PB0016

DATABASE

Click here to access PB0016 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0016	P62805	H4 clustered histone 1	H4C1	HIST1H4A, Histone H4, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FA, H4-16, H4C11, H4C12, H4C13, H4C14, H4C15	Homo_sapiens	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Domains

Gene Ontology

PF15511 (CENP-T_C)

GO:0003677 (enables) DNA binding GO:0003723 (enables) RNA binding GO:0005515 (enables) protein binding GO:0019904 (enables) protein domain specific binding GO:0046982 (enables) protein heterodimerization activity GO:0006334 (involved in) nucleosome assembly GO:0006335 (involved in) DNA replication-dependent chromatin assembly GO:0006336 (involved in) DNA replication-independent chromatin assembly GO:0006352 (involved in) DNA-templated transcription, initiation GO:0032200 (involved in) telomere organization GO:0045653 (involved in) negative regulation of megakaryocyte differentiation GO:0000228 (located in) nuclear chromosome GO:0000781 (located in) chromosome, telomeric region GO:0005576 (located in) extracellular region GO:0005634 (located in) nucleus GO:0005654 (located in) nucleoplasm GO:0005694 (located in) chromosome GO:0016020 (located in) membrane GO:0070062 (located in) extracellular exosome GO:0000786 (part of) nucleosome GO:0032991 (part of) protein-containing complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P62805|H4_HUMAN Histone H4 OS=Homo sapiens OX=9606 GN=H4C1 PE=1 SV=2 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Selected proteins from model organisms >NP_003529.1 histone H4 [Homo sapiens] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDA VTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_020742307.1 histone H4 [Odocoileus virginianus texanus] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDA VTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_040516427.1 histone H4 type VIII isoform X2 [Gallus gallus] MRNIHLRGCNPYSTTHRLTGGTAPSPATREATKTAGIPPPPRARALSPQSPIRSDLTLQMPRSPPVPTHSCSITAAVMSG RGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVT AMDVVYALKRQGRTLYGFGG >XP_031551448.1 histone H4 [Actinia tenebrosa] MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGG >NP_001011609.2 histone H4 [Apis mellifera] MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGG >XP_039265366.1 histone H4 [Styela clava] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTALDVVYALKRQGRTLYGFGG >NP_492641.1 Histone H4 [Caenorhabditis elegans] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRK TVTAMDVVYALKRQGRTLYGFGG >XP_030830328.1 histone H3, embryonic-like [Strongylocentrotus purpuratus] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TELRFQSSAVMALQEASEAYLVGLFEDTNLSIHTNMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_038066798.1 histone H3, embryonic-like [Patiria miniata] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRK TVTAMDVVYALKRQGRTLYGFGGYNTIKMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREI RRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIR GERA >NP_001027352.1 histone H4 [Drosophila melanogaster] MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTALDVVYALKRQGRTLYGFGG >XP_043305354.1 histone H4-like [Cervus canadensis] MIQSLQAPCLAAIAVTKRQISEGRELNVVTAPALAVFKQVRSVTINTLKGALNIVRSCSICGSKMSGRGKGGKGLGKGGA KRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGR TLYGFGG >XP_015799297.1 PREDICTED: histone H4-like [Nothobranchius furzeri] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGGYLVLDKLKLNGSFKSLPPQSKVPNPYLLVITGKIKFPKKSACQQYCTSLLAHLML >OCT77458.1 hypothetical protein XELAEV_18028549mg [Xenopus laevis] MPDPAKSAPAAKKGSKKAVTKTQKKDGKKRRKSRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFERIAGEASR LAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAKEFAAMSGRGKGGKGLGKGGAKRHRKVLRDNIQGI TKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_017200428.1 PREDICTED: histone H4-like [Oryctolagus cuniculus] MEDYTWNSHNLKHTFLVCKPDIHLQRLWCFKYRDILLRHFSPPRVSLTRGWGLNAVSRLFWSSCLQTGPHTCHISGLAAS EAIASLGSSSSFAEMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENV IRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_009423180.2 histone H4 [Pan troglodytes] MFSNRSASREYKPWSAPSNHSGRPDFLLSRRCAFRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_034791304.1 histone H4 [Pan paniscus] MFSNRSASREYKPWSAPGNHSRRPDFLLRRRCASRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_022270160.2 histone H3.1 [Canis lupus familiaris] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLCSACAMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_017894042.1 PREDICTED: histone H3.1-like [Capra hircus] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLSTVVADMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGV KRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >BAB27698.1 unnamed protein product [Mus musculus] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRE TVTAMDVVYALKRQGRTLYGFGG >XP_011479935.2 histone H3 [Oryzias latipes] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >KAF4013677.1 hypothetical protein G4228_004792 [Cervus hanglu yarkandensis] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLAPMSGRGKGGKGLGKGGAKRHRKVLRDNIQGIT KPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_002816625.2 histone H3.1-like [Pongo abelii] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNFCLVQAMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_009301181.2 uncharacterized protein si:ch73-368j24.3 [Danio rerio] MSSWQPCFKYVATFTKRYIRSQNWNCLQVAAMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL REIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHIIMSGRGKGGKGLGK GGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKR QGRTLYGFGG >XP_008769995.2 histone H3.1 [Rattus norvegicus] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLCIVLVMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_042093142.1 histone H3.1 [Ovis aries] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLCLLFIMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVK RISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_030868143.1 histone H3-like centromeric protein HTR12 [Gorilla gorilla gorilla] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFK TDLRFQSSAVMALQEACEAYLVGLFEDTNLVLTKRWVKLLFLIMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRR LARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >OWK13171.1 hypothetical protein Celaphus_00014536 [Cervus elaphus hippelaphus] MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFPDLDQTMSGRGK GGKGLGKGGAKRHRKVLRDNMQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMD VVYALKRQGRTLYGFGG >PKK29811.1 histone H3 [Columba livia] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGGLMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQ KSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA >XP_005226918.4 histone H4 [Bos taurus] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFAG >XP_005665718.2 LOW QUALITY PROTEIN: histone H4 [Sus scrofa] MSGRGKGGKGXGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGG >XP_006024250.1 histone H4-like [Alligator sinensis] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLLYEATRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRTLYGFGG >XP_040176861.1 uncharacterized protein LOC120909205 [Rana temporaria] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRK TVTAMDVVYALKRQGRAAQPVFYHTCVSSAMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALR EIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRMSGRGKGGKGLGK GGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKR QGRTLYGFGG >XP_030298080.1 histone H4-like [Sparus aurata] MMQPGSLDVWPHGPPPTRTRVVTSCRAVPPINGGFQQQREPDPTVCIRPLKLFAVNRLNSNNERQRKGGKGLGKGGAKRH RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLY GFGG >XP_006268909.2 PREDICTED: histone H4-like [Alligator mississippiensis] MALRVKSMFRFLDWVLASNPQRLSPGDLALKPAMGWVCLGGKGGAKRHRKVLRDNIRGFTKPAIRRLARRGGVKSISGLI YEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Mafft alignment of selected proteins >NP_003529.1 histone H4 [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_020742307.1 histone H4 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_040516427.1 histone H4 type VIII isoform X2 [Gallus gallus] MRNI-------------------------------------------------------- ---------------HLR--------------------------------GCNPYSTTHR LTGGTAPSPAT------REATKTAGIPPPPRAR--------------------------- --AL------SPQSPIRSD-----------LTLQMPRSPPVP------------------ --THSCSITAAV--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_031551448.1 histone H4 [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKILR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >NP_001011609.2 histone H4 [Apis mellifera] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_039265366.1 histone H4 [Styela clava] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA LDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >NP_492641.1 Histone H4 [Caenorhabditis elegans] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_030830328.1 histone H3, embryonic-like [Strongylocentrotus purpuratus] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTELRFQSSAVMALQEASEAYLVG LFEDTNLSIHTN--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_038066798.1 histone H3, embryonic-like [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTA MDVVYALKRQGRTLYGFGGYNTIKMARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV KKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEA SEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA >NP_001027352.1 histone H4 [Drosophila melanogaster] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MTGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA LDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_043305354.1 histone H4-like [Cervus canadensis] ------------------------------------------------------------ --------------------------------------------------------MIQS LQA-----------------PCLAAIAVTKRQI---------------SEGRELNVVTA- -PAL------AVFKQVRS------------VTINTLKGALNI------------------ --VRSCSICGSK--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_015799297.1 PREDICTED: histone H4-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGGY----LVLDKLKLNGSFKSLPPQSKVPNPYL---LVITGKI KFPKK-----------------------------------------------------SA CQQYCTSLLAHLML-------------------------- >OCT77458.1 hypothetical protein XELAEV_18028549mg [Xenopus laevis] ------------------------------------------------------------ --------------------------------------------------M---PDPAKS APAAKKGSKKAVTKTQKKDG------KKRRKSRKESYAIYVYKVLKQVHPDTGISSKAM- -SIMNSFVNDVFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEG-TKA VTKYTSAKEFAA--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_017200428.1 PREDICTED: histone H4-like [Oryctolagus cuniculus] ------------------------------------------------------------ --------------------------------------------------MEDYTWNSH- ------------------NLKHTFLVCKP------DIHL---QRLWCF-KYRDILLRHFS PP---------RVSLTRG-------------WGLNAVSRL-FWSSCLQTGPHTC--HISG LAASEAIASLGSS--------SSFAEMSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_009423180.2 histone H4 [Pan troglodytes] ------------------------------------------------------------ --------------------------------------------------------MFSN RSASREYKPWS---------------APSNHSG--------------------------- ----------------RPD-----------FLLS-------------------------- ---RRC---AFR--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_034791304.1 histone H4 [Pan paniscus] ------------------------------------------------------------ --------------------------------------------------------MFSN RSASREYKPWS---------------APGNHSR--------------------------- ----------------RPD-----------FLLR-------------------------- ---RRC---ASR--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_022270160.2 histone H3.1 [Canis lupus familiaris] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLCSACA--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_017894042.1 PREDICTED: histone H3.1-like [Capra hircus] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLSTVVAD-------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >BAB27698.1 unnamed protein product [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRETVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_011479935.2 histone H3 [Oryzias latipes] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEASEAYLVG LFEDTNLCAIHA--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >KAF4013677.1 hypothetical protein G4228_004792 [Cervus hanglu yarkandensis] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLCAIHAKRVTIMPKDIQLAPMSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_002816625.2 histone H3.1-like [Pongo abelii] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNFCLVQA--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_009301181.2 uncharacterized protein si:ch73-368j24.3 [Danio rerio] MSS---------------------------WQPCFK------------------------ ----------------------------YVATFTKRYIRSQNWNCLQVAAMARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEASEAYLVG LFEDTNLCAIHII-------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_008769995.2 histone H3.1 [Rattus norvegicus] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLCIVLV--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_042093142.1 histone H3.1 [Ovis aries] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLCLLFI--------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_030868143.1 histone H3-like centromeric protein HTR12 [Gorilla gorilla gorilla] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEACEAYLVG LFEDTNLVLTKRW------VKLLFLIMSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >OWK13171.1 hypothetical protein Celaphus_00014536 [Cervus elaphus hippelaphus] ------------------------------------------------------------ --------------------------------------------------MARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FPDLDQT------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNMQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >PKK29811.1 histone H3 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGGL----MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGV KKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEA SEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA >XP_005226918.4 histone H4 [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFAG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_005665718.2 LOW QUALITY PROTEIN: histone H4 [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGX----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_006024250.1 histone H4-like [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLLYEATRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_040176861.1 uncharacterized protein LOC120909205 [Rana temporaria] MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRAAQPVFYHTCVSSAMARTKQTARK STGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVAL---REIRRYQKSTELLIRKL- -P---------FQRLVRE-------------IAQDFKTDLRFQSSAVMALQEASEAYLVG LFEDTNLCAIHAK------------RMSGRGKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_030298080.1 histone H4-like [Sparus aurata] ------------------------------------------------------------ --------------------------------------------------MMQ-PGSLDV WPHGPPPTRTRVVTSCRAVPPINGGFQQQREPDP-TVCI---RPLKLF------------ ---------------------------------------------AVNRLNSN------- --------------------------NERQRKGGKGL----------GKGGAKRHRKVLR DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ---------------------------------------- >XP_006268909.2 PREDICTED: histone H4-like [Alligator mississippiensis] ------------------------------------------------------------ --------------------------------------------------M--------- -----------------------------------ALRV---KSMFRF------------ ---------------------------------------------LDWVLASN------- --------------------------PQRLSPGDLALKPAMGWVCLGGKGGAKRHRKVLR DNIRGFTKPAIRRLARRGGVKSISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTA MDVVYALKRQGRTLYGFGG----------------------------------------- ------------------------------------------------------------ ----------------------------------------
BMGE Cleaned alignment of selected proteins >NP_003529.1 histone H4 [Homo sapiens] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_020742307.1 histone H4 [Odocoileus virginianus texanus] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_040516427.1 histone H4 type VIII isoform X2 [Gallus gallus] TTHRLTGGTAPSPATPPPPRARMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_031551448.1 histone H4 [Actinia tenebrosa] ----------------------MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >NP_001011609.2 histone H4 [Apis mellifera] ----------------------MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_039265366.1 histone H4 [Styela clava] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTALDVVYALKRQGRTLYGFGG >NP_492641.1 Histone H4 [Caenorhabditis elegans] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_030830328.1 histone H3, embryonic-like [Strongylocentrotus purpuratus] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_038066798.1 histone H3, embryonic-like [Patiria miniata] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVVYALKRQGRTLYGFGG >NP_001027352.1 histone H4 [Drosophila melanogaster] ----------------------MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTALDVVYALKRQGRTLYGFGG >XP_043305354.1 histone H4-like [Cervus canadensis] MIQSLQA--------AVTKRQIMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_015799297.1 PREDICTED: histone H4-like [Nothobranchius furzeri] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >OCT77458.1 hypothetical protein XELAEV_18028549mg [Xenopus laevis] PAKSAPAAKKGSKKAKKRRKSRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_017200428.1 PREDICTED: histone H4-like [Oryctolagus cuniculus] NSH------------CKP----MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_009423180.2 histone H4 [Pan troglodytes] MFSNRSASREYKPWSAPSNHSGMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_034791304.1 histone H4 [Pan paniscus] MFSNRSASREYKPWSAPGNHSRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_022270160.2 histone H3.1 [Canis lupus familiaris] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_017894042.1 PREDICTED: histone H3.1-like [Capra hircus] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >BAB27698.1 unnamed protein product [Mus musculus] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRETVTAMDVVYALKRQGRTLYGFGG >XP_011479935.2 histone H3 [Oryzias latipes] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >KAF4013677.1 hypothetical protein G4228_004792 [Cervus hanglu yarkandensis] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_002816625.2 histone H3.1-like [Pongo abelii] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_009301181.2 uncharacterized protein si:ch73-368j24.3 [Danio rerio] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_008769995.2 histone H3.1 [Rattus norvegicus] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_042093142.1 histone H3.1 [Ovis aries] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_030868143.1 histone H3-like centromeric protein HTR12 [Gorilla gorilla gorilla] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >OWK13171.1 hypothetical protein Celaphus_00014536 [Cervus elaphus hippelaphus] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNMQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >PKK29811.1 histone H3 [Columba livia] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_005226918.4 histone H4 [Bos taurus] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFAG >XP_005665718.2 LOW QUALITY PROTEIN: histone H4 [Sus scrofa] ----------------------MSGRGKGGKGXGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_006024250.1 histone H4-like [Alligator sinensis] ----------------------MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLLYEATRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_040176861.1 uncharacterized protein LOC120909205 [Rana temporaria] TARKSTGGKAPRKQLKKPHRYRMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_030298080.1 histone H4-like [Sparus aurata] SLDVWPHGPPPTRTRQQQREPDNERQRKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG >XP_006268909.2 PREDICTED: histone H4-like [Alligator mississippiensis] ----------------------PQRLSPGDLALGKGGAKRHRKVLRDNIRGFTKPAIRRLARRGGVKSISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
PhyML tree of selected proteins (OCT77458_1_hypothetical_protein_XELAEV_18028549mg__Xenopus_laevis_:0.09051892,(XP_006268909_2_PREDICTED__histone_H4_like__Alligator_mississippiensis_:4.25978376,XP_030298080_1_histone_H4_like__Sparus_aurata_:0.00000002):0.82206255,((((XP_015799297_1_PREDICTED__histone_H4_like__Nothobranchius_furzeri_:0.00000001,(XP_020742307_1_histone_H4__Odocoileus_virginianus_texanus_:0.00000001,(NP_003529_1_histone_H4__Homo_sapiens_:0.00000001,PKK29811_1_histone_H3__Columba_livia_:0.00000001):0.00000001):0.00000001):0.00000002,(XP_005226918_4_histone_H4__Bos_taurus_:0.25574847,(XP_005665718_2_LOW_QUALITY_PROTEIN__histone_H4__Sus_scrofa_:0.00000002,(((XP_030868143_1_histone_H3_like_centromeric_protein_HTR12__Gorilla_gorilla_gorilla_:0.00000001,(XP_042093142_1_histone_H3_1__Ovis_aries_:0.00000001,(XP_008769995_2_histone_H3_1__Rattus_norvegicus_:0.00000001,(XP_009301181_2_uncharacterized_protein_si_ch73_368j24_3__Danio_rerio_:0.00000001,(XP_002816625_2_histone_H3_1_like__Pongo_abelii_:0.00000001,(KAF4013677_1_hypothetical_protein_G4228_004792__Cervus_hanglu_yarkandensis_:0.00000001,(XP_011479935_2_histone_H3__Oryzias_latipes_:0.00000001,(XP_017894042_1_PREDICTED__histone_H3_1_like__Capra_hircus_:0.00000001,(XP_022270160_2_histone_H3_1__Canis_lupus_familiaris_:0.00000001,XP_040176861_1_uncharacterized_protein_LOC120909205__Rana_temporaria_:0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000002,OWK13171_1_hypothetical_protein_Celaphus_00014536__Cervus_elaphus_hippelaphus_:0.01015959):0.00000002,(XP_030830328_1_histone_H3__embryonic_like__Strongylocentrotus_purpuratus_:0.00000002,(NP_492641_1_Histone_H4__Caenorhabditis_elegans_:0.00000001,XP_038066798_1_histone_H3__embryonic_like__Patiria_miniata_:0.00000001):0.00000002):0.01016849):0.00000127):0.00031346):0.00010713):0.01397711,(XP_017200428_1_PREDICTED__histone_H4_like__Oryctolagus_cuniculus_:0.09955097,(BAB27698_1_unnamed_protein_product__Mus_musculus_:0.25974998,(XP_040516427_1_histone_H4_type_VIII_isoform_X2__Gallus_gallus_:0.03174527,((XP_006024250_1_histone_H4_like__Alligator_sinensis_:0.53262402,(XP_039265366_1_histone_H4__Styela_clava_:0.26163863,(XP_009423180_2_histone_H4__Pan_troglodytes_:0.01076397,XP_034791304_1_histone_H4__Pan_paniscus_:0.00823002):0.02357951):0.06234621):0.05145867,(XP_043305354_1_histone_H4_like__Cervus_canadensis_:0.03210361,XP_031551448_1_histone_H4__Actinia_tenebrosa_:0.25662005):0.14173434):0.29243979):0.00791671):0.09617506):0.1212065):0.1215874,(NP_001011609_2_histone_H4__Apis_mellifera_:0.00000002,NP_001027352_1_histone_H4__Drosophila_melanogaster_:0.26357019):0.25788163):0.07991555);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)