PB0038

DATABASE

Click here to access PB0038 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0038	P24593	Insulin-like growth factor-binding protein 5	IGFBP5	IBP5	Homo_sapiens	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Domains

Gene Ontology

PF00086 (Thyroglobulin_1) PF00219 (IGFBP)

GO:0001968 (enables) fibronectin binding GO:0005515 (enables) protein binding GO:0005520 (enables) insulin-like growth factor binding GO:0019838 (enables) growth factor binding GO:0031994 (enables) insulin-like growth factor I binding GO:0031995 (enables) insulin-like growth factor II binding GO:0001558 (involved in) regulation of cell growth GO:0001649 (involved in) osteoblast differentiation GO:0007165 (involved in) signal transduction GO:0007565 (involved in) female pregnancy GO:0007568 (involved in) aging GO:0014912 (involved in) negative regulation of smooth muscle cell migration GO:0017148 (involved in) negative regulation of translation GO:0030336 (involved in) negative regulation of cell migration GO:0031069 (involved in) hair follicle morphogenesis GO:0035556 (involved in) intracellular signal transduction GO:0040008 (involved in) regulation of growth GO:0042593 (involved in) glucose homeostasis GO:0043567 (involved in) regulation of insulin-like growth factor receptor signaling pathway GO:0043568 (involved in) positive regulation of insulin-like growth factor receptor signaling pathway GO:0043569 (involved in) negative regulation of insulin-like growth factor receptor signaling pathway GO:0044342 (involved in) type B pancreatic cell proliferation GO:0045668 (involved in) negative regulation of osteoblast differentiation GO:0045926 (involved in) negative regulation of growth GO:0048286 (involved in) lung alveolus development GO:0048662 (involved in) negative regulation of smooth muscle cell proliferation GO:0051146 (involved in) striated muscle cell differentiation GO:0051897 (involved in) positive regulation of protein kinase B signaling GO:0060056 (involved in) mammary gland involution GO:0060416 (involved in) response to growth hormone GO:0071320 (involved in) cellular response to cAMP GO:0071407 (involved in) cellular response to organic cyclic compound GO:1901862 (involved in) negative regulation of muscle tissue development GO:1904205 (involved in) negative regulation of skeletal muscle hypertrophy GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation GO:1904754 (involved in) positive regulation of vascular associated smooth muscle cell migration GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005788 (located in) endoplasmic reticulum lumen GO:0016942 (part of) insulin-like growth factor binding protein complex GO:0042567 (part of) insulin-like growth factor ternary complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P24593|IBP5_HUMAN Insulin-like growth factor-binding protein 5 OS=Homo sapiens OX=9606 GN=IGFBP5 PE=1 SV=1 MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCA LAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHE EPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISA PEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGI CWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >tr|B0S525|B0S525_DANRE Insulin-like growth factor-binding protein 5 OS=Danio rerio OX=7955 GN=igfbp5b PE=4 SV=1 MALLVLGTFLTVLSVSGGSFVPCEPCDQKALSMCPPVPVGCQLVKEPGCGCCYTCALAEG QACGVYTGTCTHGLRCLPRNGEEKPLHALLHGRGVCTNEKGYKPPHPPIDRESIEHDDTV KPDTTEDQIPKIPLYPKPDVINSKKQAALFKDKKKQQEKLRSVGSLDYSPLPIDKHEPEF GPCRRKLDGIIQSMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGV QLPGTDYSGGNIQCKDLENSNNNNE
Selected proteins from model organisms >NP_000590.1 insulin-like growth factor-binding protein 5 precursor [Homo sapiens] MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVY TERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMV PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >tr|B0S525|B0S525_DANRE Insulin-like growth factor-binding protein 5 OS=Danio rerio OX=7955 GN=igfbp5b PE=4 SV=1 MALLVLGTFLTVLSVSGGSFVPCEPCDQKALSMCPPVPVGCQLVKEPGCGCCYTCALAEG QACGVYTGTCTHGLRCLPRNGEEKPLHALLHGRGVCTNEKGYKPPHPPIDRESIEHDDTV KPDTTEDQIPKIPLYPKPDVINSKKQAALFKDKKKQQEKLRSVGSLDYSPLPIDKHEPEF GPCRRKLDGIIQSMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGV QLPGTDYSGGNIQCKDLENSNNNNE >XP_043300705.1 insulin-like growth factor-binding protein 5 isoform X2 [Cervus canadensis] MVLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCL PRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLT QSKFVGGAENTAHPRVIAAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGIC WCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >KAB0358867.1 hypothetical protein FD754_003023 [Muntiacus muntjak] MVLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCL PRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLT QSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGIC WCVDKYGMKLPGVEYVDGDFQCHTFDSSNVE >XP_018094172.1 insulin-like growth factor-binding protein 5 [Xenopus laevis] MLLPMCLLLVSLCLGQCQALGSFVHCEPCDDKAMSMCPPTPVGCELVKEPGCGCCMTCALAEGHRCGVYTEHCAKGLRCL PEQGEEKPLHALLHGRGVCLNLKNHRDQSKIDRESKEEPTTSETEDKYPLKHGGKLSLSQQQKAIAINNLRQKKHSQSRI VSVEKVQSPSTPEHSFEIDMGPCRRQVETLMQEMKLSHRVYPRAFYLPNCDRKGFFKRKQCKPSRGRKRGLCWCVDKYGL KLPGIDYVNGDLQCHSFDSSNTE >XP_023806685.1 insulin-like growth factor-binding protein 5 [Oryzias latipes] MFLSFCLLVTFLLGLSGCLGSYVPCEPCDDKAMSMCPPVPLGCQLVKEPGCGCCLTCALSEGHACGVYTGTCSKGLRCLP RSGEEKPLYALLHGRGVCTNEKGYKPAVPPAEFESREHEDTITPEIPGELQPAKVPLHPKDIVNSKKNIAVRKEQKRKQT KQRSMGATLDYTPLSIVKHEPEFGPCRRKLDGIIQGMKDASRVIARSLYLPNCDRRGFFKRKQCKPSSGRKRGICWCVDK YGIQLPGIDYTGGNFQCKDLESTNNE >XP_015830827.1 PREDICTED: insulin-like growth factor-binding protein 5 [Nothobranchius furzeri] MLLSFCLLVTFILEVSRCRASYVPCEPCDEKALSMCPPVPVGCQLVKEPGCGCCLTCALVEGQACGVYTGTCTKGLRCLP RSGEEKPLHALLHGRGVCTNEKGYKPALPSSDRESREHEETITPENIGELQPVKVPLNPIDRVNSKKVIAARKDKRRTLG KQRSLGPTVDYSFMALEKHEPEFGPCRRKLDGIIHDMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDK YGLQIPGTVYSGGDIQCKDLESSNNE >KAB0375616.1 hypothetical protein FD755_012259 [Muntiacus reevesi] MLPARPALWAAALTALALLRGPPAARAGTGTMGTGPVVRCEPCDAHALAQCAPPPPSPPCAELVREPGCGCCLTCALREG QPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVGRLRPYLLPAPPAPGNGSESEEDHSMGSTENQALPSTH RVPDSKFHPVHTKMDVIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFMNMLSPRGIHIP NCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGFDVKGKGDVHCYSMDSK >KAF4020195.1 hypothetical protein G4228_011719 [Cervus hanglu yarkandensis] MLRARPALWAAALTALALLRGPPAARAGAGTMGTGPVVRCEPCDAHALAQCAPPPPSPPCAELVREPGCGCCLTCALREG QPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVGRLRPYLLPAPPAPGELPAPDALPKRNPGPRSEASGLS SPEDENLSFVTRRSSLRWALKHSTPAGAALSSHSGLQGDVPSHRERGPAGGSPRPASPSWDLLSSPGGVSLMASFRKRRL STIEASEVSSEQLGSNSDPFDFEEDPPVPASATQQQKRQGKSPPAKRSPPNLGLPGIPDTARKRPRDLKRLAAVTERVRQ WELHLLQSIEEATQHELTIEDD >XP_039251864.1 insulin-like growth factor-binding protein 5 [Styela clava] MASITMTSKANFLLISSAALIFLFLDAGALTAASPVHRPSKCTKCTDADRAQCPTVVPGPNCEVIEEPNCGCCKMCAKKL GEKCGVATGLCETGLECIPPPMTSEEYRDYGPADYFMEAVMGDFICVTRQQFIDILTGVAYEDGDENEEGVYIPELYDPL TGMGLEDNTVHTVEVPDNEQPEKPTEDMSHLNPFIPKIEPVTQSTRPVEPPTAPFQNAPEPCIYHAEKVWGKLHFDPHEW IPSCEKDGHYFPEQCELSYGLERGRCWCVDRDGNPVSKFTPGDEARPELCLPKFKKI >NP_034648.2 insulin-like growth factor-binding protein 5 precursor [Mus musculus] MVISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE >NP_036949.1 insulin-like growth factor-binding protein 5 precursor [Rattus norvegicus] MVISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQEFKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE >NP_999264.1 insulin-like growth factor-binding protein 5 precursor [Sus scrofa] MVLTAVLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVILAPEMRQESEQGPCRRHMEASLQELKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHSFDSSNVE >XP_010800619.1 insulin-like growth factor-binding protein 5 isoform X1 [Bos taurus] MVLTAVLLLLAACAGSAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQKSEQVTPWGLATPLTPPIRTQGPCRR HMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCH TFDSSNVE >XP_422069.4 insulin-like growth factor-binding protein 5 [Gallus gallus] MLLRLLVLLGACPGLSRCLGSFVQCEPCDGKALSLCPPPPLGCELVKEPGCGCCLTCALPAGQPCGVYTE RCARGLRCLPRQGEEKPLHALLHGTAVCLSEKSYREQAKAERESREHEEPTTSEMTEETYPPKAYRPKHG RLSDLKAEALKKDRRKKLTLAKFVGMAENTAHPRVVIPELRQEFELGPCRRHMEASLQELKSSQRMVPRA VHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLPGTDYLSGDLQCHAFDSSNVE >XP_011966279.1 insulin-like growth factor-binding protein 5 isoform X1 [Ovis aries] MVLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPELRQESEQVTPWGLATPLTPPIRTQGPCRR HMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCH TFDSSNVE >XP_852885.1 insulin-like growth factor-binding protein 5 [Canis lupus familiaris] MVLTAVLLLLASCAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_003309513.1 insulin-like growth factor-binding protein 5 [Pan troglodytes] MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVY TERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMV PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_002712514.1 PREDICTED: insulin-like growth factor-binding protein 5 [Oryctolagus cuniculus] MVLTAVLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKVFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIVSPPEMRQESEQGPCRRHMEASLQELKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYADGDFQCHAFDSSNVE >XP_009236354.2 insulin-like growth factor-binding protein 5 [Pongo abelii] MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVY TERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMV PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_017909736.1 PREDICTED: insulin-like growth factor-binding protein 5 isoform X1 [Capra hircus] MVLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIAERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPELRQESEQVTPWGLATPLTPPIRTQGPCR RHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQC HTFDSSNVE >XP_003818638.1 insulin-like growth factor-binding protein 5 [Pan paniscus] MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVY TERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMV PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_003991177.1 insulin-like growth factor-binding protein 5 [Felis catus] MVLTAVLLLLASCAGLAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCTTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKGSPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_018877633.1 insulin-like growth factor-binding protein 5 [Gorilla gorilla gorilla] MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVY TERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPK HTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMV PRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_005498635.2 insulin-like growth factor-binding protein 5 [Columba livia] MERESREHEEPTTSEMTEETYPPKAYRPKHGRLSELKAEALKKDRRKKLTLAKFVGMAENTAHPRVVIPE LRQEFELGPCRRHMEASLQELKSSQRMVPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLP GTDYLSGDLQCHAFDSSNVE >XP_006258950.1 PREDICTED: insulin-like growth factor-binding protein 5 [Alligator mississippiensis] MLRRVLVLCVCLGTTRSLGSLVHCEPCDEKALSLCPPRPAGCELVKEPGCGCCLTCALPAGQPCGVYTER CAQGLRCLPRPGEDKPLHALLHGRGLCLADKGPADKDKDKDKDRAKPDKESREHEEPTTSEMTEETYAPK GYRPKHPRLSELKAEALKKDRRKKLTSSKFVGAAENTAHPRVAAPELRPEFELGPCRRQMEASLQELKTS QRMIPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGLKLPGSGYVSGDLQCHHFDSSNTE >XP_010711906.1 insulin-like growth factor-binding protein 5 [Meleagris gallopavo] MTEETYPPKAYRPKHGRLSDLKAEALKKDRRKKLTLAKFVGMAENTAHPRVVIPELRQEFELGPCRRHME ASLQELKSSQRMVPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLPGTDYLSGDLQCHAFD SSNVE >XP_020768950.1 insulin-like growth factor-binding protein 5 [Odocoileus virginianus texanus] MVLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYT ERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQAKIERDSREHEEPTTSEMAEETYSPKIFRPKH TRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVP RAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE >XP_030283802.1 insulin-like growth factor-binding protein 5 [Sparus aurata] MFLSFCLLVTFILGLSGCLGSYVPCEPCDQKALSMCPPVPVGCQLVKEPGCGCCLTCALSEGQACGVYTG TCTQGLRCLPRSGEEKPLHALLHGRGVCTNEKGYKPAHPPIDRESHEDAITTEITEELQPAKVPLLPKDI VNSKKVHAVRKEQKNKLSKQRNMGTSMDYSPLPIDKHEPEFGPCRRKLDGIIQGMKDTSRVMALSLYLPN CDRKGFFKRKQCKPSRGRKRGICWCVDKYGVQLPGTDYSGGDIQCKDLESSNNNE >XP_040214133.1 insulin-like growth factor-binding protein 5 [Rana temporaria] MIVPACFLLTLCLGMCQCLGSFVHCEPCDEKAMSMCPPTPVACELVKEPGCGCCMTCALAEGQSCGVYTE RCAGGLRCLPKQGEEKPLHALLHGRGVCLNEKIYRDQVKIERESREEDPTTSETEETYPTKPRKRGQGVS DHKAIALNNFRQKKQSASRIVSVENNKGQTHSLPEYSIESEMGPCRRQMETVMQDMKMSHRVYPRAFYIP NCDRKGFFKRKQCKPSRGRKRGICWCVDKYGLKLPGSDYAAGDLQCHSFDSSNIE
Mafft alignment of selected proteins >NP_000590.1 insulin-like growth factor-binding protein 5 precursor [Homo sapiens] MV------------LLTAVLLLLAAYAGPA--------------QSLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRIISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >tr|B0S525|B0S525_DANRE Insulin-like growth factor-binding protein 5 OS=Danio rerio OX=7955 GN=igfbp5b PE=4 SV=1 ---------------MALL-VLGTFLTVLS--------------VSGGSFVPCEPCDQKA LSMC---PPVPVGCQLVKEPGCGCCYTCALAEGQACGVYTGTCTHGLRCLPRN------- --GEEKPLHALLHGRGVCTNEKGY--------------------KP---PHPPI-DRESI EHDDTVKPDTTEDQI-PKIPLYPKPDVIN------------SKKQAALFKDKKKQQEKLR SVG-SLDYS-----PLPIDKHEPE-----------------FGPCRRKLDGIIQSMKDTS RVMALSLYLPNCDRKGF----------------------FKRKQCKPSRG----RKRGIC WCVDKY--GVQLPGTDYSG----GNI----------------QCKDLENS-----NNNNE >XP_043300705.1 insulin-like growth factor-binding protein 5 isoform X2 [Cervus canadensis] -M------------VLTALLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVIAAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >KAB0358867.1 hypothetical protein FD754_003023 [Muntiacus muntjak] -M------------VLTALLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGVEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_018094172.1 insulin-like growth factor-binding protein 5 [Xenopus laevis] -M------------LLPMCLLLVSLCLGQC--------------QALGSFVHCEPCDDKA MSMC---PPTPVGCELVKEPGCGCCMTCALAEGHRCGVYTEHCAKGLRCLPEQ------- --GEEKPLHALLHGRGVCLNLKNH--------------------RD----QSKI-DRESK E--EPTTSE-TEDKY-PLKHGGKL-SLSQ------------QQKAIAINNLRQKKHSQSR IVSVE-KVQSP---STPEHSFEID-----------------MGPCRRQVETLMQEMKLSH RVYPRAFYLPNCDRKGF----------------------FKRKQCKPSRG----RKRGLC WCVDKY--GLKLPGIDYVN----GDL----------------QCHSFDSS-----NTE-- >XP_023806685.1 insulin-like growth factor-binding protein 5 [Oryzias latipes] -M------------FLSFC-LLVTFLLGLS--------------GCLGSYVPCEPCDDKA MSMC---PPVPLGCQLVKEPGCGCCLTCALSEGHACGVYTGTCSKGLRCLPRS------- --GEEKPLYALLHGRGVCTNEKGY--------------------KP---AVPPA-EFESR EHEDTITPEIPGELQPAKVPLHPK-DIVN------------SKKNIAVRKEQKRKQTKQR SMGATLDYT-----PLSIVKHEPE-----------------FGPCRRKLDGIIQGMKDAS RVIARSLYLPNCDRRGF----------------------FKRKQCKPSSG----RKRGIC WCVDKY--GIQLPGIDYTG----GNF----------------QCKDLEST-----NNE-- >XP_015830827.1 PREDICTED: insulin-like growth factor-binding protein 5 [Nothobranchius furzeri] -M------------LLSFC-LLVTFILEVS--------------RCRASYVPCEPCDEKA LSMC---PPVPVGCQLVKEPGCGCCLTCALVEGQACGVYTGTCTKGLRCLPRS------- --GEEKPLHALLHGRGVCTNEKGY--------------------KP---ALPSS-DRESR EHEETITPENIGELQPVKVPLNPI-DRVN------------SKKVIAARKDKRRTLGKQR SLGPTVDYS-----FMALEKHEPE-----------------FGPCRRKLDGIIHDMKDTS RVMALSLYLPNCDRKGF----------------------FKRKQCKPSRG----RKRGIC WCVDKY--GLQIPGTVYSG----GDI----------------QCKDLESS-----NNE-- >KAB0375616.1 hypothetical protein FD755_012259 [Muntiacus reevesi] -M------------LPARPALWAAALTALALLRGPPAARAGTGTMGTGPVVRCEPCDAHA LAQCAPPPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPP------- --GDPRPLQALLDGRGLCANASAV-----------------GRLRPYLLPAPPA-PGNGS ESEEDHSMGSTENQALPSTHRVPD-SKFHPVHTKMD-----VIKKGHAKDSQRYKVDYES QSTDTQNF-------SSESKRETE-----------------YGPCRREMEDTLNHLKFMN MLSPRGIHIPNCDKKGF----------------------YKKKQCRPSKG----RKRGFC WCVDKY--GQPLPGFDVKGK---GDV----------------HCYSMDSK---------- >KAF4020195.1 hypothetical protein G4228_011719 [Cervus hanglu yarkandensis] -M------------LRARPALWAAALTALALLRGPPAARAGAGTMGTGPVVRCEPCDAHA LAQCAPPPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPP------- --GDPRPLQALLDGRGLCANASAV-----------------GRLRPYLLPAPPA-PGELP APD-----------ALPKRNPGPR-SEASGLSSPEDENLSFVTRRSSLRWALKHSTPAGA ALSSHSGL-------QGDVPSHRE-----------------RGPAGGSPRPASPSWDLLS --SPGGVSLMASFRKRRLSTIEASEVSSEQLGSNSDPFDFEEDPPVPASATQQQKRQGKS PPAKRSPPNLGLPGIPDTARKRPRDLKRLAAVTERVRQWELHLLQSIEEATQHELTIEDD >XP_039251864.1 insulin-like growth factor-binding protein 5 [Styela clava] -MASITMTSKANFLLISSAALIFLFLDAGALTAASPVHRPS----------KCTKCTDAD RAQCPTVVPGP-NCEVIEEPNCGCCKMCAKKLGEKCGVATGLCETGLECIPPPMTSEEYR DYGPADYFMEAVMGDFICVTRQQFIDILTGVAYEDGDENEEGVYIPEL--YDPL-TGMGL EDNTVHTVEVPDNEQ-PEKPTEDM-SHLNPF----------IPKIEPVTQSTRP------ --------V-----EPPTAPFQNA-----------------PEPCIYHAEKVWGKLHFDP HE-----WIPSCEKDGH----------------------YFPEQCELSYG----LERGRC WCVDRD--GN--PVSKFTP----GDEARPE------------LCLPKFKK------I--- >NP_034648.2 insulin-like growth factor-binding protein 5 precursor [Mus musculus] -M------------VISVVLLLLAAYAVPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------GE----QTKI-ERDSR EHEEPTTSEMAEETYSPKVFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVIPAPEMRQESE-----------------QGPCRRHMEASLQEFKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHAFDSS-----NVE-- >NP_036949.1 insulin-like growth factor-binding protein 5 precursor [Rattus norvegicus] -M------------VISVVLLLLAACAVPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------GE----QTKI-ERDSR EHEEPTTSEMAEETYSPKVFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVIPAPEMRQESD-----------------QGPCRRHMEASLQEFKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHAFDSS-----NVE-- >NP_999264.1 insulin-like growth factor-binding protein 5 precursor [Sus scrofa] -M------------VLTAVLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVILAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHSFDSS-----NVE-- >XP_010800619.1 insulin-like growth factor-binding protein 5 isoform X1 [Bos taurus] -M------------VLTAVLLLLAACAGSA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQKSEQVTPWGLATPLTPPIRTQGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_422069.4 insulin-like growth factor-binding protein 5 [Gallus gallus] --------------MLLRLLVLLGACPGLS--------------RCLGSFVQCEPCDGKA LSLC---PPPPLGCELVKEPGCGCCLTCALPAGQPCGVYTERCARGLRCLPRQ------- --GEEKPLHALLHGTAVCLSEKSY--------------------RE----QAKA-ERESR EHEEPTTSEMTEETYPPKAYRPKH-GRLS------------DLKAEALKKDRRKKLTLAK FVGMAENTAHPRV-VIPELRQEFE-----------------LGPCRRHMEASLQELKSSQ RMVPRAVHLPNCDRKGF----------------------YKRKQCKPSRG----RKRGLC WCVDKY--GMKLPGTDYLS----GDL----------------QCHAFDSS-----NVE-- >XP_011966279.1 insulin-like growth factor-binding protein 5 isoform X1 [Ovis aries] -M------------VLTALLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPELRQESEQVTPWGLATPLTPPIRTQGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_852885.1 insulin-like growth factor-binding protein 5 [Canis lupus familiaris] -M------------VLTAVLLLLASCAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_003309513.1 insulin-like growth factor-binding protein 5 [Pan troglodytes] MV------------LLTAVLLLLAAYAGPA--------------QSLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_002712514.1 PREDICTED: insulin-like growth factor-binding protein 5 [Oryctolagus cuniculus] -M------------VLTAVLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKVFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRIVSPPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYAD----GDF----------------QCHAFDSS-----NVE-- >XP_009236354.2 insulin-like growth factor-binding protein 5 [Pongo abelii] MV------------LLTAVLLLLAAYAGPA--------------QSLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_017909736.1 PREDICTED: insulin-like growth factor-binding protein 5 isoform X1 [Capra hircus] -M------------VLTALLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKIAERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPELRQESEQVTPWGLATPLTPPIRTQGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_003818638.1 insulin-like growth factor-binding protein 5 [Pan paniscus] MV------------LLTAVLLLLAAYAGPA--------------QSLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_003991177.1 insulin-like growth factor-binding protein 5 [Felis catus] -M------------VLTAVLLLLASCAGLA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCTTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKGSP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_018877633.1 insulin-like growth factor-binding protein 5 [Gorilla gorilla gorilla] MV------------LLTAVLLLLAAYAGPA--------------QSLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QVKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_005498635.2 insulin-like growth factor-binding protein 5 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------M-ERESR EHEEPTTSEMTEETYPPKAYRPKH-GRLS------------ELKAEALKKDRRKKLTLAK FVGMAENTAHPRV-VIPELRQEFE-----------------LGPCRRHMEASLQELKSSQ RMVPRAVHLPNCDRKGF----------------------YKRKQCKPSRG----RKRGLC WCVDKY--GMKLPGTDYLS----GDL----------------QCHAFDSS-----NVE-- >XP_006258950.1 PREDICTED: insulin-like growth factor-binding protein 5 [Alligator mississippiensis] ---------------MLRRVLVLCVCLGTT--------------RSLGSLVHCEPCDEKA LSLC---PPRPAGCELVKEPGCGCCLTCALPAGQPCGVYTERCAQGLRCLPRP------- --GEDKPLHALLHGRGLCLADKGPAD-------KDK-----DKDKD----RAKP-DKESR EHEEPTTSEMTEETYAPKGYRPKH-PRLS------------ELKAEALKKDRRKKLTSSK FVGAAENTAHPRV-AAPELRPEFE-----------------LGPCRRQMEASLQELKTSQ RMIPRAVHLPNCDRKGF----------------------YKRKQCKPSRG----RKRGLC WCVDKY--GLKLPGSGYVS----GDL----------------QCHHFDSS-----NTE-- >XP_010711906.1 insulin-like growth factor-binding protein 5 [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MTEETYPPKAYRPKH-GRLS------------DLKAEALKKDRRKKLTLAK FVGMAENTAHPRV-VIPELRQEFE-----------------LGPCRRHMEASLQELKSSQ RMVPRAVHLPNCDRKGF----------------------YKRKQCKPSRG----RKRGLC WCVDKY--GMKLPGTDYLS----GDL----------------QCHAFDSS-----NVE-- >XP_020768950.1 insulin-like growth factor-binding protein 5 [Odocoileus virginianus texanus] -M------------VLTALLLLLAACAGPA--------------QGLGSFVHCEPCDEKA LSMC---PPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQ------- --DEEKPLHALLHGRGVCLNEKSY--------------------RE----QAKI-ERDSR EHEEPTTSEMAEETYSPKIFRPKH-TRIS------------ELKAEAVKKDRRKKLTQSK FVGGAENTAHPRVISAPEMRQESE-----------------QGPCRRHMEASLQELKASP RMVPRAVYLPNCDRKGF----------------------YKRKQCKPSRG----RKRGIC WCVDKY--GMKLPGMEYVD----GDF----------------QCHTFDSS-----NVE-- >XP_030283802.1 insulin-like growth factor-binding protein 5 [Sparus aurata] -M------------FLSFC-LLVTFILGLS--------------GCLGSYVPCEPCDQKA LSMC---PPVPVGCQLVKEPGCGCCLTCALSEGQACGVYTGTCTQGLRCLPRS------- --GEEKPLHALLHGRGVCTNEKGY--------------------KP---AHPPI-DRES- -HEDAITTEITEELQPAKVPLLPK-DIVN------------SKKVHAVRKEQKNKLSKQR NMGTSMDYS-----PLPIDKHEPE-----------------FGPCRRKLDGIIQGMKDTS RVMALSLYLPNCDRKGF----------------------FKRKQCKPSRG----RKRGIC WCVDKY--GVQLPGTDYSG----GDI----------------QCKDLESS-----NNNE- >XP_040214133.1 insulin-like growth factor-binding protein 5 [Rana temporaria] -M------------IVPAC-FLLTLCLGMC--------------QCLGSFVHCEPCDEKA MSMC---PPTPVACELVKEPGCGCCMTCALAEGQSCGVYTERCAGGLRCLPKQ------- --GEEKPLHALLHGRGVCLNEKIY--------------------RD----QVKI-ERESR E-EDPTTSE-TEETY-PTKPRKRG-QGVS------------DHKAIALNNFRQKKQSASR IVSVENNKGQTH--SLPEYSIESE-----------------MGPCRRQMETVMQDMKMSH RVYPRAFYIPNCDRKGF----------------------FKRKQCKPSRG----RKRGIC WCVDKY--GLKLPGSDYAA----GDL----------------QCHSFDSS-----NIE--
BMGE Cleaned alignment of selected proteins >NP_000590.1 insulin-like growth factor-binding protein 5 precursor [Homo sapiens] LLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >tr|B0S525|B0S525_DANRE Insulin-like growth factor-binding protein 5 OS=Danio rerio OX=7955 GN=igfbp5b PE=4 SV=1 -MALL-VLGTFLTVLSVSGGSFVPCEPCDQKALSMCPPVPVGCQLVKEPGCGCCYTCALAEGQACGVYTGTCTHGLRCLPRNGEEKPLHALLHGRGVCTNEKGYDRESIEHDDTVKPDTTEDQI-PKIPLYPKSKKQAALFKDKKKQQEKLRSVG-SLDYS-----PLPIDKHEPEFGPCRRKLDGIIQSMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGVQLPGTDYSGQCKDLENS >XP_043300705.1 insulin-like growth factor-binding protein 5 isoform X2 [Cervus canadensis] VLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIAAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >KAB0358867.1 hypothetical protein FD754_003023 [Muntiacus muntjak] VLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGVEYVDQCHTFDSS >XP_018094172.1 insulin-like growth factor-binding protein 5 [Xenopus laevis] LLPMCLLLVSLCLGQCQALGSFVHCEPCDDKAMSMCPPTPVGCELVKEPGCGCCMTCALAEGHRCGVYTEHCAKGLRCLPEQGEEKPLHALLHGRGVCLNLKNHDRESKE--EPTTSE-TEDKY-PLKHGGKLQQKAIAINNLRQKKHSQSRIVSVE-KVQSP---STPEHSFEIDMGPCRRQVETLMQEMKLSHRVYPRAFYLPNCDRKGFFKRKQCKPSRGRKRGLCWCVDKYGLKLPGIDYVNQCHSFDSS >XP_023806685.1 insulin-like growth factor-binding protein 5 [Oryzias latipes] FLSFC-LLVTFLLGLSGCLGSYVPCEPCDDKAMSMCPPVPLGCQLVKEPGCGCCLTCALSEGHACGVYTGTCSKGLRCLPRSGEEKPLYALLHGRGVCTNEKGYEFESREHEDTITPEIPGELQPAKVPLHPKSKKNIAVRKEQKRKQTKQRSMGATLDYT-----PLSIVKHEPEFGPCRRKLDGIIQGMKDASRVIARSLYLPNCDRRGFFKRKQCKPSSGRKRGICWCVDKYGIQLPGIDYTGQCKDLEST >XP_015830827.1 PREDICTED: insulin-like growth factor-binding protein 5 [Nothobranchius furzeri] LLSFC-LLVTFILEVSRCRASYVPCEPCDEKALSMCPPVPVGCQLVKEPGCGCCLTCALVEGQACGVYTGTCTKGLRCLPRSGEEKPLHALLHGRGVCTNEKGYDRESREHEETITPENIGELQPVKVPLNPISKKVIAARKDKRRTLGKQRSLGPTVDYS-----FMALEKHEPEFGPCRRKLDGIIHDMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGLQIPGTVYSGQCKDLESS >KAB0375616.1 hypothetical protein FD755_012259 [Muntiacus reevesi] LPARPALWAAALTALAMGTGPVVRCEPCDAHALAQCPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVPGNGSESEEDHSMGSTENQALPSTHRVPDVIKKGHAKDSQRYKVDYESQSTDTQNF-------SSESKRETEYGPCRREMEDTLNHLKFMNMLSPRGIHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGFDVKGHCYSMDSK >KAF4020195.1 hypothetical protein G4228_011719 [Cervus hanglu yarkandensis] LRARPALWAAALTALAMGTGPVVRCEPCDAHALAQCPPSPPCAELVREPGCGCCLTCALREGQPCGVYTERCGSGLRCQPPPGDPRPLQALLDGRGLCANASAVPGELPAPD-----------ALPKRNPGPRVTRRSSLRWALKHSTPAGAALSSHSGL-------QGDVPSHRERGPAGGSPRPASPSWDLLS--SPGGVSLMASFRKRRFEEDPPVPASAKRQGKSPPAKRSNLGLPGIPDTALLQSIEEA >XP_039251864.1 insulin-like growth factor-binding protein 5 [Styela clava] LISSAALIFLFLDAGA-------KCTKCTDADRAQCVPGP-NCEVIEEPNCGCCKMCAKKLGEKCGVATGLCETGLECIPPPGPADYFMEAVMGDFICVTRQQFTGMGLEDNTVHTVEVPDNEQ-PEKPTEDMIPKIEPVTQSTRP--------------V-----EPPTAPFQNAPEPCIYHAEKVWGKLHFDPHE-----WIPSCEKDGHYFPEQCELSYGLERGRCWCVDRDGN--PVSKFTPLCLPKFKK >NP_034648.2 insulin-like growth factor-binding protein 5 precursor [Mus musculus] VISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKVFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHAFDSS >NP_036949.1 insulin-like growth factor-binding protein 5 precursor [Rattus norvegicus] VISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKVFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHAFDSS >NP_999264.1 insulin-like growth factor-binding protein 5 precursor [Sus scrofa] VLTAVLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVILAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHSFDSS >XP_010800619.1 insulin-like growth factor-binding protein 5 isoform X1 [Bos taurus] VLTAVLLLLAACAGSAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQKSEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_422069.4 insulin-like growth factor-binding protein 5 [Gallus gallus] MLLRLLVLLGACPGLSRCLGSFVQCEPCDGKALSLCPPPPLGCELVKEPGCGCCLTCALPAGQPCGVYTERCARGLRCLPRQGEEKPLHALLHGTAVCLSEKSYERESREHEEPTTSEMTEETYPPKAYRPKHDLKAEALKKDRRKKLTLAKFVGMAENTAHPRV-VIPELRQEFELGPCRRHMEASLQELKSSQRMVPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLPGTDYLSQCHAFDSS >XP_011966279.1 insulin-like growth factor-binding protein 5 isoform X1 [Ovis aries] VLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPELRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_852885.1 insulin-like growth factor-binding protein 5 [Canis lupus familiaris] VLTAVLLLLASCAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_003309513.1 insulin-like growth factor-binding protein 5 [Pan troglodytes] LLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_002712514.1 PREDICTED: insulin-like growth factor-binding protein 5 [Oryctolagus cuniculus] VLTAVLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKVFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIVSPPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYADQCHAFDSS >XP_009236354.2 insulin-like growth factor-binding protein 5 [Pongo abelii] LLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_017909736.1 PREDICTED: insulin-like growth factor-binding protein 5 isoform X1 [Capra hircus] VLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPELRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_003818638.1 insulin-like growth factor-binding protein 5 [Pan paniscus] LLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_003991177.1 insulin-like growth factor-binding protein 5 [Felis catus] VLTAVLLLLASCAGLAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCTTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKGSPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_018877633.1 insulin-like growth factor-binding protein 5 [Gorilla gorilla gorilla] LLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_005498635.2 insulin-like growth factor-binding protein 5 [Columba livia] --------------------------------------------------------------------------------------------------------ERESREHEEPTTSEMTEETYPPKAYRPKHELKAEALKKDRRKKLTLAKFVGMAENTAHPRV-VIPELRQEFELGPCRRHMEASLQELKSSQRMVPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLPGTDYLSQCHAFDSS >XP_006258950.1 PREDICTED: insulin-like growth factor-binding protein 5 [Alligator mississippiensis] -MLRRVLVLCVCLGTTRSLGSLVHCEPCDEKALSLCPPRPAGCELVKEPGCGCCLTCALPAGQPCGVYTERCAQGLRCLPRPGEDKPLHALLHGRGLCLADKGPDKESREHEEPTTSEMTEETYAPKGYRPKHELKAEALKKDRRKKLTSSKFVGAAENTAHPRV-AAPELRPEFELGPCRRQMEASLQELKTSQRMIPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGLKLPGSGYVSQCHHFDSS >XP_010711906.1 insulin-like growth factor-binding protein 5 [Meleagris gallopavo] ----------------------------------------------------------------------------------------------------------------------MTEETYPPKAYRPKHDLKAEALKKDRRKKLTLAKFVGMAENTAHPRV-VIPELRQEFELGPCRRHMEASLQELKSSQRMVPRAVHLPNCDRKGFYKRKQCKPSRGRKRGLCWCVDKYGMKLPGTDYLSQCHAFDSS >XP_020768950.1 insulin-like growth factor-binding protein 5 [Odocoileus virginianus texanus] VLTALLLLLAACAGPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYERDSREHEEPTTSEMAEETYSPKIFRPKHELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDQCHTFDSS >XP_030283802.1 insulin-like growth factor-binding protein 5 [Sparus aurata] FLSFC-LLVTFILGLSGCLGSYVPCEPCDQKALSMCPPVPVGCQLVKEPGCGCCLTCALSEGQACGVYTGTCTQGLRCLPRSGEEKPLHALLHGRGVCTNEKGYDRES--HEDAITTEITEELQPAKVPLLPKSKKVHAVRKEQKNKLSKQRNMGTSMDYS-----PLPIDKHEPEFGPCRRKLDGIIQGMKDTSRVMALSLYLPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGVQLPGTDYSGQCKDLESS >XP_040214133.1 insulin-like growth factor-binding protein 5 [Rana temporaria] IVPAC-FLLTLCLGMCQCLGSFVHCEPCDEKAMSMCPPTPVACELVKEPGCGCCMTCALAEGQSCGVYTERCAGGLRCLPKQGEEKPLHALLHGRGVCLNEKIYERESRE-EDPTTSE-TEETY-PTKPRKRGDHKAIALNNFRQKKQSASRIVSVENNKGQTH--SLPEYSIESEMGPCRRQMETVMQDMKMSHRVYPRAFYIPNCDRKGFFKRKQCKPSRGRKRGICWCVDKYGLKLPGSDYAAQCHSFDSS
PhyML tree of selected proteins (XP_040214133_1_insulin_like_growth_factor_binding_protein_5__Rana_temporaria_:0.10780089,XP_018094172_1_insulin_like_growth_factor_binding_protein_5__Xenopus_laevis_:0.22039877,((tr_B0S525_B0S525_DANRE_Insulin_like_growth_factor_binding_protein_5_OS_Danio_rerio_OX_7955_GN_igfbp5b_PE_4_SV_1:0.22968442,(XP_030283802_1_insulin_like_growth_factor_binding_protein_5__Sparus_aurata_:0.03833341,(XP_023806685_1_insulin_like_growth_factor_binding_protein_5__Oryzias_latipes_:0.1326675,XP_015830827_1_PREDICTED__insulin_like_growth_factor_binding_protein_5__Nothobranchius_furzeri_:0.17280195):0.02327787):0.02737151):0.57598082,(((XP_039251864_1_insulin_like_growth_factor_binding_protein_5__Styela_clava_:3.67121267,(KAF4020195_1_hypothetical_protein_G4228_011719__Cervus_hanglu_yarkandensis_:1.40568551,KAB0375616_1_hypothetical_protein_FD755_012259__Muntiacus_reevesi_:0.00000001):0.74182322):0.67191496,((XP_002712514_1_PREDICTED__insulin_like_growth_factor_binding_protein_5__Oryctolagus_cuniculus_:0.01626731,(NP_999264_1_insulin_like_growth_factor_binding_protein_5_precursor__Sus_scrofa_:0.00677318,(((XP_043300705_1_insulin_like_growth_factor_binding_protein_5_isoform_X2__Cervus_canadensis_:0.0040132,(XP_020768950_1_insulin_like_growth_factor_binding_protein_5__Odocoileus_virginianus_texanus_:0.00000001,(KAB0358867_1_hypothetical_protein_FD754_003023__Muntiacus_muntjak_:0.0040493,(XP_011966279_1_insulin_like_growth_factor_binding_protein_5_isoform_X1__Ovis_aries_:0.00000001,XP_017909736_1_PREDICTED__insulin_like_growth_factor_binding_protein_5_isoform_X1__Capra_hircus_:0.00000001):0.00402079):0.00000001):0.00000001):0.00402509,(XP_010800619_1_insulin_like_growth_factor_binding_protein_5_isoform_X1__Bos_taurus_:0.00796667,(XP_003991177_1_insulin_like_growth_factor_binding_protein_5__Felis_catus_:0.01206607,XP_852885_1_insulin_like_growth_factor_binding_protein_5__Canis_lupus_familiaris_:0.00000001):0.00398205):0.00000001):0.00000001,((XP_003818638_1_insulin_like_growth_factor_binding_protein_5__Pan_paniscus_:0.00000001,(XP_009236354_2_insulin_like_growth_factor_binding_protein_5__Pongo_abelii_:0.00000001,(XP_003309513_1_insulin_like_growth_factor_binding_protein_5__Pan_troglodytes_:0.00000001,XP_018877633_1_insulin_like_growth_factor_binding_protein_5__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001,NP_000590_1_insulin_like_growth_factor_binding_protein_5_precursor__Homo_sapiens_:0.00398133):0.01214123):0.00169217):0.00758556):0.00000001,(NP_036949_1_insulin_like_growth_factor_binding_protein_5_precursor__Rattus_norvegicus_:0.00394993,NP_034648_2_insulin_like_growth_factor_binding_protein_5_precursor__Mus_musculus_:0.00400995):0.02497287):0.05152813):0.03330636,(XP_006258950_1_PREDICTED__insulin_like_growth_factor_binding_protein_5__Alligator_mississippiensis_:0.16353796,(XP_005498635_2_insulin_like_growth_factor_binding_protein_5__Columba_livia_:0.00000001,(XP_010711906_1_insulin_like_growth_factor_binding_protein_5__Meleagris_gallopavo_:0.00000001,XP_422069_4_insulin_like_growth_factor_binding_protein_5__Gallus_gallus_:0.00000001):0.00940668):0.07500689):0.08842456):0.18118185):0.15664748);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)