PB0036

DATABASE

Click here to access PB0036 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0036	Q92743	Serine protease HTRA1	HTRA1	ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11, HtrA serine peptidase 1	Homo_sapiens	Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Domains

Gene Ontology

PF00219 (IGFBP) PF07648 (Kazal_2) PF17820 (PDZ_6)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0005520 (enables) insulin-like growth factor binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0019838 (enables) growth factor binding GO:0042802 (enables) identical protein binding GO:0001890 (involved in) placenta development GO:0006508 (involved in) proteolysis GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway GO:0030514 (involved in) negative regulation of BMP signaling pathway GO:0050679 (involved in) positive regulation of epithelial cell proliferation GO:0050687 (involved in) negative regulation of defense response to virus GO:0060718 (involved in) chorionic trophoblast cell differentiation GO:0097187 (involved in) dentinogenesis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005737 (located in) cytoplasm GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q92743|HTRA1_HUMAN Serine protease HTRA1 OS=Homo sapiens OX=9606 GN=HTRA1 PE=1 SV=1 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >sp|A9JRB3|HTR1B_DANRE Serine protease HTRA1B OS=Danio rerio OX=7955 GN=htra1b PE=2 SV=1 MRLLILCASIILVPLLCDARIIKRYVIGCPERCDKSLCPPIPPDCLAGDILDQCDCCPVC AAGEGESCGGTGKLGDPECGEGLECAVSDGVGATTTVRRRGKTGVCVCKSSEPVCGSDGV SYRNICELKRVSNRAQKLQQPPIIFIQRGACGKGHEENPDSLRHRYNFIADVVEKIAPAV VHIELFRKNVFNREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKD VDEKADIALIKIDAPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGG KELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFL AESHDRQAKGKTATKKKYIGVRMMTLTPTLAKELKQRKNDFPDVTSGAYVIEVIPKTPAE VGGLKESDVIISINGQRITSASDVSTAIKTDESLRAVVRRGNEDIILTIIPEEIDP >sp|Q6GMI0|HTR1A_DANRE Serine protease HTRA1A OS=Danio rerio OX=7955 GN=htra1a PE=2 SV=1 MILVTLFCICALVTSLQADARLSKRYVIGGCPSHCDKSMCPTMPKDCSTGQVMDHCNCCL VCASGEGEACGGVGKLGDPVCGESLECSVTGGVSYSATVRRRGKQGVCVCKSSDPVCGSD GVSYRDICELKRVSNRAQSLQQPPVLFIQRGACGTSLHDNPNSLRYKYNFIADVVEKIAP AVVHIELYRKMVYSKREMAVASGSGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAK IKDVDEKADIALIKIDLPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQ RGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIR QFLAESYDRLARGRGTTKKRYIGVRMMTLTPSLSKELKGRLRDFPDITSGAYVIEVISKT PAAAGGLKEHDVIISINGQRISTATDVSAIIKKESSLRVVVRRGNEDIILTIIPMEIDP
Selected proteins from model organisms >NP_002766.1 serine protease HTRA1 precursor [Homo sapiens] MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGA PEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSE RLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVS EDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVV AIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAG ISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] MASGNVVHFSKHRNPIVLLRRICHKEGQPGNNAKVATVARPYSQGSDQNNQNNGNKKIPITLFGAMLGISSGAVLLNKKR NSQQPSILHAAEGEDRAAGGGSSRRNNNNFIADVVEMSGSAVVFIARFARVPFMRKQVEVSHGSGFIVESQGLVITNAHV VGNQSKLKVRLQDGREFEGVVLGVDEGLDLAAVEIRSRDLPYLPLGCSNDIRPGEWVVAMGSPLNLKNTVTAGIVSNIHR AGKELGLHDHETRDMEYIQTDAMINFGNSGGPLINLDGEVIGVNSMMASAGIGFAIPVDYVKDFLTRLKEALKERRRSSS GQTRLPTGRRKYIGITMLTLTEDIVDQLRLRNPDFPNVAKGVLVHRVQYNSPADKAGVQDNDVIIKIDDKDIFSTQDVFQ ALSKSNIQLTVIRGDKTIKLRIEPEEVL >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] MAASMYRQSLKLSRLIRSNTPLLWRYSPTVNPQSTQVVISRTITQNQMHENQKIFFKRVAQFVGFGVFLYVISPWARQLK GAKFESRRDKKRRRLAAEQNEVENTSISHGVPSLNYQESSPPSRGILPVVKAADVTDFGTGYVTPRSQQFNFIADAVAKA SPSVVFIEIHGRHPYQRGVVGPISNGSGFIVSPDGLILTNAHVVANKRLGKQSVKVKLYDGRLVDGKVVAVDPVSDLALL KIDTKDPLPVMRMGNSSAARPGEWVIAMGSPLSLSNTITAGIISTVSRTSKELGLNKSIDYIQTDAAINVGNSGGPLVNL DGEAIGINTMRVTTGISFAIPIDCARDFVDKVQKQMKASGGGWFGKSGPQGPALTTPSKAGKQGYIGITMLSLTPSLIFD LRQRAPDFPNVSHGVLIYRITMESPAQVAGLKAGDIITHINDQPIKSSQELYDRVQAKESLKVTAVRGKETMKLTITPEE SQ >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] MAASMIRRVMQSLPIFRSKVPVFTTNRQILQSLKPQTAICRTITQQQMEKNKKQFQKRMFQYLMVIVIVAVISPYVRDLR FASFEPRRDKKRRKLQALKEAEEREKLGDNFQQTESDHNISSSDDSFRPITQEEQSSVFPVVKAAKVFDEGDGYVPPRSN RFNFIADAVDIAAPSVVYIEIQGRHPMMGRQQVSISNGSGFIVSQDGLILTNAHVVANKIRGPQSVKVKLPDGRMVDGHV VAVDSVSDLAAVKIDDGKNLPVMKLGKSSHLRPGEWVIAMGSPLTLSNTITAGIVSTVSRTSKELGLSKDIDYIQTDAAI NFGNSGGPLVNLDGEAIGINTMKVTSGISFAIPIDNAREFLEEVQKRMKSGDASQGWTGWFAGGKKSPSTQGDKRGYIGI TMLTLNPGLLNDLKSRMADFPNVSHGVLVYRIIVGSPAQVAGMKAGDIITHIDGKPVKSATAVYNAVHTLQKMEVAVVRG SSSQKLTLTLMPEEAQ >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] MALRGSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAA IIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVI NKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQR ASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYP VKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSK TLDIVILRGVKQMHVTITPEDP >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] MAAPLTRTSWTVLRRNHFQYKQFLTVSCVNRFSQYKYSHQQDKKFRTSEKTVRNVLFYTIFFSGFGYVLYKWKDDCQNRF SNLIKSMFTIYAKPVSWDGGNNRNKYNFIADVVEKSAPAVVYIEIQNNRRFDFQTGKPFNISNGSGFIVESDGLILTNAH VVTAKPHTTVKVRLYDGSVYTGTVEDIDVHSDLATVRINKTNLPVMKLGSSSNLRPGEFVVAIGSPLALSNTITSGVISS VNRHSQELGLLNKQMAYIQTDAAITFGNSGGPLVNLDAEAIGINAMKVTSGISFAIPIDYAKDFLRKAELRRKNKGTQFA MEKTKTQYIGITMLTLTPDLFYELQKKLKGIPHNIRYGVLVYKVIVGSPAHLGGLQAGDIITQVNDEPVVSSASIYKAIE AAKILRMTVIRGLEVLHLRIEPEEI >CAE1315992.1 HTRA2 [Sepia pharaonis] MFVVCDGQDHLSEMAFNSVSKDGQCIDEFIYSTYKICLESSNSIAVHSGWCRRICIGSGGVYGGSPPCKKAAPAVVYIEV ANRHPYYTVLSNGSGFIVKEDGLILTNAHVVVNRHKVIVKLQDGTKVEGKVLLVDPVSDLAAIKINVAGLPILNLGESNS LRPGEWVIAMGSPLSLTNTVTSGIVSTPHRGSAELGLHHRNMTYIQTDAVINFGNSGGPLVNLDGEAIGINTLKVATGIS FAIPSDYAKGFLHKAEKDDECPTK >XP_043331167.1 serine protease HTRA1 isoform X2 [Cervus canadensis] MQSPRSPFLPPPLLLLLLLLPASASAQPARAGRSAPGAAGCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAEC GLQEGPCGEGLQCVVPFGVPASATVRRRAQSGLCVCASNEPVCGSDAKTYANLCQLRAASRRSERLHQPPVIVLQRGACG QGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGA TYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDY IQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAK ELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPE EIDP >XP_004080793.1 serine protease HTRA1 [Oryzias latipes] MQLRLPVCVTALFASSWLLAEAQIVKRAAIGCPERCDRSACAPVLQDCLSGDELDRCGCCPVCASGEGAPCGAPGDQECV EGMECVVTDGVEASATVRRRARAGVCTCISTDPVCGSDGVSYRNVCELKRVSSRATELQQPPVIFIQRGACGKGQQSPDS LRYKYNFIADVVEKIAPAVVHIELFRKMVFSKREVSVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKD IDEKADIALIKIDTPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIIN YGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKILQFLAESHDRQAKGKTLAKKKYIGVRMMSLTPTLAKELKARHPD FPDLTSGAYVMEVIGRTPAEAAGLKERDVIISINGEHITSANDVSTTIKREQNLRMVVRRGNEDVMLTVIPEEIDP >XP_030257094.1 serine protease HTRA1 [Sparus aurata] MRLQLVLCVMAVLVCPYLLAEARIAKRFAIGCPEKCDKSQCPPIPADCLAGDVLDRCDCCPVCASGEGETCGGPEERECA EGMECVVTDGVEVSATVRHRGKAGVCACTSSDPVCGSDGVSYRNICELKRVSNRAMKLQQPPVIFIQRGACGKAQQNPDS LRFKYNFIADVVEKIAPAVVHIELYRKMIFSKREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKSGATFDAKIKD VDEKADIALIKIDTPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIIN YGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESHDRQSKGKTHQKKKYIGVRMMSLTPALAKELKERQSD FPDVTSGAYVIEVISRTPAETAGLQESDVIISINNERITSASDVSAAIKRDETLRTVVRRGNEDVILTIIPEEIEP >XP_015800249.1 PREDICTED: serine protease HTRA1A-like [Nothobranchius furzeri] MFRSLLVVCAAVASLPADAQLSSRFVVGCPSQCDKSMCPRLPADCSAGKGLDVCHCCPVCASGEGEACGGSGKLGDPVCG DGLECSVPGGVAYSVTVRRRSKSGSCVCKSTEPVCGSDGVSYRSICELKQVSRRAQKLQQPPVLFIQRGACGKAQDNPDS PRHKYNFIADVVEKIAPSVVHIELFRKMTYSKREVAVASGSGFVVSEDGQIVTNAHVVANKHRVKVELKSGASYDAKIKD VDEKSDIALIKIDAPNKLPVLLLGRSSDLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGRELGLRNSDMDYIQTDAIIN YGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRQSRGRTDAKKKYIGVRMMTLTPVLAKELKTQHRD FPDITSGAYVMEVIAKTPAEIGGLKEHDVIISINGQRISTATDVSTVIKRENILKVVVRRGNEDAILTVVPVEIDP >NP_001088796.2 serine protease HTRA1 precursor [Xenopus laevis] MTMLWLAVLLTCGAPAALLPTSGVGCPARCDPSSCSPAPTNCQSGETALRCGCCSVCAAAENERCGEGPEDPLCASGLRC VRNGGVTRCQCPSNQPVCGSDGKTYSSLCRLQAESKAVQGRGVAAIIPIQRGDCQQGQKDPDSPRYKYNFIADVVEKIAP AVVHIELFRILPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKAKGK LPVLLLGRSEELRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVVG INTLKVTAGISFAIPSDKIRKFMAESHNRQSTGQGTKKKKYLGIRMMSLSQGKLKELKEQVKDFPENTSGAYIVEVLPDT PAEEAGLKEGDIIISISGKTVTSSSEVSEAIKKEGTLQMVIRRGNEDIPISVTPKEIEF >KAB0373197.1 hypothetical protein FD755_014856 [Muntiacus reevesi] MTRPLRRPAGLGPCVLLWLLLPAPTGRGVQAGRAWPVPPCPAACEPTRCPPLPRCSTGTAPVLDRCGCCRVCAAAEGEAC GGPLGRPCAPGLQCRAPRAPQPFGGRPLGTCGCPAAGATVCGSDGRTYPSLCALRAENRAARLRGALPAVPVQKGGCGDP GTGSAGWLRSKFNFIASVVEKVAPSVVHLQLFRRSPLGSEDVPASSASGFIVSEDGLIVTNAHVLTNQQRIQVELQSGVQ YEATVKDIDHKLDLALIKIEPNTDLPVLLLGKSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDMDYI QTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDCIRQFLAEFHERQLKGKALSQKKYLGLRMLPLTMNLLQE MKRQDPEFPDVTSGVFVHEVIQGTAAESSGLKDHDVIVSINGLPVTTTTDVIEAVKANDSLSLLVRRKSQTLILTVTPEI IN >OWK07540.1 HTRA1 [Cervus elaphus hippelaphus] MTRGIRVAFQPLLLTLLRGWHLAQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMD YIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKA KELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIP EEIDP >KAB0347983.1 hypothetical protein FD754_012840 [Muntiacus muntjak] MTRPLRRPAGLGPCVLLWLLLPAPTGRGVQAGRAWPVPPCPATCEPTRCPPLPRCSTGTAPVLDRCGCCRHLFAGTGSAG WLRSKFNFIASVVEKVAPSVVHLQLFRRSPLGSEDVPASSASGFIVSEDGLIVTNAHVLTNQQRIQVELQSGVQYEATVK DIDHKLDLALIKIEPNTDLPVLLLGKSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGSKELGLKDSDMDYIQTDAII NHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLAEFHERQLKGKALSQKKYLGLRMLPLTMNLLQEMKRQDP EFPDVTSGVFVHEVIQGTAAESSGLKDHDVIVSINGLPVTTTTDVIEAVKANDSLSLLVRRKSQTLILTVTPEIIN >sp|A9JRB3|HTR1B_DANRE Serine protease HTRA1B OS=Danio rerio OX=7955 GN=htra1b PE=2 SV=1 MRLLILCASIILVPLLCDARIIKRYVIGCPERCDKSLCPPIPPDCLAGDILDQCDCCPVC AAGEGESCGGTGKLGDPECGEGLECAVSDGVGATTTVRRRGKTGVCVCKSSEPVCGSDGV SYRNICELKRVSNRAQKLQQPPIIFIQRGACGKGHEENPDSLRHRYNFIADVVEKIAPAV VHIELFRKNVFNREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKD VDEKADIALIKIDAPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGG KELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFL AESHDRQAKGKTATKKKYIGVRMMTLTPTLAKELKQRKNDFPDVTSGAYVIEVIPKTPAE VGGLKESDVIISINGQRITSASDVSTAIKTDESLRAVVRRGNEDIILTIIPEEIDP >sp|Q6GMI0|HTR1A_DANRE Serine protease HTRA1A OS=Danio rerio OX=7955 GN=htra1a PE=2 SV=1 MILVTLFCICALVTSLQADARLSKRYVIGGCPSHCDKSMCPTMPKDCSTGQVMDHCNCCL VCASGEGEACGGVGKLGDPVCGESLECSVTGGVSYSATVRRRGKQGVCVCKSSDPVCGSD GVSYRDICELKRVSNRAQSLQQPPVLFIQRGACGTSLHDNPNSLRYKYNFIADVVEKIAP AVVHIELYRKMVYSKREMAVASGSGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAK IKDVDEKADIALIKIDLPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQ RGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIR QFLAESYDRLARGRGTTKKRYIGVRMMTLTPSLSKELKGRLRDFPDITSGAYVIEVISKT PAAAGGLKEHDVIISINGQRISTATDVSAIIKKESSLRVVVRRGNEDIILTIIPMEIDP >NP_062510.2 serine protease HTRA1 precursor [Mus musculus] MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGA LEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSE KLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVS EDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVV AIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAG ISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPD TPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP >NP_113909.1 serine protease HTRA1 precursor [Rattus norvegicus] MQFLRTALLSLLLLLLAAPSLALPSGISRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGA LEGAVCGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSE KLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVS EDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVV AIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAG ISFAIPSDKIKKFLTESHDRQAKGKTVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD TPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVVPEEIDP >NP_001269011.1 serine protease HTRA1 precursor [Bos taurus] MQPPRAPFLPPPTPPLLLLLLLLAAPASAQPARAGRSAPGAAGCPERCDPARCAPPPGSCEGGRVRDACG CCEVCGAPEGAECGLQEGPCGEGLQCVVPFGVPASATVRRRAQSGLCVCASNEPVCGSDAKTYTNLCQLR AASRRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVAS GSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSEL RPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGIN TLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAY IIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_016775034.1 serine protease HTRA1 [Pan troglodytes] MGWAARPRALAPAAPEALLHSPRRRSPALALSAATAAAARVAMQIPRAALLPLLLLLLAAPASAQLSRAG RSAPLAAGCPDRCEPARCPPQPEHCESGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPAS ATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHK YNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATY EAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELG LRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAIT KKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDV SDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_038295584.1 serine protease HTRA1 isoform X1 [Canis lupus familiaris] MMHVVQNRGGAEPPSHPGLPGPPRAPAPGSGANPRVYKHAAHRGARGTRERRAGARTREGGPRPARPARP ALPPPRAVPARPPAPPAIRPPRARPQGGRHRREANGLGRAAAARTHSRPAALPRSARRRSPVLASPPAAA PLLLLAAPAPAPAQPSRAGRSAAAGCPERCEPARCLPPPGPCEGGRVRDACGCCEVCGAPEGAACGLQEG PCGEGLQCVVPFGVPASATVRRRAQAGVCVCASGEPVCGSDANTYANLCQLRAASRRAERLHQPPVIVLQ RGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHV VTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHEGRLPVLLLGRSSELRPGEFVVAIGSPFSLQNT VTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIK KFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDHHRDFPDVLSGAYIIEVIPDTPAEAGGLKEN DVIISINGQSVVSASDVSDVIKKENTLNMVVRRGNEDIMITVIPEEIDP >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] MGWAARPRALAPAAPKALRSSPRRCCPARAQLAAVGAAMQSSRAARLLPLLLLLLAAPAWAQPPRAGRSA PAATSPVAGCPERCEPARCAPPPTNCEGGRVRDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVSFGVPA SATVRRRSQAGVCVCASNEPVCGSDANTYANLCQLRAASRRSERLQQPPVIVLQRGACGQGQEDPNSLRH KYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGAT YEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKEL GLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAI TKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSAND VSDVIKKDSTLNMVVRRGNEDIMITVIPEEIDP >XP_002821267.1 serine protease HTRA1 [Pongo abelii] MGWAARPRALAPAAPEALPHSPRRRSPALALSAAAAAAARVAMQIPRAALLPLLLLLLAAPASAQLSRAG RSAPLAAGCPERCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPAS ATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHK YNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATY EAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELG LRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAIT KKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDV SDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_003133256.3 LOW QUALITY PROTEIN: serine protease HTRA1 [Sus scrofa] MQPPRASFLPLLLLLLLAAPGXALPPRAGRSAPGAAGCPERCEPARCAPPPGHCEGGRVRDACGCCEVCG APEGAECGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASNEPVCGSDANTYANLCQLRAASRRS ERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIV SEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADXALIKIDHQGKLPVLLLGRSSELRPGEFV VAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTA GISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIP DTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDVMVTVIPEEIDP >XP_010713179.1 serine protease HTRA1 [Meleagris gallopavo] MCSVSISGQEHPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPYSKREIPVASGSGFIVSEDGLIVTNAH VVTNKNRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLRPGEFVVAIGSPFSLQN TVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI KKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKARELKDRHKDFPDVVSGAYVIDVIPETPAEAGGLKD NDVIISINGQSITSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_015144381.1 serine protease HTRA1 [Gallus gallus] MLPPWCRSALLLAVLPALLLAAPPPPACPERCDRSRCPPLPSSCPGGPVLDACGCCRVCGAEEGEPCGVG EGGPPCGEGLRCSVPPGGGVPASGTVRKRAAVGRCVCASSEPVCGSDAVTYASPCQLRAASRRAERLRQP PIIAIQRGGCGQGQEHPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPYSKREIPVASGSGFIVSEDGLI VTNAHVVTNKNRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLRPGEFVVAIGSP FSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAI PSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAGELKDRHKDFPDVVSGAYVIDVIPETPAEA GGLKDNDVIISINGQSITSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_034787526.1 serine protease HTRA1 [Pan paniscus] MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCESGRARDACGCCEVCGA PEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSE RLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVS EDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVV AIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAG ISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_023096805.1 serine protease HTRA1 [Felis catus] MQPPRASCLPPPLLLLLLLAAPAPAQPSRAGRSAPAAAAGCPERCEPARCSPPPAHCEGGRVRDACGCCE VCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRSQAGLCVCASSEPVCGSDANTYANLCQLRAAS RRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSG FIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELRPG EFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK VTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIE VIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_027816436.2 serine protease HTRA1 [Ovis aries] MQPPRAPFLPPPPPPLLLLLLLLAAPASAQPARAGRSAPGAAVCPERCDPARCAPPPGSCEGGRVRDACG CCEVCGAPEGAECGLQEGPCGEGLQCVVPFGVPGSATVRRRAQSGLCVCASNEPVCGSDAKTYTNLCQLR AASRRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVAS GSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSEL RPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGIN TLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAY IIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMVTVIPEEIDP >XP_004050262.1 serine protease HTRA1 [Gorilla gorilla gorilla] MGWAARPRALAPAAPEALLHSPRRRSPALALSAATAAAARVAMQIPRAALLPLLLLLLLAAPASAQLSRA GRSAPLAAGCPDRCEPARCPPQPQHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPA SATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLQLPPVIVLQRGACGQGQEDPNSLRH KYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGAT YEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKEL GLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAI TKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSAND VSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_005505857.1 serine protease HTRA1 [Columba livia] MACQEHPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPYSKREIPVASGSGFIVSEDGLIVTNAHVVTNK NRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSADLRPGEFVVAIGSPFSLQNTVTTG IVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLT ESHDRQAKGKAVTTKKYIGIRMMSLTPSKARELKDRHKDFPDVVSGAYVIEVIPETPAEAGGLKDNDVII SINGQSISSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_017896995.1 PREDICTED: serine protease HTRA1 [Capra hircus] MQPPRAPFLPPPPPLLLLLLLLAAPASAQPARAGRSAPGAAVCPERCDPARCAPPPGSCEGGRVRDACGC CEVCGAPEGAECGLQEGPCGEGLQCVVPFGVPGSATVRRRAQSGLCVCASNEPVCGSDAKTYTNLCQLRA ASRRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASG SGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINT LKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYI IEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMVTVIPEEIDP >XP_019341413.1 PREDICTED: serine protease HTRA1 [Alligator mississippiensis] MVSLFGAFDRSQYHFELVDQGFVQDFVIDTLERCPLPVLNILGISFLCQQFEDSQRYPLFRPLLEDAQEV QPEEGSKGLVEIDGFCGSESTIHPFIQASTKCFTVILVLSFEDLESFLFSFSGQEDPNSLRHKYNFIADV VEKIAPAVVHIELFRKLPFTKREVPVASGSGFVVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDV DEKADIALIKIDAQGKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMD YIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQSKGKAVTKKKYIGI RMMSLTPSKAKELKDHHKDFPDVISGAYIIEIIPDTPAEAGGLKENDVIISINGQAIISANDVSDIIKKD STLNMVVRRGNEDIMVTVVPEEIDP >XP_020753960.1 serine protease HTRA1 [Odocoileus virginianus texanus] MKVYHIRAIPGFNCERASPSQPASQVAAEKAARSGYVGSGDREAQPREPAPARCAPPPGSCEGGRVRDAC GCCEVCGAPEGAECGLQEGPCGEGLQCVVPFGVPASATVRRRAQSGLCVCASNEPVCGSDAKTYANLCQL RAASRRSERLHQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVA SGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSE LRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGI NTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGA YIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_040217876.1 serine protease HTRA1 [Rana temporaria] MWYPLVSSIGITMLWVLVLLSCGVPAASIPAPVSRCPSRCDPSSCPPSPTNCPSGETALRCGCCTVCAAD EGDRCGEGPADPTCASALRCVKSGLLGSARTCQCSSPQPVCGSDGNTYSSLCKLQAESKAVQNQGSAAII PIQRGDCQLGQSDPDSPRYKYNFIADVVEKIAPAVVHIELFRMLNFFGKREVPSASGSGFIVSEDGLILT NAHVVTNKQRLKVERSDGSTYDAKIIDVDEKADIALIKIKPKGKLPVLQLGRSEDLRPGEFVVAIGSPFS LQNTVTTGIVSTAQRGGKELGLKNSDMEYIQTDAIINYGNSGGPLVNLDGEVVGINTLKVTAGISFAIPS DKIRKFLAESHSRQSAGQGIKKKKYLGIRMLSLSPGKVKELREQLKDFPNVTSGAYIVEVIPDTPAEEAG LKESDVIISIGSQTVTSSNDVSEAIKQEGPLRMVLRRGNEDVVITVTPKEINF
Mafft alignment of selected proteins >NP_002766.1 serine protease HTRA1 precursor [Homo sapiens] ------------------------------------------------------------ ---------------------------MQIPRA--------------------------A LLP------------------LLLLLLAAP----ASAQLSRAGRSAP-LA----A-GCPD RCEPARCPPQPEHCEGGR--ARDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LHRPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKRE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] ------------------------------------------------------------ ---------------------------MASGNV--------------------------- ----------------------------------VHFSKHRNPIVLL------------- ----------------------------RRICHKEGQP---------------------- -------------GNNAKVATVARPYSQGS---------DQN-NQNNGNKKIPITLFGAM LGISSGAVLLNKKRN--------SQQPSILHAAEGEDR-----------------A-AGG GSSRRNNNNFIADVVEMSGSAVVFIARFARVPF---MRKQVEVSHGSGFIVESQGLVITN AHVVGNQSK----LKVRLQDGREFEGVVLGVDEGLDLAAVEIRS-RDLPYLPLGCSNDIR PGEWVVAMGSPLNLKNTVTAGIVSNIHRAGKELGLHDHETRDMEYIQTDAMINFGNSGGP LINLDGEVIGVNSMMASAGIGFAIPVDYVKDFLTRLKEALKERRRSSSGQ---------- ----TRLPTGRRKYIGITMLTLTEDIVDQLRLRNPDFP-NVAKGVLVHRVQYNSPADKAG VQDNDVIIKIDDKDIFSTQDVFQALSK--SNIQLTVIRG--DKTIKLRIEPEEVL- >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] ------------------------------------------------------------ ---------------------------MAASMY--------------------------- ------------------------------------RQSLKLSRLIR------------- ----SNTPLLWRYSPTVN-PQSTQVVISRTITQNQMHENQKI--FFKRVAQFVGFGVFLY VISPWARQLKG--AKFESRRDKKRRRLAAE---------QNE-VENTSISHGVPSLNYQE SSPPSR------------------GILPVVKAADVTDF-----------------G-TGY VTPRSQQFNFIADAVAKASPSVVFIEIHGRHPY--QRGVVGPISNGSGFIVSPDGLILTN AHVVANKRLGKQSVKVKLYDGRLVDGKVVAVDPVSDLALLKIDTKDPLPVMRMGNSSAAR PGEWVIAMGSPLSLSNTITAGIISTVSRTSKELGL-N---KSIDYIQTDAAINVGNSGGP LVNLDGEAIGINTMRVTTGISFAIPIDCARDFVDKVQKQMKASGGGWFGK-----SGPQG PALTTPSKAGKQGYIGITMLSLTPSLIFDLRQRAPDFP-NVSHGVLIYRITMESPAQVAG LKAGDIITHINDQPIKSSQELYDRVQAK-ESLKVTAVRG--KETMKLTITPEESQ- >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] ------------------------------------------------------------ ---------------------------MAASMI--------------------------- ------------------------------------RRVMQSLPIFR------------- ----SKVPVFTTNRQILQ-SLKPQTAICRTITQQQMEKNKKQ--FQKRMFQYLMVIVIVA VISPYVRDLRF--ASFEPRRDKKRRKLQALKEAEEREKLGDN-FQQTESDHNISSSDDSF RPITQEEQ---------------SSVFPVVKAAKVFDE-----------------G-DGY VPPRSNRFNFIADAVDIAAPSVVYIEIQGRHPM--MGRQQVSISNGSGFIVSQDGLILTN AHVVANKIRGPQSVKVKLPDGRMVDGHVVAVDSVSDLAAVKIDDGKNLPVMKLGKSSHLR PGEWVIAMGSPLTLSNTITAGIVSTVSRTSKELGL-S---KDIDYIQTDAAINFGNSGGP LVNLDGEAIGINTMKVTSGISFAIPIDNAREFLEEVQKRMK-SGDASQGWTGWFAGGKKS PS----TQGDKRGYIGITMLTLNPGLLNDLKSRMADFP-NVSHGVLVYRIIVGSPAQVAG MKAGDIITHIDGKPVKSATAVYNAVHTL-QKMEVAVVRGSSSQKLTLTLMPEEAQ- >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] ------------------------------------------------------------ ---------------------------MAL------------------------------ ------------------------------------RGSHRLEVIFK------------- ------------------------------------------------------------ ------RCIAS--PVLHSHAANRRSSQLAI---------KEG-DPNSNGNSGQYQQNGEQ KEKGWRRLVR-------FFVP--FSLGAVVSAAIIQREDLTPTI-----------A-ASK MTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTN AHVVINKPH--TMVQVRLSDGRTFPATIEDVDQTSDLATLRIQV-NNLSVMRLGKSSTLR SGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRN---RDINYLQTDAAITFGNSGGP LVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRK-KGSAYK------------ ------TGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGG LQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRG--VKQMHVTITPEDP-- >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] ------------------------------------------------------------ ---------------------------MAA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PLTRTSWTVLRRNHFQY---------KQF-LTVSCVNRFSQYKYSHQ QDKKFRTSEKT-VRNVLFYTIFFSGFGYVLYKWKDDCQNRFSNLIKSMFTIYAKPV-SWD GGNNRNKYNFIADVVEKSAPAVVYIEIQNNRRFDFQTGKPFNISNGSGFIVESDGLILTN AHVVTAKPH--TTVKVRLYDGSVYTGTVEDIDVHSDLATVRINK-TNLPVMKLGSSSNLR PGEFVVAIGSPLALSNTITSGVISSVNRHSQELGLLN---KQMAYIQTDAAITFGNSGGP LVNLDAEAIGINAMKVTSGISFAIPIDYAKDFLRKAELRRKNKGTQFA------------ ------MEKTKTQYIGITMLTLTPDLFYELQKKLKGIPHNIRYGVLVYKVIVGSPAHLGG LQAGDIITQVNDEPVVSSASIYKAIEAA-KILRMTVIRG--LEVLHLRIEPEEI-- >CAE1315992.1 HTRA2 [Sepia pharaonis] ------------------------------------------------------------ ---------------------------MFVV----------------------------- ----------------------------------CDGQDHLSEMAFN------------- ------------------------------------------------------------ ---------------------------------------SVS-KDGQCIDEFIYSTYKIC LESSNSIAVH-------------SGWCRRICIGSGGVYG----------------G---- -----------SPPCKKAAPAVVYIEVANRHPY------YTVLSNGSGFIVKEDGLILTN AHVVVNRHK----VIVKLQDGTKVEGKVLLVDPVSDLAAIKINV-AGLPILNLGESNSLR PGEWVIAMGSPLSLTNTVTSGIVSTPHRGSAELGLHH---RNMTYIQTDAVINFGNSGGP LVNLDGEAIGINTLKVATGISFAIPSDYAKGFLHKAEKDDE------------------- ------------------------------------CP---------------------- -----------------------------------------TK------------- >XP_043331167.1 serine protease HTRA1 isoform X2 [Cervus canadensis] ------------------------------------------------------------ ---------------------------MQSPRS--------------------------P FLP--------------PPLLLLLLLLPAS----ASAQPARAGRSAP-GA----A-GCPE RCDPARCAPPPGSCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQSGLCVC------ASN-EPVCGSDAKTYANLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_004080793.1 serine protease HTRA1 [Oryzias latipes] ------------------------------------------------------------ ---------------------------MQLRLP--------------------------- --------------------VCVTALFASS----WLLAEAQIVKRAA-------I-GCPE RCDRSACAPVLQDCLSGD--ELDRCGCCPVCASGEGAPCGA---PGDQ------------ ECVEGMECVVT--DGVEASATVRRRARAGVCTC------IST-DPVCGSDGVSYRNVCEL KRVSSRATE--------------LQQPPVIFIQRGACGK----------------G-QQS PDSLRYKYNFIADVVEKIAPAVVHIELFRKMVF---SKREVSVASGSGFVVSEDGLIVTN AHVVANKHR----VKVELKSGATYDAKIKDIDEKADIALIKIDTPNKLPVLLLGRSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKILQFLAESHDRQA-KGKTLA------------ ----------KKKYIGVRMMSLTPTLAKELKARHPDFP-DLTSGAYVMEVIGRTPAEAAG LKERDVIISINGEHITSANDVSTTIKRE-QNLRMVVRRG--NEDVMLTVIPEEIDP >XP_030257094.1 serine protease HTRA1 [Sparus aurata] ------------------------------------------------------------ ---------------------------MRLQLV--------------------------- --------------------LCVMAVLVCP----YLLAEARIAKRFA-------I-GCPE KCDKSQCPPIPADCLAGD--VLDRCDCCPVCASGEGETCGG---PEER------------ ECAEGMECVVT--DGVEVSATVRHRGKAGVCAC------TSS-DPVCGSDGVSYRNICEL KRVSNRAMK--------------LQQPPVIFIQRGACGK----------------A-QQN PDSLRFKYNFIADVVEKIAPAVVHIELYRKMIF---SKREVAVASGSGFVVSEDGLIVTN AHVVANKHR----VKVELKSGATFDAKIKDVDEKADIALIKIDTPMKLPVLLLGRSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESHDRQS-KGKTHQ------------ ----------KKKYIGVRMMSLTPALAKELKERQSDFP-DVTSGAYVIEVISRTPAETAG LQESDVIISINNERITSASDVSAAIKRD-ETLRTVVRRG--NEDVILTIIPEEIEP >XP_015800249.1 PREDICTED: serine protease HTRA1A-like [Nothobranchius furzeri] ------------------------------------------------------------ ---------------------------MFRSL---------------------------- --------------------LVVCAAVAS------LPADAQLSSRFV-------V-GCPS QCDKSMCPRLPADCSAGK--GLDVCHCCPVCASGEGEACGGSGKLGDP------------ VCGDGLECSVP--GGVAYSVTVRRRSKSGSCVC------KST-EPVCGSDGVSYRSICEL KQVSRRAQK--------------LQQPPVLFIQRGACGK----------------A-QDN PDSPRHKYNFIADVVEKIAPSVVHIELFRKMTY---SKREVAVASGSGFVVSEDGQIVTN AHVVANKHR----VKVELKSGASYDAKIKDVDEKSDIALIKIDAPNKLPVLLLGRSSDLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGRELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRQS-RGRTDA------------ ----------KKKYIGVRMMTLTPVLAKELKTQHRDFP-DITSGAYVMEVIAKTPAEIGG LKEHDVIISINGQRISTATDVSTVIKRE-NILKVVVRRG--NEDAILTVVPVEIDP >NP_001088796.2 serine protease HTRA1 precursor [Xenopus laevis] ------------------------------------------------------------ ---------------------------M-------------------------------- ------------------TMLWLAVLLTC-------GAPAALLPTSG-------V-GCPA RCDPSSCSPAPTNCQSGE--TALRCGCCSVCAAAENERCGEG--PEDP------------ LCASGLRCVRN--------------GGVTRCQC------PSN-QPVCGSDGKTYSSLCRL QAESKAVQG--------------RGVAAIIPIQRGDCQQ----------------G-QKD PDSPRYKYNFIADVVEKIAPAVVHIELFRILPF---FKREVPAASGSGFIVSEDGLILTN AHVVTNKHR----LKVERSDGSTYDAQIIDVDEKADIALIKIKAKGKLPVLLLGRSEELR PGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVVGINTLKVTAGISFAIPSDKIRKFMAESHNRQS-TGQGTK------------ ----------KKKYLGIRMMSLSQGKLKELKEQVKDFP-ENTSGAYIVEVLPDTPAEEAG LKEGDIIISISGKTVTSSSEVSEAIKKE-GTLQMVIRRG--NEDIPISVTPKEIEF >KAB0373197.1 hypothetical protein FD755_014856 [Muntiacus reevesi] ------------------------------------------------------------ ---------------------------MTRPLRR------------------------PA GLG---------------PCVLLWLLLPAP-----TGRGVQAGRAWP-------VPPCPA ACEPTRCPPLPR-CSTGTAPVLDRCGCCRVCAAAEGEACGG---PLGR------------ PCAPGLQCRAP------RAPQPFGGRPLGTCGC------PAAGATVCGSDGRTYPSLCAL RAENRAARL--------------RGALPAVPVQKGGCGD---------------PG-TGS AGWLRSKFNFIASVVEKVAPSVVHLQLFRRSPL---GSEDVPASSASGFIVSEDGLIVTN AHVLTNQQR----IQVELQSGVQYEATVKDIDHKLDLALIKIEPNTDLPVLLLGKSSDLR AGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKD---SDMDYIQTDAIINHGNSGGP LVNLDGDVIGINTLKVTAGISFAIPSDCIRQFLAEFHERQL-KGKALS------------ ----------QKKYLGLRMLPLTMNLLQEMKRQDPEFP-DVTSGVFVHEVIQGTAAESSG LKDHDVIVSINGLPVTTTTDVIEAVKAN-DSLSLLVRRK--SQTLILTVTPEIIN- >OWK07540.1 HTRA1 [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MTRG------------ -----------------------------------------------------------I RVAF---------------------QPLLLTLLRG------------------------- ----------------------WHL----------------------------------- -------------------------------------------AQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMITVIPEEIDP >KAB0347983.1 hypothetical protein FD754_012840 [Muntiacus muntjak] ------------------------------------------------------------ ---------------------------MTRPLRR------------------------PA GLG---------------PCVLLWLLLPAP-----TGRGVQAGRAWP-------VPPCPA TCEPTRCPPLPR-CSTGTAPVLDRCGCCRHLFA--------------------------- ------------------------------------------------------------ -------------------------------------------------------G-TGS AGWLRSKFNFIASVVEKVAPSVVHLQLFRRSPL---GSEDVPASSASGFIVSEDGLIVTN AHVLTNQQR----IQVELQSGVQYEATVKDIDHKLDLALIKIEPNTDLPVLLLGKSSDLR AGEFVVALGSPFSLQNTVTAGIVSTTQRGSKELGLKD---SDMDYIQTDAIINHGNSGGP LVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLAEFHERQL-KGKALS------------ ----------QKKYLGLRMLPLTMNLLQEMKRQDPEFP-DVTSGVFVHEVIQGTAAESSG LKDHDVIVSINGLPVTTTTDVIEAVKAN-DSLSLLVRRK--SQTLILTVTPEIIN- >sp|A9JRB3|HTR1B_DANRE Serine protease HTRA1B OS=Danio rerio OX=7955 GN=htra1b PE=2 SV=1 ------------------------------------------------------------ ---------------------------MRL-LI--------------------------- --------------------LCASIILVP------LLCDARIIKRYV-------I-GCPE RCDKSLCPPIPPDCLAGD--ILDQCDCCPVCAAGEGESCGGTGKLGDP------------ ECGEGLECAVS--DGVGATTTVRRRGKTGVCVC------KSS-EPVCGSDGVSYRNICEL KRVSNRAQK--------------LQQPPIIFIQRGACGK----------------GHEEN PDSLRHRYNFIADVVEKIAPAVVHIELFRKNVF---N-REVAVASGSGFVVSEDGLIVTN AHVVANKHR----VKVELKTGTTYDAKIKDVDEKADIALIKIDAPMKLPVLLLGRSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESHDRQA-KGKTAT------------ ----------KKKYIGVRMMTLTPTLAKELKQRKNDFP-DVTSGAYVIEVIPKTPAEVGG LKESDVIISINGQRITSASDVSTAIKTD-ESLRAVVRRG--NEDIILTIIPEEIDP >sp|Q6GMI0|HTR1A_DANRE Serine protease HTRA1A OS=Danio rerio OX=7955 GN=htra1a PE=2 SV=1 ------------------------------------------------------------ ---------------------------MILVTL--------------------------- --------------------FCICALVTS------LQADARLSKRYV-------IGGCPS HCDKSMCPTMPKDCSTGQ--VMDHCNCCLVCASGEGEACGGVGKLGDP------------ VCGESLECSVT--GGVSYSATVRRRGKQGVCVC------KSS-DPVCGSDGVSYRDICEL KRVSNRAQS--------------LQQPPVLFIQRGACGT----------------SLHDN PNSLRYKYNFIADVVEKIAPAVVHIELYRKMVY---SKREMAVASGSGFVVSDDGLIVTN AHVVANKNR----VKVELKNGASYDAKIKDVDEKADIALIKIDLPNKLPVLLLGRSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRLA-RGRGTT------------ ----------KKRYIGVRMMTLTPSLSKELKGRLRDFP-DITSGAYVIEVISKTPAAAGG LKEHDVIISINGQRISTATDVSAIIKKE-SSLRVVVRRG--NEDIILTIIPMEIDP >NP_062510.2 serine protease HTRA1 precursor [Mus musculus] ------------------------------------------------------------ ---------------------------MQSLRT--------------------------T LLS------------------LLLLLLAAP----SLALPSGTGRSAP-AA----T-VCPE HCDPTRCAPPPTDCEGGR--VRDACGCCEVCGALEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDAKTYTNLCQL RAASRRSEK--------------LRQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELYRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKNR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAVT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVTANDVSDVIKKE-NTLNMVVRRG--NEDIVITVIPEEIDP >NP_113909.1 serine protease HTRA1 precursor [Rattus norvegicus] ------------------------------------------------------------ ---------------------------MQFLRT--------------------------A LLS------------------LLLLLLAAP----SLALPSGISRSAP-AA----T-VCPE HCDPTRCAPPPTDCEGGR--VRDACGCCEVCGALEGAVCG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDAKTYTNLCQL RAASRRSEK--------------LRQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELYRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKNR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKTVT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVTANDVSDVIKKE-NTLNMVVRRG--NEDIVITVVPEEIDP >NP_001269011.1 serine protease HTRA1 precursor [Bos taurus] ------------------------------------------------------------ ---------------------------MQPPRA--------------------------P FLPP-----------PTPPLLLLLLLLAAP----ASAQPARAGRSAP-GA----A-GCPE RCDPARCAPPPGSCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQSGLCVC------ASN-EPVCGSDAKTYTNLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_016775034.1 serine protease HTRA1 [Pan troglodytes] M----------------GWAARPRALAP---AAPEALLHS-------------------- -PRRRSPALALSAATAAA-----ARVAMQIPRA--------------------------A LLP------------------LLLLLLAAP----ASAQLSRAGRSAP-LA----A-GCPD RCEPARCPPQPEHCESGR--ARDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LHRPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKRE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_038295584.1 serine protease HTRA1 isoform X1 [Canis lupus familiaris] MMHVVQNRGGAEPPSHPGLPGPPRAPAPGSGANPRVYKHAAHRGARGTRERRAGARTREG GPRPARPARPALPPPRAVPARPPAPPAIRPPRARPQGGRHRREANGLGRAAAARTHSRPA ALPRSARRRSPVLASPPAAAPLLLLAAPAP----APAQPSRAGRSAA-------A-GCPE RCEPARCLPPPGPCEGGR--VRDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGVCVC------ASG-EPVCGSDANTYANLCQL RAASRRAER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHEGRLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDHHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSASDVSDVIKKE-NTLNMVVRRG--NEDIMITVIPEEIDP >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] M----------------GWAARPRALAP---AAPKALRSS-------------------- -PRRCCPARAQLAAVGA---------AMQSSRA-------------------------AR LLP------------------LLLLLLAAP----AWAQPPRAGRSAP-AATSPVA-GCPE RCEPARCAPPPTNCEGGR--VRDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVS--FGVPASATVRRRSQAGVCVC------ASN-EPVCGSDANTYANLCQL RAASRRSER--------------LQQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKD-STLNMVVRRG--NEDIMITVIPEEIDP >XP_002821267.1 serine protease HTRA1 [Pongo abelii] M----------------GWAARPRALAP---AAPEALPHS-------------------- -PRRRSPALALSAAAAAA-----ARVAMQIPRA--------------------------A LLP------------------LLLLLLAAP----ASAQLSRAGRSAP-LA----A-GCPE RCEPARCPPQPEHCEGGR--ARDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LHRPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKRE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_003133256.3 LOW QUALITY PROTEIN: serine protease HTRA1 [Sus scrofa] ------------------------------------------------------------ ---------------------------MQPPRA--------------------------S FLP-----------------LLLLLLLAAP----GXALPPRAGRSAP-GA----A-GCPE RCEPARCAPPPGHCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASN-EPVCGSDANTYANLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADXALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDVMVTVIPEEIDP >XP_010713179.1 serine protease HTRA1 [Meleagris gallopavo] ------------------------------------------------------------ ---------------------------M-------------------------------- ------------------------------------------------------------ ---------------------------CSV------------------------------ ------------------------------------------------------------ ------------------------------------SIS----------------G-QEH PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPY---SKREIPVASGSGFIVSEDGLIVTN AHVVTNKNR----VKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKARELKDRHKDFP-DVVSGAYVIDVIPETPAEAGG LKDNDVIISINGQSITSASDVSDIIKKD-STLNMVVRRG--NEDVMLTVIPEEIDP >XP_015144381.1 serine protease HTRA1 [Gallus gallus] ------------------------------------------------------------ ---------------------------MLPPWCRS-----------------------AL LLA-----------------VLPALLLAAP------------------PP----P-ACPE RCDRSRCPPLPSSCPGGP--VLDACGCCRVCGAEEGEPCG----VGEGG----------P PCGEGLRCSVPPGGGVPASGTVRKRAAVGRCVC------ASS-EPVCGSDAVTYASPCQL RAASRRAER--------------LRQPPIIAIQRGGCGQ----------------G-QEH PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPY---SKREIPVASGSGFIVSEDGLIVTN AHVVTNKNR----VKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAGELKDRHKDFP-DVVSGAYVIDVIPETPAEAGG LKDNDVIISINGQSITSASDVSDIIKKD-STLNMVVRRG--NEDVMLTVIPEEIDP >XP_034787526.1 serine protease HTRA1 [Pan paniscus] ------------------------------------------------------------ ---------------------------MQIPRA--------------------------A LLP------------------LLLLLLAAP----ASAQLSRAGRSAP-LA----A-GCPD RCEPARCPPQPEHCESGR--ARDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LHRPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKRE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_023096805.1 serine protease HTRA1 [Felis catus] ------------------------------------------------------------ ---------------------------MQPPRA--------------------------S CLPP-----------P----LLLLLLLAAP----APAQPSRAGRSAPAAA----A-GCPE RCEPARCSPPPAHCEGGR--VRDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRSQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_027816436.2 serine protease HTRA1 [Ovis aries] ------------------------------------------------------------ ---------------------------MQPPRA--------------------------P FLPP-----------PPPPLLLLLLLLAAP----ASAQPARAGRSAP-GA----A-VCPE RCDPARCAPPPGSCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPGSATVRRRAQSGLCVC------ASN-EPVCGSDAKTYTNLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMVTVIPEEIDP >XP_004050262.1 serine protease HTRA1 [Gorilla gorilla gorilla] M----------------GWAARPRALAP---AAPEALLHS-------------------- -PRRRSPALALSAATAAA-----ARVAMQIPRA--------------------------A LLP-----------------LLLLLLLAAP----ASAQLSRAGRSAP-LA----A-GCPD RCEPARCPPQPQHCEGGR--ARDACGCCEVCGAPEGAACG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQAGLCVC------ASS-EPVCGSDANTYANLCQL RAASRRSER--------------LQLPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKRE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_005505857.1 serine protease HTRA1 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MA----------------C-QEH PNSLRHKYNFIADVVEKIAPAVVHIELYRKLPY---SKREIPVASGSGFIVSEDGLIVTN AHVVTNKNR----VKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAVT------------ ----------TKKYIGIRMMSLTPSKARELKDRHKDFP-DVVSGAYVIEVIPETPAEAGG LKDNDVIISINGQSISSASDVSDIIKKD-STLNMVVRRG--NEDVMLTVIPEEIDP >XP_017896995.1 PREDICTED: serine protease HTRA1 [Capra hircus] ------------------------------------------------------------ ---------------------------MQPPRA--------------------------P FLP------------PPPPLLLLLLLLAAP----ASAQPARAGRSAP-GA----A-VCPE RCDPARCAPPPGSCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPGSATVRRRAQSGLCVC------ASN-EPVCGSDAKTYTNLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMVTVIPEEIDP >XP_019341413.1 PREDICTED: serine protease HTRA1 [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MVSLFGAF----DRSQYHFELVDQG-FVQDFVI-DTLE RC------PLP---------VLNILGISFLCQQFEDSQRY----PLFR------------ PLLEDAQEVQP------EEGSKGLVEIDGFCGS------ESTIHPFIQASTKCFTVILVL SFEDLESFL--------------F------------SFS----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---TKREVPVASGSGFVVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDAQGKLPVLLLGRSADLR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQS-KGKAVT------------ ----------KKKYIGIRMMSLTPSKAKELKDHHKDFP-DVISGAYIIEIIPDTPAEAGG LKENDVIISINGQAIISANDVSDIIKKD-STLNMVVRRG--NEDIMVTVVPEEIDP >XP_020753960.1 serine protease HTRA1 [Odocoileus virginianus texanus] ------------------------------------------------------------ ---------------------------MKVYHI--------------------------R AIP------------------GFNCERASPSQPASQVAAEKAARSGY-VGSGDRE-AQPR EPAPARCAPPPGSCEGGR--VRDACGCCEVCGAPEGAECG----LQEG------------ PCGEGLQCVVP--FGVPASATVRRRAQSGLCVC------ASN-EPVCGSDAKTYANLCQL RAASRRSER--------------LHQPPVIVLQRGACGQ----------------G-QED PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTN AHVVTNKHR----VKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELR PGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQA-KGKAIT------------ ----------KKKYIGIRMMSLTPSKAKELKDRHRDFP-DVLSGAYIIEVIPDTPAEAGG LKENDVIISINGQSVVSANDVSDVIKKE-STLNMVVRRG--NEDIMITVIPEEIDP >XP_040217876.1 serine protease HTRA1 [Rana temporaria] ------------------------------------------------------------ ---------------------------MWYPLV--------------------------S SIG--------------ITMLWVLVLLSC-------GVPAASIPAPV-------S-RCPS RCDPSSCPPSPTNCPSGE--TALRCGCCTVCAADEGDRCGEG--PADP------------ TCASALRCVKS--GLL---------GSARTCQC------SSP-QPVCGSDGNTYSSLCKL QAESKAVQN--------------QGSAAIIPIQRGDCQL----------------G-QSD PDSPRYKYNFIADVVEKIAPAVVHIELFRMLNF--FGKREVPSASGSGFIVSEDGLILTN AHVVTNKQR----LKVERSDGSTYDAKIIDVDEKADIALIKIKPKGKLPVLQLGRSEDLR PGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLKN---SDMEYIQTDAIINYGNSGGP LVNLDGEVVGINTLKVTAGISFAIPSDKIRKFLAESHSRQS-AGQGIK------------ ----------KKKYLGIRMLSLSPGKVKELREQLKDFP-NVTSGAYIVEVIPDTPAEEAG LKESDVIISIGSQTVTSSNDVSEAIKQE-GPLRMVLRRG--NEDVVITVTPKEINF
BMGE Cleaned alignment of selected proteins >NP_002766.1 serine protease HTRA1 precursor [Homo sapiens] -LLLLLLAAPSRAGRSAPGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] ----------------------HFSKHRNPIV----------------------------IC------------HKEGQPGNNAVATVA--RPYSQGSDQNNQNNGNKK--------ISSGAVLLNKKRNSQQAGGGSSRRNNNNFIADVVEMSGSAVVFIARFARVPFMRKQVEVSHGSGFIVESQGLVITNAHVVGNQSKLKVRLQDGREFEGVVLGVDEGLDLAAVEIRS-RDLPYLPLGCSNDIRPGEWVVAMGSPLNLKNTVTAGIVSNIHRAGKELGLHDRDMEYIQTDAMINFGNSGGPLINLDGEVIGVNSMMASAGIGFAIPVDYVKDFLTRLKEALKERRRSSRRKYIGITMLTLTEDIVDQLRLRNPDFPNVAKGVLVHRVQYNSPADKAGVQDNDVIIKIDDKDIFSTQDVFQALSK-SNIQLTVIRGDKTIKLRIEPEEVL- >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] ----------LKLSRLIR--------SNTPLLWRYSPTVNQSTQVVISRTITQNQMHENQVISPWARQLKGAKFESRRDKKRRRAAEQNE-VENTSISHGVPSLNYQESSPPSR---GILPVVKAADVTDFG-TGYVTPRSQQFNFIADAVAKASPSVVFIEIHGRHPYRGVVGPISNGSGFIVSPDGLILTNAHVVANKRLVKVKLYDGRLVDGKVVAVDPVSDLALLKIDTKDPLPVMRMGNSSAARPGEWVIAMGSPLSLSNTITAGIISTVSRTSKELGL-NKSIDYIQTDAAINVGNSGGPLVNLDGEAIGINTMRVTTGISFAIPIDCARDFVDKVQKQMKASGGGWKQGYIGITMLSLTPSLIFDLRQRAPDFPNVSHGVLIYRITMESPAQVAGLKAGDIITHINDQPIKSSQELYDRVQAKESLKVTAVRGKETMKLTITPEESQ- >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] ----------MQSLPIFR--------SKVPVFTTNRQILQLKPQTAICRTITQQQMEKNKVISPYVRDLRFASFEPRRDKKRRKQALKEAEFQQTESDHNISSSDDSFRPITQEEQSSVFPVVKAAKVFDEG-DGYVPPRSNRFNFIADAVDIAAPSVVYIEIQGRHPMGRQQVSISNGSGFIVSQDGLILTNAHVVANKIRVKVKLPDGRMVDGHVVAVDSVSDLAAVKIDDGKNLPVMKLGKSSHLRPGEWVIAMGSPLTLSNTITAGIVSTVSRTSKELGL-SKDIDYIQTDAAINFGNSGGPLVNLDGEAIGINTMKVTSGISFAIPIDNAREFLEEVQKRMKSGDASQKRGYIGITMLTLNPGLLNDLKSRMADFPNVSHGVLVYRIIVGSPAQVAGMKAGDIITHIDGKPVKSATAVYNAVHTLQKMEVAVVRGSQKLTLTLMPEEAQ- >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] --------------------------HRLEVIFK--------------------------------RCIASPVLHSHAANRRSSLAIKEG-DPNSNGNSGQYQQNGEQKEKGWRRLVFSLGAVVSAAIIQREDASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHVQVRLSDGRTFPATIEDVDQTSDLATLRIQV-NNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKVKRYMGITMLTLTPDILFELKSRSQNMPNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNKTLDIVILRGVKQMHVTITPEDP-- >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] --------------------------------------------------------------------------RTSWTVLRRNFQYKQF-LTVSCVNRFSQYKYSHQQDKKFRTSESGFGYVLYKWKDDCQNSWDGGNNRNKYNFIADVVEKSAPAVVYIEIQNNRRFTGKPFNISNGSGFIVESDGLILTNAHVVTAKPHVKVRLYDGSVYTGTVEDIDVHSDLATVRINK-TNLPVMKLGSSSNLRPGEFVVAIGSPLALSNTITSGVISSVNRHSQELGLLNKQMAYIQTDAAITFGNSGGPLVNLDAEAIGINAMKVTSGISFAIPIDYAKDFLRKAELRRKNKGTQFKTQYIGITMLTLTPDLFYELQKKLKGIPNIRYGVLVYKVIVGSPAHLGGLQAGDIITQVNDEPVVSSASIYKAIEAAKILRMTVIRGLEVLHLRIEPEEI-- >CAE1315992.1 HTRA2 [Sepia pharaonis] ------------------------------------------------------------VC-----------------------------------DGQDHLSEMAFNSVSKDGQCLESSNSIAVHSGWCRRSGGVYGG-------SPPCKKAAPAVVYIEVANRHPY---YTVLSNGSGFIVKEDGLILTNAHVVVNRHKVIVKLQDGTKVEGKVLLVDPVSDLAAIKINV-AGLPILNLGESNSLRPGEWVIAMGSPLSLTNTVTSGIVSTPHRGSAELGLHHRNMTYIQTDAVINFGNSGGPLVNLDGEAIGINTLKVATGISFAIPSDYAKGFLHKAEKD--------------------------------DECP-----------------------------------------------------------TK------------- >XP_043331167.1 serine protease HTRA1 isoform X2 [Cervus canadensis] LLLLLLLPASARAGRSAPGCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPASATVRRRASGLCVCAEPVCGSDAKTYANLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_004080793.1 serine protease HTRA1 [Oryzias latipes] VCVTALFASSAQIVKRAAGCPERCDRSACAPVLQDCLSGDELDRCGCCPVCASGEGAPCGECVEGMECVVTDGVEASATVRRRAAGVCTCIDPVCGSDGVSYRNVCELKRVSSRATELQQPPVIFIQRGACGKQQSPDSLRYKYNFIADVVEKIAPAVVHIELFRKMVFSKREVSVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKSGATYDAKIKDIDEKADIALIKIDTPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKILQFLAESHDRQAKGKTLAKKKYIGVRMMSLTPTLAKELKARHPDFPDLTSGAYVMEVIGRTPAEAAGLKERDVIISINGEHITSANDVSTTIKREQNLRMVVRRGNEDVMLTVIPEEIDP >XP_030257094.1 serine protease HTRA1 [Sparus aurata] LCVMAVLVCPARIAKRFAGCPEKCDKSQCPPIPADCLAGDVLDRCDCCPVCASGEGETCGECAEGMECVVTDGVEVSATVRHRGAGVCACTDPVCGSDGVSYRNICELKRVSNRAMKLQQPPVIFIQRGACGKQQNPDSLRFKYNFIADVVEKIAPAVVHIELYRKMIFSKREVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKSGATFDAKIKDVDEKADIALIKIDTPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESHDRQSKGKTHQKKKYIGVRMMSLTPALAKELKERQSDFPDVTSGAYVIEVISRTPAETAGLQESDVIISINNERITSASDVSAAIKRDETLRTVVRRGNEDVILTIIPEEIEP >XP_015800249.1 PREDICTED: serine protease HTRA1A-like [Nothobranchius furzeri] LVVCAAVAS-AQLSSRFVGCPSQCDKSMCPRLPADCSAGKGLDVCHCCPVCASGEGEACGVCGDGLECSVPGGVAYSVTVRRRSSGSCVCKEPVCGSDGVSYRSICELKQVSRRAQKLQQPPVLFIQRGACGKQDNPDSPRHKYNFIADVVEKIAPSVVHIELFRKMTYSKREVAVASGSGFVVSEDGQIVTNAHVVANKHRVKVELKSGASYDAKIKDVDEKSDIALIKIDAPNKLPVLLLGRSSDLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGRELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRQSRGRTDAKKKYIGVRMMTLTPVLAKELKTQHRDFPDITSGAYVMEVIAKTPAEIGGLKEHDVIISINGQRISTATDVSTVIKRENILKVVVRRGNEDAILTVVPVEIDP >NP_001088796.2 serine protease HTRA1 precursor [Xenopus laevis] LWLAVLLTC-AALLPTSGGCPARCDPSSCSPAPTNCQSGETALRCGCCSVCAAAENERCGLCASGLRCVRN------------GVTRCQCPQPVCGSDGKTYSSLCRLQAESKAVQGRGVAAIIPIQRGDCQQQKDPDSPRYKYNFIADVVEKIAPAVVHIELFRILPFFKREVPAASGSGFIVSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQIIDVDEKADIALIKIKAKGKLPVLLLGRSEELRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVVGINTLKVTAGISFAIPSDKIRKFMAESHNRQSTGQGTKKKKYLGIRMMSLSQGKLKELKEQVKDFPENTSGAYIVEVLPDTPAEEAGLKEGDIIISISGKTVTSSSEVSEAIKKEGTLQMVIRRGNEDIPISVTPKEIEF >KAB0373197.1 hypothetical protein FD755_014856 [Muntiacus reevesi] VLLWLLLPAPVQAGRAWPPCPAACEPTRCPPLPR-CSTGTVLDRCGCCRVCAAAEGEACGPCAPGLQCRAP----RAPQPFGGRLGTCGCPATVCGSDGRTYPSLCALRAENRAARLRGALPAVPVQKGGCGDTGSAGWLRSKFNFIASVVEKVAPSVVHLQLFRRSPLGSEDVPASSASGFIVSEDGLIVTNAHVLTNQQRIQVELQSGVQYEATVKDIDHKLDLALIKIEPNTDLPVLLLGKSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDMDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDCIRQFLAEFHERQLKGKALSQKKYLGLRMLPLTMNLLQEMKRQDPEFPDVTSGVFVHEVIQGTAAESSGLKDHDVIVSINGLPVTTTTDVIEAVKANDSLSLLVRRKSQTLILTVTPEIIN- >OWK07540.1 HTRA1 [Cervus elaphus hippelaphus] -----------------------------------------------------------------------------------------------------------IRVAF-------QPLLLTLLRG-----------------------------WHL-----------------------------------------------------------------------AQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >KAB0347983.1 hypothetical protein FD754_012840 [Muntiacus muntjak] VLLWLLLPAPVQAGRAWPPCPATCEPTRCPPLPR-CSTGTVLDRCGCCRHLFA--------------------------------------------------------------------------------TGSAGWLRSKFNFIASVVEKVAPSVVHLQLFRRSPLGSEDVPASSASGFIVSEDGLIVTNAHVLTNQQRIQVELQSGVQYEATVKDIDHKLDLALIKIEPNTDLPVLLLGKSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGSKELGLKDSDMDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLAEFHERQLKGKALSQKKYLGLRMLPLTMNLLQEMKRQDPEFPDVTSGVFVHEVIQGTAAESSGLKDHDVIVSINGLPVTTTTDVIEAVKANDSLSLLVRRKSQTLILTVTPEIIN- >sp|A9JRB3|HTR1B_DANRE Serine protease HTRA1B OS=Danio rerio OX=7955 GN=htra1b PE=2 SV=1 LCASIILVP-ARIIKRYVGCPERCDKSLCPPIPPDCLAGDILDQCDCCPVCAAGEGESCGECGEGLECAVSDGVGATTTVRRRGTGVCVCKEPVCGSDGVSYRNICELKRVSNRAQKLQQPPIIFIQRGACGKEENPDSLRHRYNFIADVVEKIAPAVVHIELFRKNVFN-REVAVASGSGFVVSEDGLIVTNAHVVANKHRVKVELKTGTTYDAKIKDVDEKADIALIKIDAPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESHDRQAKGKTATKKKYIGVRMMTLTPTLAKELKQRKNDFPDVTSGAYVIEVIPKTPAEVGGLKESDVIISINGQRITSASDVSTAIKTDESLRAVVRRGNEDIILTIIPEEIDP >sp|Q6GMI0|HTR1A_DANRE Serine protease HTRA1A OS=Danio rerio OX=7955 GN=htra1a PE=2 SV=1 FCICALVTS-ARLSKRYVGCPSHCDKSMCPTMPKDCSTGQVMDHCNCCLVCASGEGEACGVCGESLECSVTGGVSYSATVRRRGQGVCVCKDPVCGSDGVSYRDICELKRVSNRAQSLQQPPVLFIQRGACGTHDNPNSLRYKYNFIADVVEKIAPAVVHIELYRKMVYSKREMAVASGSGFVVSDDGLIVTNAHVVANKNRVKVELKNGASYDAKIKDVDEKADIALIKIDLPNKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRQFLAESYDRLARGRGTTKKRYIGVRMMTLTPSLSKELKGRLRDFPDITSGAYVIEVISKTPAAAGGLKEHDVIISINGQRISTATDVSAIIKKESSLRVVVRRGNEDIILTIIPMEIDP >NP_062510.2 serine protease HTRA1 precursor [Mus musculus] -LLLLLLAAPSGTGRSAPVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP >NP_113909.1 serine protease HTRA1 precursor [Rattus norvegicus] -LLLLLLAAPSGISRSAPVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAVCGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKTVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVVPEEIDP >NP_001269011.1 serine protease HTRA1 precursor [Bos taurus] LLLLLLLAAPARAGRSAPGCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPASATVRRRASGLCVCAEPVCGSDAKTYTNLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_016775034.1 serine protease HTRA1 [Pan troglodytes] -LLLLLLAAPSRAGRSAPGCPDRCEPARCPPQPEHCESGRARDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_038295584.1 serine protease HTRA1 isoform X1 [Canis lupus familiaris] PLLLLAAPAPSRAGRSAAGCPERCEPARCLPPPGPCEGGRVRDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGVCVCAEPVCGSDANTYANLCQLRAASRRAERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHEGRLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDHHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSASDVSDVIKKENTLNMVVRRGNEDIMITVIPEEIDP >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] -LLLLLLAAPPRAGRSAPGCPERCEPARCAPPPTNCEGGRVRDACGCCEVCGAPEGAACGPCGEGLQCVVSFGVPASATVRRRSAGVCVCAEPVCGSDANTYANLCQLRAASRRSERLQQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKDSTLNMVVRRGNEDIMITVIPEEIDP >XP_002821267.1 serine protease HTRA1 [Pongo abelii] -LLLLLLAAPSRAGRSAPGCPERCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_003133256.3 LOW QUALITY PROTEIN: serine protease HTRA1 [Sus scrofa] LLLLLLLAAPPRAGRSAPGCPERCEPARCAPPPGHCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADXALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDVMVTVIPEEIDP >XP_010713179.1 serine protease HTRA1 [Meleagris gallopavo] -------------------------------------------------------------------CSVS------------------------------------------------------------ISQEHPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPYSKREIPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKARELKDRHKDFPDVVSGAYVIDVIPETPAEAGGLKDNDVIISINGQSITSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_015144381.1 serine protease HTRA1 [Gallus gallus] VLPALLLAAP------PPACPERCDRSRCPPLPSSCPGGPVLDACGCCRVCGAEEGEPCGPCGEGLRCSVPGGVPASGTVRKRAVGRCVCAEPVCGSDAVTYASPCQLRAASRRAERLRQPPIIAIQRGGCGQQEHPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPYSKREIPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSGDLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAGELKDRHKDFPDVVSGAYVIDVIPETPAEAGGLKDNDVIISINGQSITSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_034787526.1 serine protease HTRA1 [Pan paniscus] -LLLLLLAAPSRAGRSAPGCPDRCEPARCPPQPEHCESGRARDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_023096805.1 serine protease HTRA1 [Felis catus] LLLLLLLAAPSRAGRSAPGCPERCEPARCSPPPAHCEGGRVRDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRSAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHEGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_027816436.2 serine protease HTRA1 [Ovis aries] LLLLLLLAAPARAGRSAPVCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPGSATVRRRASGLCVCAEPVCGSDAKTYTNLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMVTVIPEEIDP >XP_004050262.1 serine protease HTRA1 [Gorilla gorilla gorilla] LLLLLLLAAPSRAGRSAPGCPDRCEPARCPPQPQHCEGGRARDACGCCEVCGAPEGAACGPCGEGLQCVVPFGVPASATVRRRAAGLCVCAEPVCGSDANTYANLCQLRAASRRSERLQLPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP >XP_005505857.1 serine protease HTRA1 [Columba livia] -----------------------------------------------------------------------------------------------------------------------------------MAQEHPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPYSKREIPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGETYEAKIKDVDEKADIALIKIDAQGKLPVLLLGQSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTTKKYIGIRMMSLTPSKARELKDRHKDFPDVVSGAYVIEVIPETPAEAGGLKDNDVIISINGQSISSASDVSDIIKKDSTLNMVVRRGNEDVMLTVIPEEIDP >XP_017896995.1 PREDICTED: serine protease HTRA1 [Capra hircus] LLLLLLLAAPARAGRSAPVCPERCDPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPGSATVRRRASGLCVCAEPVCGSDAKTYTNLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMVTVIPEEIDP >XP_019341413.1 PREDICTED: serine protease HTRA1 [Alligator mississippiensis] --MVSLFGAFHFELVDQGDTLERC------PLP-------VLNILGISFLCQQFEDSQRYPLLEDAQEVQP----EEGSKGLVEDGFCGSEHPFIQASTKCFTVILVLSFEDLESFLF------------SFSQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFTKREVPVASGSGFVVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDAQGKLPVLLLGRSADLRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQSKGKAVTKKKYIGIRMMSLTPSKAKELKDHHKDFPDVISGAYIIEIIPDTPAEAGGLKENDVIISINGQAIISANDVSDIIKKDSTLNMVVRRGNEDIMVTVVPEEIDP >XP_020753960.1 serine protease HTRA1 [Odocoileus virginianus texanus] -GFNCERASPEKAARSGYAQPREPAPARCAPPPGSCEGGRVRDACGCCEVCGAPEGAECGPCGEGLQCVVPFGVPASATVRRRASGLCVCAEPVCGSDAKTYANLCQLRAASRRSERLHQPPVIVLQRGACGQQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTPSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKESTLNMVVRRGNEDIMITVIPEEIDP >XP_040217876.1 serine protease HTRA1 [Rana temporaria] LWVLVLLSC-AASIPAPVRCPSRCDPSSCPPSPTNCPSGETALRCGCCTVCAADEGDRCGTCASALRCVKSGLL---------GARTCQCSQPVCGSDGNTYSSLCKLQAESKAVQNQGSAAIIPIQRGDCQLQSDPDSPRYKYNFIADVVEKIAPAVVHIELFRMLNFGKREVPSASGSGFIVSEDGLILTNAHVVTNKQRLKVERSDGSTYDAKIIDVDEKADIALIKIKPKGKLPVLQLGRSEDLRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLKNSDMEYIQTDAIINYGNSGGPLVNLDGEVVGINTLKVTAGISFAIPSDKIRKFLAESHSRQSAGQGIKKKKYLGIRMLSLSPGKVKELREQLKDFPNVTSGAYIVEVIPDTPAEEAGLKESDVIISIGSQTVTSSNDVSEAIKQEGPLRMVLRRGNEDVVITVTPKEINF
PhyML tree of selected proteins (XP_040217876_1_serine_protease_HTRA1__Rana_temporaria_:0.11259,NP_001088796_2_serine_protease_HTRA1_precursor__Xenopus_laevis_:0.11775622,(((XP_039270049_1_serine_protease_HTRA2__mitochondrial_like__Styela_clava_:1.47617821,((XP_624354_1_serine_protease_HTRA2__mitochondrial__Apis_mellifera_:0.87562567,NP_001262565_1_HTRA2_related_serine_protease__isoform_B__Drosophila_melanogaster_:0.81445546):0.36059178,(CAE1315992_1_HTRA2__Sepia_pharaonis_:1.5597742,(XP_038046351_1_serine_protease_HTRA2__mitochondrial_like__Patiria_miniata_:0.38571297,XP_001197113_4_serine_protease_HTRA2__mitochondrial__Strongylocentrotus_purpuratus_:0.54382989):0.43680678):0.25869385):0.338172):0.90064038,(KAB0347983_1_hypothetical_protein_FD754_012840__Muntiacus_muntjak_:0.01969609,KAB0373197_1_hypothetical_protein_FD755_014856__Muntiacus_reevesi_:0.00332032):0.53969274):0.21474869,(((XP_015144381_1_serine_protease_HTRA1__Gallus_gallus_:0.00932596,(XP_005505857_1_serine_protease_HTRA1__Columba_livia_:0.03793701,XP_010713179_1_serine_protease_HTRA1__Meleagris_gallopavo_:0.00651458):0.0171998):0.09376458,(XP_019341413_1_PREDICTED__serine_protease_HTRA1__Alligator_mississippiensis_:0.41918383,(OWK07540_1_HTRA1__Cervus_elaphus_hippelaphus_:0.0666561,((XP_020753960_1_serine_protease_HTRA1__Odocoileus_virginianus_texanus_:0.04289772,(NP_001269011_1_serine_protease_HTRA1_precursor__Bos_taurus_:0.00000001,((XP_027816436_2_serine_protease_HTRA1__Ovis_aries_:0.00000001,XP_017896995_1_PREDICTED__serine_protease_HTRA1__Capra_hircus_:0.00000001):0.00506401,(NP_113909_1_serine_protease_HTRA1_precursor__Rattus_norvegicus_:0.01553306,NP_062510_2_serine_protease_HTRA1_precursor__Mus_musculus_:0.00000001):0.04966264):0.00269946):0.00257401):0.00000001,(XP_043331167_1_serine_protease_HTRA1_isoform_X2__Cervus_canadensis_:0.00515882,(XP_003133256_3_LOW_QUALITY_PROTEIN__serine_protease_HTRA1__Sus_scrofa_:0.00770027,(XP_038295584_1_serine_protease_HTRA1_isoform_X1__Canis_lupus_familiaris_:0.03494626,((XP_008268840_1_PREDICTED__serine_protease_HTRA1__Oryctolagus_cuniculus_:0.01589228,XP_023096805_1_serine_protease_HTRA1__Felis_catus_:0.00504056):0.00389588,(XP_002821267_1_serine_protease_HTRA1__Pongo_abelii_:0.0023453,(XP_004050262_1_serine_protease_HTRA1__Gorilla_gorilla_gorilla_:0.00771725,(NP_002766_1_serine_protease_HTRA1_precursor__Homo_sapiens_:0.00000001,(XP_016775034_1_serine_protease_HTRA1__Pan_troglodytes_:0.00000001,XP_034787526_1_serine_protease_HTRA1__Pan_paniscus_:0.00000001):0.00257051):0.00000001):0.00279603):0.01825377):0.00118937):0.0028736):0.01309455):0.00000001):0.00953168):0.03633292):0.04152339):0.05649901,((XP_015800249_1_PREDICTED__serine_protease_HTRA1A_like__Nothobranchius_furzeri_:0.12693788,sp_Q6GMI0_HTR1A_DANRE_Serine_protease_HTRA1A_OS_Danio_rerio_OX_7955_GN_htra1a_PE_2_SV_1:0.11116235):0.09414265,(sp_A9JRB3_HTR1B_DANRE_Serine_protease_HTRA1B_OS_Danio_rerio_OX_7955_GN_htra1b_PE_2_SV_1:0.08949052,(XP_030257094_1_serine_protease_HTRA1__Sparus_aurata_:0.06585755,XP_004080793_1_serine_protease_HTRA1__Oryzias_latipes_:0.12985447):0.04627983):0.02614348):0.20539838):0.08056097):0.33842058);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)