PB0024

DATABASE

Click here to access PB0024 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0024	Q6FH22	EGF containing fibulin extracellular matrix protein 2	EFEMP2	EFEMP2 protein, ARCL1B, FBLN4, MBP1, UPH1	Homo_sapiens

Domains	Gene Ontology
PF07645 (3_EGF_CA) PF12662 (2_cEGF)	GO:0005509 (enables) calcium ion binding GO:0048251 (involved in) elastic fiber assembly GO:0005615 (located in) extracellular space

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >tr|Q6FH22|Q6FH22_HUMAN EFEMP2 protein OS=Homo sapiens OX=9606 GN=EFEMP2 PE=2 SV=1 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLT IPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDS CVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFS CSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTC VNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSKRSVPADV FQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >tr|A2CEN1|A2CEN1_DANRE EGF-containing fibulin extracellular matrix protein 2a OS=Danio rerio OX=7955 GN=efemp2a PE=1 SV=1 MRPGCVLLFCMCISVFLHRAISQPPTETDTYTECTDGYHWDSQTQHCKDINECETITEAC KGEMKCFNHYGGYLCLPRSASVIPAAEPPNQIDPSLENRVSEPFNSCPLGFEPQQDSCVD VDECERDSHDCQPSQQCFNTEGSFSCQCPDGYRKVGTECIDIDECRYRYCQHRCVNVPGS FSCQCEPGFQLAGNNRSCIDVDECGMGAPCSQRCYNTYGTFLCRCEQGYELGPDGFACND IDECSYSSYLCQYQCVNEHGKFSCVCPEGYQLLGTRLCQDINECETGAHQCSEGQTCVNI HGGHKCVDNKSCQDPYMQVSENRCMCPVSKPACRDMPYSIVHRYMSITSERSVPSDIFQI QATSVYPGAYNTFRIRSGDDNGDFYIRQINNISAMLVLARAVNGPQEYVLDLEMVSINPL MSYHSSSALRLTIYVGPYAF
Selected proteins from model organisms >NP_058634.4 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Homo sapiens] MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >KAG6798541.1 fibrillin-1 [Apis mellifera caucasica] MTRFTDLRMIFFLLLTIQLEKFFLRKQGILFSEARMEEQFEKCCGLGTSWALEGLRCEKFTGPVSGVPTVEQGLCLEAVD ICCVRAYHEQQCKKGKLDAHAGLACVSGSKSKRLGPGDYHRDCCEACKLGILTGSMGQGCAFKKFTFGNPWDPAFLECCY EASPSTTTTFTTNLTNATSSSETTNSESTSISSPSSSSSSSSSSSSSSSSSSSSSSSLSTQTTLASSTSFSPSIPTPPLD DICQLMKGLLCSDICVPTPGSYYCKCREGFTLLEDGKTCRQDLPIDRCKSSNPCEQRCTDNGVAVICSCNPGYVLAEDKH SCLPKASEAKTTTIPEDNDFSLLCPAGYRYNATNQVCDDVNECIERRICPGYCENTIGSYICTSKNRLKIDSYEDCPPGY QWESTTGLCSDIDECLILSKPCPGIKNVCVNTQGSFSCLEMKGIKSCPAGFKFNNFSQQCEDVDECAEKIHSCLEDTEKC RNTEGAYECDIKCDKGFIYSINLGICIDVDECLGSNNLCLDPNTTCKNILGGYECLSLNRSIVSIDEQTEPSICSAGYKP MNDSNDACIDVDECKEQLHSCEINEQCVNDIGSYRCEPLNYHEVTNLNGKDKDHHNYLYERNGHKSYIQRYDINGYKSQI SVSPAFNQTVICNEGFIFDQRTLSCIDIDECSNGLANCKIDEKCINFNGGYKCSPICPSGFQYNDTYYSSRNEPSCRDIN ECALGLHSCNVSTHYCVNTNGSYSCKEFATTISSPRISKQLNSKKDYIMQNTNHYSFLEPCKKGYIRDVKSGECVDIDEC ASIRACQEHEVCRNVPGDFECTPLCTTGWYFNTVTKGCQDVDECLLGRHDCPENTHKCVNTNGSFFCELIPPCSTGYKRS FFNGSCVDIDECEENLHSCRLELHQYCVNRNGTFECLTRLPSCPTGYEYSLATRRCEDIDECVTNQYTCDSRLFERCINL PGTYRCERPASIRQHQRQKPACPSGYRYHPRLKKCTDIDECAEGLDSCEGEVCYNQPGGYSCAKLPKPRTRKPPTTALPL PKNKKCIPGTKLVNNRCVDIDECREIEDACSSNEECINTVGSYSCECKLGFQRENLTQACVDINECQTQTDSCTQGQRCD NTIGSYTCTRYLSCGTGYTLNAATEICEDDDECLLGTHDCGKGYHCRNTLGSYRCDRNPRVPFLESRFDIATTTTTKSTS IAPTSTTLSSQEQINCQRGFESVPGDKCEDIDECEKNPNICGRTMRCLNTLGSYRCVSKVLCSNGYTLDPVVGRYCIDID ECANGTHECTADQTCENRIGGYVCSCPSGHVVGPNKDCIDIDECSLYGNICGSNSRCENTVGSFKCNCENGFEHVSSFAG NTCQDIDECARTPGLCQHNCFNTWGSYKCICKSGFKLNPDNRSCTDIDECTEFKDNLCVGICENTPGSYACKCPDGYKLG HNGRTCEDIDECQAGHICRDADEICHNVRGSYRCNKIKCPNGYHRDHERKNRCVRSWPCHINDHACIRQPSHYSYNFITL VSMLPVMPNRPEELFKMKGYHLPGSAIQFSMAFLEARAPPGIQRATESCFALRKPEPTQAVLVMTQSIQGPQEIELDLNM EVYHNAHFAGSAIAKILIFVSQYEF >CAE1173162.1 FBLN1_2 [Sepia pharaonis] MLTFLSLSLLLLLGLPKAHSSLLDIRDICCTLGSQYGALKNTCSRYIAPLTNIKPEDEENCRVIVEICCMKEIHYKQCLK GRTDAEEKKLCQVNADVYGAEQYSQCCQCCRLGKVAVQSGLHCNLTNYGDPCDTTFRECCQAERIRLSGGNPYSSCDLNN PCDHFCENDGYSFKCICRTGFVLNADRRTCSDINECLQFPRPCPDRQRCINIPGNFICRQEANCPEHAIFNRLTSSCRCQ SKMVYNVTSKECQCPPGFAYNIVERLCEDIDECIVQAHNCNISHQCLNLEGSFQCCRTGFTANQDQLQCEDIDECGLADS CPLGLQCYNSPGSFVCRRSRSCGTGYSLNEITQQCDDIDECAQGVHNCGTSRCKNIQGSFRCEMPSHSTPCPAGSIFNSQ TETCESQSRETCDPGFWIKNGICVDINECTERVDQCGLHQVCHNTRGSYQCSNTISCGPGLWYDDVGSRCKDIDECAAGN HTCHSNQVCRNTPGGFECDCLAGYLALSNGFCEDINECSHHRRYCPRNANCINTPGSFRCECKAGYESIGTSRQCKDIDE CSMQNPCDHHCQNTLGSFKCSCETGYELSLNRRSCQDVDECADPYKQCSYQCQNLPGSFQCSCPSGFRMASDQKSCLDID ECKETPSICRNYDATCINVRGGYKCPIVQCPSAYTKSAYGNPGNSVRCQRPNICPLRDVECLTSPISLSYNFMTFPSKIK IPTTLFTISGRVIASRYFRFNLNLISAEPQAPGVLKITQQYFNLRITGSSAAVELRQEIPGPQDVELQLIMDMYNSDKHQ LIGQAESKLFIYVT >NP_001293876.1 Fibulin-1 [Caenorhabditis elegans] MRICFLLLAFLVAETFANELTRCCAGGTRHFKNSNTCSSIKSEGTSMTCQRAASICCLRSLLDNACDSGTDIAKEEESCP SNINILGGGLKKECCDCCLLAKDLLNRNEPCVAPVGFSAGCLRSFNKCCNGDIEITHASEIITGRPLNDPHVLHLGDRCA SSHCEHLCHDRGGEKVECSCRSGFDLAPDGMACVDRNECLTRQSPCTQSEDCVNTIGGYICQRRISRLVPHRHRANRIGN APRRMRDDPYSRAGEYREASQANTEFGCPMGWLFQHGHCVDVDECNLGSHDCGPLYQCRNTQGSYRCDAKKCGDGELQNP MTGECTSITCPNGYYPKNGMCNDIDECVTGHNCGAGEECVNTPGSFRCQQKGNLCAHGYEVNGATGFCEDVNECTTGIAA CEQKCVNIPGSYQCICDRGFALGPDGTKCEDIDECSIWAGSGNDLCMGGCINTKGSYLCQCPPGYKIQPDGRTCVDVDEC AMGECAGSDKVCVNTLGSFKCHSIDCPTNYIHDSLNKNQIADGYSCIKVCSTEDTECLGNHTREVLYQFRAVPSLKTIIS PIEVSRIVTHMGVPFSVDYNLDYVGQRHFRIVQERNIGIVQLVKPISGPTVETIKVNIHTKSRTGVILAFNEAIIEISVS KYPF >XP_039248222.1 fibulin-1-like isoform X2 [Styela clava] MMNRILIYIAVSLLCDLTYGDTVMKSLLVTSGKNGAVCGDGLRYSEGQGCGDIDECREIVPCQLGQRCRNYYGSYQCVCP RGYNMDIKTNECVDKDECAMGFCGNGQKCTNTLGSFHCECSQGMQRIGRFCRDINECMHKPCADNQYCINTRGSYVCQCK AGYREAGNGTCADVDECRQGMCGALGETCKNTDGSYECVCKPGYGKDEMTQGRYCKDIDECKIRSTCPQYSECQNLPGSF LCRCHRGFTYINGACVDKHECTHGEGRKCQWKCTDLPGSYKCICPEGYEQINFNCIDINECDRHMSSCGSGETCVNTRGG FECVRPPKCPLTASGDSIYRKVMKTDEFGYRQVTTNICRRQRCGKMAERDSMSVKECKAEPLSVSYHYVAVTSGLPKPTA VLHISYPARRRRQRYNFSIVQGNEEGIFMIKQHSMYMPRAQLVVTGNLNGPSRHTVKIDMATYQPNGKMRDSRMLTITIF TSMYDF >XP_787649.4 fibulin-1 isoform X2 [Strongylocentrotus purpuratus] MKVYISLITLLVCFSFCHASLIDVMPDCCERGASFAGLGRTCDDLEAIPDIAPGDHGICMVIMKSCCANSLGPVLCERAL NHRMNVGSCQTMNNDTCFSAGRECCDCCELGINAFHDGIECESMRTGTSCDRAFAYCCKAAASSFDENECSLQTSHRLCT ERCVNLIDNYVCECHPGNHLLEDNITCVADGDTRPPPRYLACSQAPCQHECRQVGREYECYCRTGYELLSDGYTCEDVDE CAVTDSLACNYAERCLNTIGSFNCISDVVCRSGLKYDPVNQYCVDIDECAERTDTCDERSICENRYASYTCQHASCPTGY YYDRTVSQCNDIDECARGTHECLDGARCDNLPGSFHCTRIVPCGTGYTINGVTQQCVDVDECSQQSHDCEINELCINIRG SYDCQSCPRGFKTNGNVNRCTQDINECQEGTFDCREGTRCENNVGSYTCISICMTGFEYNRILRACMDVDECRRGLANCA TYEICQNTNGSFSCGCRQGFRQNNYGQCVDIDECREGLSECKPNQRCYNLQGQYQCRNMCRNGFRFNNFNSACEDIDECA EGLDVCQNNQRCINQEGGYVCQCPAGHQANRDRATCEDIDECSLGLCRGTCENLPGSYVCTCPAGYALMENNVTCKDLDE CSTGTDTCIQDEVCFNTRGGHKCESVVCPEYYQVRTSNDNIQCVKTCPRTGNAPDCPPGNLNSTISHTFVALPSIPFLRQ PIRLLTIGLPNYRSAYGGSSQTYFRSISGNEDQYFVITRLFPRGLPTGYVSLQKPISGPFETVLHLEIVTEVRNPVTRRT EVTATSYLMIHIDVGEQSY >XP_038061268.1 fibulin-1-like isoform X2 [Patiria miniata] MWHQVASVLLAFLITANAVQLQHSISICCDVGAEYANEHSSCEAIDSEPVPDMGPMEDEDIQDCHVMMRSCCIKQLQRNM CFDGLFTRANIGSCDRVQGDSCGSIEKTCCECCELGIKAFHESAPCDGTDLGTECDFAFRDCCGRASSNNDMDECTLARE NNHRLCSSKCVNLITSFVCECPVGYVLAAADNMTCIRDREEPANACDESPCEQRCQPNGSSYVCGCNDGYELQENGYSCL ENNPPPSLGCLYASCDYACRSVDASSYECYCDTGYDLDSDGTTCIDIDECQEENVCPLHKRCQNYRGGFYCETTRCAEGE QFVFDESNNIQCRDVDECARGTHNCQDGFRCDNSPGSFRCTRISPCGTGYTVNSLTQQCRDIDECLQDTDDCPPEFYCQN TMGSYKCRPCRQGFKADSADGCTRDINECEEQADVCPRGQACVNTYGSYRCNPACPQGFQYSVIYRECRDINECALGTDD CQANQVCQNREGAYECGCRNGMEFNEVTRECDDINECETNTNNCRYNEQCHNTVGSFACQQRCQLNYRYVEEEGCVDVNE CEQAQYPCFGNSQCVNVPGSYRCQQCPRGQIANRDTRRCEDVDECKYQGASCMGGCVNTFGSYMCTCPNGYELLNRFNCR DINECRRNIHNCSSQSACFDTRGGFKCKNIQCPQYYRKEINGDEVRCVKVTLCPNNDFNCVDDPVKLITYNKIALPSLTR ELRQPLQLLRLQIGDLTVSQANGLRFVLTQGNELGLFSVTKDLNRDRLGNWFATGTLYLERAVTGPFETDLRLEMQLFST TQENQLLSVTTAVFSIDVSPNSF >NP_001284712.1 uncharacterized protein Dmel_CG31999, isoform C [Drosophila melanogaster] MFYKLCAFMCFLIVGGHVTTTMASDSISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDH QDCELGRLAALDGTRCDGEGNVTSSSYATCCRSCQIGLAVKASKANCKDPLFSFIFLIESYRACCYGSADFKDQPGIDEI DKANSITDEGELPFVSEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGY NLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFS LHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYIC TRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRY PYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDG KSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECK AGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPG SYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEE CYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVNVILKKSL EGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQHTF >tr|A2CEN1|A2CEN1_DANRE EGF-containing fibulin extracellular matrix protein 2a OS=Danio rerio OX=7955 GN=efemp2a PE=1 SV=1 MRPGCVLLFCMCISVFLHRAISQPPTETDTYTECTDGYHWDSQTQHCKDINECETITEAC KGEMKCFNHYGGYLCLPRSASVIPAAEPPNQIDPSLENRVSEPFNSCPLGFEPQQDSCVD VDECERDSHDCQPSQQCFNTEGSFSCQCPDGYRKVGTECIDIDECRYRYCQHRCVNVPGS FSCQCEPGFQLAGNNRSCIDVDECGMGAPCSQRCYNTYGTFLCRCEQGYELGPDGFACND IDECSYSSYLCQYQCVNEHGKFSCVCPEGYQLLGTRLCQDINECETGAHQCSEGQTCVNI HGGHKCVDNKSCQDPYMQVSENRCMCPVSKPACRDMPYSIVHRYMSITSERSVPSDIFQI QATSVYPGAYNTFRIRSGDDNGDFYIRQINNISAMLVLARAVNGPQEYVLDLEMVSINPL MSYHSSSALRLTIYVGPYAF >NP_067449.3 EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor [Mus musculus] MLPFASCLPGSLLLWAFLLLLLGAASPQDPEEPDSYTECTDGYEWDADSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVISDLHGEGPPPPAAHAQQPNPCPQGYEPDEQESCVDVDECTQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRSGNTQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_018113173.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X3 [Xenopus laevis] MLLFSSVLFSLLLVSSRQQESEGPNSYTECTDGYEWDRERQHCRDINECQTIPDACKGELKCINHYGGYLCLPPSASVIS DSQTEQGTSELQPPVDHELDQRPNTCPSGYQLDPQGQGSCVDVDECEHQLHDCLPSQDCINMLGSYHCKCPEGYRKIGNE CVDIDECRYRYCQHRCVNYPGSFVCQCEPGFQLASNNRSCVDVNECSMGTPCQQRCYNTYGTFLCRCNQGYELSHDGYTC TDIDECSYSSYLCQHQCVNEPGSFSCSCPEGYQLLGTRLCQDINECELGTHSCSEQQTCVNFHGGYQCVEKNRCQEPFIQ VSENRCMCPGTNPLCHDEPGSVVYRYMSITSDRSVPSEIFQIQATSVYPGAYNIFQIRSGNEQGEFFIRQINNLTAMLVL ARPVIGPKEYVLDLEMLTTNSLLSYRSSSVLRLTVFVGAHSF >XP_025004920.1 EGF-containing fibulin-like extracellular matrix protein 1 [Gallus gallus] MMLTAMFLAALILITVHSQETEETITYTQCTDGYEWDPVRQRCKDIDECEIVPDACKGGMKCVNHYGGYLCLPRTAQIIV NEREEAAAESTSGRNNVIRRTPADPHRAPPNPTHQIQCAAGYEQSEHNVCQDIDECATGTHNCRADQVCVNLRGSFSCQC PPGYQKRGEQCVDIDECTLPPYCHHRCVNTPGSYYCQCNAGFQLASNNHTCVDINECDANNPCAQQCYNILGSFICQCNP GFELSSDRINCEDTDECRTSSYICQYQCVNEPGKFSCVCPEGYQVVGGRTCQDINECETTNECREDEICWNYHGGFRCYP INPCQEPYVLTSENRCVCPVSNTICRELPYSVVYKYMSIRSDRTVPSDIFQIQATTIYPNTINTFRIKSGNENGEFYLRQ TSAVSAMLVLVKSLSGPREHIVDLEMLTVNSLNYRTSSVLRLTIIVGPYAF >XP_006021628.1 EGF-containing fibulin-like extracellular matrix protein 1 [Alligator sinensis] MMLTVTFLAAFVLTTVSSQETEETITYTQCTDGYEWDPYRQQCKDIDECEIVPDACKGGMKCVNHYGGYLCLPRTAQIIV NEQDAATADSAGGRNSVIRRTPVDVQQGPPNPTHQIQCATGYEQSEHNVCQDIDECATGAHNCRTDQACVNLRGSFRCQC LPGFQKRGEQCIDIDECTLPPYCHHRCVNTPGSYYCQCNPGFQLASNNHTCVDINECDANNPCAQQCYNILGSFICQCNP GFELSSDRINCEDVDECGTSSYICHYQCVNEPGKFSCVCPEGYQVVGGRTCQDINECETTNECREDEMCWNYHGGFRCYP RNPCQEPYVLTSENRCVCPVSNTICRELPYSIVYKYMSIRSDRNVPSDIFQIQATTIYPNTINTFRIKSGNENGEFYLRQ TSALSAMLVLVKSLSGPREHIVDLEMLTVNSLNYRTSSVLRLTIIVGPFAF >KAF4018076.1 hypothetical protein G4228_009546 [Cervus hanglu yarkandensis] MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEADLPNARRKEVEAIHTILRSENERLKKLCADLEE KHEASELQIKQQSMNYRHQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVNSGAGGVPATTASSSFGYGLSHHASGFHD DDMDFGDIISSQREINRLSNEVSRLESEVGHWRHIAQTSKAQGSDIADQSEICKLQNIIKELKQNRSQEIDNHQHEMSVL QNAHQQKLAEITRRHREELSDYEDRIEELENLLQQDAENEIKRLSNLNQDNNLAEDNLKLKMHVQVLEKENSLLNQEKEE LHMSLSKLNNEYEVVKSTAARDVDLDSELRDLRRNLEAKEQELNQSITEKEILIAELEELDKQNQEATKHMILIKDQLSK QQNEGDNIISKLKKDLSDEKTRVHQLENDKMNITRELDVQKEKLIQSELVLNDLHLSKQKLEDKVDDLVDQLNKSHTQNL SIQKENFELQEHIKQKEEELSRVRDELMQSLNQDSDSNFKDNLLKEREAEVRNLKQNLSEIERLNENLKKVAFDLKVENE KLNLACEDVRHQLEESLAGNSLIAVEKNAIVEALKLEKEQLEAELRQAEKRLLEEASKYEQTIEELSHARHSSTSALQLD HERLIKLNQEKDFEITELKKNIEQMATDHKETKKILSSSLEEQKQLTQLVNEKESFIEKLKERSSELQEELNKYTQALRK NEILRQTIEEKDRSLGSMKEENSHLKEELERLREQQSRAAPVAEPKTLDSITELESEVNQLNIIKDNLEEEIKHHQKIIE DQNQSKIQLLQSLQEQKKEMDEFRYQHEQMNTTHTQLFLEKDEQIKNLQKTIEQIKTQLHEERSDIQTENSDIFQETKVR GLSIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSY PQDVVYLQQQLQAYAMEREQVLAVLSEKTRENSHLKTEYHKMMDIVAAKEAALNKLQDENKKLFTRFESSGQDMFRETIQ NLSRIIREKDIEIDALSQKCQTLLTVLQASNSGNEVGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA QLQEELHQLQAQVLVDSNNSSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPPLSSES STASQTAESLRIINSDVSSESSKQEIEELRRSLQEKDATIRTLQENNHRLSDSIAASSELERKEHEQTDSEIKLLKEKQE SLQKSLKEKDLLIKAKSDQLLSLNENFTNKVNENELLRQAVTNLKERTLILEMDICKLKGENEKIIETSRGKETEYQALQ ETNMKFSMMLREKEFECHSLKEKALAFEQLLKEKEQVQHLRDKELRLNQELERLRNHLLESEDSYTREALAAEDREAKLR KKVTILEEKLVSSSSAMENASHQANLQVESLQEQLNVVSKQRDETALQLSLSQEQAKQYALSLSNLQMVLEHFQQEEKAM YSAELEKHKQLVAEWKKKAENLEGKLVSLQERLDEANAALDSASRLTEQLDLKEEQIEELKKQNELQQEMLDDVQKKLMN LVNSTEGKVDKVLMRNLFTGHFHTPKHQRHEVLRLMGSILGIKKEEMDQQQCTNGFDLDRSSGQCLDVDECRTIPEACRG DMMCVNQNGGYLCIPRTNPVYRGPYSNPYSNPYSGSYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDS HQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATEN PCVQTCVNTYGSFICRCDPGYELEDDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDDNRSCQDINECEHR NHTCILQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYP GAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_043345635.1 fibulin-5 isoform X2 [Cervus canadensis] MPGFKRILTVTILALCLPSPGNAQQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPY SNPYSNPYSGSYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW LLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELED DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDDNRSCQDINECEHRNHTCILQQTCYNLQGGFKCIDPIRC EEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPI SATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_002719642.1 PREDICTED: fibulin-5 [Oryctolagus cuniculus] MPGFGRILTVTILALCLPSPGNAQQQCTNGFDLDRQTGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPY SNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW LLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELAD DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCTLQQTCYNLQGGFKCIDPIRC DEPYLRISDNRCMCPAENPGCRDQPFTILFRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPI SATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_003206713.1 fibulin-5 [Meleagris gallopavo] MQGLKRILTAFTLIICISSPGKAQQQCTNGFDLDRASGQCLDIDECRTIPEACRGDMVCVNQNGGYLCVPRTNPVYRSPY LNPYSNIYPPPQAPGPVPNYPTVTRPLICRFGYQLDENNQCADIDECASDSHQCNPTQICINTEGGYTCSCTEGYWLLEG QCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECTGENPCSQTCVNTYGSFLCRCEPGYELEADGVN CSDMDECSFSEFLCQHECVNGPGSYYCVCPSGYNLLDDSRSCQDINECETRNFTCTLQQTCFNIPGEYKCLDPVRCEEPY IQINENRCMCPAENPGCRDQPFTILYRVMDVLSGRSVPSDIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATL VMTRPVKGPRTVQLDLEMITVNTVINFRGSSVIRLRIFVSQYSF >XP_005506202.1 fibulin-5 [Columba livia] MQGLKRILTAFTLAVCLSSPGKAQQQCTNGFDLDRASGQCIDIDECRTIPEACRGDMVCVNQNGGYLCVPRTNPVYRSPY LNPYSNIYPPVPAPGPVPNYPTVTRPLICRFGYQLDENNQCADVDECASDSHQCNPTQICINTEGGYTCSCTEGYWLLEG QCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECTSENPCTQTCVNTYGSFLCRCEPGYELEADGVN CSDMDECSFSEFLCQHECVNGPGSYYCICPSGYNLLDDSRSCQDINECETRNFTCTPQQTCFNIPGEYKCLDPVRCEDPY IQINENRCMCPAENPGCRDQPFTVLYRVMDMVSGRSVPSDIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATL VMTRPVKGPRTIQLDLEMITVNTVINFRGSSVIRLTIYVSQYSF >XP_031553546.1 fibulin-1-like [Actinia tenebrosa] MTGFIWTRRCLSLILVFVVFIAYVGLTQAAMIDWVNRCCIKGRQKAENFKGHFEVCNKDDLDRRTFTSVMDRMVCRMSER VCCVKELQKVACERGKYQAFQAKSCARPHGNAGADRYIECCDCCALGIKARSVGVGCDTVKWNDPCKTVYQECCSGQKVT ASPYLTLSPPILTPAPSTKQPIAQRCAAGVCQHICREDSSRNPICYCRNGYFIASDSKNCLDVNECTMSTPVCSDDQKCI NTEGSYRCIPKSKPTPTLLAACSNDGYELVRGSCQDINECERGTSTCSSEQTCVNTIGSYRCTCARGYEVSGQRCVDKDE CRTSEARCPPGSVCRNLPGTYICSRPNQCPAGKRKTASGCVDIDECAGGNSPCGSDTRCINTDGSYRCVPCGKGFRADNN RCVDKNECTNGEARCPQRTVCRNTPGSYTCTRITCPAGKRSTASGCVDIDECATNLAKCTGNRRCINTDGSYRCAPCPTG TRAENNACVDIDECAENRYRCQSNQKCVNTPGSYRCVDVPVIACLSGYENVNGKCVDIDECVKYKSICPSGKQCKNEKGS YSCLSQSQCQNGYKLVNGRCEDIDECVEYRVRCPTGQVCSNIRGSYRCERRQQCTSGYEFKNGRCLDIDECTISNACRSA GQRCENYAGSYRCVDVVSRSCSRGYKLVDGKCVVSDDPCADILCPSGYECKLKSNRPVCKDIDECLRNPCKRDETCVNKP GTHLCVCKSGYEKNQFDRQCRDINECFRGYCEHNCVNSPPGSFTCSCHPGFRLDINKRSCIDINECATQRPCQNGRCTNT RGSYYCSCHQGFRLTANGRCEDIDECNANVYGRPCEYNCTNIVGSYRCECPSGYEQTADRHSCRDIDECKQGSAICGRGT LCRNTNGHYRCIPFSCPRPYYSLQGDSKCLRNCPEGDRACSQLKDKVYQFWTFNIVVGSPPGNIFAYKIIAQGYRKPDIR YRFRRGNELGHFEIKRVGADQAQIWNRITFRQRHDYVLEFVGELFDGGDLISRYVHTLYVFVSAYR >XP_006230804.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Rattus norvegicus] MFVRFWEAQNPVTRRCECTEGFRRHSPRMLPFASCLPGSLLLWAFLLLLLGAASPQDSEEPDSYTECTDG YEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISDLHSEGPPPPAASAQHPNPCPPG YEPDEQESCVDVDECTQAIHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPG SFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECSYSSY LCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQV SDNRCLCPASNPLCREQPSSIVHRYMSITSERSVPADVFQIQATSVYPGAYNAFQIRAGNTQGDFYIRQI NNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_508563.4 EGF-containing fibulin-like extracellular matrix protein 2 [Pan troglodytes] MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDNQESCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_013976587.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Canis lupus familiaris] MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEYPNPCLPGYEPDEQERCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCNDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >NP_001069517.1 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Bos taurus] MLPFASCLPGSLLLWALLLLVLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEHPHPCLPGYEPDEQERCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_009244407.2 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Pongo abelii] MEGVGEAVCSERTTWLKTVLGVEGRREREGQFCSWEPLVPGHCPSQPSRQSRGPRGRRGPNPRMLPCASC LPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGG YLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQESCVDVDECAQALHDCRPSQDCHNLPGSY QCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRC FNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCQCPQGYQLLATRLCQDIDEC ESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVP ADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYR ASSVLRLTVFVGAYTF >XP_005660736.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sus scrofa] MLPFASCLPGSLLLWTLLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVSPAEHATPCLPGYEPDEQENCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYAF >XP_034788933.1 EGF-containing fibulin-like extracellular matrix protein 2 [Pan paniscus] MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQESCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_023095846.1 EGF-containing fibulin-like extracellular matrix protein 2 [Felis catus] MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEHPNPCLPGYEPDEQERCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCNDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGTHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_027815637.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Ovis aries] MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEHPHPCLPGYEPDEQERCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_030871753.1 EGF-containing fibulin-like extracellular matrix protein 2 [Gorilla gorilla gorilla] MLPCASCLPGSLLLWALLLLFLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQESCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_023814831.1 EGF-containing fibulin-like extracellular matrix protein 2 [Oryzias latipes] MQAACVSNLCVCICVSVLLHSVLSQLQRETDTYTECTDGYHWDPQTDHCRDINECETIPDACKGEMKCFN HYGGYLCLPRSASVIAASESPIAPTVPFNPCPVGYESHGDSCVDVDECVRHEHDCQPSQECINTLGSFTC QCPRGYRKVGMECIDIDECRYRYCQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECEMGAPCSQRCYN TYGTFLCRCDQGYELGQDGFTCNDIDECSFSSYLCQFQCVNEPGKFSCVCPEGYQLQGTRTCQDINECET GEHQCTDTQTCVNIHGRYQCVDNDRCQDPYVQVSDNRCVCPIINPVCRDLPFSVVHRYMSITSERTVPSD VFQIQATSVSVGAYNTFRIRSGDDNGDFYIRQINNLSAMLVLARSVSGPREYTLDLEMVSINPLLNYQGS HQSSSVLRLSIYVGQHAF >XP_017898583.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 [Capra hircus] MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEHPHPCLPGYEPDEQERCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_019347973.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Alligator mississippiensis] MEMSQRRGLPAGGGACAPGAGPGGRQRVGRRILGPAAAQQGPEGRAGPGSGPCRPPGHGPGVVAAAGGAG AGRAVPGAGGAGHVHGVHRRLRVGRRDPVLQRRGRVRDDRGRLQGRDEVHQPLRRLPLPAALRLRHQRRH RPGPRPPGSATAPPASAPTPPQPLSPRLRPRQPGRLRGRGRVRAGAARLPAQPGLPQRARRLPLRLPVRI PQDIDECRFRYCQHRCVNSPGSFACQCEPGFQLASNNRSCVDVDECGMGAPCAQRCLNTYGTFICRCGPG YELDADGFACNDIDECSYSSYLCQFRCVNEPGKFSCTCPQGYQLLGTRLCQDINECETGTHECTESQTCF NFHGGWRCLEKNRCVEPYVQVSDNRCVCPASNPRCREQPSSIVFRTMALAAERPVPADVFQIQATSVYPG AYNSFHIRAGNDQGDFYIRQITNVSAMLVLARPLTGPRELVLDLEMVTTNALLSYRARALLRLTVLVGAH PF >XP_015804092.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Nothobranchius furzeri] MQGACVSVLCVCICVSVLLRSAISQSHRETDTHTECTDGYHWDPQTEHCKDINECETIPDACKGEMKCFN HYGGYLCLPRSASVIPAPEPPITPTEAFNPCPLGYEQLGDSCVDVDECERDEHDCQPSQQCINTLGAFTC QCPDGYRKVGTECIDIDECRYRYCQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECEMGAPCSQRCYN TYGTFLCRCDQGYELGPDGFTCNDIDECSYSSYLCQYQCVNEPGKFSCMCPEGYQLLGTRMCQDINECET GQHQCSESQTCVNIHGRYQCVDNDRCQDPYIQVSDNRCVCPVNKPACRDLPFSVVHRYMSITSERSVPSD IFQIQATSVSAGAYNTFRIRSGDDNGDFYIRQINNISAMLVLARAVSGPREYTLDLEMVSVNPLLSYQGS YQTSSALRLSIYVGPYSF >XP_020762130.1 EGF-containing fibulin-like extracellular matrix protein 2 [Odocoileus virginianus texanus] MLPFASCLPGSLLLWALLLLLLGAASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMK CINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAEHPHPCLPGYEPDEQESCVDVDECAQALHDCRPSQEC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMG APCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRL CQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYVQVSDNRCLCPASNPLCREQPSSIVHRYMSI TSERSVPADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTM NSLMSYRASSVLRLTVFVGAYTF >XP_030252235.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sparus aurata] MQGACVSVLCVCICVSVLLRSAISQPPKESDTYTECTDGYHWDAQTEHCKDINECETIPDACKGQMKCYN HYGGYLCLPHTAEVFPAPEPAITPTVTNPCPLGYESQGDSCVDIDECERDEHDCQPSQQCINSLGAFTCQ CPDGYRKVGTECIDIDECRYRYCQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECDMGAPCSQRCYNT YGTFLCRCDQGYELGPDGFACNDIDECSYSSYLCQYQCVNEPGKFSCVCPEGYQRQGTRLCQDINECETG EHQCTDTQTCVNIHGRYQCVDSNRCQDPYVQVSENRCVCPVNKPLCRDLPFSIVHRYMSITSERSVPSDI FQIQATSVSPGAYNTFRIRSGDENGDFYIRQINNISAMLVLARAVSGPREYTLDLEMVSVNPLLSYQGSY QTSSALRLSIYVGPHTF >XP_040184836.1 EGF-containing fibulin-like extracellular matrix protein 2 [Rana temporaria] MRLSCYLVFCVLLVPSLQQENEEPNTFTECTDGYEWDSERHHCKDINECLTIPDACKGEMKCINHYGGYL CLPRSASVISDSQPDPGPAGSPQGGAETDQRNNPCPNGYQPDSQGLDTCVDVDECALEMDDCLPSQDCVN IPGSFHCKCPEGYRKIGNECIDIDECRYRYCQHRCVNSPGSFTCQCEPGFQLASNNRSCVDVNECSMGAP CQQRCYNTYGTFLCRCNQGYELDQDGYTCNDIDECSYSSYLCQHQCVNEPGRFSCICPDGYSLLGTRLCQ DINECETGAHTCTEQQSCVNFHGGYRCVEKNLCIEPYIQVSDNRCMCPSSNPLCRDEPGSVVYRYMSIMS DRSVPSDIFQIQATSVYPRAYNTFQIRSGNEQGDFYIRQINNISAMLVLARAITGPQEYVLDLEMLTTNS LLSYRSSSVLRLTIFVGAHSF
Mafft alignment of selected proteins >NP_058634.4 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Homo sapiens] ------------------------------------------------------------ ----MLPC---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGSASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDDQ-----DSCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCINEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYI Q-VSEN--------RC-----LCPASNPLCR--EQPSS-IVHRYMTITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >KAG6798541.1 fibrillin-1 [Apis mellifera caucasica] ------------------------------------------------------------ ----MTRFTDLR----MIFFLLLTIQLEKFFLRKQGILFSEARMEEQFEKCCGLGTSWAL EG----LRCEKFTG-PVSGVPT---VEQGLCLEAVD-------------ICCVRAYHEQQ CKKGKLDA---------HAGLACVSGSKSKRLGPGDYHRDCCEACKLGILTGSMGQGCAF KKFTFGNPWDPAFL------------------------------------ECCYEASPST TTTFT------------------------------------------------------- ----TNLTNATSSSETT-----------------NSESTSISSPSSSSSSSSSSSSSSSS SSSSSSS--------LSTQTTLASSTSFSPSIPTPPLDDICQLMKGLLCSDICVPTPGSY YCKCREGFTL-------LEDGKTCRQDLPIDRCK------------------------SS NPCEQRCTD-------NGVAVICSCNPGYVLAE---DKHSCLPKASEAKTTTIPEDNDFS L----------------------------LCPAGYRYNATNQ----VCDDVNECIERRIC P----GYCENTIGSYICTSKNRLKIDSYED----CPPGYQWESTTGLCSDIDECLILSKP CPGIKNVCVNTQGSFSCLEMKGIKSCPAGFKFNNFSQQCEDVDECAEKIHSCLEDTEKCR NTEGAYECDIKCDKGFIYSINLGICIDVDECLGSNNLCLDPNTTCKNI-------LGGY- -ECLSLNRSIVSIDEQ-------TEPSICSAGYKPMNDSNDACIDVDECKEQL--HSCEI NEQCVNDIG---------------SYRCEPLNYHEVTNLNGKDKDHHNY--LYERNGHKS YIQRYDINGYKSQI------------------------------SVSPAFNQTVICNEGF IFDQRTLSCIDIDECSNGLANCKIDEKCINFNGGYKCSPICPSG-----FQYN-DTYYSS RNE---------------------------------PSCRDINECAL------------- -GLHSCNV----------STHYCVNTNGSYSCKEFATTISSPRISK--QLNSKKDYIMQN TNHYSFLEPCKKGYIRDV----------------------KSGEC---VDIDECA-SIRA CQEHEVCRNVPGDFECTPLCTTGWYFNTVTKGCQDVDECLLGRHDC---PENTHKCVNTN GSFFCELIPPCSTGYK--------RSFFNGSCVDIDECEENLHSCRLEL-------HQYC VNRNGTFECLT-RLPSCPTGYE---------------YSLATRRCEDIDEC----VTN-- QYT-------CDSRL-FERCINLP-----------------------GTYRCERPAS--- -----IRQHQRQKPACPSGYRYHPRLKKCTDIDECAEGLDSCEGEVCYNQPGGYSCAKLP KPRTRKPPTTALPLPKNKKCIPGTKLVNNRCVDIDECREI-EDAC--SSNEECINTVGSY SCE---CKLG--FQRENLTQ-ACVDINECQTQ---------------------------- -------------TDSCTQGQRCDNTIGSYTCTR-------------------------- ------------------------------------------------------------ ------------YLSCGTGYTLNAATEICEDDDECLLGTHDCGKGYHCRNTLGSYRCDRN PRVPFLESRFDIATTTT---------------TKST--SIAP-TSTTLSSQEQINCQRGF ESV-PGDKCE-DIDECEKNPNIC-GRTMRCLNTLGSYRCVSK------------------ -------VLCSNGYTLDPVVG----RYCIDIDECANGTHECTADQTCENRIGGYVC---- -----------------SCPSGH----VVGP----NKDCIDIDECSLYGNICG-SNSRCE NT-VGSFKCN-----CENGFEHVSSF-AGNTCQDIDECARTPGLCQH--NCFNTWGSYKC -ICKSGFKLNPDNRSCTDIDECT---EFKDNLCVGICENTPGSYACKCPDGYKLGHNGRT CEDIDECQAG---HICRDADEICHNVRGSYRC-NKIKCPN-----------------GYH R-DHER------KNRCVRS-WPCHINDHACI--RQPSH-YSYNFITLVSM---LPVMPNR PEE---LFKMKGYHL--PGSAIQF---SMAFLEARAP-PGIQRATESCFALRKPE----- ---PTQAVLVMTQSIQGPQEIELDLNMEVYHNA------HFAGSAIAKILIFVSQYEF >CAE1173162.1 FBLN1_2 [Sepia pharaonis] ------------------------------------------------------------ ----MLTFLS------LSLLLLLGLPK------------AHSSLLDIRDICCTLGSQYGA LK----NTCSRYIA-PLTNIKP---EDEENCRVIVE-------------ICCMKEIHYKQ CLKGRTDA---------EEKKLCQVNADVY---GAEQYSQCCQCCRLGKVAVQSGLHCNL --TNYGDPCDTTFR------------------------------------ECCQAER--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------IRLSGGN------------------------- ----------------------------------------PYSSCDL------------- --NNPC-------------DHFCENDGYSFKCI--------------------------- ---------CRTGFVL-------------------------NADR-------------RT CS---------------------------------------------------------- ---------------------------------DINECLQFPRPCPD---------RQRC INIPGNFICR--QEANCPEHAI----------------------------------FNRL TSS-------CRCQ---SKMVYNV-----------------------TSKEC-------- --------------QCPPGFAYNI------------------------------------ --------------------------VERLCEDIDECIVQ-AHNC--NISHQCLNLEGSF QC----CRTG--FTANQDQL-QCEDIDECGLA---------------------------- --------------DSCPLGLQCYNSPGSFVCRR-------------------------- ------------------------------------------------------------ ------------SRSCGTGYSLNEITQQCDDIDECAQGVHNC-GTSRCKNIQGSFRCEMP SHST---------------------------PCPAG--SIFNSQTETCESQSRETCDPGF WIK--NGICV-DINECTERVDQC-GLHQVCHNTRGSYQCSNT------------------ -------ISCGPGLW-YDDVG----SRCKDIDECAAGNHTCHSNQVCRNTPGGFEC---- -----------------DCLAGY----LALS----NGFCEDINECSHHRRYCP-RNANCI NT-PGSFRCE-----CKAGYESIGT---SRQCKDIDECS-MQNPCDH--HCQNTLGSFKC -SCETGYELSLNRRSCQDVDECA----DPYKQCSYQCQNLPGSFQCSCPSGFRMASDQKS CLDIDECKETP--SICRNYDATCINVRGGYKC-PIVQCPS-----------------AYT KSAYGNP---GNSVRCQRP-NICPLRDVECL--TSPIS-LSYNFMTFPSK---IKI---- PTT---LFTISGRVI--ASRYFRF---NLNLISAEPQAPGVLKITQQYFNLRIT------ ---GSSAAVELRQEIPGPQDVELQLIMDMYNSDK----HQLIGQAESKLFIYVT---- >NP_001293876.1 Fibulin-1 [Caenorhabditis elegans] ------------------------------------------------------------ ----MR-----------ICFLLLAFLV-------------AETFANELTRCCAGGTRHFK NS----NTCSSIKS----------EGTSMTCQRAAS-------------ICCLRSLLDNA CDSGTDIA---------KEEESCPSNINIL---GGGLKKECCDCCLLAKDLLNRNEPCVA -PVGFSAGCLRSFN------------------------------------KCCNGDI--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EITHA------------------------------------------ ------------------------------------------------------------ -------------------SEIITG----------------------------------- -------RPLNDPHVL------------------------HLGDR--------------- ------------------------------------------------------------ -------------------------------------CAS--SHC-----------EHLC HDRGGE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KVEC--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SCRSGFDLAPDGMACVDRNECLTRQSPCTQSEDCVNTIGGYICQRR ISRLVPHRHRANRIGNA---------------------------------PRRMRDDP-- ------------------------------YSRAGEYREASQAN---------------- -----TEFGCPMGWL-------FQHGHCVDVDECNLGSHDCGPLYQCRNTQGSYRCDAKK CGDGELQNPMTGECTSITCPNGY----YPKN-----GMCNDIDECVTG-HNCG-AGEECV NT-PGSFRCQQKGNLCAHGYEVNGA---TGFCEDVNECTTGIAACEQ--KCVNIPGSYQC -ICDRGFALGPDGTKCEDIDECSIWAGSGNDLCMGGCINTKGSYLCQCPPGYKIQPDGRT CVDVDECAMGE----CAGSDKVCVNTLGSFKC-HSIDCPT-----------------NYI H-DSLNKNQIADGYSCIK---VCSTEDTECL-GNHTRE-VLYQFRAVPSL---KTII--S PIE---VSRIVTHMG-VPFSVDY----NLDYVG------------QRHFRIVQE------ ---RNIGIVQLVKPISGPTVETIKVNIHTKSRTG-----VILAFNEAIIEISVSKYPF >XP_039248222.1 fibulin-1-like isoform X2 [Styela clava] ------------------------------------------------------------ ----MMN----------RILIYIAVSL--------------------------------- ------------------------------------------------------------ ---------------------LCDLTYGDT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VMKSLLV------------------------TSGKN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAVCGDGLRYSE-GQGCGDIDECREIV-PCQLGQRCRNYYGSYQCV-- -------------------------------------------------------CPRGY NMDIKTNECV-DKDECAMG--FC-GNGQKCTNTLGSFHC--------------------- --------ECSQGMQ---RIG----RFCRDINECMH--KPCADNQYCINTRGSYVC---- -----------------QCKAGY----REAG----NGTCADVDECRQ--GMCGALGETCK NT-DGSYECV-----CKPGYGKDEMT-QGRYCKDIDECK-IRSTCPQYSECQNLPGSFLC -RCHRGFTY--INGACVDKHECT---HGEGRKCQWKCTDLPGSYKCICPEGYEQI--NFN CIDINECDRHM--SSCGS-GETCVNTRGGFECVRPPKCPLTASGDSIYRKVMKTDEFGYR Q-VTTNI---CRRQRCGKMAERDSMSVKECK--AEPLS-VSYHYVAVTSG---LPK---- PTA---VLHISYPAR-RRRQRYN-----FSIVQGNEE---------GIFMIKQHSM---- --YMPRAQLVVTGNLNGPSRHTVKIDMATYQPNG-----KMRDSRMLTITIFTSMYDF >XP_787649.4 fibulin-1 isoform X2 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ----MKVYI-------SLITLLVCFSF------------CHASLIDVMPDCCERGASFAG LG----RTCDDLEA--IPDIAP---GDHGICMVIMK-------------SCCANSLGPVL CERALNHR---------MNVGSCQTMNNDT---CFSAGRECCDCCELGINAFHDGIECES --MRTGTSCDRAFA------------------------------------YCCKAAA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SSFDENECSL------------Q TSHRLC-------------TERCVNLIDNYVCE--------------------------- ---------CHPGNHL-------------------------LEDN-------------IT CVADGDTRPPPRYL---------------------------------------------- ------------------------------------ACSQ--APC-----------QHEC RQVGREYECY------CRTGYE---------------LLSDGYTCEDVDEC---AVTD-- SLA-------CNYA---ERCLNTI-----------------------GSFNCISD----- -------------VVCRSGLKYDP------------------------------------ --------------------------VNQYCVDIDECAER-TDTC--DERSICENRYASY TCQHASCPTG--YYYDRTVS-QCNDIDECARG---------------------------- -------------THECLDGARCDNLPGSFHCTR-------------------------- ------------------------------------------------------------ ------------IVPCGTGYTINGVTQQCVDVDECSQQSHDCEINELCINIRGSYDCQS- -------------------------------------------------------CPRGF KTNGNVNRCTQDINECQEGTFDC-REGTRCENNVGSYTCISI------------------ ---------CMTGFE-YNRIL----RACMDVDECRRGLANCATYEICQNTNGSFSC---- -----------------GCRQGF----RQNN----YGQCVDIDECREGLSECK-PNQRCY NL-QGQYQCRN---MCRNGFRFNNF---NSACEDIDECAEGLDVCQNNQRCINQEGGYVC -QCPAGHQANRDRATCEDIDECSL------GLCRGTCENLPGSYVCTCPAGYALMENNVT CKDLDECSTGT--DTCIQ-DEVCFNTRGGHKC-ESVVCPE-----------------YYQ VRTSND------NIQCVKT-CPRTGNAPDCPPGNLNST-ISHTFVALPSIPF-LRQ---- PIR---LLTIGLPN--YRSAYGGSSQTYFRSISGNED---------QYFVITRLFPRG-- ---LPTGYVSLQKPISGPFETVLHLEIVTEVRNPVTRRTEVTATSYLMIHIDVGEQSY >XP_038061268.1 fibulin-1-like isoform X2 [Patiria miniata] ------------------------------------------------------------ ----MWHQV-------ASVLLAFLITA------------NAVQLQHSISICCDVGAEYAN EH----SSCEAIDSEPVPDMGPMEDEDIQDCHVMMR-------------SCCIKQLQRNM CFDGLFTR---------ANIGSCDRVQGDS---CGSIEKTCCECCELGIKAFHESAPCDG --TDLGTECDFAFR------------------------------------DCCGRAS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SNNDMDECTLA----------RE NNHRLC-------------SSKCVNLITSFVCE--------------------------- ---------CPVGYVL------------------------AAADN-------------MT CIRD---REEPA------------------------------------------------ -----------------------------------NACDE--SPC-----------EQRC QPNGSSYVCG------CNDGYE---------------LQENGYSCLENNPP---PSLGCL YAS-------CDYA---CRSVDA------------------------SSYEC-------- --------------YCDTGYDLDS------------------------------------ --------------------------DGTTCIDIDECQEE--NVC--PLHKRCQNYRGGF YCETTRCAEGEQFVFDESNNIQCRDVDECARG---------------------------- -------------THNCQDGFRCDNSPGSFRCTR-------------------------- ------------------------------------------------------------ ------------ISPCGTGYTVNSLTQQCRDIDECLQDTDDCPPEFYCQNTMGSYKCRP- -------------------------------------------------------CRQGF KAD-SADGCTRDINECEEQADVC-PRGQACVNTYGSYRCNPA------------------ ---------CPQGFQ-YSVIY----RECRDINECALGTDDCQANQVCQNREGAYEC---- -----------------GCRNGMEF--NEVT-----RECDDINECETNTNNCR-YNEQCH NT-VGSFACQQ---RCQLNYRYVE----EEGCVDVNECEQAQYPCFGNSQCVNVPGSYRC QQCPRGQIANRDTRRCEDVDECK----YQGASCMGGCVNTFGSYMCTCPNGYELL-NRFN CRDINECRRNI--HNCSS-QSACFDTRGGFKC-KNIQCPQ-----------------YYR KEINGD------EVRCVKV-TLCPNNDFNCV--DDPVKLITYNKIALPSLTRELRQ---- PLQ---LLRLQIGDL-TVSQANGL---RFVLTQGNEL---------GLFSVTKDLNRDRL GNWFATGTLYLERAVTGPFETDLRLEMQLFSTTQ---ENQLLSVTTAVFSIDVSPNSF >NP_001284712.1 uncharacterized protein Dmel_CG31999, isoform C [Drosophila melanogaster] ------------------------------------------------------------ ----MFYKLCA-----FMCFLIVGGHVTT-------TM-ASDSISGYIRKCCINGLRHAR TT----ASCKKIDI--APTIIP--QLWLGLCHSTLE-------------VCCSRELDHQD CELGRLAA---------LDGTRCDGEGNVT----SSSYATCCRSCQIGLAVKASKANCKD -PLFSFIFLIESYR------------------------------------ACCYGSA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DFKDQPGIDEIDKA--------NSITDEGELPFVSEEDMNVTIV------------ -------------------------------------LTGDDDICGK------------- -IENLC-------------AHICENTFDAYQCK--------------------------- ---------CHPGFML-------------------------DNNN-------------VT CSPMKT------------------------------------------------------ --------QICPSGYN--------LDKLDNKCIDIDECREDLHDCKS---------SQYC HNTNGGYHCLNVKEKECPPGFH---------------YDHDYDACKD------------- DYK-------CKDR------------------------------------KCVKI----- -------------QSCDKGFSL-------------------------------------- --------------------------HNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSY SCN---CLPG--FNLDATLN-KCVDINECSIN---------------------------- -------------NHNCLPTQRCDNTIGSYICTR-------------------------- ------------------------------------------------------------ ------------LQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRK ISTMLTTRTTSTTVPPL-SLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF YRN-TLGACI-DTNECMEQ-NPC-GNHERCINTNGHFRCESL------------------ -------LQCSPGYK-STVDG----KSCIDIDECDTGEHNCGERQICRNRNGGFVC---- -----------------SCPIGHELK-RSIG---GASTCVDTNECALEQRVCP-LNAQCF NT-IGAYYCE-----CKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQ--KCLNFWGGYRC -TCNSGYQLGPDNRTCNDINECEV--HKDYKLCMGLCINTPGSYQCSCPRGYILAADMNT CRDVDECATDSINQVCTGRNDICTNIRGSYKC-TTVNCPL-----------------GYS I-DPEQ------KNRCRQN--LNFCEGEECY--TQPSA-FTYNFITFVSK---LMI---- PPDGRTIFTLRGPLW-YDNIEFD-----LKIVRIQAT-TNIQKATDGSFDTLQN------ ---NNQVNVILKKSLEGPQDIELELSMTVYTNG------MPRGKSVAKLFLFVSQHTF >tr|A2CEN1|A2CEN1_DANRE EGF-containing fibulin extracellular matrix protein 2a OS=Danio rerio OX=7955 GN=efemp2a PE=1 SV=1 ------------------------------------------------------------ ----MR------------------------------------------------------ ------------------------------------------------------------ --------------------PGC------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------FC--MCISVFLHRAIS- ------------------------------------------------------------ -----------------QPPTETDT----------------------------------- ------------------------------------------------------------ ------------YTECTDGYHWDSQTQHCKDINECETITEACKGEMKCFNHYGGYLCLPR SASVIPAAEPPNQ------------------------------IDPSLENRVSEPFNS-- ------------------------------------------------------------ ---------CPLGFE--PQQ-----DSCVDVDECERDSHDCQPSQQCFNTEGSFSC---- -----------------QCPDGY----RKVG-----TECIDIDECRY--RYC---QHRCV NV-PGSFSCQ-----CEPGFQLAGN---NRSCIDVDECG-MGAPCSQ--RCYNTYGTFLC -RCEQGYELGPDGFACNDIDECS----YSSYLCQYQCVNEHGKFSCVCPEGYQLL-GTRL CQDINECETGA--HQCSE-GQTCVNIHGGHKCVDNKSCQD-----------------PYM Q-VSEN--------RC-----MCPVSKPACR--DMPYS-IVHRYMSITSE---RSV---- PSD---IFQIQATSV-YPGAYNT-----FRIRSGDDN---------GDFYIRQIN----- ---NISAMLVLARAVNGPQEYVLDLEMVSINPLM-----SYHSSSALRLTIYVGPYAF >NP_067449.3 EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor [Mus musculus] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--AFLLLLLGAASP- ------------------------------------------------------------ -----------------QDPEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVISDLHGE---------------------------------GPPPPAAHAQQPNP-- ------------------------------------------------------------ ---------CPQGYE-PDEQ-----ESCVDVDECTQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCNQGYELHRDGFSCSDIDECG----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECETGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRSGNTQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_018113173.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X3 [Xenopus laevis] ------------------------------------------------------------ ----ML------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LF-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SS--VLFSLLLVSSRQ- ------------------------------------------------------------ -----------------QESEGPNS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDRERQHCRDINECQTIPDACKGELKCINHYGGYLCLPP SASVISDSQTEQGTSE---------------------------LQPPVDHELDQRPNT-- ------------------------------------------------------------ ---------CPSGYQ-LDPQGQ---GSCVDVDECEHQLHDCLPSQDCINMLGSYHC---- -----------------KCPEGY----RKIG-----NECVDIDECRY--RYC---QHRCV NY-PGSFVCQ-----CEPGFQLASN---NRSCVDVNECS-MGTPCQQ--RCYNTYGTFLC -RCNQGYELSHDGYTCTDIDECS----YSSYLCQHQCVNEPGSFSCSCPEGYQLL-GTRL CQDINECELGT--HSCSE-QQTCVNFHGGYQCVEKNRCQE-----------------PFI Q-VSEN--------RC-----MCPGTNPLCH--DEPGS-VVYRYMSITSD---RSV---- PSE---IFQIQATSV-YPGAYNI-----FQIRSGNEQ---------GEFFIRQIN----- ---NLTAMLVLARPVIGPKEYVLDLEMLTTNSLL-----SYRSSSVLRLTVFVGAHSF >XP_025004920.1 EGF-containing fibulin-like extracellular matrix protein 1 [Gallus gallus] ------------------------------------------------------------ ----MM------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AM--FLAALILITVHS- ------------------------------------------------------------ -----------------QETEETIT----------------------------------- ------------------------------------------------------------ ------------YTQCTDGYEWDPVRQRCKDIDECEIVPDACKGGMKCVNHYGGYLCLPR TAQIIVNEREEAAAEST-SGRNNV-------------------IRRTPADPHRAPPNP-- THQ--------------------------------------------------------- -------IQCAAGYE-QSEH-----NVCQDIDECATGTHNCRADQVCVNLRGSFSC---- -----------------QCPPGY----QKRG-----EQCVDIDECTLP-PYC---HHRCV NT-PGSYYCQ-----CNAGFQLASN---NHTCVDINECD-ANNPCAQ--QCYNILGSFIC -QCNPGFELSSDRINCEDTDECR----TSSYICQYQCVNEPGKFSCVCPEGYQVV-GGRT CQDINECET-T--NECRE-DEICWNYHGGFRCYPINPCQE-----------------PYV L-TSEN--------RC-----VCPVSNTICR--ELPYS-VVYKYMSIRSD---RTV---- PSD---IFQIQATTI-YPNTINT-----FRIKSGNEN---------GEFYLRQTS----- ---AVSAMLVLVKSLSGPREHIVDLEMLTVNSL------NYRTSSVLRLTIIVGPYAF >XP_006021628.1 EGF-containing fibulin-like extracellular matrix protein 1 [Alligator sinensis] ------------------------------------------------------------ ----MM------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VT--FLAAFVLTTVSS- ------------------------------------------------------------ -----------------QETEETIT----------------------------------- ------------------------------------------------------------ ------------YTQCTDGYEWDPYRQQCKDIDECEIVPDACKGGMKCVNHYGGYLCLPR TAQIIVNEQDAATADSA-GGRNSV-------------------IRRTPVDVQQGPPNP-- THQ--------------------------------------------------------- -------IQCATGYE-QSEH-----NVCQDIDECATGAHNCRTDQACVNLRGSFRC---- -----------------QCLPGF----QKRG-----EQCIDIDECTLP-PYC---HHRCV NT-PGSYYCQ-----CNPGFQLASN---NHTCVDINECD-ANNPCAQ--QCYNILGSFIC -QCNPGFELSSDRINCEDVDECG----TSSYICHYQCVNEPGKFSCVCPEGYQVV-GGRT CQDINECET-T--NECRE-DEMCWNYHGGFRCYPRNPCQE-----------------PYV L-TSEN--------RC-----VCPVSNTICR--ELPYS-IVYKYMSIRSD---RNV---- PSD---IFQIQATTI-YPNTINT-----FRIKSGNEN---------GEFYLRQTS----- ---ALSAMLVLVKSLSGPREHIVDLEMLTVNSL------NYRTSSVLRLTIIVGPFAF >KAF4018076.1 hypothetical protein G4228_009546 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ----MSSWLGGLGSGLGQSLGQVGGSLAS----------LTGQISNFTKDMLMEGTEEVE ADLP-NARRKEVEA-IHTILRSENERLKKLCADLEEKHEASELQIKQQSMNYRHQLQQKE VEISHLKARQIALQDQLLKLQSAAQSVNSG--AGGVPATTASSSFGYGLSHHASGFHDDD --MDFGDIISSQREINRLSNEVSRLESEVGHWRHIAQTSKAQGSDIADQSEICKLQNIIK ELKQNRSQEIDNHQHEMSVLQNAHQQKLAEITRRHREELSDYEDRIEELENLLQQDAENE IKRLSNLNQDNNLAEDNLKLKMHVQVLEKENSLLNQEKEELHMSLSKLNNEYEVVKSTAA RDVDLDSELRDLRRNLEAKEQELNQSITEKEILIAELEELDKQNQEATKHMILIKDQLSK --QQNEGDNIISKLKKDLSDEKTRVHQLENDKMNITRELDVQKEKLIQSELVLNDLHLSK QKLEDKVDDLVDQLNKSHTQNLSIQKENFELQEHIKQKEEELSRVRDELMQSLNQDSDSN FKDNLLKEREAEVRNLKQNLSEIERLNENLKKVAFDLKVENEKLNLACEDVRHQLEESLA GNSLIAVEKNAIVEALKLEKEQLEAELRQAEKRLLEEASKYEQTIEELSHARHSSTSALQ LDHERLIKLNQEKDFEITELK-----------KNIEQMATDHKETKKILSSSLEEQKQLT QLVNEKE-------SFIEKLK-ERSSELQEELNKYTQALRKNEILRQTIEEKDRSLGSMK EENSHLKEELERLREQQSRAAPVAEPKTLDSITELESEVNQLNIIKDNLEEEIKHHQKII EDQNQSKIQLLQSLQEQKKEMDEFRYQHEQMNTTHTQLFLEKDEQIKNLQKTIEQIKTQL HEERSDIQTENSDIFQETKVRGLSIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN ISLTKQIDQLSKDEVGKLTQI--IQQKDLEIQALHARISSTSYPQDVVYLQQQLQAYAME REQVLAVLSEKTRENSHLKTEYHKMMDIVAAKEAALNKLQDENKKLFTRFESSGQDMFRE TIQNLSRIIREKDIEIDALSQKCQTLLTVLQASNSGNEVGGVNSNQFEELLQERDKLKQQ VKK---MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSNNSSKLQVDYTG-LIQS YEQNETKLKNFGQELAQVQHSIGQLCNT--------KDLLLGKLDIISPPLSSESSTASQ TAESLRIINSDVSSESSKQEIEELRRSLQEKDATIRTLQENNHRLSDSIAASSELERKEH EQTDSEIKLLKEKQESLQKSLKEKDLLIKAKSDQLLSLNENFTNKVNENELLRQAVTNLK ERTLILEMDICKLKGENEKIIETSRGKETEYQALQETNMKFSMMLREKEFECHSLKEKAL AFEQLLKEKEQVQHLRDKELRLNQELERLR--NHLLESEDSY------------------ -------------------------TREALAAEDREAKLR-KKVT--ILEEKLVSSSSAM ENASHQANLQ-VESLQEQLNVVSKQRDETALQLSLSQEQAKQYALSLSNLQMVLEHFQQE EKAMYSAELEKHKQLVAEWKKKAENLEGKLVSLQERLDEANAALDSASRLTEQLDLKEEQ IEELKKQNELQQEMLDDVQKKLMNLVNSTEGKVDKVLMRNLFTGHFHTPKHQRHEVLRLM GSILGIKKEEMDQQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPR TNPVYRGPYSNPYSNPY-SG-----------------------SYPAAAPPLSAPNYPTI SRP--------------------------------------------------------- -------LICRFGYQ-MDES-----NQCVDVDECATDSHQCNPTQICINTEGGYTC---- -----------------SCTDGY----WLLE-----GQCLDIDECRY--GYC---QQLCA NV-PGSYSCT-----CNPGFTLNED---GRSCQDVNECA-TENPCVQ--TCVNTYGSFIC -RCDPGYELEDDGVHCSDMDECS----FSEFLCQHECVNQPGTYFCSCPAGYILLDDNRS CQDINECEHRN--HTCIL-QQTCYNLQGGFKCIDPIRCEE-----------------PYL R-ISDN--------RC-----MCPAENPGCR--DQPFT-ILYRDMDVVSG---RSV---- PAD---IFQMQATTR-YPGAYYI-----FQIKSGNEG---------REFYMRQTG----- ---PISATLVMTRPIKGPRDIQLDLEMITVNTVI-----NFRGSSVIRLRIYVSQYPF >XP_043345635.1 fibulin-5 isoform X2 [Cervus canadensis] ------------------------------------------------------------ ----MP------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KRILT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VT--ILALCLPSPGNA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPR TNPVYRGPYSNPYSNPY-SG-----------------------SYPAAAPPLSAPNYPTI SRP--------------------------------------------------------- -------LICRFGYQ-MDES-----NQCVDVDECATDSHQCNPTQICINTEGGYTC---- -----------------SCTDGY----WLLE-----GQCLDIDECRY--GYC---QQLCA NV-PGSYSCT-----CNPGFTLNED---GRSCQDVNECA-TENPCVQ--TCVNTYGSFIC -RCDPGYELEDDGVHCSDMDECS----FSEFLCQHECVNQPGTYFCSCPAGYILLDDNRS CQDINECEHRN--HTCIL-QQTCYNLQGGFKCIDPIRCEE-----------------PYL R-ISDN--------RC-----MCPAENPGCR--DQPFT-ILYRDMDVVSG---RSV---- PAD---IFQMQATTR-YPGAYYI-----FQIKSGNEG---------REFYMRQTG----- ---PISATLVMTRPIKGPRDIQLDLEMITVNTVI-----NFRGSSVIRLRIYVSQYPF >XP_002719642.1 PREDICTED: fibulin-5 [Oryctolagus cuniculus] ------------------------------------------------------------ ----MP------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GF----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GRILT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VT--ILALCLPSPGNA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QQQCTNGFDLDRQTGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPR TNPVYRGPYSNPYSTPY-SG-----------------------PYPAAAPPLSAPNYPTI SRP--------------------------------------------------------- -------LICRFGYQ-MDEG-----NQCVDVDECATDSHQCNPTQICINTEGGYTC---- -----------------SCTDGY----WLLE-----GQCLDIDECRY--GYC---QQLCA NV-PGSYSCT-----CNPGFTLNED---GRSCQDVNECA-TENPCVQ--TCVNTYGSFIC -RCDPGYELADDGVHCSDMDECS----FSEFLCQHECVNQPGTYFCSCPPGYILLDDNRS CQDINECEHRN--HTCTL-QQTCYNLQGGFKCIDPIRCDE-----------------PYL R-ISDN--------RC-----MCPAENPGCR--DQPFT-ILFRDMDVVSG---RSV---- PAD---IFQMQATTR-YPGAYYI-----FQIKSGNEG---------REFYMRQTG----- ---PISATLVMTRPIKGPRDIQLDLEMITVNTVI-----NFRGSSVIRLRIYVSQYPF >XP_003206713.1 fibulin-5 [Meleagris gallopavo] ------------------------------------------------------------ ----MQ------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KRILT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AF--TLIICISSPGKA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QQQCTNGFDLDRASGQCLDIDECRTIPEACRGDMVCVNQNGGYLCVPR TNPVYRSPYLNPYSN----------------------------IYPPPQAPGPVPNYPTV TRP--------------------------------------------------------- -------LICRFGYQ-LDEN-----NQCADIDECASDSHQCNPTQICINTEGGYTC---- -----------------SCTEGY----WLLE-----GQCLDIDECRY--GYC---QQLCA NV-PGSYSCT-----CNPGFTLNDD---GRSCQDVNECT-GENPCSQ--TCVNTYGSFLC -RCEPGYELEADGVNCSDMDECS----FSEFLCQHECVNGPGSYYCVCPSGYNLLDDSRS CQDINECETRN--FTCTL-QQTCFNIPGEYKCLDPVRCEE-----------------PYI Q-INEN--------RC-----MCPAENPGCR--DQPFT-ILYRVMDVLSG---RSV---- PSD---IFQMQATTR-YPGAYYI-----FQIKSGNEG---------REFYMRQTG----- ---PISATLVMTRPVKGPRTVQLDLEMITVNTVI-----NFRGSSVIRLRIFVSQYSF >XP_005506202.1 fibulin-5 [Columba livia] ------------------------------------------------------------ ----MQ------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KRILT-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AF--TLAVCLSSPGKA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QQQCTNGFDLDRASGQCIDIDECRTIPEACRGDMVCVNQNGGYLCVPR TNPVYRSPYLNPYSN----------------------------IYPPVPAPGPVPNYPTV TRP--------------------------------------------------------- -------LICRFGYQ-LDEN-----NQCADVDECASDSHQCNPTQICINTEGGYTC---- -----------------SCTEGY----WLLE-----GQCLDIDECRY--GYC---QQLCA NV-PGSYSCT-----CNPGFTLNDD---GRSCQDVNECT-SENPCTQ--TCVNTYGSFLC -RCEPGYELEADGVNCSDMDECS----FSEFLCQHECVNGPGSYYCICPSGYNLLDDSRS CQDINECETRN--FTCTP-QQTCFNIPGEYKCLDPVRCED-----------------PYI Q-INEN--------RC-----MCPAENPGCR--DQPFT-VLYRVMDMVSG---RSV---- PSD---IFQMQATTR-YPGAYYI-----FQIKSGNEG---------REFYMRQTG----- ---PISATLVMTRPVKGPRTIQLDLEMITVNTVI-----NFRGSSVIRLTIYVSQYSF >XP_031553546.1 fibulin-1-like [Actinia tenebrosa] ------------------------------------------------------------ ----MTGFIWTRR--CLSLILVFVVFIAY-------VGLTQAAMIDWVNRCCIKGRQKAE NFKGHFEVCNKDDLDRRTFTSV---MDRMVCRMSER-------------VCCVKELQKVA CERGKYQA---------FQAKSCARPHGNA---GADRYIECCDCCALGIKARSVGVGCDT --VKWNDPCKTVYQ------------------------------------ECCSGQKVTA SPY--------------------------------------------------------- ------LTL--------------------------------------------------- ----------------------------SPPILTP------------------APS---- ----------------------------------------------------------TK QPIAQRCAA--------------------------------------------------- ------------------------------------------------------------ -----GVCQ--------------------------------------------------- -------------------------------------------------HICREDS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SRNPICYCRNGY FIASDSKNCLDVNECTMSTPVCSDDQKCINTEGSYRCIPKSKPTPTLLAACSN-DGYELV R-----------------------------------GSCQDINECER------------- -GTSTCS-----------SEQTCVNTIGSYRCT--------------------------- ---------CARGYEV-------------------------SGQRC--VDKDECRTSEAR CPPGSVCRNLPGTYICSR-------------------------------P---------- --------NQCPAGKR----------KTASGCVDIDECAGGNSPCGS---------DTRC INTDGSYRCV-----PCGKGFR-----------------ADNNRCVDKNEC-----TNG- EAR-------CPQR---TVCRNTP-----------------------GSYTCTR------ -------------ITCPAGKRS-------------------------------------- --------------------------TASGCVDIDECATN-LAKC--TGNRRCINTDGSY RCAP--CPTG-----TRAENNACVDIDECAEN---------------------------- -------------RYRCQSNQKCVNTPGSYRCVDV------------------------- ------------------------------------------------------------ -----------PVIACLSGY--ENVNGKCVDIDECVKYKSICPSGKQCKNEKGSYSCLSQ SQCQNGYKLVNGRCEDI------DECVEYRVRCPTG--QVCSNIRGSYRCERRQQCTSGY EFK--NGRCL-DIDECTIS-NACRSAGQRCENYAGSYRCVDVVSRSCSRGYKLVDGKCVV SDDPCADILCPSGYECKLKSNR---PVCKDIDECLR--NPCKRDETCVNKPGTHLC---- -----------------VCKSGYEK--NQFD-----RQCRDINECFR--GYC---EHNCV NSPPGSFTCS-----CHPGFRLDIN---KRSCIDINECA-TQRPCQN-GRCTNTRGSYYC -SCHQGFRLTANG-RCEDIDECNA--NVYGRPCEYNCTNIVGSYRCECPSGYEQTADRHS CRDIDECKQGS--AICGR-GTLCRNTNGHYRC-IPFSCPR-----------------PYY S-LQGD-------SKCLRN---CPEGDRAC---SQLKD-KVYQFWTFNIV---VGS---P PGN---IFAYKIIAQGYRKPDIR-----YRFRRGNEL---------GHFEIKRVG----- ---ADQAQIWNRITFRQRHDYVLEFVGELFDGG------DLISRYVHTLYVFVSAYR- >XP_006230804.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Rattus norvegicus] M------------------------------FVRFWEAQNP------VTRRCECTEGFRR HSPRMLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--AFLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVISDLHSE---------------------------------GPPPPAASAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDEQ-----ESCVDVDECTQAIHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCNQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECETGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNTQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_508563.4 EGF-containing fibulin-like extracellular matrix protein 2 [Pan troglodytes] ------------------------------------------------------------ ----MLPC---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGSASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDNQ-----ESCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYI Q-VSEN--------RC-----LCPASNPLCR--EQPSS-IVHRYMTITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_013976587.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Canis lupus familiaris] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEYPNP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ERCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCNDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >NP_001069517.1 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Bos taurus] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLVLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEHPHP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ERCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_009244407.2 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Pongo abelii] MEGVGEAVCSERTTWLKTVLGVEGRREREGQFCS-WEPLVPGHCPSQPSRQSRGPRGRRG PNPRMLPC---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGSASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDDQ-----ESCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCQCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYI Q-VSEN--------RC-----LCPASNPLCR--EQPSS-IVHRYMTITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_005660736.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sus scrofa] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--TLLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVSPAEHATP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ENCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYAF >XP_034788933.1 EGF-containing fibulin-like extracellular matrix protein 2 [Pan paniscus] ------------------------------------------------------------ ----MLPC---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGSASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDDQ-----ESCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYI Q-VSEN--------RC-----LCPASNPLCR--EQPSS-IVHRYMTITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_023095846.1 EGF-containing fibulin-like extracellular matrix protein 2 [Felis catus] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEHPNP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ERCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCNDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGT--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_027815637.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Ovis aries] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEHPHP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ERCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_030871753.1 EGF-containing fibulin-like extracellular matrix protein 2 [Gorilla gorilla gorilla] ------------------------------------------------------------ ----MLPC---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLFLGSASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAQHPNP-- ------------------------------------------------------------ ---------CPPGYE-PDDQ-----ESCVDVDECAQALHDCRPSQDCHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYI Q-VSEN--------RC-----LCPASNPLCR--EQPSS-IVHRYMTITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_023814831.1 EGF-containing fibulin-like extracellular matrix protein 2 [Oryzias latipes] ------------------------------------------------------------ ----MQ------------------------------------------------------ ------------------------------------------------------------ --------------------AACV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SNLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VC--ICVSVLLHSVLS- ------------------------------------------------------------ -----------------QLQRETDT----------------------------------- ------------------------------------------------------------ ------------YTECTDGYHWDPQTDHCRDINECETIPDACKGEMKCFNHYGGYLCLPR SASVIAASESP--------------------------------IAPT------VPFNP-- ------------------------------------------------------------ ---------CPVGYE--SHG-----DSCVDVDECVRHEHDCQPSQECINTLGSFTC---- -----------------QCPRGY----RKVG-----MECIDIDECRY--RYC---QHRCV NV-PGSFSCQ-----CEPGFQLAGN---NRSCIDVNECE-MGAPCSQ--RCYNTYGTFLC -RCDQGYELGQDGFTCNDIDECS----FSSYLCQFQCVNEPGKFSCVCPEGYQLQ-GTRT CQDINECETGE--HQCTD-TQTCVNIHGRYQCVDNDRCQD-----------------PYV Q-VSDN--------RC-----VCPIINPVCR--DLPFS-VVHRYMSITSE---RTV---- PSD---VFQIQATSV-SVGAYNT-----FRIRSGDDN---------GDFYIRQIN----- ---NLSAMLVLARSVSGPREYTLDLEMVSINPLLN-YQGSHQSSSVLRLSIYVGQHAF >XP_017898583.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 [Capra hircus] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEHPHP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ERCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_019347973.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Alligator mississippiensis] ------------------------------------------------------------ ----ME------------------------------------------------------ -----MSQRRGLPA---------------------------------------------- ------------------GGGACAPGAGPG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GRQ--RVGRRILGPAAA- ------------------------------------------------------------ -----------------QQGPEGRAGPG-------------------------------- ------------------------------------------------------------ ------------SGPCRPPGHGPGVVAAAGGAGAGRAVPGA--GGAGHVHGVHRRLRVGR RDPVLQRRGRVRDDRGRLQGRDEVHQPLRRLPLP---------AALRLRHQRRHRPGP-- ------------------------------------------------------------ ---------RPPGSA-TAPPASA-PTPPQPLSPRLRPRQPGRLRGRGRVRAGAARL---- -----------------PAQPGLPQRARRLPLRLPVRIPQDIDECRF--RYC---QHRCV NS-PGSFACQ-----CEPGFQLASN---NRSCVDVDECG-MGAPCAQ--RCLNTYGTFIC -RCGPGYELDADGFACNDIDECS----YSSYLCQFRCVNEPGKFSCTCPQGYQLL-GTRL CQDINECETGT--HECTE-SQTCFNFHGGWRCLEKNRCVE-----------------PYV Q-VSDN--------RC-----VCPASNPRCR--EQPSS-IVFRTMALAAE---RPV---- PAD---VFQIQATSV-YPGAYNS-----FHIRAGNDQ---------GDFYIRQIT----- ---NVSAMLVLARPLTGPRELVLDLEMVTTNALL-----SYRARALLRLTVLVGAHPF >XP_015804092.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Nothobranchius furzeri] ------------------------------------------------------------ ----MQ------------------------------------------------------ ------------------------------------------------------------ --------------------GACV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SVLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VC--ICVSVLLRSAIS- ------------------------------------------------------------ -----------------QSHRETDT----------------------------------- ------------------------------------------------------------ ------------HTECTDGYHWDPQTEHCKDINECETIPDACKGEMKCFNHYGGYLCLPR SASVIPAPEPP--------------------------------ITPT------EAFNP-- ------------------------------------------------------------ ---------CPLGYE--QLG-----DSCVDVDECERDEHDCQPSQQCINTLGAFTC---- -----------------QCPDGY----RKVG-----TECIDIDECRY--RYC---QHRCV NV-PGSFSCQ-----CEPGFQLAGN---NRSCIDVNECE-MGAPCSQ--RCYNTYGTFLC -RCDQGYELGPDGFTCNDIDECS----YSSYLCQYQCVNEPGKFSCMCPEGYQLL-GTRM CQDINECETGQ--HQCSE-SQTCVNIHGRYQCVDNDRCQD-----------------PYI Q-VSDN--------RC-----VCPVNKPACR--DLPFS-VVHRYMSITSE---RSV---- PSD---IFQIQATSV-SAGAYNT-----FRIRSGDDN---------GDFYIRQIN----- ---NISAMLVLARAVSGPREYTLDLEMVSVNPLLS-YQGSYQTSSALRLSIYVGPYSF >XP_020762130.1 EGF-containing fibulin-like extracellular matrix protein 2 [Odocoileus virginianus texanus] ------------------------------------------------------------ ----MLPF---------------------------------------------------- ------------------------------------------------------------ --------------------ASCL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PGSLL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LW--ALLLLLLGAASP- ------------------------------------------------------------ -----------------QDSEEPDS----------------------------------- ------------------------------------------------------------ ------------YTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPR SAAVINDLHGE---------------------------------GPPPPVPPAEHPHP-- ------------------------------------------------------------ ---------CLPGYE-PDEQ-----ESCVDVDECAQALHDCRPSQECHNLPGSYQC---- -----------------TCPDGY----RKIG-----PECVDIDECRY--RYC---QHRCV NL-PGSFRCQ-----CEPGFQLGPN---NRSCVDVNECD-MGAPCEQ--RCFNSYGTFLC -RCHQGYELHRDGFSCSDIDECS----YSSYLCQYRCVNEPGRFSCHCPQGYQLL-ATRL CQDIDECESGA--HQCSE-AQTCVNFHGGYRCVDTNRCVE-----------------PYV Q-VSDN--------RC-----LCPASNPLCR--EQPSS-IVHRYMSITSE---RSV---- PAD---VFQIQATSV-YPGAYNA-----FQIRAGNSQ---------GDFYIRQIN----- ---NVSAMLVLARPVTGPREYVLDLEMVTMNSLM-----SYRASSVLRLTVFVGAYTF >XP_030252235.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sparus aurata] ------------------------------------------------------------ ----MQ------------------------------------------------------ ------------------------------------------------------------ --------------------GACV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SVLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------VC--ICVSVLLRSAIS- ------------------------------------------------------------ -----------------QPPKESDT----------------------------------- ------------------------------------------------------------ ------------YTECTDGYHWDAQTEHCKDINECETIPDACKGQMKCYNHYGGYLCLPH TAEVFPAPEPA--------------------------------ITPT-------VTNP-- ------------------------------------------------------------ ---------CPLGYE--SQG-----DSCVDIDECERDEHDCQPSQQCINSLGAFTC---- -----------------QCPDGY----RKVG-----TECIDIDECRY--RYC---QHRCV NV-PGSFSCQ-----CEPGFQLAGN---NRSCIDVNECD-MGAPCSQ--RCYNTYGTFLC -RCDQGYELGPDGFACNDIDECS----YSSYLCQYQCVNEPGKFSCVCPEGYQRQ-GTRL CQDINECETGE--HQCTD-TQTCVNIHGRYQCVDSNRCQD-----------------PYV Q-VSEN--------RC-----VCPVNKPLCR--DLPFS-IVHRYMSITSE---RSV---- PSD---IFQIQATSV-SPGAYNT-----FRIRSGDEN---------GDFYIRQIN----- ---NISAMLVLARAVSGPREYTLDLEMVSVNPLLS-YQGSYQTSSALRLSIYVGPHTF >XP_040184836.1 EGF-containing fibulin-like extracellular matrix protein 2 [Rana temporaria] ------------------------------------------------------------ ----MR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CY--LVFCVLLVPSLQ- ------------------------------------------------------------ -----------------QENEEPNT----------------------------------- ------------------------------------------------------------ ------------FTECTDGYEWDSERHHCKDINECLTIPDACKGEMKCINHYGGYLCLPR SASVISDSQPDPGPAG----------------------------SPQGGAETDQRNNP-- ------------------------------------------------------------ ---------CPNGYQ-PDSQGL---DTCVDVDECALEMDDCLPSQDCVNIPGSFHC---- -----------------KCPEGY----RKIG-----NECIDIDECRY--RYC---QHRCV NS-PGSFTCQ-----CEPGFQLASN---NRSCVDVNECS-MGAPCQQ--RCYNTYGTFLC -RCNQGYELDQDGYTCNDIDECS----YSSYLCQHQCVNEPGRFSCICPDGYSLL-GTRL CQDINECETGA--HTCTE-QQSCVNFHGGYRCVEKNLCIE-----------------PYI Q-VSDN--------RC-----MCPSSNPLCR--DEPGS-VVYRYMSIMSD---RSV---- PSD---IFQIQATSV-YPRAYNT-----FQIRSGNEQ---------GDFYIRQIN----- ---NISAMLVLARAITGPQEYVLDLEMLTTNSLL-----SYRSSSVLRLTIFVGAHSF
BMGE Cleaned alignment of selected proteins >NP_058634.4 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Homo sapiens] PGSLLALLLLLLGSQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCPPGYESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMTITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >KAG6798541.1 fibrillin-1 [Apis mellifera caucasica] KGYIRSSNEECINTTQGQRCDNLSCGTGYTLNAATEICEDDDECLLGTHDCGKGYHCRNTLGSYRCDRNPRVPFLCSNGYTYCIDIDECANGTHECTADQTCENRIGGYVCSCPSGHKDCIDIDECSLNSRCENTVGSFKCNCENGFEHVSSGNTCQDIDECATPGLCQHNCFNTWGSYKCICKSGFKLNPDNRSCTDIDECTFKDNLCVGICENTPGSYACKCPDGYKLGNGRTCEDIDECQAG-DEICHNVRGSYRC-NKIKCPNPCHINDHACIRQPSHYSYNFITLVSMLFKMKGYHL-PGSAIQMAFLEARASCFALRKPEPTQAVLVMTQSIQGPQEIELDLNMEVYHNA-HFAGSAIAKILIFVSQYEF >CAE1173162.1 FBLN1_2 [Sepia pharaonis] TGFVLNISHQCLNLPLGLQCYNRSCGTGYSLNEITQQCDDIDECAQGVHNC-GTSRCKNIQGSFRCEMPSHST--CGPGLWRCKDIDECAAGNHTCHSNQVCRNTPGGFECDCLAGYGFCEDINECSHNANCINTPGSFRCECKAGYESIGTSRQCKDIDECSMQNPCDHHCQNTLGSFKCSCETGYELSLNRRSCQDVDECADPYKQCSYQCQNLPGSFQCSCPSGFRMADQKSCLDIDECKETPDATCINVRGGYKC-PIVQCPSICPLRDVECLTSPISLSYNFMTFPSKLFTISGRVI-ASRYFRLNLISAEPQYFNLRIT-GSSAAVELRQEIPGPQDVELQLIMDMYNSDKQLIGQAESKLFIYVT---- >NP_001293876.1 Fibulin-1 [Caenorhabditis elegans] DPHVL------------------SCRSGFDLAPDGMACVDRNECLTRQSPCTQSEDCVNTIGGYICQRRISRLVPCPMGWLHCVDVDECNLGSHDCGPLYQCRNTQGSYRCTCPNGYGMCNDIDECVTGEECVNTPGSFRCQCAHGYEVNGATGFCEDVNECTGIAACEQKCVNIPGSYQCICDRGFALGPDGTKCEDIDECSSGNDLCMGGCINTKGSYLCQCPPGYKIQDGRTCVDVDECAMGEDKVCVNTLGSFKC-HSIDCPTVCSTEDTECLNHTREVLYQFRAVPSLVSRIVTHMGVPFSVDYLDYVG---RHFRIVQE-RNIGIVQLVKPISGPTVETIKVNIHTKSRTGVILAFNEAIIEISVSKYPF >XP_039248222.1 fibulin-1-like isoform X2 [Styela clava] KSLLV-----------------AVCGDGLRYSE-GQGCGDIDECREIV-PCQLGQRCRNYYGSYQCV--------CSQGMQFCRDINECMH--KPCADNQYCINTRGSYVCQCKAGYGTCADVDECRQGETCKNTDGSYECVCKPGYGKDEMGRYCKDIDECKIRSTCPQECQNLPGSFLCRCHRGFTY--INGACVDKHECTGEGRKCQWKCTDLPGSYKCICPEGYEQI-NFNCIDINECDRHMGETCVNTRGGFECVRPPKCPLRDSMSVKECKAEPLSVSYHYVAVTSGVLHISYPARRRRQRYNFSIVQGNEGIFMIKQHSMPRAQLVVTGNLNGPSRHTVKIDMATYQPNGKMRDSRMLTITIFTSMYDF >XP_787649.4 fibulin-1 isoform X2 [Strongylocentrotus purpuratus] PGNHLDERSICENRLDGARCDNVPCGTGYTINGVTQQCVDVDECSQQSHDCEINELCINIRGSYDCQS-------CMTGFEACMDVDECRRGLANCATYEICQNTNGSFSCGCRQGFGQCVDIDECRENQRCYNLQGQYQCRCRNGFRFNNFNSACEDIDECAGLDVCQNRCINQEGGYVCQCPAGHQANRDRATCEDIDECS---GLCRGTCENLPGSYVCTCPAGYALMNNVTCKDLDECSTGTDEVCFNTRGGHKC-ESVVCPEPRTGNAPDCPNLNSTISHTFVALPSILLTIGLPN-YRSAYGGFRSISGNEQYFVITRLFLPTGYVSLQKPISGPFETVLHLEIVTEVRNPEVTATSYLMIHIDVGEQSY >XP_038061268.1 fibulin-1-like isoform X2 [Patiria miniata] VGYVLPLHKRCQNYQDGFRCDNSPCGTGYTVNSLTQQCRDIDECLQDTDDCPPEFYCQNTMGSYKCRP-------CPQGFQECRDINECALGTDDCQANQVCQNREGAYECGCRNGMRECDDINECETNEQCHNTVGSFACQCQLNYRYVE-EEGCVDVNECEAQYPCFGQCVNVPGSYRCQCPRGQIANRDTRRCEDVDECKYQGASCMGGCVNTFGSYMCTCPNGYELLNRFNCRDINECRRNIQSACFDTRGGFKC-KNIQCPQLCPNNDFNCVDDPVKITYNKIALPSLLLRLQIGDLTVSQANGFVLTQGNEGLFSVTKDLFATGTLYLERAVTGPFETDLRLEMQLFSTTQQLLSVTTAVFSIDVSPNSF >NP_001284712.1 uncharacterized protein Dmel_CG31999, isoform C [Drosophila melanogaster] PGFMLNSNQECVNTLPTQRCDNQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTCSPGYKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHSTCVDTNECALNAQCFNTIGAYYCECKAGFQKKSDSTQCFDIDECQIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEKDYKLCMGLCINTPGSYQCSCPRGYILADMNTCRDVDECATDSNDICTNIRGSYKC-TTVNCPLLNFCEGEECYTQPSAFTYNFITFVSKIFTLRGPLWYDNIEFDLKIVRIQAGSFDTLQN-NNQVNVILKKSLEGPQDIELELSMTVYTNG-MPRGKSVAKLFLFVSQHTF >tr|A2CEN1|A2CEN1_DANRE EGF-containing fibulin extracellular matrix protein 2a OS=Danio rerio OX=7955 GN=efemp2a PE=1 SV=1 --VLLMCISVFLHRQPPTETDTTECTDGYHWDSQTQHCKDINECETITEACKGEMKCFNHYGGYLCLPRSASVIPCPLGFESCVDVDECERDSHDCQPSQQCFNTEGSFSCQCPDGYTECIDIDECRYQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVDECGMGAPCSQRCYNTYGTFLCRCEQGYELGPDGFACNDIDECSYSSYLCQYQCVNEHGKFSCVCPEGYQLLGTRLCQDINECETGAGQTCVNIHGGHKCVDNKSCQDMCPVSKPACRDMPYSIVHRYMSITSEIFQIQATSVYPGAYNTFRIRSGDDGDFYIRQINNISAMLVLARAVNGPQEYVLDLEMVSINPLMSYHSSSALRLTIYVGPYAF >NP_067449.3 EGF-containing fibulin-like extracellular matrix protein 2 isoform 1 precursor [Mus musculus] PGSLLAFLLLLLGAQDPEEPDSTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISCPQGYESCVDVDECTQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECGYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRSGNTGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_018113173.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X3 [Xenopus laevis] ---LFVLFSLLLVSQESEGPNSTECTDGYEWDRERQHCRDINECQTIPDACKGELKCINHYGGYLCLPPSASVISCPSGYQSCVDVDECEHQLHDCLPSQDCINMLGSYHCKCPEGYNECVDIDECRYQHRCVNYPGSFVCQCEPGFQLASNNRSCVDVNECSMGTPCQQRCYNTYGTFLCRCNQGYELSHDGYTCTDIDECSYSSYLCQHQCVNEPGSFSCSCPEGYQLLGTRLCQDINECELGTQQTCVNFHGGYQCVEKNRCQEMCPGTNPLCHDEPGSVVYRYMSITSDIFQIQATSVYPGAYNIFQIRSGNEGEFFIRQINNLTAMLVLARPVIGPKEYVLDLEMLTTNSLLSYRSSSVLRLTVFVGAHSF >XP_025004920.1 EGF-containing fibulin-like extracellular matrix protein 1 [Gallus gallus] ---LTFLAALILITQETEETITTQCTDGYEWDPVRQRCKDIDECEIVPDACKGGMKCVNHYGGYLCLPRTAQIIVCAAGYEVCQDIDECATGTHNCRADQVCVNLRGSFSCQCPPGYEQCVDIDECTLHHRCVNTPGSYYCQCNAGFQLASNNHTCVDINECDANNPCAQQCYNILGSFICQCNPGFELSSDRINCEDTDECRTSSYICQYQCVNEPGKFSCVCPEGYQVVGGRTCQDINECET-TDEICWNYHGGFRCYPINPCQEVCPVSNTICRELPYSVVYKYMSIRSDIFQIQATTIYPNTINTFRIKSGNEGEFYLRQTSAVSAMLVLVKSLSGPREHIVDLEMLTVNSL-NYRTSSVLRLTIIVGPYAF >XP_006021628.1 EGF-containing fibulin-like extracellular matrix protein 1 [Alligator sinensis] ---LTFLAAFVLTTQETEETITTQCTDGYEWDPYRQQCKDIDECEIVPDACKGGMKCVNHYGGYLCLPRTAQIIVCATGYEVCQDIDECATGAHNCRTDQACVNLRGSFRCQCLPGFEQCIDIDECTLHHRCVNTPGSYYCQCNPGFQLASNNHTCVDINECDANNPCAQQCYNILGSFICQCNPGFELSSDRINCEDVDECGTSSYICHYQCVNEPGKFSCVCPEGYQVVGGRTCQDINECET-TDEMCWNYHGGFRCYPRNPCQEVCPVSNTICRELPYSIVYKYMSIRSDIFQIQATTIYPNTINTFRIKSGNEGEFYLRQTSALSAMLVLVKSLSGPREHIVDLEMLTVNSL-NYRTSSVLRLTIIVGPFAF >KAF4018076.1 hypothetical protein G4228_009546 [Cervus hanglu yarkandensis] QQVMTILEEKLVSSEWKKKAENQQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRCRFGYQQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYGQCLDIDECRYQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEDDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDNRSCQDINECEHRNQQTCYNLQGGFKCIDPIRCEEMCPAENPGCRDQPFTILYRDMDVVSGIFQMQATTRYPGAYYIFQIKSGNEREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_043345635.1 fibulin-5 isoform X2 [Cervus canadensis] KRILTILALCLPSP--------QQCTNGFDLDRSSGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRCRFGYQQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYGQCLDIDECRYQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEDDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPAGYILLDNRSCQDINECEHRNQQTCYNLQGGFKCIDPIRCEEMCPAENPGCRDQPFTILYRDMDVVSGIFQMQATTRYPGAYYIFQIKSGNEREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_002719642.1 PREDICTED: fibulin-5 [Oryctolagus cuniculus] GRILTILALCLPSP--------QQCTNGFDLDRQTGQCLDVDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRCRFGYQQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYGQCLDIDECRYQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELADDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDNRSCQDINECEHRNQQTCYNLQGGFKCIDPIRCDEMCPAENPGCRDQPFTILFRDMDVVSGIFQMQATTRYPGAYYIFQIKSGNEREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF >XP_003206713.1 fibulin-5 [Meleagris gallopavo] KRILTTLIICISSP--------QQCTNGFDLDRASGQCLDIDECRTIPEACRGDMVCVNQNGGYLCVPRTNPVYRCRFGYQQCADIDECASDSHQCNPTQICINTEGGYTCSCTEGYGQCLDIDECRYQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECTGENPCSQTCVNTYGSFLCRCEPGYELEADGVNCSDMDECSFSEFLCQHECVNGPGSYYCVCPSGYNLLDSRSCQDINECETRNQQTCFNIPGEYKCLDPVRCEEMCPAENPGCRDQPFTILYRVMDVLSGIFQMQATTRYPGAYYIFQIKSGNEREFYMRQTGPISATLVMTRPVKGPRTVQLDLEMITVNTVINFRGSSVIRLRIFVSQYSF >XP_005506202.1 fibulin-5 [Columba livia] KRILTTLAVCLSSP--------QQCTNGFDLDRASGQCIDIDECRTIPEACRGDMVCVNQNGGYLCVPRTNPVYRCRFGYQQCADVDECASDSHQCNPTQICINTEGGYTCSCTEGYGQCLDIDECRYQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECTSENPCTQTCVNTYGSFLCRCEPGYELEADGVNCSDMDECSFSEFLCQHECVNGPGSYYCICPSGYNLLDSRSCQDINECETRNQQTCFNIPGEYKCLDPVRCEDMCPAENPGCRDQPFTVLYRVMDMVSGIFQMQATTRYPGAYYIFQIKSGNEREFYMRQTGPISATLVMTRPVKGPRTIQLDLEMITVNTVINFRGSSVIRLTIYVSQYSF >XP_031553546.1 fibulin-1-like [Actinia tenebrosa] RGYEVTGNRRCINTQSNQKCVNIACLSGY--ENVNGKCVDIDECVKYKSICPSGKQCKNEKGSYSCLSQSQCQNGCPSGYEVCKDIDECLR--NPCKRDETCVNKPGTHLCVCKSGYRQCRDINECFREHNCVNSPGSFTCSCHPGFRLDINKRSCIDINECATQRPCQNRCTNTRGSYYCSCHQGFRLTANG-RCEDIDECNVYGRPCEYNCTNIVGSYRCECPSGYEQTDRHSCRDIDECKQGSGTLCRNTNGHYRC-IPFSCPR-CPEGDRAC-SQLKDKVYQFWTFNIVIFAYKIIAQYRKPDIRYRFRRGNEGHFEIKRVGADQAQIWNRITFRQRHDYVLEFVGELFDGG-DLISRYVHTLYVFVSAYR- >XP_006230804.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Rattus norvegicus] PGSLLAFLLLLLGAQDSEEPDSTECTDGYEWDADSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVISCPPGYESCVDVDECTQAIHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCNQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECETGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNTGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_508563.4 EGF-containing fibulin-like extracellular matrix protein 2 [Pan troglodytes] PGSLLALLLLLLGSQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCPPGYESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMTITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_013976587.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Canis lupus familiaris] PGSLLALLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYERCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCNDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >NP_001069517.1 EGF-containing fibulin-like extracellular matrix protein 2 precursor [Bos taurus] PGSLLALLLLVLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYERCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_009244407.2 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Pongo abelii] PGSLLALLLLLLGSQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCPPGYESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCQCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMTITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_005660736.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sus scrofa] PGSLLTLLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYENCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYAF >XP_034788933.1 EGF-containing fibulin-like extracellular matrix protein 2 [Pan paniscus] PGSLLALLLLLLGSQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCPPGYESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMTITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_023095846.1 EGF-containing fibulin-like extracellular matrix protein 2 [Felis catus] PGSLLALLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYERCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCNDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGTAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_027815637.1 EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Ovis aries] PGSLLALLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYERCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_030871753.1 EGF-containing fibulin-like extracellular matrix protein 2 [Gorilla gorilla gorilla] PGSLLALLLLFLGSQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCPPGYESCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMTITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_023814831.1 EGF-containing fibulin-like extracellular matrix protein 2 [Oryzias latipes] -SNLCICVSVLLHSQLQRETDTTECTDGYHWDPQTDHCRDINECETIPDACKGEMKCFNHYGGYLCLPRSASVIACPVGYESCVDVDECVRHEHDCQPSQECINTLGSFTCQCPRGYMECIDIDECRYQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECEMGAPCSQRCYNTYGTFLCRCDQGYELGQDGFTCNDIDECSFSSYLCQFQCVNEPGKFSCVCPEGYQLQGTRTCQDINECETGETQTCVNIHGRYQCVDNDRCQDVCPIINPVCRDLPFSVVHRYMSITSEVFQIQATSVSVGAYNTFRIRSGDDGDFYIRQINNLSAMLVLARSVSGPREYTLDLEMVSINPLLSHQSSSVLRLSIYVGQHAF >XP_017898583.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 [Capra hircus] PGSLLALLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYERCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_019347973.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Alligator mississippiensis] -----RVGRRILGPQQGPEGRAGPCRPPGHGPGVVAAAGGAGAGRAVPGA--GGAGHVHGVHRRLRVGRRDPVLQRPPGSAPPQPLSPRLRPRQPGRLRGRGRVRAGAARLPAQPGLRIPQDIDECRFQHRCVNSPGSFACQCEPGFQLASNNRSCVDVDECGMGAPCAQRCLNTYGTFICRCGPGYELDADGFACNDIDECSYSSYLCQFRCVNEPGKFSCTCPQGYQLLGTRLCQDINECETGTSQTCFNFHGGWRCLEKNRCVEVCPASNPRCREQPSSIVFRTMALAAEVFQIQATSVYPGAYNSFHIRAGNDGDFYIRQITNVSAMLVLARPLTGPRELVLDLEMVTTNALLSYRARALLRLTVLVGAHPF >XP_015804092.1 PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 isoform X1 [Nothobranchius furzeri] -SVLCICVSVLLRSQSHRETDTTECTDGYHWDPQTEHCKDINECETIPDACKGEMKCFNHYGGYLCLPRSASVIPCPLGYESCVDVDECERDEHDCQPSQQCINTLGAFTCQCPDGYTECIDIDECRYQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECEMGAPCSQRCYNTYGTFLCRCDQGYELGPDGFTCNDIDECSYSSYLCQYQCVNEPGKFSCMCPEGYQLLGTRMCQDINECETGQSQTCVNIHGRYQCVDNDRCQDVCPVNKPACRDLPFSVVHRYMSITSEIFQIQATSVSAGAYNTFRIRSGDDGDFYIRQINNISAMLVLARAVSGPREYTLDLEMVSVNPLLSYQTSSALRLSIYVGPYSF >XP_020762130.1 EGF-containing fibulin-like extracellular matrix protein 2 [Odocoileus virginianus texanus] PGSLLALLLLLLGAQDSEEPDSTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINCLPGYESCVDVDECAQALHDCRPSQECHNLPGSYQCTCPDGYPECVDIDECRYQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAAQTCVNFHGGYRCVDTNRCVELCPASNPLCREQPSSIVHRYMSITSEVFQIQATSVYPGAYNAFQIRAGNSGDFYIRQINNVSAMLVLARPVTGPREYVLDLEMVTMNSLMSYRASSVLRLTVFVGAYTF >XP_030252235.1 EGF-containing fibulin-like extracellular matrix protein 2 [Sparus aurata] -SVLCICVSVLLRSQPPKESDTTECTDGYHWDAQTEHCKDINECETIPDACKGQMKCYNHYGGYLCLPHTAEVFPCPLGYESCVDIDECERDEHDCQPSQQCINSLGAFTCQCPDGYTECIDIDECRYQHRCVNVPGSFSCQCEPGFQLAGNNRSCIDVNECDMGAPCSQRCYNTYGTFLCRCDQGYELGPDGFACNDIDECSYSSYLCQYQCVNEPGKFSCVCPEGYQRQGTRLCQDINECETGETQTCVNIHGRYQCVDSNRCQDVCPVNKPLCRDLPFSIVHRYMSITSEIFQIQATSVSPGAYNTFRIRSGDEGDFYIRQINNISAMLVLARAVSGPREYTLDLEMVSVNPLLSYQTSSALRLSIYVGPHTF >XP_040184836.1 EGF-containing fibulin-like extracellular matrix protein 2 [Rana temporaria] ---LSLVFCVLLVPQENEEPNTTECTDGYEWDSERHHCKDINECLTIPDACKGEMKCINHYGGYLCLPRSASVISCPNGYQTCVDVDECALEMDDCLPSQDCVNIPGSFHCKCPEGYNECIDIDECRYQHRCVNSPGSFTCQCEPGFQLASNNRSCVDVNECSMGAPCQQRCYNTYGTFLCRCNQGYELDQDGYTCNDIDECSYSSYLCQHQCVNEPGRFSCICPDGYSLLGTRLCQDINECETGAQQSCVNFHGGYRCVEKNLCIEMCPSSNPLCRDEPGSVVYRYMSIMSDIFQIQATSVYPRAYNTFQIRSGNEGDFYIRQINNISAMLVLARAITGPQEYVLDLEMLTTNSLLSYRSSSVLRLTIFVGAHSF
PhyML tree of selected proteins ((((((XP_039248222_1_fibulin_1_like_isoform_X2__Styela_clava_:1.59779627,(XP_031553546_1_fibulin_1_like__Actinia_tenebrosa_:1.50825852,((CAE1173162_1_FBLN1_2__Sepia_pharaonis_:0.79231651,(KAG6798541_1_fibrillin_1__Apis_mellifera_caucasica_:0.6046231,NP_001284712_1_uncharacterized_protein_Dmel_CG31999__isoform_C__Drosophila_melanogaster_:0.64384787):0.26719103):0.32964553,(NP_001293876_1_Fibulin_1__Caenorhabditis_elegans_:1.50839673,(XP_038061268_1_fibulin_1_like_isoform_X2__Patiria_miniata_:0.82003704,XP_787649_4_fibulin_1_isoform_X2__Strongylocentrotus_purpuratus_:0.96730401):0.23393706):0.21698732):0.18292455):0.27484045):0.45243049,((XP_005506202_1_fibulin_5__Columba_livia_:0.01631354,XP_003206713_1_fibulin_5__Meleagris_gallopavo_:0.02557582):0.04551543,(KAF4018076_1_hypothetical_protein_G4228_009546__Cervus_hanglu_yarkandensis_:0.02685063,(XP_043345635_1_fibulin_5_isoform_X2__Cervus_canadensis_:0.00000001,XP_002719642_1_PREDICTED__fibulin_5__Oryctolagus_cuniculus_:0.0192948):0):0.07088876):0.43626518):0.22894842,(XP_025004920_1_EGF_containing_fibulin_like_extracellular_matrix_protein_1__Gallus_gallus_:0.02829508,XP_006021628_1_EGF_containing_fibulin_like_extracellular_matrix_protein_1__Alligator_sinensis_:0.03347056):0.39872052):0.11289977,(tr_A2CEN1_A2CEN1_DANRE_EGF_containing_fibulin_extracellular_matrix_protein_2a_OS_Danio_rerio_OX_7955_GN_efemp2a_PE_1_SV_1:0.07237003,(XP_030252235_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Sparus_aurata_:0.05059847,(XP_015804092_1_PREDICTED__EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Nothobranchius_furzeri_:0.00875056,XP_023814831_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Oryzias_latipes_:0.09833315):0.02310748):0.05616972):0.13244309):0.07275312,(XP_019347973_1_PREDICTED__EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Alligator_mississippiensis_:0.70087527,((XP_006230804_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Rattus_norvegicus_:0.00255503,NP_067449_3_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_1_precursor__Mus_musculus_:0.01087294):0.00704781,(((XP_508563_4_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Pan_troglodytes_:0.00000001,XP_034788933_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Pan_paniscus_:0.00000001):0.00000001,(XP_009244407_2_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Pongo_abelii_:0.00267287,(XP_030871753_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Gorilla_gorilla_gorilla_:0.00267299,NP_058634_4_EGF_containing_fibulin_like_extracellular_matrix_protein_2_precursor__Homo_sapiens_:0.00267207):0.00000001):0.00000001):0.00530845,(XP_005660736_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Sus_scrofa_:0.00812747,(XP_020762130_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Odocoileus_virginianus_texanus_:0.00000001,(NP_001069517_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2_precursor__Bos_taurus_:0.00268799,((XP_027815637_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Ovis_aries_:0.00000001,XP_017898583_1_PREDICTED__EGF_containing_fibulin_like_extracellular_matrix_protein_2__Capra_hircus_:0.00000001):0.00000001,(XP_023095846_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Felis_catus_:0.00269479,XP_013976587_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X1__Canis_lupus_familiaris_:0.00000001):0.00268676):0.00000001):0.00268943):0.00266329):0.00275745):0.01214253):0.10617742):0.0670026):0.06992889,XP_018113173_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2_isoform_X3__Xenopus_laevis_:0.10195306,XP_040184836_1_EGF_containing_fibulin_like_extracellular_matrix_protein_2__Rana_temporaria_:0.08190401);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)