoform X1 [Pongo abelii] PLGLSILLLLLTAEICLLPLDYGPCRALLARYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDEACWRIEKVPKVCRLQDDQCEGSEKYFFNLSSMTCEKFFSGGCHRNENRFPDEATCM-IPSFCYSPKDEGLCFANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALRKKRFASRIRKI >XP_005667666.2 tissue factor pathway inhibitor 2 [Sus scrofa] THGLVLLPLLLVSEICLLPPDEGPCRALVPSYYYDRYTQSCREFMYGGCEGNANNFETWEACDEACWRIEKVPKICRLEKRQCGELEEYFFNLSSMTCEKFLSGGCHGNANRFLDEATCM-SPSFCYSPKDEGLCSANVTRYYFNPRHKACETFTYTGCGGNDNNFVSMKDCKRACVKALKKELLASRRLKI >XP_003809768.1 tissue factor pathway inhibitor 2 [Pan paniscus] PLGLSILLLFLTAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTWEACDEACWRIEKVPKVCRLQDDQCEGSEKYFFNLSSMTCEKFFSGGCHRNENRFPDEATCM-IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKKKRFASRIRKI >XP_003982808.1 tissue factor pathway inhibitor 2 [Felis catus] PLGLLLLPLLLLAEICLLPPDEGPCRARIPSYYYDRYTQSCRKFMYGGCEGNDNNFETWEACDEACWRIEKVPKICRLEEGQCGEPEQYFFNLSSMTCEKFLSGGCHSNENRFPDEATCM-GPSFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNENNFINMKDCKHVCVKALKKEFFANRRLKI >XP_004007771.1 tissue factor pathway inhibitor 2 [Ovis aries] PLWLMLLSLLLVAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKQCGELEQYFFNLSSMTCEKFISGGCHSDENRFPDKASCM-APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNDNNFVNLKDCKRTCVKALKKELFANRRLKI >XP_004045805.1 tissue factor pathway inhibitor 2 isoform X1 [Gorilla gorilla gorilla] PLGLSILLLFLTAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFDTWEACDEACWRIEKVPKVCRLQDDQCEGSEKYFFNLSSMTCEKFLSGGCHRNENRFPDEATCM-IPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRACAKALKRKRFASRIRKI >XP_004073873.1 tissue factor pathway inhibitor 2 [Oryzias latipes] -----MLTLFALKGACLLRVDEGPCRGQIERYFYNTITQKCEVFYYGGCHGNANNFMSFQKCQKTCFRIPKVPQICRFPEGHCRALPSYFFNMSTMQCEPFSYGGCGGNSNRFRDLTSCMSVPILCLDPLDKGKCSASMRRFYYNKATKTCEEFAYSGCGGSSNNFVSRESCEDVCLKGAKKHRLMKRNKKT >XP_021146623.1 tissue factor pathway inhibitor 2 [Columba livia] -----------------------------------------------------------------------------MEGGPCRSHKRYAFNLSSMRCEEFIYGGCYGNGNNFRDLQSCVTGPLLCYSPKDEGLCSSSVPRYYYDSSSKSCKEFKYTGCGGNANNFVTEKDCYNVCRKGTQKPAFRRKMMRK >XP_017902909.1 PREDICTED: tissue factor pathway inhibitor 2 [Capra hircus] SLWLMLLSLLLVAEICLLPLDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKECGELEQYFFNLSSMTCEKFISGGCHSNENRFPDKASCM-APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNDNNFVNLKDCKRTCVKALKKELFANRRLKI >XP_025062584.1 tissue factor pathway inhibitor 2 [Alligator sinensis] YLVVN-------QRNCLLPVDDGPCRALLPRWYYDRYTQTCEPFSYGGCQGNANNFESSEDCEKSCWFIRKVPKICRMEPGPCRSYSRYAFNLSSMMCEPFIYGGCYGNDNNFRKYDSCMTGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYTGCGGNSNNFVSKTDCYKVCRKGNKKPKVMRKMMRK >XP_006258519.2 PREDICTED: tissue factor pathway inhibitor 2 isoform X1 [Alligator mississippiensis] RLV--PLPLLLLQRSCLLPVDDGPCRALLPRWYYDRYTQTCEPFSYGGCQGNANNFESSEDCEKSCWLIRKVPKICRMEPGPCRSYSRYAFNLSSMMCEPFIYGGCYGNDNNFRKYDSCMTGPSLCYSPKDEGLCSASITRYYYNSKSKLCEEFSYTGCGGNSNNFVSKTDCYKVCRKGNKKPKVMRKMMRK >XP_015811336.1 PREDICTED: tissue factor pathway inhibitor 2 [Nothobranchius furzeri] -----LLALFTIKGACLLQVDEGPCKGNIERFYYNTITQNCELFYYGGCLGNSNNFRSYPECQKTCFRIPKVPQICRFPEGHCRAIPRYFFNMTSMKCEPFFYGGCGGNSNRFQDLTSCMTVPMLCLDPLDKGKCSASITRYYYNTATKSCQDFVYTGCGGSSNNFVSQQSCMDVCVKGRKKHRRRGQKKMK >XP_020769431.1 tissue factor pathway inhibitor 2 [Odocoileus virginianus texanus] PLWLMLLSLLLVAEICLLPPDDGPCRARIPSYYYDRYTQSCREFMYGGCEGNANNFETLEACNEACWKIEKVPKICRLKKKQCGELEQYFFNLSSMTCEKFISGGCHNNENRFPDEATCM-APAFCYSPKDEGLCSANVTRYYFNPRHKACEAFTYTGCGGNNNNFVNLKDCKRTCVKALKKELFASRRLKI >XP_030267071.1 tissue factor pathway inhibitor 2 [Sparus aurata] -----TLTLFALKAVCLLQVDEGPCRGDIERYYYNTITQKCEVFYYGGCQGNANNFRSYQECQKTCFRIPKIPQICRFTEGPCRGLPRYFFNMTTMQCEPFSFGGCAGNSNNFYNLDSCMSVPVLCLDPLDKGKCSASIPRYYYNTATKMCEEFVYSGCGGSSNNFVSRQSCTDVCVRGGKKHRRMRRNRNN
PhyML tree of selected proteins (XP_030267071_1_tissue_factor_pathway_inhibitor_2__Sparus_aurata_:0.08165743,(XP_004073873_1_tissue_factor_pathway_inhibitor_2__Oryzias_latipes_:0.12767465,XP_015811336_1_PREDICTED__tissue_factor_pathway_inhibitor_2__Nothobranchius_furzeri_:0.21199382):0.05710062,(((((XP_532462_3_tissue_factor_pathway_inhibitor_2__Canis_lupus_familiaris_:0.14429534,(XP_005667666_2_tissue_factor_pathway_inhibitor_2__Sus_scrofa_:0.08379131,(XP_003982808_1_tissue_factor_pathway_inhibitor_2__Felis_catus_:0.0626156,((NP_877589_1_tissue_factor_pathway_inhibitor_2_precursor__Bos_taurus_:0.02198976,(XP_020769431_1_tissue_factor_pathway_inhibitor_2__Odocoileus_virginianus_texanus_:0.00978929,(KAB0344074_1_hypothetical_protein_FD754_021000__Muntiacus_muntjak_:0.02127488,XP_043318540_1_tissue_factor_pathway_inhibitor_2__Cervus_canadensis_:0.01165463):0.00605675):0.00647283):0.00000001,(XP_004007771_1_tissue_factor_pathway_inhibitor_2__Ovis_aries_:0.00539221,XP_017902909_1_PREDICTED__tissue_factor_pathway_inhibitor_2__Capra_hircus_:0.01077106):0.01639497):0.08099039):0.01992368):0.01870004):0.09750064,(XP_004045805_1_tissue_factor_pathway_inhibitor_2_isoform_X1__Gorilla_gorilla_gorilla_:0.00561829,(XP_002818297_1_tissue_factor_pathway_inhibitor_2_isoform_X1__Pongo_abelii_:0.02210089,((XP_001168275_1_tissue_factor_pathway_inhibitor_2__Pan_troglodytes_:0.00000001,XP_003809768_1_tissue_factor_pathway_inhibitor_2__Pan_paniscus_:0.00000001):0.00000001,NP_006519_1_tissue_factor_pathway_inhibitor_2_isoform_1_precursor__Homo_sapiens_:0.00543483):0.00000001):0.01107879):0.14779208):0.08885021,(NP_775164_2_tissue_factor_pathway_inhibitor_2_precursor__Rattus_norvegicus_:0.10342531,NP_033390_1_tissue_factor_pathway_inhibitor_2_isoform_1_precursor__Mus_musculus_:0.0701393):0.6888378):0.4888694,((XP_040208262_1_tissue_factor_pathway_inhibitor_2_like__Rana_temporaria_:0.1982635,XP_041421830_1_tissue_factor_pathway_inhibitor_2__Xenopus_laevis_:0.19927375):0.22098421,((XP_015137423_1_tissue_factor_pathway_inhibitor_2_isoform_X1__Gallus_gallus_:0.05063326,XP_021146623_1_tissue_factor_pathway_inhibitor_2__Columba_livia_:0.06220707):0.23221159,(XP_025062584_1_tissue_factor_pathway_inhibitor_2__Alligator_sinensis_:0.01724801,XP_006258519_2_PREDICTED__tissue_factor_pathway_inhibitor_2_isoform_X1__Alligator_mississippiensis_:0.00000001):0.11501476):0.15356446):0.03523211):0.28064588,((OWK09488_1_hypothetical_protein_Celaphus_00006368__Cervus_elaphus_hippelaphus_:2.39558394,XP_031550075_1_carboxypeptidase_inhibitor_SmCI_like__Actinia_tenebrosa_:0.70062671):0.70064221,(tr_B0S6C1_B0S6C1_DANRE_Tissue_factor_pathway_inhibitor_OS_Danio_rerio_OX_7955_GN_tfpia_PE_4_SV_1:0.92966859,(KAF4026309_1_hypothetical_protein_G4228_018521__Cervus_hanglu_yarkandensis_:0.05837613,AAB26836_1_tissue_factor_pathway_inhibitor__Oryctolagus_cuniculus_:0.13666839):0.72177084):0.31276867):0.29024748):0.44753755);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)