PB0003

DATABASE

Click here to access PB0003 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0003	P00734	Prothrombin	F2	PT, THPH1, RPRGL2, coagulation factor II	Homo_sapiens	Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Domains

Gene Ontology

PF00051 (2_Kringle) PF00089 (Trypsin) PF00594 (Gla) PF09396 (Thrombin_light)

GO:0009897 (colocalizes with) external side of plasma membrane GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0001530 (enables) lipopolysaccharide binding GO:0004252 (enables) serine-type endopeptidase activity GO:0005102 (enables) signaling receptor binding GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008083 (enables) growth factor activity GO:0008201 (enables) heparin binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0070053 (enables) thrombospondin receptor activity GO:0001934 (involved in) positive regulation of protein phosphorylation GO:0006508 (involved in) proteolysis GO:0006953 (involved in) acute-phase response GO:0007166 (involved in) cell surface receptor signaling pathway GO:0007275 (involved in) multicellular organism development GO:0007596 (involved in) blood coagulation GO:0007599 (involved in) hemostasis GO:0008284 (involved in) positive regulation of cell population proliferation GO:0008360 (involved in) regulation of cell shape GO:0009611 (involved in) response to wounding GO:0010468 (involved in) regulation of gene expression GO:0010544 (involved in) negative regulation of platelet activation GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling GO:0030168 (involved in) platelet activation GO:0030193 (involved in) regulation of blood coagulation GO:0030194 (involved in) positive regulation of blood coagulation GO:0030307 (involved in) positive regulation of cell growth GO:0032967 (involved in) positive regulation of collagen biosynthetic process GO:0042730 (involved in) fibrinolysis GO:0045861 (involved in) negative regulation of proteolysis GO:0046427 (involved in) positive regulation of receptor signaling pathway via JAK-STAT GO:0048712 (involved in) negative regulation of astrocyte differentiation GO:0051281 (involved in) positive regulation of release of sequestered calcium ion into cytosol GO:0051480 (involved in) regulation of cytosolic calcium ion concentration GO:0051838 (involved in) cytolysis by host of symbiont cells GO:0051918 (involved in) negative regulation of fibrinolysis GO:0061844 (involved in) antimicrobial humoral immune response mediated by antimicrobial peptide GO:0070945 (involved in) neutrophil-mediated killing of gram-negative bacterium GO:0090218 (involved in) positive regulation of lipid kinase activity GO:1900016 (involved in) negative regulation of cytokine production involved in inflammatory response GO:1900182 (involved in) positive regulation of protein localization to nucleus GO:1900738 (involved in) positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:2000379 (involved in) positive regulation of reactive oxygen species metabolic process GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005788 (located in) endoplasmic reticulum lumen GO:0005796 (located in) Golgi lumen GO:0005886 (located in) plasma membrane GO:0070062 (located in) extracellular exosome GO:0072562 (located in) blood microparticle

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P00734|THRB_HUMAN Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE >tr|E7FAN5|E7FAN5_DANRE Activation peptide fragment 1 OS=Danio rerio OX=7955 GN=f2 PE=1 SV=1 MLQVFSGLQAQSLSRMGAKLAPLLLFLIFGQVFHLTLCHNVFIDSKEASQIIRAKRANTV FEELKPGNLERECVEEICDHEEAREVFERVDKTEIFWAKYLGCEGTTLSRTPQNINSLRI CATTEGDCFINIGAKYAGKVSVTKSGKACQYWKSNFPHKIDEFNVTQLKLPENFCRNPDK HKDGPWCFTRDPTVRRETCNVPKCGEAVVPPPKAPTAKPEQRHVISKCLPGNGETYTGEL FVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNPDGDMEGPWCYIKAASGNITI DYCDLELCDAPLDKFVEEGGGRERTTLDQRKAFFNPRSFGNGELDCGERPLFEKINKADK NEKELLMSYTGSRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISDEWILTAAHCILY PPWNKNFTINDIIVRLGKHSRTKYERGIEKIVAIDEIIVHPKYNWKENLNRDIALLHMKK PVVFTSEIHPVCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTSNPTNLPTVLQQIHLPIV DQSICRNSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPSDNRWYQIGIVSWG EGCDRDGKYGFYTHLFRMRRWMKKVIEKTDSGDDE
Selected proteins from model organisms >NP_000497.1 prothrombin preproprotein [Homo sapiens] MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEA FEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKP EINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPL EQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKP GDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAA SLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_038061951.1 mannan-binding lectin serine protease 1-like isoform X2 [Patiria miniata] MTAAMGLARTWWLAVVLVFLACTCVTNVAFSIDGWPSLAALNMGSEQASGVKPIATDVSDGSVTLDWSDWYREIDGESLF LVRFIIKYRIADNDATMQYEIAAEPRNYETRHTVTGLKERTRYEFIVEGVRLGLEGEEVGPTTQPLVVITPCGAPSQVSN AVVWPQNGTGKVLKLSWGRPDDPDCSPSSYIVEFRQLSLGQCEREAQVLDSTSLAGSTELTQFTIGGLQPHSTYTVYVTS RNRYGISQAWRHNVTTNEEVPSAAPTGLQSKYVDGTKLRVSWDPVPCGHRGGIITGYTYILLDVTTDQVSYSDHTSDTNV VLPESRALRRYKFLVAANTAVGRGPYAAFSVDAQPKILDICGRPAPYDASRDIVQKISTGTDARKGSAPWLAQLWYVDKG TLFCHGSILDNRWILTAAHCIRARNATKNDIMIRLGDHDKSLPEMEEQVYRVEDIKVHRSFSTKLFDADVALVKLTQAIQ FTDYVKPICLPVKPLSKSMLRPGTYGTVSGWGKVSSHDENYPRHLKRVTLPVQDQVVCRRSTHFEVTPNMFCAGYSAANR GDSCEGDSGAPFAVQHMNTDRWYILGVVSWGEGCDRKDKYGFYVRLHRYTAWIRKQTGIKLS >XP_039266936.1 plasminogen-like [Styela clava] MIALRFLIFFAILFGNRTSEGATVTPYWTSWSTYGPCTVTCRRGVRYRTRSCVGGLPGEYGCPGRWYEGIQCVETYNCFA VISTTTSTTTTVTTTTTPPPTTAVRIQNFSGCMKPDEPGSYRGTVYRTISGYTCQRWDSQLPHPHNYSPDKHPGAGLEKN NYCRNPDMDVKPWCFTTNPNKQWEYCEVVICTDDSIPELESTRRDCYNSSNPQSYTGTMSTTTTGLTCQYWNSSSPHKNL FPRDQYESVHLGDHNYCRNPDNDTRPWCFTVDPTKNWEYCDVPMCSDTENNNLDTNGLSIQCGRPQIAMKPHSTSRVAFA PMFADFNHHRASLFGRAILEGVPEVHETEDLENIIGGFEVTPGSIPWQASIRRTYFGSHFCGGALINVRWIVTAAHCITQ PQNPTSYFALLGDHNQYDENENQIRIDFDVIFRHHAYSSVTLNNDIALMKTTRPVHMNSFVSAICLPSTGLTESEYTGIV SGWGTMQNTGSNELLHQASVPLIEDSSCKRLMSDIMEGMMCAGYEDGGKGSCQGDSGGPLVVKMEDGGFKLVGIVSWGYG CAAENKPVVYTKVSHHIGWINYIVNT >XP_030855970.1 low-density lipoprotein receptor-related protein 5-like [Strongylocentrotus purpuratus] MYPSNFPDITIPDDFNITNMLVNRNHAVALAVDLEDGLVFYSDVASKAIGMASLRVGSTVRYITGATGSVEGMAVDWLTK HLYWTDNPRGTIEVSRYDGSYRTTLLKDKVLRPRSIAIDPAKKVMFWTEFGPPTQIERASLDGTGRMEIIGPTQGVGQMS GLVIDYKEKRLYFADIARGIISSVDYDGGGIRQVISKPNSLFFEVTLYKDYIMWTELGPNQGIFISNKETGEAVRAFPMT EEVYGITMYADTRQKIIHNPCRSYNGGCQQLCLNSYEQTNGYVCHCSMGYYLADNGRDCHSDLVDHDFLLVTDTYHRGIY QVDLYSNFKPEALRLNGVKNPIGISFDPVERMVYWTDVEKREVNRASLDGSRQDTIAIENIGQPDGIAVDSISKLVYWSD LATRSISVSTLDGSDRKTLVTNIAKPRAIVLHPVEGIMFWSDWRSSTVIERSYMDGDMRRVIINTGLRWTNGLAIDFEEN RLYWCDGGLDVIESSDFSGRDRRVVLNLGDGRHAFGISVIDQSVYWTDWMVKGLLKADKLTGQNNVVLGKRDFTRPNALF VVTNASLPSGINSCSENNGGCSTLCLPTAIGRSCACADGVDLAQDGLTCVSELDIQCPLDFIYGGVEESCDRSAGSTCSV ICYSGLVPAVDYVICQNSGSWDIPRSAICREEQCEALDVPNHAIFSGPCNPPYDQGKLCILECEPGYVRTSGKPRRVCAH GGEWLGTPIVCEEMVEPPPEGECSSELAFQETPEDYSPVQDDLVQQSCTTNSPQADITWYKDGVRLMTGSVNGIYILPSN DLLIPGFDTHHQGHYACVASFSGRECLRVEVDFAFDPYRHFEAVPANASLDVGDHHLFECQAQSAIDSVTWWKDGSRVHQ TDQIILISGGSLLIRNLVRQDSGKYTCIVSDQRGNQRGKAYAWLTVADTMNPPTINITEVCGTVTSPEATMFTTPGPRDG RVVGGQQSLPGSAPYMGRIWHKADRTFVCGATLLNQRWVITAAHCIVLYQLQFRDILLYFGDHDTLTSEDHQVIAEVDQI IQHEDFDEESFDKDIALIRLKQPFAEFTDYIRPICIPPAWLAKMLLQPDMMGRVTGWGQIAEGGPYPRYLTEVDLPVVKS KKCKDATTFEVTRYMFCAGYASAEEKKDACQGDSGGPFAMLHENRWYQLGIVSWGEGCARDSKYGYYTKILRLHSWIDRN ISD >XP_031563420.1 uncharacterized protein LOC116298966 isoform X2 [Actinia tenebrosa] MDSRVSTARFVIVLTIFLIKGQAIGLDGVHVFASHGFHEIQESISSRIDPFSNEFLQGSSKIADLKSSSGEHLSELSSLQ RVRKRRDVVSGGLQVQGLSASQGCNGIILEWDALPLPYSAKLQYVSSEFKHFNVYRSNSFFSDVTGMAPHASGVTDPRLR AVDNRRWIDFYPPPMANWFYAVTIVDGKGREQTRVAAKKVIFVGAIEKEGKPFLMIPSVLRGRAMHHSVAFNPNRNEYLV AFDWDMNHDGTSDHLYAARLDQAGKIVDKKVLNFSASIPGWVSGEQGWPAVAFNPSSNEYLVLFHFRSTKHFSNRHVILA QRILAAQSERAASPSVTATADGADIKEPKLLYNPKTGGYVASVVVTKPKKDVIGLFLDKNGKVAKVGQVCSFRYDAYEHN LFHDSKRDEFYFTCTIENKGTIANPQLETRPFMVLMTKMDAFGVHASNTPSSGTKTLIGYSNKRHTRHEGYYNQKTDRLV MFWEDLKNGKNTLSSSSLLMTRALFLLEVGKYDCHLDREVKTPVLLPMPISGGHYLLWQERSQLSWSIGGQLMKDGNFRL TSGIQKNPTVVYNVNRDMGFVVWQEDVGRQVKLIGRHFTYSSSHTCSSACPPNQRCVQQNTCDSDRCSSNNGGCSHKCQV KAGGLLTQCICPKDMELDADQKTCINNLPCRGMTPMKNPLTSQDMYCGRGPLHVDCLEGSYCHIHPTDKFAKCCPDLLPG YAILVASQNTIWKAVINENQQKANVSRMPFTQGFMQVVAIAYDPKEKRMYWSDVMGQTIKRALMDGTGEETILRSNVHTP DGLYLDTVDRELYWTDAGQETIEKSKLDGSGRRVLVNKGLDQPRAIVLYKKRRQMYWTDWGKIPKIERSLEDGTTRETIV TRGLGWPNGLAIDEDLRQLYWADAKVDKIETSDLEGRNRRVLVGGDKAKHPFSIGILNNRLFWSDWEKEGVQSVDKQTGK DYAEILNGLENPKGMFLFMTESQPLNTCPDPGRPNNGNRFPAPGPTGRYDVGVSLIFTCNPGYTLIGPINRQCKRTGKWS RKVTECVAPPFLTATPINTTVDEGKAAVLRCSSSIDRSHPIQVQWFKNGSPLAPDPDIRYHVAFTGHLIFSLTRYSDRGL YKCVAQNKGGKVSATAHLKVRGSVKLKECGRPGFNTRARIIGGRRADRGAHPWQVMLWNKLDKRHFCGGTLITDRWLVTA AHCVHAKLLFPSNIKIRLGKHVRTRTERNEQSMNADMIKIHPNYNAMDRTYDSDIALVRTSKKVIFTDYIQPICLPTKEQ DFQLMRVNTSGVISGWGSRKVFRDSARRLYEAGVPIVSTSACKASHPAYIITPNMFCAGQKNSSLGDACQGDSGGPFSVN SPLPSKRNVKRHVLLGVISWGDGCGHYGKYGVYTRVTNFVDWIMNEID >XP_016769420.1 trypsin-1 [Apis mellifera] MCIRTTICLAVIVAVVACTVNCEEVQSSVIKEGINLNATQYNATINDDKNFWDWILAGILSPSDSTTENPKPGTPEECLP CKCGLTNVQRRIVGGVETQVNQYPWMVLLMYRGRFYCGGSVISSFYVVTAAHCVDRFDPKLISVRILEHDRNSTTEAKTQ EFRVDKVIKHSGYSTYNYNNDIALIKLKDAIRFEGKMRPVCLPERAKTFAGLNGTVTGWGATAESGAISQTLQEVTVPIL SNADCRASKYPSQRITDNMLCAGYKEGSKDSCQGDSGGPLHVVNVDTYQIVGIVSWGEGCARPGYPGVYTRVNRYLSWIS RNTEDSCYC >CAE1319957.1 F2 [Sepia pharaonis] MAERESHLWLECRHIIDTKGVKLESPGFPESYPSNHQCVYIIRSPPEETVTLTFHKFKLEKGENCQYDYVKIKDGESAAA DVLDKLCGVQDNKTYKSSGRSLRLDFVTDVGVSFMGFSATYTFSNCPLRCYNGGTCHNNTCKCSYGYQGPQCQYHKSCKD KPCENNATCSERRIGYHCHCTTQYTGYNCERKKYEVKLTGRERVQRRDNVEFKCFLNGKAARNAKWFFNENRLQVHTNDR AQIDKHVLYIHHVTEEDEGDYLCAVYKDDNAYYDVKKLKVSARCRLRVEEARNITVSSNQTARLFCPIRTHHGVKVSWKK NGHPIRLSSRKVAAGRTLKFESVISVDEGKYTCIAVGPNGCSAKADVWLTYERKDIPQECGRNNFHMHDHGLLAKIKSGH RAALGSAPWFVNFVEAAVTKSFCGGTLISRTHIVTAAHCIKLFKGPFDNANVHVYLGTQNCSGLGGIKVQIKKVTVHPRY NQSSLFDSDIAIVELQEKLYFNKIIQPLCLVDSAVVEEVAFYSGVFGTVVGCGMTSTGYHPHHLNEVKVPYVSNESCRST LHVGHNITSKMFCAGSIQAHQGDSCQGDSGGPYAVQLPSSSRWILVGIVSWGYKCDQSDSYGVYTNVGQFFDWITRIMSE P >NP_989936.1 prothrombin precursor [Gallus gallus] MAHSKTTMLQGLLLFGLLHLTLSHDGVFLEKGQALSLLKRPRRANKGFLEEMIKGNLERECLEETCNYEE AFEALESTVDTDAFWAKYQVCQGTKMPRTTLDACLEGNCAANLGQNYRGTINYTKSGIECQVWTSKYPHI PKFNASIYPDLTENYCRNPDNNSEGPWCYTRDPTVEREECPIPVCGQERTTVEFTPRVKPSTTGQPCESE KGMLYTGTLSVTVSGARCLPWASEKAKALLQDKTINPEVKLLENYCRNPDADDEGVWCVIDEPPYFEYCD LHYCDSSLEDENEQVEEIAGRTIFQEFKTFFDEKTFGEGEADCGTRPLFEKKQITDQSEKELMDSYMGGR VVHGNDAEVGSAPWQVMLYKKSPQELLCGASLISNSWILTAAHCLLYPPWDKNLTTNDILVRMGLHFRAK YERNKEKIVLLDKVIIHPKYNWKENMDRDIALLHLKRPVIFSDYIHPVCLPTKELVQRLMLAGFKGRVTG WGNLKETWATTPENLPTVLQQLNLPIVDQNTCKASTRVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFVM KNPDDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKTIEKQG >XP_023818208.1 prothrombin [Oryzias latipes] MVEPTLRTSAVVLLLILHNCAANHVFLKGQQASQVLVRNPRANQMFEELKPGNLERECFEEICDHEEAREVFEQTDKTEI FWAKYLDCEGTVKHRTTKTIGLIRDCVEGHCVSGNGHNYNGNIHITKSGRVCQHWSHSFPHPIFREFNASEPNSILQENF CRNPDKRSEGPWCFTKDPSVQKETCRVPKCGEKFVPPTVAPEVVKTTICLPNYGVDYTGDLSVTLGGHTCIQWSSPQAKA LSKDKEFIPEVQLTGNKCRNPDNDPEGPWCYVHISGNITVDYCDLDLCEDPLLAQEQETETEGRERSVLAPAKKLFFNPR TFGEGESSCGLRPLFELKSKKDAKEQELLDSYREQRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWIVTAAHC VLYPPWNKNLTTEDILVRLGKHNRAKFERGVEKIVAIDEIIVHPKYDWKQNLNRDVALLHLRRPITFSDEIYPICLPNKQ VARNLMMQGYKGRVTGWGNLKESWNPAARNLPTVLQQIHLPIVDQEICRQSTSVRVTDNMFCAGFKPDDSQRGDACEGDS GGPFVMKHPGENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMGRWIKKVIEKSGGDDE >XP_030265053.1 prothrombin [Sparus aurata] MVERLLKPASVLLLFLLHGCLAQNVFLNSHVAAQVLVRSRRANQLFEEVKPGNLERECVEEICDHEEARE VFEQTDKTETFWGKYLDCKGTQLTRTQDNIDMVRQCVEGQCISGTGVSYAGNVNITESGIQCQHWSSSFP HPIIREFNASEPDSILHENFCRNPDNQADGPWCYTKNPVIVKQKCRVPKCGEPFVPTTVAPEPVRTGECL PNYGIDYVGDLAVTLGGHTCLLWSSPEAKALSQDKEFIPEVGLPGNKCRNPDNDPEGPWCYVRVNGNVTV DYCDLHLCEDSLVEDSLTTENEGTERSVLGPAKKLFFSPRSFGQGEANCGKRPLFEQKAIKDKKEDELLA SYRESRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWILTAAHCILYPPWNKNFTKDDILVRLG KHMRAKFERDTEKIVAIDEIIVHPKYNWKENLNRDIALLHMRRPVTFTDEIYPVCLPSKKVARTMLTEGF KGRVTGWGNLKETWNPAARNLPAVLQQIHLPIVDEQICRTSTSVRITDNMFCAGYKPEDAKRGDACEGDS GGPFVMKYPAEERWYQMGIVSWGEGCDRDGKYGFYTHVFRMARWMRKVITKSGSNDGDD >OCT83731.1 hypothetical protein XELAEV_18021869mg [Xenopus laevis] MTVLKRSRRANSGFEEFRQGNFERECIEEICSYEELREIKESTVETNSFWTKYKDCEPEKKSRDAREDCLKGTSTCAEGT GTHYRGNVSVTRSGKECQFSPDINPSLAKNYCRNPNNNPTGPWCYTTDPQKQWEECVISVCGTNRTTVEPLLIKQDQPVK MEPCETDFGLNYEGKLAKTISGLPCLPWDSPSVQKFSRKDFMPEIKLQENYCRNPDNDGEGLWCFVSHPNMTYDYCNVNY CDSPIDEDILNNPAGRTTTEEHQTFFDEKTFGSGEAVCGLRPLFEQKSVEDKGEKELMESYMQGRIVKGENAEPGSAPWQ VMLFKKSPQELLCGASLLSDRWVLTAAHCIFYPPWDKNYTTDDILVRIGKHYRTKYERATERIAQLERIIVHPKYNWKEN LDRDIALIQLKRPVALSNYIHPVCLPTKDAVVKLLAAGYKGRVTGWGNLQETWSAGAQNLPQALQQINLPIVDQETCKSS TKIKITDNMFCAGYSPEDSKRGDACEGDSGGPFVMKDPDTGRWVQLGIVSWGEGCDRDGKYGFYVHVHRLRKWLMKTIEK FGSS >NP_611611.1 tracheal-prostasin [Drosophila melanogaster] MNRAWLCLLICLALSCGPSQSASQDRATNQTAASPLLKQSQNTFIQWVLSLLPQRPGSSDSENATLATLSSSSMMPDAAS TTSTTTPAPSSSTTTTRRATTPAPPTLNPPRNCSDCVCGIANIQKRIVGGQETEVHQYPWVAMLLYGGRFYCAASLLNDQ FLLTASHCVYGFRKERISVRLLEHDRKMSHMQKIDRKVAEVITHPKYNARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPG RSFKGENGIVTGWGALKVGGPTSDTLQEVQVPILSQDECRKSRYGNKITDNMLCGGYDEGGKDSCQGDSGGPLHIVASGT REHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTKQACLCQQETKKIK >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] MKVWIFLLLVGVINKVSTDNKNDVIEKVGCGLHSTNVELAQTRSAQEPADYVTLDHRLIGGSESSPHSWPWTVQLLSRLG HHRCGGSLIDPNFVLTAAHCFAKDRRPTSYSVRVGGHRSGSGSPHRVTAVSIHPWYNIGFPSSYDFAIMRIHPPVNTSTT ARPICLPSLPAVENRLCVVTGWGSTIEGSSLSAPTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCAGYSYGKIDSCQGD SGGPLMCARDGHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINLEMNRLRI >KAB0371250.1 hypothetical protein FD755_017659 [Muntiacus reevesi] MAHARGPWLPGCLALAALLSLVHGQHVFLGRRQASSLLQRARRANRGFLEELRKGDLERECLEELCSREEAFEALESLSA TDVFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRN PDGSLTGPWCYTTSPTLRREECSIPVCGQNRVTAELIPRSGGSTQGQSPVQETCIPDRGRQYRGRLAVTTHGSRCLAWSS EQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDADLGDGLGEDPDAAIEGRTSEDH FQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDR WVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIH PVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTSVTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGK RGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF >XP_043337793.1 prothrombin [Cervus canadensis] MVHVRGRRLPGCLALAALLSLVHGQHVFLGHRQASSLLQRARRANRGFLEELRKGDLERECLEEPCSREEAFEALESLSA TDVFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRN PDGSLPGPWCYTTSPTLRKEECSIPVCGQDRVTAELIPRSGGSTPRQSPGPETCIPDRGRQYRGRLAVTTHGSRCLAWSS EQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDADLGDGLGEDTDAAIEGRTSEDH FQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDR WVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIH PVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTSVTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGK RGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF >KAB0349345.1 hypothetical protein FD754_014202 [Muntiacus muntjak] MAHARGPRLPGCLALAALLSLVHGQHVFLGRRQASSLLQRARRANRGFLEELRKGDLERECLEELCSREEAFEALESLSA TDVFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRN PDGSLTGPWCYTTSPTLRREECSIPVCGQNRVTAELIPRSGGSTPGQSPVRETCIPDRGRQYRGRLAVTTHGSRCLTWSS EQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDADLGDGLGEDPDAAIEGRTSEDH FQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDR WVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIH PVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTSVTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGK RGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF >XP_003206466.1 prothrombin [Meleagris gallopavo] MAHSKTTMLQGLLLFSLLHPILSHDGVFLEKGQALSLLKRPRRANKGFLEEMIKGNLERECLEETCNYEE AFEALESTVDTDAFWAKYQVCQGIKMPRTTLDACLEGNCAVNLGQNYRGTINYTKSGIECQVWTSKYPHI PKFNASNYPDLTENYCRNPDNNSEGPWCYTRDPTVEREECPIPVCGQERTTVKFTPRVTPSTTAQPCESE KGMLYTGTLSVTVSGATCLPWASEKAKAVLQGKTINPEVKLQENYCRNPDADDEGVWCVIDEPPYFEYCD LHYCDSSLEDENEQLEEISGRTVFQEFKTFFDEKTFGEGEADCGTRPLFEKKQITDQSEKELLDSYMGGR VVHGNDAEVGSSPWQVMLYKKSPQELLCGASLISNSWVLTAAHCLLYPPWEKNLTTNDILVRIGKHFRAK YEKNKEKIVLLDKIIIHPKYNWKENMDRDIALLHLKRPVIFSDYIHPVCLPTKELVQRLMLAGFKGRVTG WGNLKETWATTPENLPTVLQQLNLPIVDQNTCKASTRVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFVM KNPDDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKTIEKQG >XP_025063735.1 prothrombin isoform X1 [Alligator sinensis] MGNSRGSMLGSLLLLCLLHLVLSQDGAGRRSLRERLSSIQKSLSEIEVFLEQQEAFSMLKRSRRANKNLL EEMLPGNLERECIEEICSYEEAYEALESTTLATEFWRKYKVCNSQRTNRATLDDCLKGDCALETGENYVG KINITKSGIECQLWRSKYPHRPEFNLTIYGNVSLTDNYCRNPDNNPKGPWCYTQDPTVRREACSIPVCGQ DATTVPFNPRSRPPSPRTKQPCEEKRGLCYTGNLSVTKSGTKCLPWNSEKAKEILQGKTVIPEVVLVENY CRNPDGDEEGVWCVTHEEPHNFNYCDLDYCDSPLDDVGDEMAVSIGRTSVPEYKAFFDPQTFGSGEAECG IRPLFEKLKIADKTEKELLESYIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWILTAAHC LFYPPWDKNFTTDDLLVRIGKHYRAKYERNQEKIVLLDKIIIHPKYNWKENLDRDIALMHLKKPVAFSNF IHPICLPTKEIVQRLMLEGYKGRVSGWGNLFETWSSTSASLPSVLQQVNLPLVDQQNCRASTKIKVTDNM FCAGYSPEDAKRGDACEGDSGGPFVMKNPDDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKTIDK HGR >XP_015813395.1 PREDICTED: prothrombin [Nothobranchius furzeri] MVEPSKRAAVLLLLVLHGYAAHDVFLNSQQALQVLVRSRRANHLFEEMKPGNLERECVEEICDNEEAREV FEQGDKTADFWTTYLDCKGTQTKRTQNSIPLIRKCITGYCISGNGFNYKGQVNITQSGKLCQHWKHNFPH PISRYFNTSAADSNLQENFCRNPDKHPGGPWCFTTDPTVQRETCRVPKCGEDFVPTTLAPERTRAATTCL TSYGVDYTGDKSETMNGHTCLSWSSPEVVALSKDKEFIPEVTLPGSKCRNPDNDPEGPWCFVDVSGNITV DYCDLELCEDPLTGDEETNSQGTERSVQVQNKKLFFSPRSFGQGESVCGVRPLFEQVSRVDNGEKEMLES YREQRIVGGDSAEVASAPWQVMLYKRSPQELLCGASLLSDQWILTAAHCILYPPWNKNFTINDILVRLGK HNRAKFERGIEKIVAIDEIIIHPKYNWKENLNRDVALLHMKRPVTFSNEIHPVCLPSKQVARTLMTNGFK GRVTGWGNLQETWNPAARNLPTVLQQIHLPIVDQEICRQSTSVRITDNMFCAGYKPEESQRGDACEGDSG GPFVMKYPAENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMNRWIKKVIDRTGDDDE >XP_040184143.1 prothrombin [Rana temporaria] MHRTEFPPTMPHRTMIIWGIALAFLLPPALGHNVFLDNQAASTVLSRSRRANTLWEEVKAGNMERECVEE ICNYEEAREIKESDDATKIFWQQYQACQPGVGKKQPREVLLTCLQGDCASGLGQNYRGTLSVTRSGTECQ YWGSHFPHKTKVNPDTHSEKNLTENFCRNPDDNPLGPWCYTKNPEKTREECAVPVCGTEKTTVEKIPIVK QEPVQTEEEEHCEPNRGIDYEGTLAVTVSGFPCLPWDSAEVELHSRKEFRKEAVLKGNYCRNPDGDDEGV WCYVSHPNVTFDYCALKYCDSPIDEETVSVIGGRTDTAQHQTFFDEKSFGKGESVCGQRPLFEQKKVQDK GEEELILSMQGRVVKGEDAERGSAPWQVMIYKRQPQELLCGASLISDTWILTAAHCIFYPPWDKNFTVDD LLVRIGKHNRLKYEKPDERILQLQRIIVHQRYNWRENLDRDIALMQLKRPLLFTSYIHPVCLPTKDIVQS LFQSGYKGRVTGWGNLQENWSTGGPKQPQILQQINLPIVEQERCKSSTKVKVTDNMFCAGYRPEDNKRGD ACEGDSGGPFTMKDPVSNRWYQMGIVSWGEGCDRDNKYGFYVHVHRLRKWVMKTVEQNALS >KAF4009430.1 hypothetical protein G4228_000592 [Cervus hanglu yarkandensis] MVHVRGRRLPGCLALAALLSLVHGQHVFLGHRQASSLLQRARRANRGFLEELRKGDLERECLEEPCSREEAFEALESLSA TVRPHGVSASFLACESARNPREKLNECLEGQDRVTAELIPRSGGSTPRQSPGPETCIPDRGRQYRGRLAVTTHGSRCLAW SSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDADLGDGLGEDTDAAIEGRTSE DHFQPFFNEKTFGAGEAGKARGSLRAGGQAGARRPSASHGPACPLDCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQD AEVGLAPWCVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVEKISMLDKIYI HPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTSVTEVQPSVLQVVNLP LVERPVCKASTRIRITDNMFCAGNTAVLSQGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYG FYTHVFRLKKWIQKVIDRF >XP_020737482.1 prothrombin [Odocoileus virginianus texanus] MAHVRGLRLPGCLALAALLSLAHSQHVFLGRRQASSLLQRARRANKGFLEELRKGDLERECLEEPCSREEAFEALESLSA TDVFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRN PDGSLTGPWCYTTSPTLRREECSIPVCGQDRVTAELIPRSGGSTLRQSPGPETCIPDRGRQYRGRLAVTTHGSRCLAWSS EQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLDYCGEPVDADLGDGLGEDPDAAIEGRTSKGH FQPFFNEKTFGSGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDR WVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIH PVCLPDKETAAKLLQAGFKGRVTGWGNRRETWTTSVTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGK RGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF >NP_034298.1 prothrombin preproprotein [Mus musculus] MSHVRGLGLPGCLALAALVSLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEE AFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHK PEINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNLSP PLGQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAG QPGDFEYCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEK ELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLL VRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLL RAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDA CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG >NP_075213.2 prothrombin precursor [Rattus norvegicus] MSHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEE AFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHR PDINSTTHPGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSP PLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQ QPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKE LLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLV RIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQ AGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDAC EGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR >XP_005216458.2 prothrombin isoform X1 [Bos taurus] MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREE AFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHK PEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPL LETCVPDRGREYRGRLAVTTRGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQ PGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQV QDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNF TVDDLLVRIGKHSRTRCGGAPRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPV CLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCA GYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLG S >XP_005169022.1 prothrombin isoform X1 [Danio rerio] MLQVFSGLQAQSLSRMGAKLAPLLLFLIFGQVFHLTLCHNVFIDSKEASQIIRAKRANTVFEELKPGNLE RECVEEICDHEEAREVFERVDKTEIFWAKYLGCEGTTLSRTPQNINSLRICATTEGDCFINIGAKYAGKV SVTKSGKACQYWKSNFPHKIDEFNVTQLKLPENFCRNPDKHKDGPWCFTRDPTVRRETCNVPKCGEAVVP PPKAPTAKPEQRHVISKCLPGNGETYTGELFVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNP DGDMEGPWCYIKAASGNITIDYCDLELCDAPLDKFVEEGGGRERTTLDQRKAFFNPRSFGNGELDCGERP LFEKINKADKNEKELLMSYTGSRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISDEWILTAAHCILY PPWNKNFTINDIIVRLGKHSRTKYERGIEKIVAIDEIIVHPKYNWKENLNRDIALLHMKKPVVFTSEIHP VCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTSNPTNLPTVLQQIHLPIVDQSICRNSTSVIITDNMFCA GYQPDDSKRGDACEGDSGGPFVMKSPSDNRWYQIGIVSWGEGCDRDGKYGFYTHLFRMRRWMKKVIEKTD SGDDE >XP_001165233.2 prothrombin isoform X1 [Pan troglodytes] MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEA FEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKP EINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPS EQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKP GDFGYCDLNYCEEAVEEETGDGLDEDPDRAIEGRTATSEYQPFFNPRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAA SLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_002709128.1 PREDICTED: prothrombin [Oryctolagus cuniculus] MEHVPGLRLAGCLAAAALVSLVCSQQVFLAPQRAMSLLQRARRANTGFLEEMRKGNLERECYEEVCSYEE AFEALESSSATEAFWAKYTACEPVRTPRENFTNCMEGHCAQGLGTNYRGQVSVTQSGIECQLWRSRYPHN PEINFTTHPEADLKENFCRNPDGSTTGPWCYTRDPSVRREECSVPDCSQGQVTLELRPRTGHSGVTQPPP LEPCVSERGRHYQGRLAVTKQGTPCLAWSSPEAQALSRGKSFSPQVPLVENFCRNPDGDEEGAWCYVAGR PSSFEYCGLNYCEEAIEEEVLGLEEAIEGRTTEQEFQTFFNQETFGTGEADCGLRPLFEKKSLKDEREEE LLESYIHGRIVGGRDAQIGSAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVNDILV RIGKYARSRYERNMEKISTLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQ AGHKGRVTGWGNLKEMWTVNMNEVQPSVLQMVNLPLVERPICKASTRIRVTDNMFCAGYKPEEGKRGDAC EGDSGGPFVMKNPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG >NP_001116457.1 prothrombin precursor [Sus scrofa] MAHVGGLWLHGCLALAVLVSLVHSQHVFMAPQQALSLLQRARRANSGFFEEMRKGNLERECVEEQCSREE AYEALESPSETDAFWAKYTACESVRKSREKLVECLEGNCAEGLGMNYRGNISVTRSGIECQLWRSRYPHK PEVNSTMYPGADLRENFCRNPDGSITGPWCYTTSPTVRREACSIPVCGQGRVTAELIPRSGGSTVNVSPP LETCVPERGRQYQGRLAVTSHGSPCLAWGSSQAKALSKDQDFNPAVPLVENFCRNPDGDQEGAWCYVAGQ PGDFEYCDLDYCEEPVDEEVGDALGENADAAIEGRTTADDFQPFFNEKTFGAGEADCGLRPLFEKSSLED KTEKELFESYIEGRIVEGSDAEIGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTE NDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALLKLRKPITFSDYIHPVCLPDKETA TKLLRAGYKGRVTGWGNLKETWTTSASEVQPSVLQVVNLPIVERLVCKASTRIRITDNMFCAGYKPDEGK RGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWMQKVIDRFGG >NP_001126851.1 prothrombin precursor [Pongo abelii] MAHVRGLQLPGCLALAALCTLVHSQHVFLAPQQALSLLQRVRRANSVFLEEVRKGNLERECVEETCSYEE AFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHLNITQSGIQCQLWRSRYPHK PEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSGVNLSPP SEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGK PGDFGYCDLNYCEEAMEEETGGGLDEDPDRAIEGRTATSEYQTFFDPRTFGSGEADCGLRPLFEKKSLED KTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGATLISDRWVLTAAHCLLYPPWDKNFTE NDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETA ASLLQAGYKGRVTGWGNLKETWTANVGKVQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGK RGDACEGDSGGPFVMKSPFNNCWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >NP_001159667.1 prothrombin precursor [Ovis aries] MARVRGPRLPSCLALAALFSLAHSQHVFLAHQQASSLLQRARRANKGFLEELRKGNLERECLEEPCSREE AFEALESPSATDVFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNMSVTRSGIECQLWRSRYPHK PEINFTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREACSVPVCGQDRVTVEVIPRSGGSTTSQSPG LEMCVPDRGRGYQGRLAVTTRGSPCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGARCYVAGQ PGDFEYCDLDYCGEPVDGDLGDGLGEDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKKLQD KTEAELFESYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKSFTE ADLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSEYIHPVCLPDKETA AKLLRVGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKDSTRIRITENMFCAGYKPGEGK RGDACEGDSGGPFVMKSPSNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKVIDRFGS >XP_003639742.1 prothrombin [Canis lupus familiaris] MAHIRGLWLPGCLVILFSLAHSQHVFLDPQQALSLLHRVRRANSGFLEELRKGNLERECVEEQCNYEEAF EALESSTATDVFWSKYTACEPVRKPREKLVECLEGSCAEGLGMNYRGNVSFTRSGIECQLWRSRYPHKPE INSTTHPGADLQENFCRNPDGSTTGPWCYTIDPTVRREECSISLCGQQGGVTVPLTPRSGGPTVNLSPPS EHCIPERGRYYQGRLAVTTHGSPCLAWASRQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVSEEP GGFEYCDLDYCEEPVEEVGDGLAEDQDTAIEGRTTAEEFQPFFNEKTFGAGEADCGLRPLFEKRSVKDKT EGELLESYIDGRIVEGWDAEIGLAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEND LLVRIGKHSRTRYERSIEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVNFSNYIHPVCLPDRDTATR LLQAGYKGRVTGWGNLRETWTSSIGEVQPRVLQVVNLPIVDRQVCKASTRIRITDNMFCAGYKPNEGKRG DACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIEKSGG >XP_003815248.1 prothrombin [Pan paniscus] MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEA FEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKP EINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPS EQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKP GDFGYCDLNYCEEAVEEETGDGLDEDPDRAIEGRTATSEYQPFFNPRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAA SLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_003993267.1 prothrombin [Felis catus] MAHIRGLWLPGCLALAALCSLVHSQHVFLAPQQALSLLQRVRRANSGFLEEVRKGNLERECVEELCSYEE AFEALESSFATDVFWAKYTACESVRKPRDKLMECLEGNCAEGLGMNYRGNVNFTRSGIECQLWRSRYPHK PEINYTTHPGADLKENFCRNPDGSTTGPWCYTTDPTVRREECSIPICGQGGVTVQPTPRSRNSTVNLPPP SDSCIPERGRYYHGRLAVTTHGSPCLAWDSSQAKALSENQDFNPLVPLEKNFCRNPDGDEEGVWCYVSGG PGDFEYCNLDYCEEPFEDVSDGLAEDPEAPIEGRTTAEEFQTFFNEKTFGAGEADCGLRPLFEKKSLKDK TEEELLDSYIDGRIVKGWDAEIGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERSIEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPIAFSSYIHPVCLPDKATVA RLIQTGYKGRVTGWGNLKETWTTSVGEVQPSVLQVVNLPLVEQPVCRASTRIRITDNMFCAGYKPNEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKVIDQSGS >XP_004051078.1 prothrombin [Gorilla gorilla gorilla] MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECMEETCSYEEA FEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKP EINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPS EQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKP GDFGYCDLNYCEEAVEEETGDGLDEDPDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAA SLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKR GDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_005502232.1 prothrombin [Columba livia] MAHNKTGVLRGLLLSSLLHLTLGHAGVFLEKGQALSLLKRPRRANKGFLEEMLKGNLERECLEETCNYEE AFEALESTVQTEAFWSKYQVCQDIRKSRTALDACLEGNCSLGLGENYRGTISYTKSGIECQVWTSKYPHI PKYNATIYPNLIENYCRNPDNNSQGPWCYTRDPTVEREECPIPVCGEERTTVEFTPRVTPSAPVEPCEQE KGMLYTGTLSVTVSGAKCLPWNSEKAKEVLHGKHIDPEVKLLENYCRNPDGDDEGVWCVTDEAPHFEYCD LQYCDSSLEDGNEPSEGISGRTTLPQEFKTFFDDQTFGSGEADCGTRPLFEKKKITDKSEKELLESYIGG RVVHGDDAEVGSSPWQVMLYKKSPQELLCGASLISDSWVLTAAHCLYYPPWDKNLTTNDILVRIGKHMRA KYEKNKERIALLDKIIIHPKYNWKENMDRDIALMHLKRPVIFSDYIHPVCLPTKEVVQRLMLAGYKGRVT GWGNLKETWATSPSNLPTVLQQLNVPIVDQDTCKASTKVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFV MKNPDDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKVIEKHGR >XP_017914625.1 PREDICTED: prothrombin [Capra hircus] MARVRGPRLPGCLALAALFSLAHSQHVFLAHQQASSLLQRARRANKGFLEELRKGNLERECLEEPCSREE AFEALESPGATDVFWAKYTACQSARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHK PEINFTTHPGADLQENFCRNPDGSITGPWCYTTSPTLRREACSVPVCGQDRVTVEVIPRLGGSTTSQSPG LEMCVPDRGREYQGRLAVTTHGSPCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQ PGDFEYCDLDYCGEPVDGDLGDGLGEDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKKLQD KTETELFESYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLLSDRWVLTAAHCLLYPPWDKNFTE ADLLVRIGKHSRTRYERKIEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSEYIHPVCLPDKETA AKLLRVGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKDSTRIRITENMFCAGYKPGEGK RGDACEGDSGGPFVMKSPSNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKVIDRFGS >XP_006261451.1 PREDICTED: prothrombin [Alligator mississippiensis] MGNSRGSMLGSLLLLCLLHLVLSQDGVFLEQQEAFSMLKRSRRANKNLLEEMLPGNLERECIEEICSYEE AYEALESTTLATEFWRKYKVCNSQRTNRATLDDCLKGDCALETGENYVGKINITKSGIECQLWRSKYPHR PEFNLTVYGNVSLTDNYCRNPDNNPKGPWCYTQDPTVRREACSIPVCGQDATTVPFNPRSHPPSPRTKQP CEEKRGLYYTGNLSVTKSGTKCLPWNSEKAKEILQGKTVIPEVVLVENYCRNPDGDEEGVWCVTHEEPHN FNYCDLDYCDSPLDDVGDEVAVSIGRTSVPEYKPFFDPQTFGSGEAECGIRPLFEKQKIADKTEKELLES YIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWILTAAHCLFYPPWDKNFTTDDLLVRIGK HYRAKYERNQEKIVLLDKIIIHPKYNWKENLDRDIALMHLKKPVAFSNFIHPICLPTKEIVQRLMLEGYK GRVSGWGNLFETWSSTPASLPSVLQQVNLPLVDQQNCRASTKIKVTDNMFCAGYSPEDAKRGDACEGDSG GPFVMKNPDDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKTIDKHGR
Mafft alignment of selected proteins >NP_000497.1 prothrombin preproprotein [Homo sapiens] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LQLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCSLVHSQH----------------------------- ------------------------VFLAPQQARSLL-----------------------Q RVR--------------------------------------------------------- --------------RANT-FL---EEVRKGNLER-------------------------- ------------------EC-----------VEETCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWA----------KYTACET----------- --------ARTPRDK---------LAAC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGTNYRGHVNITRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDSSTTGPWCYTTDPTVRRQECSIPVCG-QDQVTVAMTPRSEGSSVNL S----PPLEQCVPDRGQ--QYQGRLAVTTHGLPCLAW---------------ASAQAKAL SKHQDFNSAVQL-VENFC--RNPDGDE--------------------------------- -EGVWCYVA--------------------------------------GKPGDFG------ ----------YCDLNY--CEEAVEEETGD-GLDE---DSDRA---IEGRTAT-SEYQTFF NPRTF---GSGEA----------------------------DCGLRPL--FEKKSLEDKT ERELLE----------SYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDRETAASL-LQAGYKGRVTGWGNLKETW TANVGKGQPSVLQVVNLPIVERPVCKDSTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDQFGE--------- >XP_038061951.1 mannan-binding lectin serine protease 1-like isoform X2 [Patiria miniata] MTAA-------------------------------------------------------- ----------------------------MGLART-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------W-------------------------------------------WL AV--------VLVFLA-------------------------------------------- -------------------CTCVTNVAFSIDG---------------------------- ------------------WPSLAALNMGSEQASGVK----PIA----------------- ------------------------------------------------------------ ------------------------TDVSDGSVTL---------------------DWS-- ---------DWYREIDGESLFLV----RFIIKYRIADNDAT------------------- ------------------------------------------------------------ -----------------------------------------------------MQYEIAA E----------------------------------------------------------- ----------------------------------------PRNYETRHT----------- ---VTGL-KERTRYEFIVEG----VRLG--LEG--------------------------- ------------------------------------------------------------ ---EEVGPTTQPLVVITPCGAPSQVSNAVVWPQN----------------------GTGK VL-KLSW-------GRPDDPDCSPSSYIVEFRQLSLGQCE-REAQVLDSTSLAGSTELTQ FTIG---GLQPHSTYTVYVTSRNRYGISQAWRHNVTT---------------NEEVPSAA PTGLQ-------------S-KYVDGTKL-------------------------------- -RVSWDPVPC------------------------------------GHRGGIIT------ -------GYTYILLDV--TTDQVSYSDHT-------SDTNVV--LPESRALR-------- ---RYKFLVAANT----------------------------AVGRGP----YAAFSVDAQ PKILDICGRPAPYDASRDIVQKISTGTDARKGSAPWLAQLWYVDKGTLFCHGSILDNRWI LTAAHCIRA----RNATKNDIMIRLGDHDKS------LPE-MEEQV-YRVEDIKVHRSFS --TKLFDADVALVKLTQAIQ-FTDYVKPICLPVKPLSKSM-LRPGTYGTVSGWGKVSSHD ENY-----PRHLKRVTLPVQDQVVCRRSTH---FEVTPNMFCA--------GYS--AANR GDSCEGDSGAPFAVQHM-----NTDRWYILGVVSWGEGCDRKDKYGFYVRLHRYTAWIRK QTGIKLS--------- >XP_039266936.1 plasminogen-like [Styela clava] ------------------------------------------------------------ ----------------------------MIALR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FLIFFA-------------------------------------------- ------------------------------------------------------------ ------------------------ILFGNRTSEGAT--VTPYWTSWSTYGPCTVTCRRGV RYRT-------------------------------------------------------- --------------RSCVGGLPG-EYGCPGRWYE-------------------------- ----------------GIQC-----------VETY------------------------- ------------------------------------------------------------ -----------------------------------------------------NCFAVIS T----------------------------------------------------------- ----------------TTST-------TTTVT----------TTTTPPP----------- --------TTAVRIQ--------------NFSG--------------------------- -----------------------------------------------C------------ -MKPDEPGSYRGTVYRTISGYTCQR-WDSQLPHP---------------HNYSPDKHPGA GLEKNNY--CRNPDMD-VKPWCFTTNPNKQWEYCEVVICT-DDSIPELEST--------- -------RRDCYNSSNP-QSYTGTMSTTTTGLTCQYW---------------NSSSPHKN LFPRDQYESVHLGDHNYC--RNPDNDTR-------------------------------- ---PWCFTV--------------------------------------DPTKNWE------ ----------YCDVPM--CSDTENNNLDTNGLSIQCGRPQIA--MKPHSTSR-VAFAPMF AD--F---NHHRA----------------------------SLFGRAI--LE--GVPEVH ETEDLE---------------NIIGGFEVTPGSIPWQASIRRTYFGSHFCGGALINVRWI VTAAHCITQP-----QNPTSYFALLGDHNQY--------DENENQIRIDFDVIFRHHAYS --SVTLNNDIALMKTTRPVH-MNSFVSAICLPSTGLTES-----EYTGIVSGWGTMQNTG S-------NELLHQASVPLIEDSSCKRLMS----DIMEGMMCA--------GYE--DGGK -GSCQGDSGGPLVVKME------DGGFKLVGIVSWGYGCAAENKPVVYTKVSHHIGWINY IVNT------------ >XP_030855970.1 low-density lipoprotein receptor-related protein 5-like [Strongylocentrotus purpuratus] MYPSNFPDITIPDDFNITNMLVNRNHAVALAVDLEDGL-VFYS----------------- ------------DVASKAIG--------MASLRV-------GSTVRYITGATGSVEGMAV DW-----------------------------------LTKHLYWTDNPRG-TIEVSRY-- ----------------DGSYRTT---------------------LLKDKVLRPR----SI AIDPAKK---VMF-W--TEFGPPTQIERASLDGTGRM---EIIGPTQGV-----GQMSGL VIDYKEK---RLYFAD-------------IARGIIS-----------SVDYDGGGIRQ-- --------------VISKPNSLFFEVTLYKDY---------------------------- ------------IMWTELGPNQG-IFISNKETGEAV-RAFPMT--EEVYG---ITMYADT RQKIIHNP---------------------------------------C------------ --------------RSYNGGC---QQLCLNSYEQTNG--------YVCHCSMG------- ----------YYLADNGRDC-----------HSDLVDHDFL-----------------LV T------------------------------------DTY-HRG-------------IYQ VDLYSNFKPEAL----------------------------RL---NGVKNPIGISFDPVE RMVYWTDVEKREVNRASLDGSRQDTIAIENIGQPDGIAVDSISKLVYWSDLATRSISVST LDGSDRKTLVTN-IAKPRAIVLHPVEGIMFWSDWRSSTVIERSYMDGDMRRVIINTGLRW TNG-LAIDFEENRLY-WCDGGLDVIESS-DFSGRDRRVVLNLGDGRHAFGISVIDQSVYW TDWMVKGLLKADKLTGQNNVVLGKRDFTRPNALFVVTNASLPSGINSCSENNGGCSTLCL PTAIGRSCACADGVDLAQDGLTCVSELDIQCPLDFIYGGVEESCDRSAGSTCSVICYSGL VP-AVDYVICQN-----SGSWDIPRSAICREEQC-------EALDVPNHAIFSGPCNPP- YDQGKLCILECEPGYVR--TSGKPRRVCAHGGEWLGTPIVCEEMVEPPPEGECSSELAFQ ETPEDYSPVQDDLVQQSCTTNSPQADITWYKDGVRLMTGSVNGIYILPSNDLLIPGFDTH HQGHYACVAS-------------FSGRECLRVEVDFAFDPYRHFEAVPANASLD--VGDH HLFECQAQSAIDSVTWWKDGSRVH------------QTDQII--LISGGSLL-IRNLVRQ DSGKYTCIVSDQR----GNQRGKAYAWLTVA----------DTMNPPTINITEVCGTVTS PEATMF-------TTPGPRDGRVVGGQQSLPGSAPYMGRIWHKADRTFVCGATLLNQRWV ITAAHCIVL----YQLQFRDILLYFGDHDTL------TSE-DHQVI-AEVDQIIQHEDFD --EESFDKDIALIRLKQPFAEFTDYIRPICIPPAWLAKML-LQPDMMGRVTGWGQIAEGG PY------PRYLTEVDLPVVKSKKCKDATT---FEVTRYMFCA--------GYASAEEKK -DACQGDSGGPFAMLHE-------NRWYQLGIVSWGEGCARDSKYGYYTKILRLHSWIDR NISD------------ >XP_031563420.1 uncharacterized protein LOC116298966 isoform X2 [Actinia tenebrosa] MDSR----VSTARFVIVLTIFLIKGQAIGL-----DGVHVFASHGFHEIQESISSRIDPF SNEFLQGSSKIADLKSSS-GEHLSELSSLQRVRKRRDVVSGGLQVQGLSASQG-CNGIIL EWDALPLPYSAKLQYVSSEFKHFNVYRSNSFFSDVTGMAPHASGVTDPRLRAVDNRRWID FYPPPMANWFYAVTIVDGKGREQTRVAAKKVIFVGAIEKEGKPFLMIPSVLRGRAMHHSV AFNPNRNEYLVAFDWDMNHDGTSDHLYAARLDQAGKIVDKKVLNFSASIPGWVSGEQGWP AVAFNPSSNEYLVLFHFRSTKHFSNRHVILAQRILAAQSERAASPSVTATADGADIKEPK LLYNPKTGGYVASVVVTKPKKDVIGLFLDKNGKVAKVGQVCSFRYDAYEHNLFHDSKRDE FYFTCTIENKGTIANPQLETRPFMVLMTKMDAFGVHASNTPSSGTKTLIG---YSNKRHT RHEGYYNQKTDRLVMFWEDLKNGKNTLSSSSLLMTRALFLLEVGKYDCHLDREVKTPVLL PMPISGGHYLLWQERSQLSWSIGGQLMKDGNFRLTSGIQKNPTVVYNVNRDMGFVVWQED VGRQVKLIGRHFTYSSSHTCSSACPPNQRCVQQNTCDSDRCSSNNGGCSHKCQVKAGGLL TQCICPKDMELDADQKTCINNLPCRGMTPMKNPLTSQDMYCGRGPLHVDCLEGSYCHIHP TDKFAKCCPDLLPGYAILVASQNTIWKAVINENQQKANVSRMPFTQGFMQVVAIAYDPKE KRMYWSDVMGQTIKRALMDGTGEETILRSNVHTPDGLYLDTVDRELYWTDAGQETIEKSK LDGSGRRVLVNKGLDQPRAIVLYKKRRQMYWTDWGKIPKIERSLEDGTTRETIVTRGLGW PNG-LAI-DEDLRQLYWADAKVDKIETS-DLEGRNRRVL--------------------- ------------------------------------------------------------ --VGGDKAKHPFSIGILNNRLFWSD-WEKEGVQS-------------------VDKQTGK DY-AEILNGLENP----KGMFLFMT------ESQPLNTCP-DPGRPNNGNRFPAPGPTGR YDVGVSLIFTCNPGYTLIGPINRQCKRTGKWSRKV-----------------TECVAPPF LTATPINTTVD------------------------------------------------- -EGKAAVLRC---------------------------------------SSSID------ -------RSHPIQVQWFKNGSPLA------------PDPDIRYHVAFTGHLI-FSLTRYS DRGLYKCVAQNKG----G-----------------------KVSATA-------HLKVRG SVKLKECGRPG-----FNTRARIIGGRRADRGAHPWQVMLWNKLDKRHFCGGTLITDRWL VTAAHCVHA----KLLFPSNIKIRLGKHVRT------RTE-RNEQS-MNADMIKIHPNYN AMDRTYDSDIALVRTSKKVI-FTDYIQPICLPTKEQDFQL-MRVNTSGVISGWGSRKVFR DS------ARRLYEAGVPIVSTSACKASHP--AYIITPNMFCA--------GQK--NSSL GDACQGDSGGPFSVNSPLPSKRNVKRHVLLGVISWGDGCGHYGKYGVYTRVTNFVDWIMN EID------------- >XP_016769420.1 trypsin-1 [Apis mellifera] M----------------------------------------------------------- ----------------------------CIRTTI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------CLAVIV-------------------------------------------- ------------------------------------------------------------ ---------------------------------AVV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TVNCEE------------VQSSVIKEGINL---------------NATQYNAT INDDK----------NFW------------------------------------------ ---DWILAGI-------------------------------------------------- --------------------------------------------LSPSDSTT-------- -----------------------------------------ENPKPG------------T PEECLPCKCGL-----TNVQRRIVGGVETQVNQYPWMVLLMYR--GRFYCGGSVISSFYV VTAAHCVDR------FDPKLISVRILEHDRN------STTEAKTQE-FRVDKVIKHSGYS --TYNYNNDIALIKLKDAIR-FEGKMRPVCLPERAKTFA-----GLNGTVTGWGATAESG AI------SQTLQEVTVPILSNADCRASKYP-SQRITDNMLCA--------GYK--EGSK -DSCQGDSGGPLHVVNV-------DTYQIVGIVSWGEGCARPGYPGVYTRVNRYLSWISR NTEDSCYC-------- >CAE1319957.1 F2 [Sepia pharaonis] ------------------------------------------------------------ ----------------------------MAERES-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------HLWLEC-------------------------------------------- --------------------RHIIDTKGVKLE---------------------------- ------------------SPGFPESYPSNHQCVYII------------------------ RSPP-------------------------------------------------------- ------------------------EETVTLTFHK-------------------------- -----------FKLEKGENC--------QYDYVKIKDGES-------------------- ------------------------------------------------------------ -----------------------------------------------------AAADVLD K----------------------------------------------------------- ------------------------------------------------------------ ---LCGV-QDNKTYK---------------SSG--------------------------- ------------------------------------------------------------ ---RSLRLDFVTDVGVSFMGFSATY-TFSNCPLR---------------------CYNGG TC-HNNT--CKCSYGY-QGPQCQY------HKSCKDKPCE-NNATCSERRI--------- -----GYHCHCTTQYTGYNCERKKYEVKLTGRERVQR--------------RDNVEFKCF LNGKAARNAKWFFNENRL--QVHTNDR-A----------------QIDKHVLYIHHVTEE DEGDYLCAVYKDDNAYYDVKKLKVSARCRLRV-------------EEARNITVSSNQTAR LFCPI-RTHHGVKVSWKKNGHPIR------------LSSRKV---AAGRTLK-FESVISV DEGKYTCIAVGPN----------------------------GCSAKA-----DVWLTYER KDIPQECGRNNFHMHDHGLLAKIKSGHRAALGSAPWFVNFVEAAVTKSFCGGTLISRTHI VTAAHCIKL--FKGPFDNANVHVYLGTQNCS----------GLGGIKVQIKKVTVHPRYN -QSSLFDSDIAIVELQEKLY-FNKIIQPLCLVDSAVVEEVAFYSGVFGTVVGCGMTSTGY H-------PHHLNEVKVPYVSNESCRSTLHV-GHNITSKMFCA--------GSI--QAHQ GDSCQGDSGGPYAVQLP-----SSSRWILVGIVSWGYKCDQSDSYGVYTNVGQFFDWITR IMSEP----------- >NP_989936.1 prothrombin precursor [Gallus gallus] ------------------------------------------------------------ ----------------------------MAHSKT-------------------------- ------------------------------------------------------------ ------------------------------------------------TMLQG------- ------------------------------------------------------------ ----------LLLFG--------------------------------------------- ----------------------LLHLTLSHDG---------------------------- ------------------------VFLEKGQALSLL-----------------------K RPR--------------------------------------------------------- --------------RANKGFL---EEMIKGNLER-------------------------- ------------------EC-----------LEETCNYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------TVDT-------DAFWA----------KYQVCQG----------- --------TKMPRTT---------LDAC--LEG--------------------------- ----------------------------------------------NC------------ --AANLGQNYRGTINYTKSGIECQV-WTSKYPHI---------------PKFNASIYP-- DL-TENY--CRNPDNNSEGPWCYTRDPTVEREECPIPVCG-QERTTVEFTPRVKPSTT-- -------GQPCESEKGM--LYTGTLSVTVSGARCLPW---------------ASEKAKAL LQDKTINPEVKL-LENYC--RNPDADD--------------------------------- -EGVWCVID--------------------------------------EPPY-FE------ ----------YCDLHY--CDSSLEDEN----------EQVEE---IAGRTIF-QEFKTFF DEKTF---GEGEA----------------------------DCGTRPL--FEKKQITDQS EKELMD----------SYMGGRVVHGNDAEVGSAPWQVMLYKKSPQELLCGASLISNSWI LTAAHCLLYPPWDKNLTTNDILVRMGLHFRA------KYERNKEKI-VLLDKVIIHPKYN -WKENMDRDIALLHLKRPVI-FSDYIHPVCLPTKELVQRL-MLAGFKGRVTGWGNLKETW ATTPENL-PTVLQQLNLPIVDQNTCKASTR---VKVTDNMFCA--------GYSPEDSKR GDACEGDSGGPFVMKNP-----DDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRK TIEKQG---------- >XP_023818208.1 prothrombin [Oryzias latipes] ------------------------------------------------------------ ----------------------------MVEPT--------------------------- ------------------------------------------------------------ ------------------------------------------------LRTSA------- ------------------------------------------------------------ ----------VVLLL--------------------------------------------- ----------------------ILHNCAANH----------------------------- ------------------------VFLKGQQASQVL-----------------------V RNP--------------------------------------------------------- --------------RANQMF----EELKPGNLER-------------------------- ------------------EC-----------FEEICDHE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAREVFE Q----------------------------------------------------------- ----------------TDKT-------EIFWA----------KYLDCEG----------- --------TVKHRTT----KTIGLIRDC--VEG--------------------------- ----------------------------------------------HC------------ --VSGNGHNYNGNIHITKSGRVCQH-WSHSFPHPIF-------------REFNAS-EPNS IL-QENF--CRNPDKRSEGPWCFTKDPSVQKETCRVPKCG-EKFVPPTVAPEVVK----- -------TTICLPNYGV--DYTGDLSVTLGGHTCIQW---------------SSPQAKAL SKDKEFIPEVQL-TGNKC--RNPDNDP--------------------------------- -EGPWCYVH-------------------------------------ISGNITVD------ ----------YCDLDL--CEDPLLAQEQ---------ETETE---GRERSVLAPAKKLFF NPRTF---GEGES----------------------------SCGLRPL--FELKSKKDAK EQELLD----------SYREQRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWI VTAAHCVLYPPWNKNLTTEDILVRLGKHNRA------KFERGVEKI-VAIDEIIVHPKYD -WKQNLNRDVALLHLRRPIT-FSDEIYPICLPNKQVARNL-MMQGYKGRVTGWGNLKESW NPAARNL-PTVLQQIHLPIVDQEICRQSTS---VRVTDNMFCA--------GFKPDDSQR GDACEGDSGGPFVMKHP-----GENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMGRWIKK VIEKSGGDDE------ >XP_030265053.1 prothrombin [Sparus aurata] ------------------------------------------------------------ ----------------------------MVERL--------------------------- ------------------------------------------------------------ ------------------------------------------------LKPAS------- ------------------------------------------------------------ ----------VLLLF--------------------------------------------- ----------------------LLHGCLAQN----------------------------- ------------------------VFLNSHVAAQVL-----------------------V RSR--------------------------------------------------------- --------------RANQLF----EEVKPGNLER-------------------------- ------------------EC-----------VEEICDHE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAREVFE Q----------------------------------------------------------- ----------------TDKT-------ETFWG----------KYLDCKG----------- --------TQLTRTQ----DNIDMVRQC--VEG--------------------------- ----------------------------------------------QC------------ --ISGTGVSYAGNVNITESGIQCQH-WSSSFPHPII-------------REFNAS-EPDS IL-HENF--CRNPDNQADGPWCYTKNPVIVKQKCRVPKCG-EPFVPTTVAPEPVR----- -------TGECLPNYGI--DYVGDLAVTLGGHTCLLW---------------SSPEAKAL SQDKEFIPEVGL-PGNKC--RNPDNDP--------------------------------- -EGPWCYVR-------------------------------------VNGNVTVD------ ----------YCDLHL--CEDSLVEDSL---------TTENE---GTERSVLGPAKKLFF SPRSF---GQGEA----------------------------NCGKRPL--FEQKAIKDKK EDELLA----------SYRESRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWI LTAAHCILYPPWNKNFTKDDILVRLGKHMRA------KFERDTEKI-VAIDEIIVHPKYN -WKENLNRDIALLHMRRPVT-FTDEIYPVCLPSKKVARTM-LTEGFKGRVTGWGNLKETW NPAARNL-PAVLQQIHLPIVDEQICRTSTS---VRITDNMFCA--------GYKPEDAKR GDACEGDSGGPFVMKYP-----AEERWYQMGIVSWGEGCDRDGKYGFYTHVFRMARWMRK VITKSGSNDGDD---- >OCT83731.1 hypothetical protein XELAEV_18021869mg [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MTVL-----------------------K RSR--------------------------------------------------------- --------------RANSGF----EEFRQGNFER-------------------------- ------------------EC-----------IEEICSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------ELREIKE S----------------------------------------------------------- ----------------TVET-------NSFWT----------KYKDCEP----------- --------EKKSRDA---------REDC--LKGT-------------------------- ---------------------------------------------STC------------ --AEGTGTHYRGNVSVTRSGKECQF--------S---------------PDINP------ SL-AKNY--CRNPNNNPTGPWCYTTDPQKQWEECVISVCG-TNRTTVEPLLIKQDQPVK- -------MEPCETDFGL--NYEGKLAKTISGLPCLPW---------------DSPSVQKF SR-KDFMPEIKL-QENYC--RNPDNDG--------------------------------- -EGLWCFVS--------------------------------------HPNMTYD------ ----------YCNVNY--CDSPIDE------------DILNN---PAGRTTT-EEHQTFF DEKTF---GSGEA----------------------------VCGLRPL--FEQKSVEDKG EKELME----------SYMQGRIVKGENAEPGSAPWQVMLFKKSPQELLCGASLLSDRWV LTAAHCIFYPPWDKNYTTDDILVRIGKHYRT------KYERATERI-AQLERIIVHPKYN -WKENLDRDIALIQLKRPVA-LSNYIHPVCLPTKDAVVKL-LAAGYKGRVTGWGNLQETW SAGAQNL-PQALQQINLPIVDQETCKSSTK---IKITDNMFCA--------GYSPEDSKR GDACEGDSGGPFVMKDP-----DTGRWVQLGIVSWGEGCDRDGKYGFYVHVHRLRKWLMK TIEKFGSS-------- >NP_611611.1 tracheal-prostasin [Drosophila melanogaster] ------------------------------------------------------------ ----------------------------MNRAWL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------CLLICL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ALSCGP------------SQSASQDRAT-----------------NQTAASPL LKQSQ---------NTFI------------------------------------------ ---QWVLSLL------------------------------------PQRPGSSD------ -------SENATLATL--SSSSMMPDAA---------STTSTTTPAPSSSTT-------- --------TTRRA----------------------------TTPAPP---------TLNP PRNCSDCVCGI-----ANIQKRIVGGQETEVHQYPWVAMLLYG--GRFYCAASLLNDQFL LTASHCVYG------FRKERISVRLLEHDRK------MSH--MQKIDRKVAEVITHPKYN --ARNYDNDIAIIKLDEPVE-FNEVLHPVCMPTPGRSFK-----GENGIVTGWGALKVGG PT------SDTLQEVQVPILSQDECRKSRY--GNKITDNMLCG--------GYD--EGGK -DSCQGDSGGPLHIVAS-----GTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKN LTKQACLCQQETKKIK >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] ------------------------------------------------------------ -----------------------------MKVWI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FLLLVG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VINKVST-------- DNKND---VIEKV----------------------------GCGLHST--NVELAQTRSA QEPADY----------VTLDHRLIGGSESSPHSWPWTVQLLSRL-GHHRCGGSLIDPNFV LTAAHCFA-----KDRRPTSYSVRVGGHRSG-----------SGSP-HRVTAVSIHPWYN -IGFPSSYDFAIMRIHPPVN-TSTTARPICLPSLPAVENR-LC-----VVTGWGSTIEGS SLS-----APTLREIHVPLLSTLFCSSLPNYIGRIHLPSMLCA--------GYS--YGKI -DSCQGDSGGPLMCARD-------GHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINL EMNRLRI--------- >KAB0371250.1 hypothetical protein FD755_017659 [Muntiacus reevesi] ------------------------------------------------------------ ----------------------------MAHARG-------------------------- ------------------------------------------------------------ ------------------------------------------------PWLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LLSLVHGQH----------------------------- ------------------------VFLGRRQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANRGFL---EELRKGDLER-------------------------- ------------------EC-----------LEELCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSAT-------DVFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-RENF--CRNPDGSLTGPWCYTTSPTLRREECSIPVCG-QNRVTAELIPRSGGSTQGQ S----PVQETCIPDRGR--QYRGRLAVTTHGSRCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGGFE------ ----------YCDLNY--CGEPVDADLGD-GLGE---DPDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKKLQDQT ETELFE----------SYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTKDDLLVRIGKHSRT------RYERKVEKI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSDYIHPVCLPDKQTAAKL-LQAGFKGRVTGWGNRRETW TTSVTEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRF----------- >XP_043337793.1 prothrombin [Cervus canadensis] ------------------------------------------------------------ ----------------------------MVHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------RRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LLSLVHGQH----------------------------- ------------------------VFLGHRQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANRGFL---EELRKGDLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSAT-------DVFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-RENF--CRNPDGSLPGPWCYTTSPTLRKEECSIPVCG-QDRVTAELIPRSGGSTPRQ S----PGPETCIPDRGR--QYRGRLAVTTHGSRCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGGFE------ ----------YCDLNY--CGEPVDADLGD-GLGE---DTDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKKLQDQT ETELFE----------SYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTKDDLLVRIGKHSRT------RYERKVERI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSDYIHPVCLPDKQTAAKL-LQAGFKGRVTGWGNRRETW TTSVTEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRF----------- >KAB0349345.1 hypothetical protein FD754_014202 [Muntiacus muntjak] ------------------------------------------------------------ ----------------------------MAHARG-------------------------- ------------------------------------------------------------ ------------------------------------------------PRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LLSLVHGQH----------------------------- ------------------------VFLGRRQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANRGFL---EELRKGDLER-------------------------- ------------------EC-----------LEELCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSAT-------DVFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-RENF--CRNPDGSLTGPWCYTTSPTLRREECSIPVCG-QNRVTAELIPRSGGSTPGQ S----PVRETCIPDRGR--QYRGRLAVTTHGSRCLTW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGGFE------ ----------YCDLNY--CGEPVDADLGD-GLGE---DPDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKKLQDQT ETELFE----------SYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTKDDLLVRIGKHSRT------RYERKVERI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSDYIHPVCLPDKQTAAKL-LQAGFKGRVTGWGNRRETW TTSVTEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRF----------- >XP_003206466.1 prothrombin [Meleagris gallopavo] ------------------------------------------------------------ ----------------------------MAHSKT-------------------------- ------------------------------------------------------------ ------------------------------------------------TMLQG------- ------------------------------------------------------------ ----------LLLFS--------------------------------------------- ----------------------LLHPILSHDG---------------------------- ------------------------VFLEKGQALSLL-----------------------K RPR--------------------------------------------------------- --------------RANKGFL---EEMIKGNLER-------------------------- ------------------EC-----------LEETCNYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------TVDT-------DAFWA----------KYQVCQG----------- --------IKMPRTT---------LDAC--LEG--------------------------- ----------------------------------------------NC------------ --AVNLGQNYRGTINYTKSGIECQV-WTSKYPHI---------------PKFNASNYP-- DL-TENY--CRNPDNNSEGPWCYTRDPTVEREECPIPVCG-QERTTVKFTPRVTPSTT-- -------AQPCESEKGM--LYTGTLSVTVSGATCLPW---------------ASEKAKAV LQGKTINPEVKL-QENYC--RNPDADD--------------------------------- -EGVWCVID--------------------------------------EPPY-FE------ ----------YCDLHY--CDSSLEDEN----------EQLEE---ISGRTVF-QEFKTFF DEKTF---GEGEA----------------------------DCGTRPL--FEKKQITDQS EKELLD----------SYMGGRVVHGNDAEVGSSPWQVMLYKKSPQELLCGASLISNSWV LTAAHCLLYPPWEKNLTTNDILVRIGKHFRA------KYEKNKEKI-VLLDKIIIHPKYN -WKENMDRDIALLHLKRPVI-FSDYIHPVCLPTKELVQRL-MLAGFKGRVTGWGNLKETW ATTPENL-PTVLQQLNLPIVDQNTCKASTR---VKVTDNMFCA--------GYSPEDSKR GDACEGDSGGPFVMKNP-----DDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRK TIEKQG---------- >XP_025063735.1 prothrombin isoform X1 [Alligator sinensis] ------------------------------------------------------------ ----------------------------MGNSRG-------------------------- ------------------------------------------------------------ ------------------------------------------------SMLGS------- ------------------------------------------------------------ ----------LLLLC--------------------------------------------- ----------------------LLHLVLSQDGAGRR-------------------SLRER ------------LSSIQKSLSEIEVFLEQQEAFSML-----------------------K RSR--------------------------------------------------------- --------------RANKNLL---EEMLPGNLER-------------------------- ------------------EC-----------IEEICSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAYEALE S----------------------------------------------------------- ----------------TTLA-------TEFWR----------KYKVCNS----------- --------QRTNRAT---------LDDC--LKG--------------------------- ----------------------------------------------DC------------ --ALETGENYVGKINITKSGIECQL-WRSKYPHR---------------PEFNLTIYGNV SL-TDNY--CRNPDNNPKGPWCYTQDPTVRREACSIPVCG-QDATTVPFNPRSRPPSP-- -----RTKQPCEEKRGL--CYTGNLSVTKSGTKCLPW---------------NSEKAKEI LQGKTVIPEVVL-VENYC--RNPDGDE--------------------------------- -EGVWCVTH--------------------------------------EEPHNFN------ ----------YCDLDY--CDSPLDDVG----------DEMAV---SIGRTSV-PEYKAFF DPQTF---GSGEA----------------------------ECGIRPL--FEKLKIADKT EKELLE----------SYIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWI LTAAHCLFYPPWDKNFTTDDLLVRIGKHYRA------KYERNQEKI-VLLDKIIIHPKYN -WKENLDRDIALMHLKKPVA-FSNFIHPICLPTKEIVQRL-MLEGYKGRVSGWGNLFETW SSTSASL-PSVLQQVNLPLVDQQNCRASTK---IKVTDNMFCA--------GYSPEDAKR GDACEGDSGGPFVMKNP------DDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQK TIDKHGR--------- >XP_015813395.1 PREDICTED: prothrombin [Nothobranchius furzeri] ------------------------------------------------------------ ----------------------------MVEPS--------------------------- ------------------------------------------------------------ -------------------------------------------------KRAA------- ------------------------------------------------------------ ----------VLLLL--------------------------------------------- ----------------------VLHGYAAHD----------------------------- ------------------------VFLNSQQALQVL-----------------------V RSR--------------------------------------------------------- --------------RANHLF----EEMKPGNLER-------------------------- ------------------EC-----------VEEICDNE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAREVFE Q----------------------------------------------------------- ----------------GDKT-------ADFWT----------TYLDCKG----------- --------TQTKRTQ----NSIPLIRKC--ITG--------------------------- ----------------------------------------------YC------------ --ISGNGFNYKGQVNITQSGKLCQH-WKHNFPHPIS-------------RYFNTS-AADS NL-QENF--CRNPDKHPGGPWCFTTDPTVQRETCRVPKCG-EDFVPTTLAPERTRA---- -------ATTCLTSYGV--DYTGDKSETMNGHTCLSW---------------SSPEVVAL SKDKEFIPEVTL-PGSKC--RNPDNDP--------------------------------- -EGPWCFVD-------------------------------------VSGNITVD------ ----------YCDLEL--CEDPLTGDE----------ETNSQ---GTERSVQVQNKKLFF SPRSF---GQGES----------------------------VCGVRPL--FEQVSRVDNG EKEMLE----------SYREQRIVGGDSAEVASAPWQVMLYKRSPQELLCGASLLSDQWI LTAAHCILYPPWNKNFTINDILVRLGKHNRA------KFERGIEKI-VAIDEIIIHPKYN -WKENLNRDVALLHMKRPVT-FSNEIHPVCLPSKQVARTL-MTNGFKGRVTGWGNLQETW NPAARNL-PTVLQQIHLPIVDQEICRQSTS---VRITDNMFCA--------GYKPEESQR GDACEGDSGGPFVMKYP-----AENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMNRWIKK VIDRTGDDDE------ >XP_040184143.1 prothrombin [Rana temporaria] MHRTEFP----------------------------------------------------- --------------------------PTMPHRT--------------------------- ------------------------------------------------------------ ------------------------------------------------MIIWG------- ------------------------------------------------------------ -----------IALAF-------------------------------------------- ----------------------LLPPALGHN----------------------------- ------------------------VFLDNQAASTVL-----------------------S RSR--------------------------------------------------------- --------------RANTLW----EEVKAGNMER-------------------------- ------------------EC-----------VEEICNYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAREIKE S----------------------------------------------------------- ----------------DDAT-------KIFWQ----------QYQACQP----------- -----GVGKKQPREV---------LLTC--LQG--------------------------- ----------------------------------------------DC------------ --ASGLGQNYRGTLSVTRSGTECQY-WGSHFPHK---------------TKVNPDTHSEK NL-TENF--CRNPDDNPLGPWCYTKNPEKTREECAVPVCG-TEKTTVEKIPIVKQEPVQT -----EEEEHCEPNRGI--DYEGTLAVTVSGFPCLPW---------------DSAEVELH SR-KEFRKEAVL-KGNYC--RNPDGDD--------------------------------- -EGVWCYVS--------------------------------------HPNVTFD------ ----------YCALKY--CDSPIDE------------ETVSV---IGGRTDT-AQHQTFF DEKSF---GKGES----------------------------VCGQRPL--FEQKKVQDKG EEELIL----------S-MQGRVVKGEDAERGSAPWQVMIYKRQPQELLCGASLISDTWI LTAAHCIFYPPWDKNFTVDDLLVRIGKHNRL------KYEKPDERI-LQLQRIIVHQRYN -WRENLDRDIALMQLKRPLL-FTSYIHPVCLPTKDIVQSL-FQSGYKGRVTGWGNLQENW STGGPKQ-PQILQQINLPIVEQERCKSSTK---VKVTDNMFCA--------GYRPEDNKR GDACEGDSGGPFTMKDP-----VSNRWYQMGIVSWGEGCDRDNKYGFYVHVHRLRKWVMK TVEQNALS-------- >KAF4009430.1 hypothetical protein G4228_000592 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ----------------------------MVHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------RRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LLSLVHGQH----------------------------- ------------------------VFLGHRQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANRGFL---EELRKGDLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSATV----RPHGVSA----------SFLACES----------- --------ARNPREK---------LNEC--LE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------G-QDRVTAELIPRSGGSTPRQ S----PGPETCIPDRGR--QYRGRLAVTTHGSRCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGGFE------ ----------YCDLNY--CGEPVDADLGD-GLGE---DTDAA---IEGRTSE-DHFQPFF NEKTF---GAGEAGKARGSLRAGGQAGARRPSASHGPACPLDCGLRPL--FEKKKLQDQT ETELFE----------SYIEGRIVEGQDAEVGLAPWCVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTKDDLLVRIGKHSRT------RYERKVEKI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSDYIHPVCLPDKQTAAKL-LQAGFKGRVTGWGNRRETW TTSVTEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCAGNTAVLSQGYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRF----------- >XP_020737482.1 prothrombin [Odocoileus virginianus texanus] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LLSLAHSQH----------------------------- ------------------------VFLGRRQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANKGFL---EELRKGDLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSAT-------DVFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-RENF--CRNPDGSLTGPWCYTTSPTLRREECSIPVCG-QDRVTAELIPRSGGSTLRQ S----PGPETCIPDRGR--QYRGRLAVTTHGSRCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGGFE------ ----------YCDLDY--CGEPVDADLGD-GLGE---DPDAA---IEGRTSK-GHFQPFF NEKTF---GSGEA----------------------------DCGLRPL--FEKKKLQDQT ETELFE----------SYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTKDDLLVRIGKHSRT------RYERKVERI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSDYIHPVCLPDKETAAKL-LQAGFKGRVTGWGNRRETW TTSVTEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRF----------- >NP_034298.1 prothrombin preproprotein [Mus musculus] ------------------------------------------------------------ ----------------------------MSHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LGLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LVSLVHSQH----------------------------- ------------------------VFLAPQQALSLL-----------------------Q RVR--------------------------------------------------------- --------------RANSGFL---EELRKGNLER-------------------------- ------------------EC-----------VEEQCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------PQDT-------DVFWA----------KYTVCDS----------- --------VRKPRET---------FMDC--LEG--------------------------- ----------------------------------------------RC------------ --AMDLGVNYLGTVNVTHTGIQCQL-WRSRYPHK---------------PEINSTTHPGA DL-KENF--CRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNL S----PPLGQCLTERGR--LYQGNLAVTTLGSPCLPW---------------NSLPAKTL SKYQDFDPEVKL-VENFC--RNPDWDE--------------------------------- -EGAWCYVA--------------------------------------GQPGDFE------ ----------YCNLNY--CEEAVGEENY---------DVDES---IAGRTTD-AEFHTFF NEKTF---GLGEA----------------------------DCGLRPL--FEKKSLKDTT EKELLD----------SYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWV LTAAHCILYPPWDKNFTENDLLVRIGKHSRT------RYERNVEKI-SMLEKIYVHPRYN -WRENLDRDIALLKLKKPVP-FSDYIHPVCLPDKQTVTSL-LRAGYKGRVTGWGNLRETW TTNINEIQPSVLQVVNLPIVERPVCKASTR---IRITDNMFCA--------GFKVNDTKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQK VIDQFG---------- >NP_075213.2 prothrombin precursor [Rattus norvegicus] ------------------------------------------------------------ ----------------------------MSHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LGLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LASLVHSQH----------------------------- ------------------------VFLAPQQALSLL-----------------------Q RVR--------------------------------------------------------- --------------RANSGFL---EELRKGNLER-------------------------- ------------------EC-----------VEEQCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------PQDT-------DVFWA----------KYTVCDS----------- --------VRKPRET---------FMDC--LEG--------------------------- ----------------------------------------------RC------------ --AMDLGLNYHGNVSVTHTGIECQL-WRSRYPHR---------------PDINSTTHPGA DL-KENF--CRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENL S----PPLGECLLERGR--LYQGNLAVTTLGSPCLAW---------------DSLPTKTL SKYQNFDPEVKL-VQNFC--RNPDRDE--------------------------------- -EGAWCFVA--------------------------------------QQPG-FE------ ----------YCSLNY--CDEAVGEENH---------DGDES---IAGRTTD-AEFHTFF DERTF---GLGEA----------------------------DCGLRPL--FEKKSLTDKT EKELLD----------SYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWV LTAAHCILYPPWDKNFTENDLLVRIGKHSRT------RYERNVEKI-SMLEKIYIHPRYN -WRENLDRDIALLKLKKPVP-FSDYIHPVCLPDKQTVTSL-LQAGYKGRVTGWGNLRETW TTNINEIQPSVLQVVNLPIVERPVCKASTR---IRITDNMFCA--------GFKVNDTKR GDACEGDSGGPFVMKSP-----YNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQK VIDQHR---------- >XP_005216458.2 prothrombin isoform X1 [Bos taurus] ------------------------------------------------------------ ----------------------------MARVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------PRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LFSLVHSQH----------------------------- ------------------------VFLAHQQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANKGFL---EEVRKGNLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------LSAT-------DAFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-RENF--CRNPDGSITGPWCYTTSPTLRREECSVPVCG-QDRVTVEVIPRSGGSTTSQ S----PLLETCVPDRGR--EYRGRLAVTTRGSRCLAW---------------SSEQAKAL SKDQDFNPAVPL-AENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------DQPGDFE------ ----------YCDLNY--CEEPVDGDLGD-RLGE-DPDPDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKQVQDQT EKELFE----------SYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRCGGAPRYERKVEKI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-LSDYIHPVCLPDKQTAAKL-LHAGFKGRVTGWGNRRETW TTSVAEVQPSVLQVVNLPLVERPVCKASTR---IRITDNMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDRLGS--------- >XP_005169022.1 prothrombin isoform X1 [Danio rerio] ------------------------------------------------------------ ----------------------------MLQVFS-------GLQAQSLS-RMG------- ------------------------------------------------------------ ------------------------------------------------AKLAP------- ------------------------------------------------------------ ----------LLLFLIFGQ----------------------------------------- ----------------------VFHLTLCHN----------------------------- ------------------------VFIDSKEASQII------------------------ RAK--------------------------------------------------------- --------------RANTVF----EELKPGNLER-------------------------- ------------------EC-----------VEEICDHE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAREVFE R----------------------------------------------------------- ----------------VDKT-------EIFWA----------KYLGCEG----------- --------TTLSRTP----QNINSLRICATTEG--------------------------- ----------------------------------------------DC------------ --FINIGAKYAGKVSVTKSGKACQY-WKSNFPHKI--------------DEFNVT---QL KL-PENF--CRNPDKHKDGPWCFTRDPTVRRETCNVPKCG-EAVVPPPKAPTAKPEQR-- -----HVISKCLPGNGE--TYTGELFVTLGLHTCLQW---------------SSAEVQAL IKKKELLPQVQL-VKNHC--RNPDGDM--------------------------------- -EGPWCYIKA------------------------------------ASGNITID------ ----------YCDLEL--CDAPLDKF-----------VEEGG---GRERTTL-DQRKAFF NPRSF---GNGEL----------------------------DCGERPL--FEKINKADKN EKELLM----------SYTGSRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISDEWI LTAAHCILYPPWNKNFTINDIIVRLGKHSRT------KYERGIEKI-VAIDEIIVHPKYN -WKENLNRDIALLHMKKPVV-FTSEIHPVCLPTKSIAKNL-MFAGYKGRVTGWGNLRESW TSNPTNL-PTVLQQIHLPIVDQSICRNSTS---VIITDNMFCA--------GYQPDDSKR GDACEGDSGGPFVMKSP-----SDNRWYQIGIVSWGEGCDRDGKYGFYTHLFRMRRWMKK VIEKTDSGDDE----- >XP_001165233.2 prothrombin isoform X1 [Pan troglodytes] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LQLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCSLVHSQH----------------------------- ------------------------VFLAPQQARSLL-----------------------Q RVR--------------------------------------------------------- --------------RANT-FL---EEVRKGNLER-------------------------- ------------------EC-----------VEETCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWA----------KYTACET----------- --------ARTPRDK---------LAAC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGTNYRGHVNITRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDSSTTGPWCYTTDPTVRRQECSIPVCG-QDQVTVAMTPRSEGSSVNL S----PPSEQCVPDRGQ--QYQGRLAVTTHGLPCLAW---------------ASAQAKAL SKHQDFNSAVQL-VENFC--RNPDGDE--------------------------------- -EGVWCYVA--------------------------------------GKPGDFG------ ----------YCDLNY--CEEAVEEETGD-GLDE---DPDRA---IEGRTAT-SEYQPFF NPRTF---GSGEA----------------------------DCGLRPL--FEKKSLEDKT ERELLE----------SYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDRETAASL-LQAGYKGRVTGWGNLKETW TANVGKGQPSVLQVVNLPIVERPVCKDSTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDQFGE--------- >XP_002709128.1 PREDICTED: prothrombin [Oryctolagus cuniculus] ------------------------------------------------------------ ----------------------------MEHVPG-------------------------- ------------------------------------------------------------ ------------------------------------------------LRLAG------- ------------------------------------------------------------ ----------CLAAAA-------------------------------------------- ----------------------LVSLVCSQQ----------------------------- ------------------------VFLAPQRAMSLL-----------------------Q RAR--------------------------------------------------------- --------------RANTGFL---EEMRKGNLER-------------------------- ------------------EC-----------YEEVCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------SSAT-------EAFWA----------KYTACEP----------- --------VRTPREN---------FTNC--MEG--------------------------- ----------------------------------------------HC------------ --AQGLGTNYRGQVSVTQSGIECQL-WRSRYPHN---------------PEINFTTHPEA DL-KENF--CRNPDGSTTGPWCYTRDPSVRREECSVPDCS-QGQVTLELRPRTGHSGVTQ P----PPLEPCVSERGR--HYQGRLAVTKQGTPCLAW---------------SSPEAQAL SRGKSFSPQVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GRPSSFE------ ----------YCGLNY--CEEAIEEEVL---------GLEEA---IEGRTTE-QEFQTFF NQETF---GTGEA----------------------------DCGLRPL--FEKKSLKDER EEELLE----------SYIHGRIVGGRDAQIGSAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTVNDILVRIGKYARS------RYERNMEKI-STLEKIIIHPGYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDKQIVTSL-LQAGHKGRVTGWGNLKEMW TVNMNEVQPSVLQMVNLPLVERPICKASTR---IRVTDNMFCA--------GYKPEEGKR GDACEGDSGGPFVMKNP-----YNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRK MVDRFG---------- >NP_001116457.1 prothrombin precursor [Sus scrofa] ------------------------------------------------------------ ----------------------------MAHVGG-------------------------- ------------------------------------------------------------ ------------------------------------------------LWLHG------- ------------------------------------------------------------ ----------CLALAV-------------------------------------------- ----------------------LVSLVHSQH----------------------------- ------------------------VFMAPQQALSLL-----------------------Q RAR--------------------------------------------------------- --------------RANSGFF---EEMRKGNLER-------------------------- ------------------EC-----------VEEQCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAYEALE S----------------------------------------------------------- ----------------PSET-------DAFWA----------KYTACES----------- --------VRKSREK---------LVEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGMNYRGNISVTRSGIECQL-WRSRYPHK---------------PEVNSTMYPGA DL-RENF--CRNPDGSITGPWCYTTSPTVRREACSIPVCG-QGRVTAELIPRSGGSTVNV S----PPLETCVPERGR--QYQGRLAVTSHGSPCLAW---------------GSSQAKAL SKDQDFNPAVPL-VENFC--RNPDGDQ--------------------------------- -EGAWCYVA--------------------------------------GQPGDFE------ ----------YCDLDY--CEEPVDEEVGD-ALGE---NADAA---IEGRTTA-DDFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKSSLEDKT EKELFE----------SYIEGRIVEGSDAEIGLAPWQVMIFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALLKLRKPIT-FSDYIHPVCLPDKETATKL-LRAGYKGRVTGWGNLKETW TTSASEVQPSVLQVVNLPIVERLVCKASTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWMQK VIDRFGG--------- >NP_001126851.1 prothrombin precursor [Pongo abelii] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LQLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCTLVHSQH----------------------------- ------------------------VFLAPQQALSLL-----------------------Q RVR--------------------------------------------------------- --------------RANSVFL---EEVRKGNLER-------------------------- ------------------EC-----------VEETCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWA----------KYTACET----------- --------ARTPRDK---------LAAC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGTNYRGHLNITQSGIQCQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDSSTTGPWCYTTDPTVRRQECSIPVCG-QDQVTVAMTPRSEGSGVNL S----PPSEQCVPDRGQ--QYQGRLAVTTHGLPCLAW---------------ASAQAKAL SKHQDFNSAVQL-VENFC--RNPDGDE--------------------------------- -EGVWCYVA--------------------------------------GKPGDFG------ ----------YCDLNY--CEEAMEEETGG-GLDE---DPDRA---IEGRTAT-SEYQTFF DPRTF---GSGEA----------------------------DCGLRPL--FEKKSLEDKT ERELLE----------SYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGATLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDRETAASL-LQAGYKGRVTGWGNLKETW TANVGKVQPSVLQVVNLPIVERPVCKDSTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNCWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDQFGE--------- >NP_001159667.1 prothrombin precursor [Ovis aries] ------------------------------------------------------------ ----------------------------MARVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------PRLPS------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LFSLAHSQH----------------------------- ------------------------VFLAHQQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANKGFL---EELRKGNLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------PSAT-------DVFWA----------KYTACES----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNMSVTRSGIECQL-WRSRYPHK---------------PEINFTTHPGA DL-RENF--CRNPDGSITGPWCYTTSPTLRREACSVPVCG-QDRVTVEVIPRSGGSTTSQ S----PGLEMCVPDRGR--GYQGRLAVTTRGSPCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGARCYVA--------------------------------------GQPGDFE------ ----------YCDLDY--CGEPVDGDLGD-GLGE---DPDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKKLQDKT EAELFE----------SYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKSFTEADLLVRIGKHSRT------RYERKVEKI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSEYIHPVCLPDKETAAKL-LRVGFKGRVTGWGNRRETW TTSVAEVQPSVLQVVNLPLVERPVCKDSTR---IRITENMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----SNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQK VIDRFGS--------- >XP_003639742.1 prothrombin [Canis lupus familiaris] ------------------------------------------------------------ ----------------------------MAHIRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LWLPG------- ------------------------------------------------------------ ----------CLVI---------------------------------------------- ----------------------LFSLAHSQH----------------------------- ------------------------VFLDPQQALSLL-----------------------H RVR--------------------------------------------------------- --------------RANSGFL---EELRKGNLER-------------------------- ------------------EC-----------VEEQCNYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWS----------KYTACEP----------- --------VRKPREK---------LVEC--LEG--------------------------- ----------------------------------------------SC------------ --AEGLGMNYRGNVSFTRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDGSTTGPWCYTIDPTVRREECSISLCGQQGGVTVPLTPRSGGPTVNL S----PPSEHCIPERGR--YYQGRLAVTTHGSPCLAW---------------ASRQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVS--------------------------------------EEPGGFE------ ----------YCDLDY--CEEPVE-EVGD-GLAE---DQDTA---IEGRTTA-EEFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKRSVKDKT EGELLE----------SYIDGRIVEGWDAEIGLAPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERSIEKI-SMLEKIYIHPRYN -WRENLDRDIALLKLKKPVN-FSNYIHPVCLPDRDTATRL-LQAGYKGRVTGWGNLRETW TSSIGEVQPRVLQVVNLPIVDRQVCKASTR---IRITDNMFCA--------GYKPNEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIEKSGG--------- >XP_003815248.1 prothrombin [Pan paniscus] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LQLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCSLVHSQH----------------------------- ------------------------VFLAPQQARSLL-----------------------Q RVR--------------------------------------------------------- --------------RANT-FL---EEVRKGNLER-------------------------- ------------------EC-----------VEETCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWA----------KYTACET----------- --------ARTPRDK---------LAAC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGTNYRGHVNITRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDSSTTGPWCYTTDPTVRRQECSIPVCG-QDQVTVAMTPRSEGSSVNL S----PPSEQCVPDRGQ--QYQGRLAVTTHGLPCLAW---------------ASAQAKAL SKHQDFNSAVQL-VENFC--RNPDGDE--------------------------------- -EGVWCYVA--------------------------------------GKPGDFG------ ----------YCDLNY--CEEAVEEETGD-GLDE---DPDRA---IEGRTAT-SEYQPFF NPRTF---GSGEA----------------------------DCGLRPL--FEKKSLEDKT ERELLE----------SYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDRETAASL-LQAGYKGRVTGWGNLKETW TANVGKGQPSVLQVVNLPIVERPVCKDSTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDQFGE--------- >XP_003993267.1 prothrombin [Felis catus] ------------------------------------------------------------ ----------------------------MAHIRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LWLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCSLVHSQH----------------------------- ------------------------VFLAPQQALSLL-----------------------Q RVR--------------------------------------------------------- --------------RANSGFL---EEVRKGNLER-------------------------- ------------------EC-----------VEELCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------SFAT-------DVFWA----------KYTACES----------- --------VRKPRDK---------LMEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGMNYRGNVNFTRSGIECQL-WRSRYPHK---------------PEINYTTHPGA DL-KENF--CRNPDGSTTGPWCYTTDPTVRREECSIPICG-QGGVTVQPTPRSRNSTVNL P----PPSDSCIPERGR--YYHGRLAVTTHGSPCLAW---------------DSSQAKAL SENQDFNPLVPL-EKNFC--RNPDGDE--------------------------------- -EGVWCYVS--------------------------------------GGPGDFE------ ----------YCNLDY--CEEPFE-DVSD-GLAE---DPEAP---IEGRTTA-EEFQTFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKSLKDKT EEELLD----------SYIDGRIVKGWDAEIGIAPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERSIEKI-SMLEKIYIHPRYN -WRENLDRDIALLKLKKPIA-FSSYIHPVCLPDKATVARL-IQTGYKGRVTGWGNLKETW TTSVGEVQPSVLQVVNLPLVEQPVCRASTR---IRITDNMFCA--------GYKPNEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRK VIDQSGS--------- >XP_004051078.1 prothrombin [Gorilla gorilla gorilla] ------------------------------------------------------------ ----------------------------MAHVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------LQLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LCSLVHSQH----------------------------- ------------------------VFLAPQQARSLL-----------------------Q RVR--------------------------------------------------------- --------------RANT-FL---EEVRKGNLER-------------------------- ------------------EC-----------MEETCSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------STAT-------DVFWA----------KYTACET----------- --------ARTPRDK---------LAAC--LEG--------------------------- ----------------------------------------------NC------------ --AEGLGTNYRGHVNITRSGIECQL-WRSRYPHK---------------PEINSTTHPGA DL-QENF--CRNPDSSTTGPWCYTTDPTVRRQECSIPVCG-QDQVTVAMTPRSEGSSVNL S----PPSEQCVPDRGQ--QYQGRLAVTTHGLPCLAW---------------ASAQAKAL SKHQDFNSAVQL-VENFC--RNPDGDE--------------------------------- -EGVWCYVA--------------------------------------GKPGDFG------ ----------YCDLNY--CEEAVEEETGD-GLDE---DPDRA---IEGRTAT-SEYQTFF NPRTF---GSGEA----------------------------DCGLRPL--FEKKSLEDKT ERELLE----------SYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWV LTAAHCLLYPPWDKNFTENDLLVRIGKHSRT------RYERNIEKI-SMLEKIYIHPRYN -WRENLDRDIALMKLKKPVA-FSDYIHPVCLPDRETAASL-LQAGYKGRVTGWGNLKETW TANVGKGQPSVLQVVNLPIVERPVCKDSTR---IRITDNMFCA--------GYKPDEGKR GDACEGDSGGPFVMKSP-----FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK VIDQFGE--------- >XP_005502232.1 prothrombin [Columba livia] ------------------------------------------------------------ ----------------------------MAHNKT-------------------------- ------------------------------------------------------------ ------------------------------------------------GVLRG------- ------------------------------------------------------------ ----------LLLSS--------------------------------------------- ----------------------LLHLTLGHAG---------------------------- ------------------------VFLEKGQALSLL-----------------------K RPR--------------------------------------------------------- --------------RANKGFL---EEMLKGNLER-------------------------- ------------------EC-----------LEETCNYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------TVQT-------EAFWS----------KYQVCQD----------- --------IRKSRTA---------LDAC--LEG--------------------------- ----------------------------------------------NC------------ --SLGLGENYRGTISYTKSGIECQV-WTSKYPHI---------------PKYNATIYP-- NL-IENY--CRNPDNNSQGPWCYTRDPTVEREECPIPVCG-EERTTVEFTPRVTPSAP-- -------VEPCEQEKGM--LYTGTLSVTVSGAKCLPW---------------NSEKAKEV LHGKHIDPEVKL-LENYC--RNPDGDD--------------------------------- -EGVWCVTD--------------------------------------EAPH-FE------ ----------YCDLQY--CDSSLEDGN----------EPSEG---ISGRTTLPQEFKTFF DDQTF---GSGEA----------------------------DCGTRPL--FEKKKITDKS EKELLE----------SYIGGRVVHGDDAEVGSSPWQVMLYKKSPQELLCGASLISDSWV LTAAHCLYYPPWDKNLTTNDILVRIGKHMRA------KYEKNKERI-ALLDKIIIHPKYN -WKENMDRDIALMHLKRPVI-FSDYIHPVCLPTKEVVQRL-MLAGYKGRVTGWGNLKETW ATSPSNL-PTVLQQLNVPIVDQDTCKASTK---VKVTDNMFCA--------GYSPEDSKR GDACEGDSGGPFVMKNP-----DDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRK VIEKHGR--------- >XP_017914625.1 PREDICTED: prothrombin [Capra hircus] ------------------------------------------------------------ ----------------------------MARVRG-------------------------- ------------------------------------------------------------ ------------------------------------------------PRLPG------- ------------------------------------------------------------ ----------CLALAA-------------------------------------------- ----------------------LFSLAHSQH----------------------------- ------------------------VFLAHQQASSLL-----------------------Q RAR--------------------------------------------------------- --------------RANKGFL---EELRKGNLER-------------------------- ------------------EC-----------LEEPCSRE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAFEALE S----------------------------------------------------------- ----------------PGAT-------DVFWA----------KYTACQS----------- --------ARNPREK---------LNEC--LEG--------------------------- ----------------------------------------------NC------------ --AEGVGMNYRGNVSVTRSGIECQL-WRSRYPHK---------------PEINFTTHPGA DL-QENF--CRNPDGSITGPWCYTTSPTLRREACSVPVCG-QDRVTVEVIPRLGGSTTSQ S----PGLEMCVPDRGR--EYQGRLAVTTHGSPCLAW---------------SSEQAKAL SKDQDFNPAVPL-VENFC--RNPDGDE--------------------------------- -EGAWCYVA--------------------------------------GQPGDFE------ ----------YCDLDY--CGEPVDGDLGD-GLGE---DPDAA---IEGRTSE-DHFQPFF NEKTF---GAGEA----------------------------DCGLRPL--FEKKKLQDKT ETELFE----------SYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLLSDRWV LTAAHCLLYPPWDKNFTEADLLVRIGKHSRT------RYERKIEKI-SMLDKIYIHPRYN -WKENLDRDIALLKLKRPIE-FSEYIHPVCLPDKETAAKL-LRVGFKGRVTGWGNRRETW TTSVAEVQPSVLQVVNLPLVERPVCKDSTR---IRITENMFCA--------GYKPGEGKR GDACEGDSGGPFVMKSP-----SNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQK VIDRFGS--------- >XP_006261451.1 PREDICTED: prothrombin [Alligator mississippiensis] ------------------------------------------------------------ ----------------------------MGNSRG-------------------------- ------------------------------------------------------------ ------------------------------------------------SMLGS------- ------------------------------------------------------------ ----------LLLLC--------------------------------------------- ----------------------LLHLVLSQDG---------------------------- ------------------------VFLEQQEAFSML-----------------------K RSR--------------------------------------------------------- --------------RANKNLL---EEMLPGNLER-------------------------- ------------------EC-----------IEEICSYE--------------------- ------------------------------------------------------------ -----------------------------------------------------EAYEALE S----------------------------------------------------------- ----------------TTLA-------TEFWR----------KYKVCNS----------- --------QRTNRAT---------LDDC--LKG--------------------------- ----------------------------------------------DC------------ --ALETGENYVGKINITKSGIECQL-WRSKYPHR---------------PEFNLTVYGNV SL-TDNY--CRNPDNNPKGPWCYTQDPTVRREACSIPVCG-QDATTVPFNPRSHPPSP-- -----RTKQPCEEKRGL--YYTGNLSVTKSGTKCLPW---------------NSEKAKEI LQGKTVIPEVVL-VENYC--RNPDGDE--------------------------------- -EGVWCVTH--------------------------------------EEPHNFN------ ----------YCDLDY--CDSPLDDVG----------DEVAV---SIGRTSV-PEYKPFF DPQTF---GSGEA----------------------------ECGIRPL--FEKQKIADKT EKELLE----------SYIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWI LTAAHCLFYPPWDKNFTTDDLLVRIGKHYRA------KYERNQEKI-VLLDKIIIHPKYN -WKENLDRDIALMHLKKPVA-FSNFIHPICLPTKEIVQRL-MLEGYKGRVSGWGNLFETW SSTPASL-PSVLQQVNLPLVDQQNCRASTK---IKVTDNMFCA--------GYSPEDAKR GDACEGDSGGPFVMKNP------DDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQK TIDKHGR---------
BMGE Cleaned alignment of selected proteins >NP_000497.1 prothrombin preproprotein [Homo sapiens] LQLPGCLALAALCSLVHSQHQARSLLRANT-FLEEVRKGNLERVEETCSYEEAFEALESDVFWAKYTACETAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRRQECSIPVCGTPRSEGSQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEIEGRTAYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_038061951.1 mannan-binding lectin serine protease 1-like isoform X2 [Patiria miniata] -----VLVFLAVTNVAFSIDQASGVK-------TDVSDGSVTLKYRIADNDMQYEIAAE-----NYETRHT-EEVGPTTQPLVVITPCGAPSQVNAVVWPQN-------GTGKVL-----GRDDPDCSPSSYIVEFRQLSLGQCETSLAGSTQPHSTYTVTSRNRYGISQAWRHNVTTNEEVPSAAPTGLQ------------KYVDGTKRVSWDPVPHRGGIITYILLDVTTDQVSPESRAL--------RYVAANTAVGRGP--YAAFSVDAQPKILDIRDIVQKISTGTDARKGSAPWLAQLWYVDKGTLFCHGSILDNRWILTAAHCIRA----RNATKNDIMIRLGDHDKSLPE-MEEQVRVEDIKVHRSFS-TKLFDADVALVKLTQAIQFTDYVKPICLPVKPLSKSMLRPGTYGTVSGWGKVSSHDE----PRHLKRVTLPVQDQVVCRRSTHFEVTPNMFCAGYS--AANRGDSCEGDSGAPFAVQHMTDRWYILGVVSWGEGCDRKDKYGFYVRLHRYTAWIRKQTGIKLS >XP_039266936.1 plasminogen-like [Styela clava] -----FLIFFA---------TSEGATRSCVGGLEYGCPGRWYEVETY----NCFAVISTTTTVTTTTTPPPKPDEPGSYRGTVYRTISGYTCQRWDSQLPHPHNYSPDKHPGAGLCRNPDMDVKPWCFTTNPNKQWEYCEVVICTST-----DCYNSSNPSYTGTMSTTTTGLTCQYWNSSSPHKNLFPRDQYESVHLDHNYCRNPDNDT--PWCFTVDPTKNWEYCDVPMCSDTENKPHSTSFAPMFAD--FNHHRASLFGRAILE--GVPEVHETEDLE-----NIIGGFEVTPGSIPWQASIRRTYFGSHFCGGALINVRWIVTAAHCITQP-----QNPTSYFALLGDHNQY--DENENQIDFDVIFRHHAYS-SVTLNNDIALMKTTRPVHMNSFVSAICLPSTGLTES----EYTGIVSGWGTMQNTGS----NELLHQASVPLIEDSSCKRLMS-DIMEGMMCAGYE--DGGK-GSCQGDSGGPLVVKMEDGGFKLVGIVSWGYGCAAENKPVVYTKVSHHIGWINYIVNT--- >XP_030855970.1 low-density lipoprotein receptor-related protein 5-like [Strongylocentrotus purpuratus] KVLRPRLYFADFFEVTLYKDETGEAVRSYNGGCQQLCLNSYEQHSDLVDHDISFDPVERIMFWSSYMDGDMAIGRSCACADGVDLAQDGLTCVSLDIQCPLDSTCSVICYSGLVPCQN----SGSWDIPRSAICREEQC------AIFSGPCECEPGYVRTSGKPRRVCAHGGEWLGTCSSELAFQETPEDYSPVQDDVQQSCNSPQADIQGHYACVAPANASLDIDSVTWDGSRVHISGGSLNLVRQDSGKYVSDQRDTMNPPTITEVCGTVTSPEATMFGPRDGRVVGGQQSLPGSAPYMGRIWHKADRTFVCGATLLNQRWVITAAHCIVL----YQLQFRDILLYFGDHDTLTSE-DHQVIEVDQIIQHEDFD-EESFDKDIALIRLKQPFAFTDYIRPICIPPAWLAKMLLQPDMMGRVTGWGQIAEGGP----PRYLTEVDLPVVKSKKCKDATTFEVTRYMFCAGYASAEEKK-DACQGDSGGPFAMLHE-NRWYQLGIVSWGEGCARDSKYGYYTKILRLHSWIDRNISD--- >XP_031563420.1 uncharacterized protein LOC116298966 isoform X2 [Actinia tenebrosa] SVLRGYLVLFHVIGLFLDKNDAFGVHRSQLSWSQLMKDGNFRLQQNTCDSDIAYDPKEKQMYWTSLEDGTTVGGDKAKHPFSIGILNNRLFWSDWEKEGVQS----VDKQTGKDYLENP---KGMFLFMT------ESQPLNTCPNRFPAPGTCNPGYTLPINRQCKRTGKWSRKV--TECVAPPFLTATPINTTVD-------------EGKAAVLR--SSSIDPIQVQWNGSPLAAFTGHLLTRYSDRGLYAQNKGKVSATA-----HLKVRGSVKLKEFNTRARIIGGRRADRGAHPWQVMLWNKLDKRHFCGGTLITDRWLVTAAHCVHA----KLLFPSNIKIRLGKHVRTRTE-RNEQSNADMIKIHPNYNMDRTYDSDIALVRTSKKVIFTDYIQPICLPTKEQDFQLMRVNTSGVISGWGSRKVFRD----ARRLYEAGVPIVSTSACKASHPYIITPNMFCAGQK--NSSLGDACQGDSGGPFSVNSPVKRHVLLGVISWGDGCGHYGKYGVYTRVTNFVDWIMNEID---- >XP_016769420.1 trypsin-1 [Apis mellifera] -----CLAVIV------------AVV------------------------------------------------------------------------------------------------------------------------------NCEE----------VQSSVIKEGINLNATQYNATINDDK---------NFW---------DWILAG-------------------SPSDST---------------ENPKPG----------TPEECLPTNVQRRIVGGVETQVNQYPWMVLLMYR--GRFYCGGSVISSFYVVTAAHCVDR------FDPKLISVRILEHDRNSTTEAKTQERVDKVIKHSGYS-TYNYNNDIALIKLKDAIRFEGKMRPVCLPERAKTFA----GLNGTVTGWGATAESGA----SQTLQEVTVPILSNADCRASKYQRITDNMLCAGYK--EGSK-DSCQGDSGGPLHVVNV-DTYQIVGIVSWGEGCARPGYPGVYTRVNRYLSWISRNTEDSCY >CAE1319957.1 F2 [Sepia pharaonis] -----HLWLECIIDTKGVKLQCVYII-------EETVTLTFHKYVKIKDGEAAADVLDK-------------RSLRLDFVTDVGVSFMGFSATYTFSNCPLR------CYNGGTCCKCSYGYQGPQCQY------HKSCKDKPCERI-----HCTTQYTGCERKKYEVKLTGRERVQRDNVEFKCFLNGKAARNAKWFNENRLQVHTNDREGDYLCAVARNITVSGVKVSWNGHPIRAAGRTLSVISVDEGKYAVGPNGCSAKA---DVWLTYERKDIPQEHGLLAKIKSGHRAALGSAPWFVNFVEAAVTKSFCGGTLISRTHIVTAAHCIKL--FKGPFDNANVHVYLGTQNCS----GLGGIQIKKVTVHPRYNQSSLFDSDIAIVELQEKLYFNKIIQPLCLVDSAVVEEVFYSGVFGTVVGCGMTSTGYH----PHHLNEVKVPYVSNESCRSTLHHNITSKMFCAGSI--QAHQGDSCQGDSGGPYAVQLPSSRWILVGIVSWGYKCDQSDSYGVYTNVGQFFDWITRIMSEP-- >NP_989936.1 prothrombin precursor [Gallus gallus] TMLQGLLLFG-LLHLTLSHDQALSLLRANKGFLEEMIKGNLERLEETCNYEEAFEALESDAFWAKYQVCQGAANLGQNYRGTINYTKSGIECQVWTSKYPHIPKFNASIYP--DLCRNPDNNEGPWCYTRDPTVEREECPIPVCGTPRVKPSPCESEKGMLYTGTLSVTVSGARCLPWASEKAKALLQDKTINPEVKLLENYCRNPDADDEGVWCVIDEPPY-FEYCDLHYCDSSLEIAGRTIFKTFFDEKTFGEGEADCGTRPLFEKKQITDQSEKELMDSYMGGRVVHGNDAEVGSAPWQVMLYKKSPQELLCGASLISNSWILTAAHCLLYPPWDKNLTTNDILVRMGLHFRAKYERNKEKILLDKVIIHPKYNWKENMDRDIALLHLKRPVIFSDYIHPVCLPTKELVQRLMLAGFKGRVTGWGNLKETWAENL-PTVLQQLNLPIVDQNTCKASTRVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFVMKNPDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKTIEKQG- >XP_023818208.1 prothrombin [Oryzias latipes] LRTSAVVLLL-ILHNCAANHQASQVLRANQMF-EELKPGNLERFEEICDHEEAREVFEQEIFWAKYLDCEGVSGNGHNYNGNIHITKSGRVCQHWSHSFPHPREFNAS-EPNSILCRNPDKREGPWCFTKDPSVQKETCRVPKCGAPEVVK-ICLPNYGVDYTGDLSVTLGGHTCIQWSSPQAKALSKDKEFIPEVQLTGNKCRNPDNDPEGPWCYVHSGNITVDYCDLDLCEDPLLGRERSVKKLFFNPRTFGEGESSCGLRPLFELKSKKDAKEQELLDSYREQRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWIVTAAHCVLYPPWNKNLTTEDILVRLGKHNRAKFERGVEKIAIDEIIVHPKYDWKQNLNRDVALLHLRRPITFSDEIYPICLPNKQVARNLMMQGYKGRVTGWGNLKESWNRNL-PTVLQQIHLPIVDQEICRQSTSVRVTDNMFCAGFKPDDSQRGDACEGDSGGPFVMKHPENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMGRWIKKVIEKSGG >XP_030265053.1 prothrombin [Sparus aurata] LKPASVLLLF-LLHGCLAQNVAAQVLRANQLF-EEVKPGNLERVEEICDHEEAREVFEQETFWGKYLDCKGISGTGVSYAGNVNITESGIQCQHWSSSFPHPREFNAS-EPDSILCRNPDNQDGPWCYTKNPVIVKQKCRVPKCGAPEPVR-ECLPNYGIDYVGDLAVTLGGHTCLLWSSPEAKALSQDKEFIPEVGLPGNKCRNPDNDPEGPWCYVRNGNVTVDYCDLHLCEDSLVGTERSVKKLFFSPRSFGQGEANCGKRPLFEQKAIKDKKEDELLASYRESRIVGGDDAEVASAPWQVMLYKRSPQELLCGASLISDQWILTAAHCILYPPWNKNFTKDDILVRLGKHMRAKFERDTEKIAIDEIIVHPKYNWKENLNRDIALLHMRRPVTFTDEIYPVCLPSKKVARTMLTEGFKGRVTGWGNLKETWNRNL-PAVLQQIHLPIVDEQICRTSTSVRITDNMFCAGYKPEDAKRGDACEGDSGGPFVMKYPEERWYQMGIVSWGEGCDRDGKYGFYTHVFRMARWMRKVITKSGS >OCT83731.1 hypothetical protein XELAEV_18021869mg [Xenopus laevis] ----------------------MTVLRANSGF-EEFRQGNFERIEEICSYEELREIKESNSFWTKYKDCEPAEGTGTHYRGNVSVTRSGKECQF-------SPDINP------SLCRNPNNNTGPWCYTTDPQKQWEECVISVCGLLIKQDQPCETDFGLNYEGKLAKTISGLPCLPWDSPSVQKFSR-KDFMPEIKLQENYCRNPDNDGEGLWCFVSHPNMTYDYCNVNYCDSPIDPAGRTTHQTFFDEKTFGSGEAVCGLRPLFEQKSVEDKGEKELMESYMQGRIVKGENAEPGSAPWQVMLFKKSPQELLCGASLLSDRWVLTAAHCIFYPPWDKNYTTDDILVRIGKHYRTKYERATERIQLERIIVHPKYNWKENLDRDIALIQLKRPVALSNYIHPVCLPTKDAVVKLLAAGYKGRVTGWGNLQETWSQNL-PQALQQINLPIVDQETCKSSTKIKITDNMFCAGYSPEDSKRGDACEGDSGGPFVMKDPTGRWVQLGIVSWGEGCDRDGKYGFYVHVHRLRKWLMKTIEKFGS >NP_611611.1 tracheal-prostasin [Drosophila melanogaster] -----CLLICL---------------------------------------------------------------------------------------------------------------------------------------------SCGP----------SQSASQDRAT--NQTAASPLLKQSQ--------NTFI---------QWVLSLQRPGSSDATLATLSSSSMMAPSSST----------TTRRATTPAPP-------TLNPPRNCSDANIQKRIVGGQETEVHQYPWVAMLLYG--GRFYCAASLLNDQFLLTASHCVYG------FRKERISVRLLEHDRKMSH--MQKIKVAEVITHPKYN-ARNYDNDIAIIKLDEPVEFNEVLHPVCMPTPGRSFK----GENGIVTGWGALKVGGP----SDTLQEVQVPILSQDECRKSRYNKITDNMLCGGYD--EGGK-DSCQGDSGGPLHIVASTREHQIAGVVSWGEGCAKAGYPGVYARVNRYGTWIKNLTKQACL >NP_494910.2 Peptidase S1 domain-containing protein [Caenorhabditis elegans] -----FLLLVG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VINKVS-----DNKNDVIEKVGCGLHSTNVELAQTRSAQEPADYVTLDHRLIGGSESSPHSWPWTVQLLSRL-GHHRCGGSLIDPNFVLTAAHCFA-----KDRRPTSYSVRVGGHRSG-----SGSPRVTAVSIHPWYNIGFPSSYDFAIMRIHPPVNTSTTARPICLPSLPAVENRLC-----VVTGWGSTIEGSS----APTLREIHVPLLSTLFCSSLPNRIHLPSMLCAGYS--YGKI-DSCQGDSGGPLMCARD-GHWELTGVVSWGIGCARPGMPGVYGNVHSASTWINLEMNRLRI >KAB0371250.1 hypothetical protein FD755_017659 [Muntiacus reevesi] PWLPGCLALAALLSLVHGQHQASSLLRANRGFLEELRKGDLERLEELCSREEAFEALESDVFWAKYTACESAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSTGPWCYTTSPTLRREECSIPVCGIPRSGGSTCIPDRGRQYRGRLAVTTHGSRCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVEKIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF-- >XP_043337793.1 prothrombin [Cervus canadensis] RRLPGCLALAALLSLVHGQHQASSLLRANRGFLEELRKGDLERLEEPCSREEAFEALESDVFWAKYTACESAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSPGPWCYTTSPTLRKEECSIPVCGIPRSGGSTCIPDRGRQYRGRLAVTTHGSRCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF-- >KAB0349345.1 hypothetical protein FD754_014202 [Muntiacus muntjak] PRLPGCLALAALLSLVHGQHQASSLLRANRGFLEELRKGDLERLEELCSREEAFEALESDVFWAKYTACESAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSTGPWCYTTSPTLRREECSIPVCGIPRSGGSTCIPDRGRQYRGRLAVTTHGSRCLTWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF-- >XP_003206466.1 prothrombin [Meleagris gallopavo] TMLQGLLLFS-LLHPILSHDQALSLLRANKGFLEEMIKGNLERLEETCNYEEAFEALESDAFWAKYQVCQGAVNLGQNYRGTINYTKSGIECQVWTSKYPHIPKFNASNYP--DLCRNPDNNEGPWCYTRDPTVEREECPIPVCGTPRVTPSPCESEKGMLYTGTLSVTVSGATCLPWASEKAKAVLQGKTINPEVKLQENYCRNPDADDEGVWCVIDEPPY-FEYCDLHYCDSSLEISGRTVFKTFFDEKTFGEGEADCGTRPLFEKKQITDQSEKELLDSYMGGRVVHGNDAEVGSSPWQVMLYKKSPQELLCGASLISNSWVLTAAHCLLYPPWEKNLTTNDILVRIGKHFRAKYEKNKEKILLDKIIIHPKYNWKENMDRDIALLHLKRPVIFSDYIHPVCLPTKELVQRLMLAGFKGRVTGWGNLKETWAENL-PTVLQQLNLPIVDQNTCKASTRVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFVMKNPDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKTIEKQG- >XP_025063735.1 prothrombin isoform X1 [Alligator sinensis] SMLGSLLLLC-LLHLVLSQDEAFSMLRANKNLLEEMLPGNLERIEEICSYEEAYEALESTEFWRKYKVCNSALETGENYVGKINITKSGIECQLWRSKYPHRPEFNLTIYGNVSLCRNPDNNKGPWCYTQDPTVRREACSIPVCGNPRSRPPPCEEKRGLCYTGNLSVTKSGTKCLPWNSEKAKEILQGKTVIPEVVLVENYCRNPDGDEEGVWCVTHEEPHNFNYCDLDYCDSPLDSIGRTSYKAFFDPQTFGSGEAECGIRPLFEKLKIADKTEKELLESYIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWILTAAHCLFYPPWDKNFTTDDLLVRIGKHYRAKYERNQEKILLDKIIIHPKYNWKENLDRDIALMHLKKPVAFSNFIHPICLPTKEIVQRLMLEGYKGRVSGWGNLFETWSASL-PSVLQQVNLPLVDQQNCRASTKIKVTDNMFCAGYSPEDAKRGDACEGDSGGPFVMKNPDDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKTIDKHGR >XP_015813395.1 PREDICTED: prothrombin [Nothobranchius furzeri] -KRAAVLLLL-VLHGYAAHDQALQVLRANHLF-EEMKPGNLERVEEICDNEEAREVFEQADFWTTYLDCKGISGNGFNYKGQVNITQSGKLCQHWKHNFPHPRYFNTS-AADSNLCRNPDKHGGPWCFTTDPTVQRETCRVPKCGAPERTRATCLTSYGVDYTGDKSETMNGHTCLSWSSPEVVALSKDKEFIPEVTLPGSKCRNPDNDPEGPWCFVDSGNITVDYCDLELCEDPLTGTERSVKKLFFSPRSFGQGESVCGVRPLFEQVSRVDNGEKEMLESYREQRIVGGDSAEVASAPWQVMLYKRSPQELLCGASLLSDQWILTAAHCILYPPWNKNFTINDILVRLGKHNRAKFERGIEKIAIDEIIIHPKYNWKENLNRDVALLHMKRPVTFSNEIHPVCLPSKQVARTLMTNGFKGRVTGWGNLQETWNRNL-PTVLQQIHLPIVDQEICRQSTSVRITDNMFCAGYKPEESQRGDACEGDSGGPFVMKYPENRWYQIGIVSWGEGCDRDGKYGFYTHLFRMNRWIKKVIDRTGD >XP_040184143.1 prothrombin [Rana temporaria] MIIWG-IALAFLLPPALGHNAASTVLRANTLW-EEVKAGNMERVEEICNYEEAREIKESKIFWQQYQACQPASGLGQNYRGTLSVTRSGTECQYWGSHFPHKTKVNPDTHSEKNLCRNPDDNLGPWCYTKNPEKTREECAVPVCGIPIVKQEHCEPNRGIDYEGTLAVTVSGFPCLPWDSAEVELHSR-KEFRKEAVLKGNYCRNPDGDDEGVWCYVSHPNVTFDYCALKYCDSPIDIGGRTDHQTFFDEKSFGKGESVCGQRPLFEQKKVQDKGEEELILS-MQGRVVKGEDAERGSAPWQVMIYKRQPQELLCGASLISDTWILTAAHCIFYPPWDKNFTVDDLLVRIGKHNRLKYEKPDERIQLQRIIVHQRYNWRENLDRDIALMQLKRPLLFTSYIHPVCLPTKDIVQSLFQSGYKGRVTGWGNLQENWSPKQ-PQILQQINLPIVEQERCKSSTKVKVTDNMFCAGYRPEDNKRGDACEGDSGGPFTMKDPSNRWYQMGIVSWGEGCDRDNKYGFYVHVHRLRKWVMKTVEQNAL >KAF4009430.1 hypothetical protein G4228_000592 [Cervus hanglu yarkandensis] RRLPGCLALAALLSLVHGQHQASSLLRANRGFLEELRKGDLERLEEPCSREEAFEALESHGVSASFLACES-------------------------------------------------------------------------GIPRSGGSTCIPDRGRQYRGRLAVTTHGSRCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLNYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWCVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVEKIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKQTAAKLLQAGFKGRVTGWGNRRETWTTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF-- >XP_020737482.1 prothrombin [Odocoileus virginianus texanus] LRLPGCLALAALLSLAHSQHQASSLLRANKGFLEELRKGDLERLEEPCSREEAFEALESDVFWAKYTACESAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSTGPWCYTTSPTLRREECSIPVCGIPRSGGSTCIPDRGRQYRGRLAVTTHGSRCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGGFEYCDLDYCGEPVDIEGRTSFQPFFNEKTFGSGEADCGLRPLFEKKKLQDQTETELFESYIEGRIVEGQDAEVGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTKDDLLVRIGKHSRTRYERKVERIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSDYIHPVCLPDKETAAKLLQAGFKGRVTGWGNRRETWTTEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRF-- >NP_034298.1 prothrombin preproprotein [Mus musculus] LGLPGCLALAALVSLVHSQHQALSLLRANSGFLEELRKGNLERVEEQCSYEEAFEALESDVFWAKYTVCDSAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRREECSVPVCGTPRSGGSQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVGIAGRTTFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKIMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTNEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG- >NP_075213.2 prothrombin precursor [Rattus norvegicus] LGLPGCLALAALASLVHSQHQALSLLRANSGFLEELRKGNLERVEEQCSYEEAFEALESDVFWAKYTVCDSAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLCRNPDSSSGPWCYTTDPTVRREECSIPVCGTPRSRGSECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPG-FEYCSLNYCDEAVGIAGRTTFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKIMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWTNEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR- >XP_005216458.2 prothrombin isoform X1 [Bos taurus] PRLPGCLALAALFSLVHSQHQASSLLRANKGFLEEVRKGNLERLEEPCSREEAFEALESDAFWAKYTACESAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSTGPWCYTTSPTLRREECSVPVCGIPRSGGSTCVPDRGREYRGRLAVTTRGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKIMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS >XP_005169022.1 prothrombin isoform X1 [Danio rerio] AKLAPLLLFLIVFHLTLCHNEASQIIRANTVF-EELKPGNLERVEEICDHEEAREVFEREIFWAKYLGCEGFINIGAKYAGKVSVTKSGKACQYWKSNFPHKDEFNVT---QLKLCRNPDKHDGPWCFTRDPTVRRETCNVPKCGAPTAKPEKCLPGNGETYTGELFVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNPDGDMEGPWCYIKSGNITIDYCDLELCDAPLDGRERTTRKAFFNPRSFGNGELDCGERPLFEKINKADKNEKELLMSYTGSRIVGGDEAEVASAPWQVMLYKRSPQELLCGASLISDEWILTAAHCILYPPWNKNFTINDIIVRLGKHSRTKYERGIEKIAIDEIIVHPKYNWKENLNRDIALLHMKKPVVFTSEIHPVCLPTKSIAKNLMFAGYKGRVTGWGNLRESWTTNL-PTVLQQIHLPIVDQSICRNSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPDNRWYQIGIVSWGEGCDRDGKYGFYTHLFRMRRWMKKVIEKTDS >XP_001165233.2 prothrombin isoform X1 [Pan troglodytes] LQLPGCLALAALCSLVHSQHQARSLLRANT-FLEEVRKGNLERVEETCSYEEAFEALESDVFWAKYTACETAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRRQECSIPVCGTPRSEGSQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEIEGRTAYQPFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_002709128.1 PREDICTED: prothrombin [Oryctolagus cuniculus] LRLAGCLAAAALVSLVCSQQRAMSLLRANTGFLEEMRKGNLERYEEVCSYEEAFEALESEAFWAKYTACEPAQGLGTNYRGQVSVTQSGIECQLWRSRYPHNPEINFTTHPEADLCRNPDGSTGPWCYTRDPSVRREECSVPDCSRPRTGHSPCVSERGRHYQGRLAVTKQGTPCLAWSSPEAQALSRGKSFSPQVPLVENFCRNPDGDEEGAWCYVAGRPSSFEYCGLNYCEEAIEIEGRTTFQTFFNQETFGTGEADCGLRPLFEKKSLKDEREEELLESYIHGRIVGGRDAQIGSAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVNDILVRIGKYARSRYERNMEKITLEKIIIHPGYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDKQIVTSLLQAGHKGRVTGWGNLKEMWTNEVQPSVLQMVNLPLVERPICKASTRIRVTDNMFCAGYKPEEGKRGDACEGDSGGPFVMKNPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKMVDRFG- >NP_001116457.1 prothrombin precursor [Sus scrofa] LWLHGCLALAVLVSLVHSQHQALSLLRANSGFFEEMRKGNLERVEEQCSREEAYEALESDAFWAKYTACESAEGLGMNYRGNISVTRSGIECQLWRSRYPHKPEVNSTMYPGADLCRNPDGSTGPWCYTTSPTVRREACSIPVCGIPRSGGSTCVPERGRQYQGRLAVTSHGSPCLAWGSSQAKALSKDQDFNPAVPLVENFCRNPDGDQEGAWCYVAGQPGDFEYCDLDYCEEPVDIEGRTTFQPFFNEKTFGAGEADCGLRPLFEKSSLEDKTEKELFESYIEGRIVEGSDAEIGLAPWQVMIFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALLKLRKPITFSDYIHPVCLPDKETATKLLRAGYKGRVTGWGNLKETWTSEVQPSVLQVVNLPIVERLVCKASTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWMQKVIDRFGG >NP_001126851.1 prothrombin precursor [Pongo abelii] LQLPGCLALAALCTLVHSQHQALSLLRANSVFLEEVRKGNLERVEETCSYEEAFEALESDVFWAKYTACETAEGLGTNYRGHLNITQSGIQCQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRRQECSIPVCGTPRSEGSQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAMEIEGRTAYQTFFDPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGATLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTGKVQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNCWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >NP_001159667.1 prothrombin precursor [Ovis aries] PRLPSCLALAALFSLAHSQHQASSLLRANKGFLEELRKGNLERLEEPCSREEAFEALESDVFWAKYTACESAEGVGMNYRGNMSVTRSGIECQLWRSRYPHKPEINFTTHPGADLCRNPDGSTGPWCYTTSPTLRREACSVPVCGIPRSGGSMCVPDRGRGYQGRLAVTTRGSPCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGARCYVAGQPGDFEYCDLDYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDKTEAELFESYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKSFTEADLLVRIGKHSRTRYERKVEKIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSEYIHPVCLPDKETAAKLLRVGFKGRVTGWGNRRETWTAEVQPSVLQVVNLPLVERPVCKDSTRIRITENMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKVIDRFGS >XP_003639742.1 prothrombin [Canis lupus familiaris] LWLPGCLVI--LFSLAHSQHQALSLLRANSGFLEELRKGNLERVEEQCNYEEAFEALESDVFWSKYTACEPAEGLGMNYRGNVSFTRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDGSTGPWCYTIDPTVRREECSISLCGTPRSGGPHCIPERGRYYQGRLAVTTHGSPCLAWASRQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVSEEPGGFEYCDLDYCEEPVEIEGRTTFQPFFNEKTFGAGEADCGLRPLFEKRSVKDKTEGELLESYIDGRIVEGWDAEIGLAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERSIEKIMLEKIYIHPRYNWRENLDRDIALLKLKKPVNFSNYIHPVCLPDRDTATRLLQAGYKGRVTGWGNLRETWTGEVQPRVLQVVNLPIVDRQVCKASTRIRITDNMFCAGYKPNEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIEKSGG >XP_003815248.1 prothrombin [Pan paniscus] LQLPGCLALAALCSLVHSQHQARSLLRANT-FLEEVRKGNLERVEETCSYEEAFEALESDVFWAKYTACETAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRRQECSIPVCGTPRSEGSQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEIEGRTAYQPFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_003993267.1 prothrombin [Felis catus] LWLPGCLALAALCSLVHSQHQALSLLRANSGFLEEVRKGNLERVEELCSYEEAFEALESDVFWAKYTACESAEGLGMNYRGNVNFTRSGIECQLWRSRYPHKPEINYTTHPGADLCRNPDGSTGPWCYTTDPTVRREECSIPICGTPRSRNSSCIPERGRYYHGRLAVTTHGSPCLAWDSSQAKALSENQDFNPLVPLEKNFCRNPDGDEEGVWCYVSGGPGDFEYCNLDYCEEPFEIEGRTTFQTFFNEKTFGAGEADCGLRPLFEKKSLKDKTEEELLDSYIDGRIVKGWDAEIGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERSIEKIMLEKIYIHPRYNWRENLDRDIALLKLKKPIAFSSYIHPVCLPDKATVARLIQTGYKGRVTGWGNLKETWTGEVQPSVLQVVNLPLVEQPVCRASTRIRITDNMFCAGYKPNEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIRKVIDQSGS >XP_004051078.1 prothrombin [Gorilla gorilla gorilla] LQLPGCLALAALCSLVHSQHQARSLLRANT-FLEEVRKGNLERMEETCSYEEAFEALESDVFWAKYTACETAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLCRNPDSSTGPWCYTTDPTVRRQECSIPVCGTPRSEGSQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEIEGRTAYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE >XP_005502232.1 prothrombin [Columba livia] GVLRGLLLSS-LLHLTLGHAQALSLLRANKGFLEEMLKGNLERLEETCNYEEAFEALESEAFWSKYQVCQDSLGLGENYRGTISYTKSGIECQVWTSKYPHIPKYNATIYP--NLCRNPDNNQGPWCYTRDPTVEREECPIPVCGTPRVTPSPCEQEKGMLYTGTLSVTVSGAKCLPWNSEKAKEVLHGKHIDPEVKLLENYCRNPDGDDEGVWCVTDEAPH-FEYCDLQYCDSSLEISGRTTFKTFFDDQTFGSGEADCGTRPLFEKKKITDKSEKELLESYIGGRVVHGDDAEVGSSPWQVMLYKKSPQELLCGASLISDSWVLTAAHCLYYPPWDKNLTTNDILVRIGKHMRAKYEKNKERILLDKIIIHPKYNWKENMDRDIALMHLKRPVIFSDYIHPVCLPTKEVVQRLMLAGYKGRVTGWGNLKETWASNL-PTVLQQLNVPIVDQDTCKASTKVKVTDNMFCAGYSPEDSKRGDACEGDSGGPFVMKNPDNRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKKWMRKVIEKHGR >XP_017914625.1 PREDICTED: prothrombin [Capra hircus] PRLPGCLALAALFSLAHSQHQASSLLRANKGFLEELRKGNLERLEEPCSREEAFEALESDVFWAKYTACQSAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINFTTHPGADLCRNPDGSTGPWCYTTSPTLRREACSVPVCGIPRLGGSMCVPDRGREYQGRLAVTTHGSPCLAWSSEQAKALSKDQDFNPAVPLVENFCRNPDGDEEGAWCYVAGQPGDFEYCDLDYCGEPVDIEGRTSFQPFFNEKTFGAGEADCGLRPLFEKKKLQDKTETELFESYIEGRIVEGQDAEVGLAPWQVMLFRKSPQELLCGASLLSDRWVLTAAHCLLYPPWDKNFTEADLLVRIGKHSRTRYERKIEKIMLDKIYIHPRYNWKENLDRDIALLKLKRPIEFSEYIHPVCLPDKETAAKLLRVGFKGRVTGWGNRRETWTAEVQPSVLQVVNLPLVERPVCKDSTRIRITENMFCAGYKPGEGKRGDACEGDSGGPFVMKSPNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKVIDRFGS >XP_006261451.1 PREDICTED: prothrombin [Alligator mississippiensis] SMLGSLLLLC-LLHLVLSQDEAFSMLRANKNLLEEMLPGNLERIEEICSYEEAYEALESTEFWRKYKVCNSALETGENYVGKINITKSGIECQLWRSKYPHRPEFNLTVYGNVSLCRNPDNNKGPWCYTQDPTVRREACSIPVCGNPRSHPPPCEEKRGLYYTGNLSVTKSGTKCLPWNSEKAKEILQGKTVIPEVVLVENYCRNPDGDEEGVWCVTHEEPHNFNYCDLDYCDSPLDSIGRTSYKPFFDPQTFGSGEAECGIRPLFEKQKIADKTEKELLESYIEARVVKGEEAEVGSAPWQVMLFRKNPQELLCGASLISDRWILTAAHCLFYPPWDKNFTTDDLLVRIGKHYRAKYERNQEKILLDKIIIHPKYNWKENLDRDIALMHLKKPVAFSNFIHPICLPTKEIVQRLMLEGYKGRVSGWGNLFETWSASL-PSVLQQVNLPLVDQQNCRASTKIKVTDNMFCAGYSPEDAKRGDACEGDSGGPFVMKNPDDRWYQVGIVSWGEGCDRDGKYGFYTHVFRLKRWIQKTIDKHGR
PhyML tree of selected proteins (((XP_005169022_1_prothrombin_isoform_X1__Danio_rerio_:0.21995399,(XP_030265053_1_prothrombin__Sparus_aurata_:0.16717807,(XP_015813395_1_PREDICTED__prothrombin__Nothobranchius_furzeri_:0.16634462,XP_023818208_1_prothrombin__Oryzias_latipes_:0.14042362):0.03230916):0.17156027):0.29513233,(((XP_002709128_1_PREDICTED__prothrombin__Oryctolagus_cuniculus_:0.12785144,((((NP_001116457_1_prothrombin_precursor__Sus_scrofa_:0.0512304,((XP_005216458_2_prothrombin_isoform_X1__Bos_taurus_:0.03432162,(XP_020737482_1_prothrombin__Odocoileus_virginianus_texanus_:0.00770281,((KAF4009430_1_hypothetical_protein_G4228_000592__Cervus_hanglu_yarkandensis_:0.02354132,XP_043337793_1_prothrombin__Cervus_canadensis_:0.00000001):0.00631359,(KAB0349345_1_hypothetical_protein_FD754_014202__Muntiacus_muntjak_:0.00208582,KAB0371250_1_hypothetical_protein_FD755_017659__Muntiacus_reevesi_:0.00417523):0.00209931):0.00698272):0.01972442):0.00955629,(XP_017914625_1_PREDICTED__prothrombin__Capra_hircus_:0.00820244,NP_001159667_1_prothrombin_precursor__Ovis_aries_:0.01536819):0.02569533):0.07324646):0.02896823,(XP_003639742_1_prothrombin__Canis_lupus_familiaris_:0.07192599,XP_003993267_1_prothrombin__Felis_catus_:0.07646793):0.01875976):0.01621264,(NP_034298_1_prothrombin_preproprotein__Mus_musculus_:0.02307338,NP_075213_2_prothrombin_precursor__Rattus_norvegicus_:0.05212663):0.10785276):0.01140528,(NP_001126851_1_prothrombin_precursor__Pongo_abelii_:0.01754103,((XP_001165233_2_prothrombin_isoform_X1__Pan_troglodytes_:0.00000001,XP_003815248_1_prothrombin__Pan_paniscus_:0.00000001):0.00204392,(NP_000497_1_prothrombin_preproprotein__Homo_sapiens_:0.00000001,XP_004051078_1_prothrombin__Gorilla_gorilla_gorilla_:0.00204255):0.00000001):0.00560444):0.07524498):0.08606214):0.23047687,((XP_006261451_1_PREDICTED__prothrombin__Alligator_mississippiensis_:0.00511109,XP_025063735_1_prothrombin_isoform_X1__Alligator_sinensis_:0.00512149):0.22558915,(XP_005502232_1_prothrombin__Columba_livia_:0.05132434,(NP_989936_1_prothrombin_precursor__Gallus_gallus_:0.02913711,XP_003206466_1_prothrombin__Meleagris_gallopavo_:0.01371947):0.07417414):0.12379832):0.1406891):0.08194015,(XP_040184143_1_prothrombin__Rana_temporaria_:0.34618459,OCT83731_1_hypothetical_protein_XELAEV_18021869mg__Xenopus_laevis_:0.19268303):0.16619155):0.10229626):0.45487298,XP_039266936_1_plasminogen_like__Styela_clava_:2.33947238,((XP_038061951_1_mannan_binding_lectin_serine_protease_1_like_isoform_X2__Patiria_miniata_:2.21909766,(XP_031563420_1_uncharacterized_protein_LOC116298966_isoform_X2__Actinia_tenebrosa_:1.73835423,(NP_494910_2_Peptidase_S1_domain_containing_protein__Caenorhabditis_elegans_:2.7894711,(XP_016769420_1_trypsin_1__Apis_mellifera_:0.77773131,NP_611611_1_tracheal_prostasin__Drosophila_melanogaster_:0.83321852):0.57654815):0.77650063):0.28631634):0.10494983,(CAE1319957_1_F2__Sepia_pharaonis_:2.59599069,XP_030855970_1_low_density_lipoprotein_receptor_related_protein_5_like__Strongylocentrotus_purpuratus_:1.68926499):0.26579347):0.67401707);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)